Green Card Senior Cloud Infrastructure Engineer Jobs
Senior Cloud Infrastructure Engineer roles qualify for EB-2 and EB-3 green card sponsorship through the PERM labor certification process, which permanently locks in your U.S. work authorization rather than requiring annual renewals. Employers file on your behalf, certifying that no qualified U.S. worker was available for the role.
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Get Access To All JobsINTRODUCTION
Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California.
SUMMARY
We are seeking a highly skilled Senior Cloud Infrastructure Engineer to architect, implement, and support cloud-first infrastructure platforms across AWS, Azure, and hybrid environments. This role will be responsible for designing scalable, secure, and highly available cloud infrastructure, managing containerized platforms, automating infrastructure deployments, and supporting critical enterprise and laboratory systems.
The ideal candidate has deep expertise in cloud technologies, Kubernetes, Docker, Infrastructure as Code (IaC), DevOps practices, and cloud security. This individual will work closely with software engineering, bioinformatics, security, laboratory operations, and compliance teams to ensure reliable and compliant infrastructure services supporting business-critical applications.
ONSITE: Monday, Tuesday, and Thursday
Responsibilities:
- Design, deploy, and manage enterprise cloud infrastructure primarily within AWS and/or Azure environments.
- Architect highly available, scalable, secure, and cost-effective cloud solutions.
- Implement cloud networking, identity management, storage, compute, monitoring, and security services.
- Support integration between cloud and on-premises infrastructure environments.
- Manage hybrid networking, VPNs, Direct Connect, ExpressRoute, and secure connectivity solutions.
- Support virtualization platforms and legacy infrastructure during cloud transformation initiatives.
- Design, deploy, and manage Kubernetes clusters in cloud and hybrid environments.
- Administer container orchestration platforms including Amazon EKS, Azure AKS, or self-managed Kubernetes environments.
- Build and maintain containerized application platforms using Docker.
- Automate infrastructure provisioning, configuration management, and deployment processes.
- Support and optimize CI/CD pipelines using GitHub Actions, GitLab CI, Azure DevOps, Jenkins, or similar platforms.
- Implement automated monitoring, alerting, scaling, backup, and recovery solutions.
- Partner with Security and Compliance teams to support HIPAA/CLIA/CAP/FDA requirements, where applicable.
- Ensure secure management of Protected Health Information (PHI) and sensitive business data.
- Partner with software engineering teams to optimize cloud-native application architectures.
REQUIRED QUALIFICATIONS:
- Bachelor's degree in Computer Science, Information Technology, Engineering, or related field.
- 7+ years of infrastructure engineering experience.
- 5+ years of hands-on cloud engineering experience in AWS, Azure, or GCP.
- 3+ years of Kubernetes administration and container platform management experience.
- Strong experience with Docker and containerized application deployment.
- Experience implementing Infrastructure as Code using Terraform or equivalent tools.
- Experience with Linux systems administration and cloud networking.
- Strong scripting and automation skills using Python, PowerShell, Bash, or similar languages.
- Experience supporting production-critical environments with high availability requirements.
TECHNICAL SKILLS:
- AWS (EC2, EKS, RDS, S3, IAM, VPC, Route53, CloudWatch, Lambda)
- Azure (AKS, Virtual Networks, Azure AD, Storage, Monitor, Key Vault)
- Multi-cloud and hybrid-cloud architectures
- Kubernetes, Docker, Helm, EKS, Terraform, Ansible and other adjacent cloud services
- Monitoring services like Splunk, Datadog or other cloud-native monitoring tools
KEY COMPETENCIES:
- Cloud Architecture & Engineering
- Kubernetes Administration
- Docker & Container Platforms
- Infrastructure Automation
- DevOps & CI/CD
- Cloud Security & Compliance
- Site Reliability Engineering (SRE)
- Disaster Recovery & Business Continuity
- Technical Leadership
- Problem Solving & Incident Management
SUCCESS METRICS:
- Cloud platform availability and reliability.
- Kubernetes cluster health and operational efficiency.
- Infrastructure automation coverage and deployment success rates.
- Compliance with HIPAA, CLIA, CAP, and security requirements.
- Cloud cost optimization and resource utilization.
- Incident response and recovery performance.
- Successful delivery of cloud modernization initiatives.
- Security and audit readiness.
The hiring range for this position is $150,000 to $180,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.
Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.
Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.
Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)
INTRODUCTION
Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California.
SUMMARY
We are seeking a highly skilled Senior Cloud Infrastructure Engineer to architect, implement, and support cloud-first infrastructure platforms across AWS, Azure, and hybrid environments. This role will be responsible for designing scalable, secure, and highly available cloud infrastructure, managing containerized platforms, automating infrastructure deployments, and supporting critical enterprise and laboratory systems.
The ideal candidate has deep expertise in cloud technologies, Kubernetes, Docker, Infrastructure as Code (IaC), DevOps practices, and cloud security. This individual will work closely with software engineering, bioinformatics, security, laboratory operations, and compliance teams to ensure reliable and compliant infrastructure services supporting business-critical applications.
ONSITE: Monday, Tuesday, and Thursday
Responsibilities:
- Design, deploy, and manage enterprise cloud infrastructure primarily within AWS and/or Azure environments.
- Architect highly available, scalable, secure, and cost-effective cloud solutions.
- Implement cloud networking, identity management, storage, compute, monitoring, and security services.
- Support integration between cloud and on-premises infrastructure environments.
- Manage hybrid networking, VPNs, Direct Connect, ExpressRoute, and secure connectivity solutions.
- Support virtualization platforms and legacy infrastructure during cloud transformation initiatives.
- Design, deploy, and manage Kubernetes clusters in cloud and hybrid environments.
- Administer container orchestration platforms including Amazon EKS, Azure AKS, or self-managed Kubernetes environments.
- Build and maintain containerized application platforms using Docker.
- Automate infrastructure provisioning, configuration management, and deployment processes.
- Support and optimize CI/CD pipelines using GitHub Actions, GitLab CI, Azure DevOps, Jenkins, or similar platforms.
- Implement automated monitoring, alerting, scaling, backup, and recovery solutions.
- Partner with Security and Compliance teams to support HIPAA/CLIA/CAP/FDA requirements, where applicable.
- Ensure secure management of Protected Health Information (PHI) and sensitive business data.
- Partner with software engineering teams to optimize cloud-native application architectures.
REQUIRED QUALIFICATIONS:
- Bachelor's degree in Computer Science, Information Technology, Engineering, or related field.
- 7+ years of infrastructure engineering experience.
- 5+ years of hands-on cloud engineering experience in AWS, Azure, or GCP.
- 3+ years of Kubernetes administration and container platform management experience.
- Strong experience with Docker and containerized application deployment.
- Experience implementing Infrastructure as Code using Terraform or equivalent tools.
- Experience with Linux systems administration and cloud networking.
- Strong scripting and automation skills using Python, PowerShell, Bash, or similar languages.
- Experience supporting production-critical environments with high availability requirements.
TECHNICAL SKILLS:
- AWS (EC2, EKS, RDS, S3, IAM, VPC, Route53, CloudWatch, Lambda)
- Azure (AKS, Virtual Networks, Azure AD, Storage, Monitor, Key Vault)
- Multi-cloud and hybrid-cloud architectures
- Kubernetes, Docker, Helm, EKS, Terraform, Ansible and other adjacent cloud services
- Monitoring services like Splunk, Datadog or other cloud-native monitoring tools
KEY COMPETENCIES:
- Cloud Architecture & Engineering
- Kubernetes Administration
- Docker & Container Platforms
- Infrastructure Automation
- DevOps & CI/CD
- Cloud Security & Compliance
- Site Reliability Engineering (SRE)
- Disaster Recovery & Business Continuity
- Technical Leadership
- Problem Solving & Incident Management
SUCCESS METRICS:
- Cloud platform availability and reliability.
- Kubernetes cluster health and operational efficiency.
- Infrastructure automation coverage and deployment success rates.
- Compliance with HIPAA, CLIA, CAP, and security requirements.
- Cloud cost optimization and resource utilization.
- Incident response and recovery performance.
- Successful delivery of cloud modernization initiatives.
- Security and audit readiness.
The hiring range for this position is $150,000 to $180,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.
Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.
Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.
Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)
See all 137+ Green Card Senior Cloud Infrastructure Engineer Jobs
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Get Access To All JobsTips for Finding Green Card Sponsorship as a Senior Cloud Infrastructure Engineer
Document your cloud credentials before applying
AWS, Azure, and GCP certifications strengthen your PERM file by demonstrating specialized qualifications beyond a generic degree. Collect original certificates, transcripts, and any employer-issued credential verification letters now, before a sponsoring employer requests them.
Target employers with active PERM filing history
Search Migrate Mate to filter Senior Cloud Infrastructure Engineer roles by employers who have filed PERM applications in the past two years. Employers with that history already understand the labor certification process and are far less likely to stall mid-hire.
Verify your degree maps to the job description
PERM requires the job description to match the minimum requirements used during the recruitment test. If your degree is in a tangentially related field, ask the hiring manager whether the role can legitimately list a range of qualifying degree fields to capture your background.
Ask about EB-2 versus EB-3 before accepting an offer
Cloud infrastructure roles often qualify under both categories. EB-2 typically moves faster for applicants from most countries; EB-3 is more appropriate if you hold only a bachelor's degree. Confirm which category the employer's immigration counsel is planning to use before you sign.
Check the prevailing wage before salary negotiations
PERM filings require your offered salary to meet the DOL prevailing wage for your job zone and location. Use the OFLC Wage Search to look up the Level I through Level IV wage for your SOC code in the metro area where you'll be working.
Understand PERM recruitment timing relative to your status
DOL typically takes six to twelve months to certify a PERM application, and I-140 adjudication adds more time. If you're on an expiring work authorization, discuss whether the employer can bridge you with an H-1B visa extension or portability under AC21 before the green card clears.
Green Card Senior Cloud Infrastructure Engineer: Frequently Asked Questions
Does a Senior Cloud Infrastructure Engineer role qualify for EB-2 or EB-3 sponsorship?
Most Senior Cloud Infrastructure Engineer positions qualify for EB-2 because they require at least a bachelor's degree in computer science, engineering, or a related field plus several years of specialized experience. If the role is structured to require only a bachelor's degree with no advanced requirements, EB-3 professional classification applies instead. USCIS evaluates the specific job description, not the job title alone, so the employer's documented minimum requirements determine which category fits.
How is green card sponsorship different from H-1B for this role?
H-1B is a temporary status requiring renewal every three years with no guaranteed path to permanency. Green card sponsorship through PERM leads to lawful permanent residency, meaning you're no longer dependent on an employer's willingness to keep renewing your status. There's no annual lottery for EB-2 or EB-3 petitions, and once your I-140 is approved, you can invoke AC21 portability to change employers without restarting the process, provided you move into a same or similar role.
How long does the PERM green card process take for a cloud infrastructure role?
From PERM filing to a green card in hand, most applicants from countries outside India and China should plan for roughly two to four years: six to twelve months for DOL to certify the PERM, six to twelve months for USCIS to approve the I-140, and then adjustment of status processing. Applicants born in India or China face significantly longer priority-date backlogs at the EB-2 and EB-3 levels and should factor that into their long-term planning before accepting a sponsoring offer.
What should I look for in a sponsoring employer's PERM job description?
The job description must reflect duties and minimum requirements the employer genuinely uses for the role. Watch for descriptions that list requirements beyond what the position actually needs, since overly narrow requirements can complicate the DOL recruitment test and invite an audit. The O*NET occupation profile for cloud infrastructure engineers provides a defensible baseline for core duties and typical education requirements that immigration counsel commonly reference when drafting PERM job descriptions.
How do I find Senior Cloud Infrastructure Engineer jobs with green card sponsorship?
Migrate Mate filters job listings specifically by employers who sponsor employment-based green cards, letting you focus your search on companies already familiar with PERM and I-140 filings. Searching by role title and filtering for green card sponsorship saves you from applying to roles where the employer has never navigated the process, which is one of the most common reasons sponsorship stalls after an offer is extended.