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Director and Head Of roles at U.S. companies can qualify for EB-2 or EB-3 green card sponsorship through the PERM labor certification process. Employers document that no qualified U.S. worker is available before filing an I-140 petition, making leadership-level sponsorship a structured, permanent path to residency rather than a temporary authorization.
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Get Access To All JobsWhat if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
ABOUT PIONEERING MEDICINES
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
Position Summary
The Senior Director, Head of Toxicology will lead and build the toxicology function within Pioneering Medicines, defining and executing nonclinical safety strategies across a diverse and rapidly evolving portfolio. This role provides scientific and strategic leadership across both investigative and regulatory toxicology, supporting a broad range of therapeutic modalities.
Working in a dynamic venture creation environment, you will collaborate closely with multidisciplinary teams to optimize candidate selection, guide preclinical development, and ensure regulatory readiness. This is a high-impact role requiring strong analytical thinking, scientific rigor, and clear communication, influencing programs from discovery through early clinical development.
Key Responsibilities
Functional Leadership & Capability Building
- Lead, build, and scale the toxicology function, including internal team development and external partnerships
- Define fit-for-purpose operating models spanning investigative and regulatory toxicology
- Serve as the primary internal expert for nonclinical safety, ensuring quality, consistency, and scalability across the portfolio
Portfolio & Program Strategy
- Define and drive toxicology strategies across multiple programs and modalities
- Translate findings into clear risk assessments, mitigation strategies, and IND/CTA-enabling plans
- Enable transparent, data-driven decision-making by articulating risks, assumptions, and trade-offs to program teams
- Oversee the design, execution, and interpretation of non-GLP and GLP toxicology studies
- Partner cross-functionally (DMPK, pharmacology, CMC, clinical) to integrate safety into development strategy
- Support diligence and evaluation of new programs within Flagship's ecosystem
External Partnerships & Regulatory
- Build and manage a high-performing CRO and consultant network, ensuring quality, timelines, and cost efficiency
- Leverage and contribute to the Flagship ecosystem, fostering knowledge sharing and collaboration across platform companies
- Lead nonclinical regulatory strategy and documentation (INDs, IBs, briefing materials)
- Ensure regulatory readiness through clear and scientifically robust safety narratives
- Represent toxicology in regulatory interactions as appropriate
Qualifications
- PhD, DVM, or equivalent in Toxicology, Pathology, Pharmacology, or related field
- ~10-15+ years of experience in nonclinical safety in biotech/pharma
- Proven track record advancing programs through IND and into clinical development
- Experience across multiple modalities preferred
- Strong experience managing CROs and external collaborations
- Experience leading or building a toxicology function or team, including management of internal scientists and/or external partners, is a plus
Leadership Profile
- Enterprise mindset; able to operate across a portfolio in a fast-paced, collaborative environment
- Analytical and goal-oriented, with the ability to operate with urgency while maintaining high standards of scientific rigor and ethics
- Strong communicator who can translate complex toxicology into clear, audience-appropriate risk assessments, from early-stage teams to large pharma partners
About Flagship
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company's annual list of the World's Most Innovative Companies.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
The salary range for this role is $228,000 - $280,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
ABOUT PIONEERING MEDICINES
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
Position Summary
The Senior Director, Head of Toxicology will lead and build the toxicology function within Pioneering Medicines, defining and executing nonclinical safety strategies across a diverse and rapidly evolving portfolio. This role provides scientific and strategic leadership across both investigative and regulatory toxicology, supporting a broad range of therapeutic modalities.
Working in a dynamic venture creation environment, you will collaborate closely with multidisciplinary teams to optimize candidate selection, guide preclinical development, and ensure regulatory readiness. This is a high-impact role requiring strong analytical thinking, scientific rigor, and clear communication, influencing programs from discovery through early clinical development.
Key Responsibilities
Functional Leadership & Capability Building
- Lead, build, and scale the toxicology function, including internal team development and external partnerships
- Define fit-for-purpose operating models spanning investigative and regulatory toxicology
- Serve as the primary internal expert for nonclinical safety, ensuring quality, consistency, and scalability across the portfolio
Portfolio & Program Strategy
- Define and drive toxicology strategies across multiple programs and modalities
- Translate findings into clear risk assessments, mitigation strategies, and IND/CTA-enabling plans
- Enable transparent, data-driven decision-making by articulating risks, assumptions, and trade-offs to program teams
- Oversee the design, execution, and interpretation of non-GLP and GLP toxicology studies
- Partner cross-functionally (DMPK, pharmacology, CMC, clinical) to integrate safety into development strategy
- Support diligence and evaluation of new programs within Flagship's ecosystem
External Partnerships & Regulatory
- Build and manage a high-performing CRO and consultant network, ensuring quality, timelines, and cost efficiency
- Leverage and contribute to the Flagship ecosystem, fostering knowledge sharing and collaboration across platform companies
- Lead nonclinical regulatory strategy and documentation (INDs, IBs, briefing materials)
- Ensure regulatory readiness through clear and scientifically robust safety narratives
- Represent toxicology in regulatory interactions as appropriate
Qualifications
- PhD, DVM, or equivalent in Toxicology, Pathology, Pharmacology, or related field
- ~10-15+ years of experience in nonclinical safety in biotech/pharma
- Proven track record advancing programs through IND and into clinical development
- Experience across multiple modalities preferred
- Strong experience managing CROs and external collaborations
- Experience leading or building a toxicology function or team, including management of internal scientists and/or external partners, is a plus
Leadership Profile
- Enterprise mindset; able to operate across a portfolio in a fast-paced, collaborative environment
- Analytical and goal-oriented, with the ability to operate with urgency while maintaining high standards of scientific rigor and ethics
- Strong communicator who can translate complex toxicology into clear, audience-appropriate risk assessments, from early-stage teams to large pharma partners
About Flagship
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company's annual list of the World's Most Innovative Companies.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
The salary range for this role is $228,000 - $280,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
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Get Access To All JobsTips for Finding Green Card Sponsorship in Director Head Of
Document your advanced degree equivalency early
Many Director roles require an advanced degree for EB-2 eligibility. If your credentials come from outside the U.S., get a credential evaluation before your first employer conversation so the PERM job description can be written around your actual qualifications.
Target employers with dedicated immigration programs
Large technology, financial services, and healthcare companies routinely sponsor Director-level roles through PERM. Prioritize organizations that already have immigration counsel on retainer, since leadership hires require more complex prevailing-wage analysis than entry-level filings.
Search green card sponsoring roles on Migrate Mate
Use Migrate Mate to filter Director and Head Of openings by employers with active EB-2 and EB-3 sponsorship history. Targeting companies that have completed PERM filings for similar roles cuts your search time significantly.
Verify prevailing wage before negotiating your offer
The DOL sets wage floors by job zone and location using the OFLC Wage Search. For Director roles, your offer must meet or exceed the Level III or Level IV prevailing wage for your metro area, or the PERM filing will fail at the certification stage.
Negotiate a written sponsorship commitment in your offer letter
Get explicit written agreement from your employer that they'll file PERM after your probationary period. Director hires often involve longer onboarding timelines, so clarifying when the I-140 process starts protects you if internal priorities shift.
Understand EB-2 NIW as a parallel self-petition path
If your Director role serves a U.S. national interest, the National Interest Waiver lets you self-petition for EB-2 without a PERM filing or employer sponsorship. USCIS evaluates your merit and the broader benefit of your work independently of any single employer.
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Find Director Head Of JobsDirector Head Of Green Card Sponsorship: Frequently Asked Questions
Do Director and Head Of roles typically qualify for EB-2 or EB-3 sponsorship?
Most Director and Head Of positions qualify under EB-2 because they require an advanced degree or its equivalent. If the role specifies a bachelor's degree with several years of progressive experience, EB-3 is also available. The employer's PERM job description determines the category, so the minimum requirements listed in that document are what USCIS and DOL evaluate, not just your personal credentials.
How does green card sponsorship differ from H-1B sponsorship for a Director-level hire?
H-1B sponsorship is temporary and subject to an annual lottery, which creates uncertainty for both you and the employer. PERM-based EB-2 or EB-3 sponsorship has no annual lottery at the petition stage and leads to permanent residency. The tradeoff is time: the PERM labor market test and I-140 adjudication typically add 12 to 24 months before you reach the adjustment of status stage.
What makes a Director role harder to sponsor than an individual contributor role?
PERM requires the employer to advertise the role openly and document that no qualified U.S. worker applied. For Director positions, the job requirements are scrutinized more closely because overly specific qualifications can trigger a DOL audit. Employers must also justify why the role requires an advanced degree rather than just experience, which means the job description drafting stage carries more risk than it does for standard professional roles.
How can I find Director and Head Of roles where the employer is already open to green card sponsorship?
Migrate Mate lets you search Director and Head Of openings filtered by employers with documented EB-2 and EB-3 sponsorship activity. Identifying companies that have already navigated PERM for comparable roles is the fastest way to avoid employers who are open to sponsorship in principle but unfamiliar with the actual process.
Can I change employers after my I-140 is approved but before I have a green card?
Yes. Once your I-140 has been approved and your priority date is current, portability rules under AC21 allow you to move to a new employer in the same or similar occupational classification without losing your place in the green card queue. For Director-level moves, the key is that the new role must be substantially similar in duties and required skills to the role described in your original PERM application.
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