Green Card Program Manager Jobs
Program Manager roles qualify for EB-2 and EB-3 green card sponsorship when the position requires a bachelor's degree or higher in business, engineering, or a related field. Employers file a PERM labor certification with DOL before sponsoring you for permanent residency, making this a direct path to a U.S. green card.
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Get Access To All JobsCompany Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities.
Position Overview: We’re looking for an outstanding program manager with experience advancing early discovery programs through IND approval. This leader will refine and reinforce our program management methodology and lead program management in our early research teams. This role reports to the Vice President, Programs and Strategy.
Responsibilities:
As a Program Manager:
- Working in partnership with research team leadership to develop and guide program strategy, set program goals and facilitate team decision making for the program
- Lead a range of program management activities across programs, including development of project plans, timeline and milestones tracking, team meeting management/minutes, and decision-making support
- Efficiently and collaboratively drive execution of program strategy and the integrated development plan with a sense of urgency
- Proactively identify risks, gaps, and resource bottlenecks; and develop and implement mitigation plans
- Develop and manage the program budget, and long-range plan, including scenario planning as needed, monitor program financials and resourcing plans
- Facilitate strong cross-functional communication by building strong working relationships across the organization
- Develop materials and present program updates/progress at internal company meetings
Enhancing the Program Management function:
- Responsible for the management and communication of Prime’s discovery-stage program plans
- Facilitate cross-functional communication, including input to Leadership Team on program progress
- Support strategic scenario planning discussions, develop risk/mitigation plans, and drive key program decisions through our governance forums
- Reinforce high standards and high performing teams to advance our science
- Support strategic & tactical program planning in partnership with Finance and Strategy/ Portfolio Management, to inform the long-range planning process, detailed investment planning, and portfolio prioritization exercises
- Ensure cross-functional and cross-program sharing of key learnings, and drive change management as applicable
Qualifications
- Direct experience in program management/program leadership for discovery through early clinical development programs; 6+ years in industry with 3+ years managing programs
- Bachelor’s degree in relevant scientific area required, additional business training or education strongly desired; genetic medicines experience highly desired
- Excellent verbal and written communication skills and strong interpersonal skills to manage relationships, set expectations, facilitate dialogue, and resolve conflict
- Proficient in prioritizing and driving complex programs to milestone completion
- Demonstrated proficiency in program management tools and methodology. Willingness to constantly improve PM tools, implement best practices, and foster change management
- Strategic and financial acumen with the ability to develop and manage program plans, budgets, and timelines.
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.
U.S. Pay Range $219,000—$232,000 USD
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities.
Position Overview: We’re looking for an outstanding program manager with experience advancing early discovery programs through IND approval. This leader will refine and reinforce our program management methodology and lead program management in our early research teams. This role reports to the Vice President, Programs and Strategy.
Responsibilities:
As a Program Manager:
- Working in partnership with research team leadership to develop and guide program strategy, set program goals and facilitate team decision making for the program
- Lead a range of program management activities across programs, including development of project plans, timeline and milestones tracking, team meeting management/minutes, and decision-making support
- Efficiently and collaboratively drive execution of program strategy and the integrated development plan with a sense of urgency
- Proactively identify risks, gaps, and resource bottlenecks; and develop and implement mitigation plans
- Develop and manage the program budget, and long-range plan, including scenario planning as needed, monitor program financials and resourcing plans
- Facilitate strong cross-functional communication by building strong working relationships across the organization
- Develop materials and present program updates/progress at internal company meetings
Enhancing the Program Management function:
- Responsible for the management and communication of Prime’s discovery-stage program plans
- Facilitate cross-functional communication, including input to Leadership Team on program progress
- Support strategic scenario planning discussions, develop risk/mitigation plans, and drive key program decisions through our governance forums
- Reinforce high standards and high performing teams to advance our science
- Support strategic & tactical program planning in partnership with Finance and Strategy/ Portfolio Management, to inform the long-range planning process, detailed investment planning, and portfolio prioritization exercises
- Ensure cross-functional and cross-program sharing of key learnings, and drive change management as applicable
Qualifications
- Direct experience in program management/program leadership for discovery through early clinical development programs; 6+ years in industry with 3+ years managing programs
- Bachelor’s degree in relevant scientific area required, additional business training or education strongly desired; genetic medicines experience highly desired
- Excellent verbal and written communication skills and strong interpersonal skills to manage relationships, set expectations, facilitate dialogue, and resolve conflict
- Proficient in prioritizing and driving complex programs to milestone completion
- Demonstrated proficiency in program management tools and methodology. Willingness to constantly improve PM tools, implement best practices, and foster change management
- Strategic and financial acumen with the ability to develop and manage program plans, budgets, and timelines.
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.
U.S. Pay Range $219,000—$232,000 USD
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
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Get Access To All JobsTips for Finding Green Card Sponsorship as a Program Manager
Align your credentials to EB-2 requirements
If you hold a master's degree in project management, business administration, or engineering, document it carefully. EB-2 sponsorship requires proving the role demands an advanced degree, which strengthens your PERM petition and your employer's case with DOL.
Target employers with active PERM filing history
Use the OFLC Wage Search to look up employers who have filed PERM applications for Program Manager roles. Consistent filing history signals that a company has an established sponsorship process and internal immigration counsel already in place.
Search green card sponsoring employers on Migrate Mate
Migrate Mate lets you filter Program Manager jobs by green card sponsorship status, so you spend time applying to employers already set up to file PERM, not cold-calling HR teams about a process they've never run.
Clarify sponsorship intent before accepting an offer
Ask hiring managers whether their standard offer letter includes an immigration sponsorship commitment. Program Manager roles often involve multi-year project cycles, so confirm the employer is prepared to carry your PERM filing through I-140 approval and adjustment of status.
Verify the prevailing wage tier for your specific role
PERM requires your offered salary to meet DOL prevailing wage levels. Program Manager titles vary widely across industries, and the wage level assigned by DOL affects how quickly your employer can proceed, so confirm the correct Standard Occupational Classification code before your offer is finalized.
Understand how EB-3 priority dates affect your timeline
For most nationalities, EB-3 priority dates are current, meaning no backlog once your I-140 is approved. Review the USCIS Visa Bulletin each month to track your position and plan your adjustment of status filing window accordingly.
Green Card Program Manager: Frequently Asked Questions
Does a Program Manager role qualify for EB-2 or EB-3 green card sponsorship?
Program Manager positions typically qualify for EB-3 sponsorship when the role requires a bachelor's degree in a related field such as business, engineering, or information technology. If the position requires a master's degree or the equivalent, your employer can pursue EB-2 sponsorship instead. The employer's job description and DOL's evaluation during PERM labor certification determine which category applies.
How is green card sponsorship different from H-1B sponsorship for Program Managers?
Green card sponsorship through PERM leads to permanent residency, not a temporary status tied to a specific employer. There is no annual lottery for EB-3, unlike the H-1B visa cap. The tradeoff is timeline: PERM labor certification, I-140 approval, and adjustment of status typically take two to four years for most nationalities, compared to H-1B's faster processing but annual renewal requirements.
What does the PERM process look like for a Program Manager position?
Your employer first obtains a prevailing wage determination from DOL, then runs a recruitment campaign to demonstrate no qualified U.S. workers are available for the role. Once DOL certifies the PERM application, your employer files an I-140 immigrant petition with USCIS. After I-140 approval, you file for adjustment of status if a visa number is available for your country.
How do I find Program Manager jobs where the employer will sponsor a green card?
Many employers sponsor Program Managers for green cards but don't advertise it in job postings. Migrate Mate lets you search specifically for Program Manager roles at companies with documented green card sponsorship activity, saving you from applying to employers who only support H-1B or who have no immigration infrastructure at all.
Can I switch employers during the green card sponsorship process?
Once your I-140 petition has been approved for at least 180 days, the AC21 portability rule lets you change employers without losing your priority date, provided the new role is in the same or a similar occupational classification. For Program Manager roles, the new position generally needs to involve comparable management and oversight responsibilities to qualify under AC21.