Rare Disease Business Manager Green Card Jobs
Rare Disease Business Manager roles qualify for EB-2 and EB-3 green card sponsorship through PERM labor certification, which permanently transfers your status rather than requiring annual lottery cycles. Biotech and specialty pharma employers file I-140 petitions after PERM approval, sponsoring you for lawful permanent residency tied to this specialized commercial role.
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Job Description
About the role:
The Regional Business Manager (RBM), Michigan, leverages strong communication and interpersonal skills with an ability to analyze data and translate into actionable strategies to assist HCPs in the acceleration diagnosis of patients within the rare metabolic space. The RBM will establish and build impactful relationships with all physicians and accounts within their geographic responsibility by providing scientific data and in-depth knowledge where appropriate for the Takeda Rare Disease portfolio of Lysosomal Storage Disorder products. Through strategic data analysis and business planning, the RBM will collaborate with multidisciplinary healthcare providers and internal stakeholders to provide educational resources and tools necessary to assist in early patient diagnosis and/or treatment. The RBM will educate and raise awareness of specific Lysosomal Storage Disorders, Gaucher Disease and Hunters (MPS II) Syndrome, with health care providers in a defined geography. When appropriate, the RBM will also partner with the cross functional members to integrate resources and help educate HCPs on facilitation of therapy for their patients. You will report to the Regional Business Director, LSD.
How you will contribute:
- You will be responsible for all business-related activities within their geographic responsibility, including achievement of sales goals through executing brand strategies.
- The RBM call points will primarily focus on target physicians seeing patients with Lysosomal Storage Disorders and assisting healthcare providers with the education necessary to aid in early diagnosis and/or treatment.
- In-depth business planning allowing for partnership with the regional counterparts that allocates appropriate disease state & product education throughout their geography.
- Advanced customer engagement to create disease state awareness within multidisciplinary health care specialties to enhance the LSD business and build support for the portfolio of products.
- RBM will educate and inform HCPs LSD portfolio of products. You will describe signs and symptoms of the diseases and inform on the differential diagnosis process. They will educate HCPs on the appropriate Takeda treatment options.
- Collaborates with the LSD cross functional team and internal business partners to coordinate efforts, maximize impact and enhance business outcomes.
- Strategically analyzes and applies market data to assess business opportunities and priorities, including relevant impact of regional health care market and patient dynamics.
- RBM will attend conferences and exhibits to raise disease state awareness; will plan and execute disease state and product programs using approved vendor.
- Partners and motivate extended team members to improve performance, fostering a culture of engagement and accountability.
- Integrates and prioritizes US LSD approved sales leads and tactics with key stakeholders activities to optimize customer engagement and account outcomes.
Minimum Requirements/Qualifications:
- Minimum of bachelor’s degree required.
- 5 or more years of direct selling experience to healthcare professionals in the pharmaceutical, biotech, medical device, or related healthcare industries required.
- Collaborating with a multidisciplinary internal and external team is required.
- Ability to demonstrate a strong marketplace acumen.
- Rare disease experience preferred; complex sales model experience required.
- You must demonstrate a consistent track record of success.
- Demonstrate strategic territory management successes.
- Work within a complex sales model.
- Biotech, biologics, and specialty pharmacy experience helpful.
- Experience with buy & bill product selling/account management preferred.
- Understand payer access and reimbursement at assigned regional, state, and local levels.
- Experience managing and communicating complex reimbursement issues.
Key Skills
- Experience working in a highly regulated marketplace.
- Excellent questioning and exploratory ability in customer calls.
- Technical competence-Excel/CRM/Data analysis.
- Consultative selling skills; excellent organizational skills.
- Proven analytical capabilities.
- Large and small group presentations.
- Teamwork and collaboration.
- Adaptability in a fluid marketplace and growing organization.
TRAVEL REQUIREMENTS:
- Candidate must live in territory.
- Must work evenings and weekends as needed.
- Extensive travel required and varies by territory (50%).
- Must have authorization and ability to drive a company leased vehicle or rental.
TRAINING REQUIREMENTS:
- This position and continued employment is contingent upon the employee successfully passing mandatory product training which includes written and oral examinations.
- External Takeda Hires Only: During that training period, the employee will be classified as a non-exempt employee and will be eligible for overtime during the training period only in accordance with applicable federal and/or state law but the employee will not be eligible for any Takeda related sales incentive programs and/or other production-based bonuses. The training period will consist of live instruction, independent study, role play, and other training related activities which should take no more than 8 hours per day and 40 hours total in a work week.
- After successful passage of the mandatory product training examinations, the employee will be transitioned to exempt status and will no longer be eligible for overtime. They will then be paid on a bi-weekly basis and eligible to participate in various Takeda related sales incentive programs and/or contests.
More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Michigan - Virtual
U.S. Hourly Wage Range:
$66.11 - $90.91
The estimated hourly wage range reflects an anticipated range for this position. The actual hourly wage offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Michigan - Virtual
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Job Exempt
No
LI-Remote

Job Description
About the role:
The Regional Business Manager (RBM), Michigan, leverages strong communication and interpersonal skills with an ability to analyze data and translate into actionable strategies to assist HCPs in the acceleration diagnosis of patients within the rare metabolic space. The RBM will establish and build impactful relationships with all physicians and accounts within their geographic responsibility by providing scientific data and in-depth knowledge where appropriate for the Takeda Rare Disease portfolio of Lysosomal Storage Disorder products. Through strategic data analysis and business planning, the RBM will collaborate with multidisciplinary healthcare providers and internal stakeholders to provide educational resources and tools necessary to assist in early patient diagnosis and/or treatment. The RBM will educate and raise awareness of specific Lysosomal Storage Disorders, Gaucher Disease and Hunters (MPS II) Syndrome, with health care providers in a defined geography. When appropriate, the RBM will also partner with the cross functional members to integrate resources and help educate HCPs on facilitation of therapy for their patients. You will report to the Regional Business Director, LSD.
How you will contribute:
- You will be responsible for all business-related activities within their geographic responsibility, including achievement of sales goals through executing brand strategies.
- The RBM call points will primarily focus on target physicians seeing patients with Lysosomal Storage Disorders and assisting healthcare providers with the education necessary to aid in early diagnosis and/or treatment.
- In-depth business planning allowing for partnership with the regional counterparts that allocates appropriate disease state & product education throughout their geography.
- Advanced customer engagement to create disease state awareness within multidisciplinary health care specialties to enhance the LSD business and build support for the portfolio of products.
- RBM will educate and inform HCPs LSD portfolio of products. You will describe signs and symptoms of the diseases and inform on the differential diagnosis process. They will educate HCPs on the appropriate Takeda treatment options.
- Collaborates with the LSD cross functional team and internal business partners to coordinate efforts, maximize impact and enhance business outcomes.
- Strategically analyzes and applies market data to assess business opportunities and priorities, including relevant impact of regional health care market and patient dynamics.
- RBM will attend conferences and exhibits to raise disease state awareness; will plan and execute disease state and product programs using approved vendor.
- Partners and motivate extended team members to improve performance, fostering a culture of engagement and accountability.
- Integrates and prioritizes US LSD approved sales leads and tactics with key stakeholders activities to optimize customer engagement and account outcomes.
Minimum Requirements/Qualifications:
- Minimum of bachelor’s degree required.
- 5 or more years of direct selling experience to healthcare professionals in the pharmaceutical, biotech, medical device, or related healthcare industries required.
- Collaborating with a multidisciplinary internal and external team is required.
- Ability to demonstrate a strong marketplace acumen.
- Rare disease experience preferred; complex sales model experience required.
- You must demonstrate a consistent track record of success.
- Demonstrate strategic territory management successes.
- Work within a complex sales model.
- Biotech, biologics, and specialty pharmacy experience helpful.
- Experience with buy & bill product selling/account management preferred.
- Understand payer access and reimbursement at assigned regional, state, and local levels.
- Experience managing and communicating complex reimbursement issues.
Key Skills
- Experience working in a highly regulated marketplace.
- Excellent questioning and exploratory ability in customer calls.
- Technical competence-Excel/CRM/Data analysis.
- Consultative selling skills; excellent organizational skills.
- Proven analytical capabilities.
- Large and small group presentations.
- Teamwork and collaboration.
- Adaptability in a fluid marketplace and growing organization.
TRAVEL REQUIREMENTS:
- Candidate must live in territory.
- Must work evenings and weekends as needed.
- Extensive travel required and varies by territory (50%).
- Must have authorization and ability to drive a company leased vehicle or rental.
TRAINING REQUIREMENTS:
- This position and continued employment is contingent upon the employee successfully passing mandatory product training which includes written and oral examinations.
- External Takeda Hires Only: During that training period, the employee will be classified as a non-exempt employee and will be eligible for overtime during the training period only in accordance with applicable federal and/or state law but the employee will not be eligible for any Takeda related sales incentive programs and/or other production-based bonuses. The training period will consist of live instruction, independent study, role play, and other training related activities which should take no more than 8 hours per day and 40 hours total in a work week.
- After successful passage of the mandatory product training examinations, the employee will be transitioned to exempt status and will no longer be eligible for overtime. They will then be paid on a bi-weekly basis and eligible to participate in various Takeda related sales incentive programs and/or contests.
More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Michigan - Virtual
U.S. Hourly Wage Range:
$66.11 - $90.91
The estimated hourly wage range reflects an anticipated range for this position. The actual hourly wage offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual hourly wage offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Michigan - Virtual
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Job Exempt
No
LI-Remote
See all 26+ Rare Disease Business Manager jobs
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Get Access To All JobsTips for Finding Green Card Sponsorship as a Rare Disease Business Manager
Document your rare disease commercial credentials
PERM requires your employer to prove no qualified U.S. worker is available. Gather performance records, launch metrics, and any cross-functional KOL or patient-advocacy work that distinguishes your rare disease commercial experience from general biotech sales backgrounds.
Target biotech employers with active PERM filings
Use Migrate Mate to filter companies that have filed PERM applications for business manager or commercial roles in rare disease or specialty pharma, so you're applying to employers already familiar with the sponsorship process rather than educating them from scratch.
Confirm your degree maps to EB-2 eligibility
EB-2 covers advanced-degree professionals, typically a master's or bachelor's plus five years of progressive experience. A life sciences, business, or pharmacy degree paired with documented rare disease commercial experience usually satisfies the advanced-degree professional standard USCIS applies.
Negotiate sponsorship timing before accepting an offer
PERM labor certification alone can take 12 to 18 months before USCIS even receives the I-140. Ask prospective employers whether they'll initiate PERM within your first year and whether they cover attorney fees, not just filing costs.
Verify prevailing wage before your PERM is filed
DOL's OFLC Wage Search publishes prevailing wage levels by occupation and geography. Confirm your offered salary meets or exceeds the Level II or Level III wage for your SOC code before PERM is submitted, or DOL will reject the application outright.
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Find Rare Disease Business Manager JobsRare Disease Business Manager Green Card Sponsorship: Frequently Asked Questions
Does a Rare Disease Business Manager role qualify for EB-2 or EB-3 green card sponsorship?
Most Rare Disease Business Manager positions qualify for both EB-2 and EB-3, depending on how the employer defines the minimum requirements in the job description. EB-2 applies if the role genuinely requires an advanced degree or equivalent. EB-3 covers professional roles requiring at least a bachelor's degree. Your employer's attorney typically recommends the category based on the actual job requirements and your qualifications.
How does the PERM green card process differ from H-1B sponsorship for this role?
H-1B is a temporary nonimmigrant visa subject to an annual lottery with a six-year maximum stay. PERM-based green card sponsorship leads to permanent residency with no annual renewal and no lottery. The tradeoff is time: PERM labor certification plus I-140 adjudication typically takes 18 to 36 months before you can adjust status, whereas H-1B can be in place within months. For rare disease roles requiring long-term relationship-building with payers and patient communities, green card sponsorship is often the more stable long-term arrangement.
How do I find Rare Disease Business Manager jobs where employers will sponsor a green card?
Use Migrate Mate to search for Rare Disease Business Manager roles filtered by employers with documented PERM filing history. Many specialty pharma and rare disease biotech companies sponsor green cards but don't always advertise it in job postings. Targeting employers who have filed PERM for similar commercial roles before significantly improves your chances of a successful sponsorship conversation.
Can my employer start the PERM process while I'm on an H-1B in this role?
Yes, and doing so is standard practice. Your employer can file the PERM labor certification while you're actively working in the role on H-1B status. Filing early also matters because once your I-140 is approved and your priority date is established, you may become eligible for H-1B extensions beyond the six-year cap under AC21 portability rules, provided the I-140 has been approved for at least 365 days.
What makes a Rare Disease Business Manager role harder to sponsor than a standard pharma sales position?
Rare disease commercial roles often involve smaller patient populations, specialized payer access strategies, and KOL engagement that employers may struggle to articulate as a defined specialty occupation in the PERM job description. If the job description is written too broadly, DOL may question whether U.S. workers could fill it. Working with an experienced immigration attorney to draft a job description that accurately reflects the specialized nature of rare disease commercialization reduces the risk of a PERM audit or denial.
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