H-1B Visa Director of Information Systems Jobs
Director of Information Systems roles qualify as H-1B visa specialty occupations, requiring at least a bachelor's degree in information systems, computer science, or a related field. Sponsoring employers file a Labor Condition Application with DOL and an I-129 petition with USCIS, covering an initial three-year period extendable to six.
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Get Access To All JobsWho We Are:
Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
What We Do:
We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.
About the Role:
We are seeking a Senior Manager/Associate Director, Enterprise Information Systems to join our Information Technology (IT) team.
The position reports to the Director, Enterprise Information Systems and will serve as the primary IT system owner for Xenon’s future Human Capital Management (HCM) system as well as other key HR systems. This individual will play a key role in the implementation of Workday HCM, including Payroll, at Xenon, ensuring the system configuration fits the functional requirements and the appropriate controls (including SOX) are in place. This individual will also partner with leaders across HR, Finance, IT, and other functions as needed to drive adoption, operations, and ongoing enhancements to the HCM ecosystem, as well as support other G&A systems.
This position will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office.
Responsibilities:
- Partnering with key HR and Finance stakeholders, manage and facilitate the implementation and adoption of Xenon’s HCM platform (Workday HCM) including design, configuration, testing, documentation, and adoption. Communicate key updates to relevant stakeholders to ensure the implementation meets milestones within agreed-to timelines.
- Support HCM-related process improvement initiatives across HR, Finance and other functions as needed.
- Collaborate with HR and Finance leadership on platform governance including developing a platform roadmap and prioritizing and coordinating change requests, enhancements and support tickets.
- Collaborate with Xenon’s Architecture Review Board to ensure the system design is consistent with company standards for security, infrastructure, and data architecture.
- Provide technical guidance and support on all Computer Software Assurance (CSA) deliverables and change control activities.
- Author, review, and approve applicable Software Development Lifecycle (SDLC) and CSA deliverables, and coordinate assurance and other testing activities.
- Develop, review, and approve procedures defining System Administration activities.
- Develop and manage the ongoing support model including onboarding and managing a qualified Application Management Services (AMS) provider.
- Ensure ongoing compliance with Xenon procedures including SaaS Release Management, Change Management, Problem Management, etc.
- Perform user administration and manage licensing and role-based access controls within the HCM.
- Own the SOX IT General Controls (ITGCs) related to the HCM – including collaborating with internal and external auditors to test and enhance controls as needed.
- Collaborate with colleagues to design, build and support technical integrations to/from the HCM.
- Serve as the IT System Owner for other key HR systems as needed.
- Support other G&A systems, including Oracle Fusion Cloud ERP and other Finance systems.
- Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics, and ensure policies are understood and followed by direct reports, if any.
- Some international travel may be required.
- Other duties as assigned.
QUALIFICATIONS
- Bachelor’s degree in Information Systems, Computer Science, Business Administration or related field.
- Minimum of 5-8 years of relevant experience, preferably in the Life Sciences industry.
- Proven experience as an HCM functional owner, HCM manager, or super user – preferably with Workday HCM implementation experience.
- Workday Pro Certification, e.g. HCM, Payroll, etc., a plus.
- Strong understanding of HR and Payroll business processes and SOX, including segregation of duties (SoD) principles.
- Knowledge of user management and role-based access controls. Knowledge of Workday security a plus.
- Experience with Computer Software Assurance/GxP Computer System Validation.
- Experience managing external consultants and vendors.
- Experience collaborating with HR and Finance counterparts to prioritize support and enhancement requests.
- Experience with system integrations (APIs, data flows, connectors).
Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short- & long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.
Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.
Compensation Range: $150K - $226.1K
Who We Are:
Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.
What We Do:
We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.
About the Role:
We are seeking a Senior Manager/Associate Director, Enterprise Information Systems to join our Information Technology (IT) team.
The position reports to the Director, Enterprise Information Systems and will serve as the primary IT system owner for Xenon’s future Human Capital Management (HCM) system as well as other key HR systems. This individual will play a key role in the implementation of Workday HCM, including Payroll, at Xenon, ensuring the system configuration fits the functional requirements and the appropriate controls (including SOX) are in place. This individual will also partner with leaders across HR, Finance, IT, and other functions as needed to drive adoption, operations, and ongoing enhancements to the HCM ecosystem, as well as support other G&A systems.
This position will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office.
Responsibilities:
- Partnering with key HR and Finance stakeholders, manage and facilitate the implementation and adoption of Xenon’s HCM platform (Workday HCM) including design, configuration, testing, documentation, and adoption. Communicate key updates to relevant stakeholders to ensure the implementation meets milestones within agreed-to timelines.
- Support HCM-related process improvement initiatives across HR, Finance and other functions as needed.
- Collaborate with HR and Finance leadership on platform governance including developing a platform roadmap and prioritizing and coordinating change requests, enhancements and support tickets.
- Collaborate with Xenon’s Architecture Review Board to ensure the system design is consistent with company standards for security, infrastructure, and data architecture.
- Provide technical guidance and support on all Computer Software Assurance (CSA) deliverables and change control activities.
- Author, review, and approve applicable Software Development Lifecycle (SDLC) and CSA deliverables, and coordinate assurance and other testing activities.
- Develop, review, and approve procedures defining System Administration activities.
- Develop and manage the ongoing support model including onboarding and managing a qualified Application Management Services (AMS) provider.
- Ensure ongoing compliance with Xenon procedures including SaaS Release Management, Change Management, Problem Management, etc.
- Perform user administration and manage licensing and role-based access controls within the HCM.
- Own the SOX IT General Controls (ITGCs) related to the HCM – including collaborating with internal and external auditors to test and enhance controls as needed.
- Collaborate with colleagues to design, build and support technical integrations to/from the HCM.
- Serve as the IT System Owner for other key HR systems as needed.
- Support other G&A systems, including Oracle Fusion Cloud ERP and other Finance systems.
- Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics, and ensure policies are understood and followed by direct reports, if any.
- Some international travel may be required.
- Other duties as assigned.
QUALIFICATIONS
- Bachelor’s degree in Information Systems, Computer Science, Business Administration or related field.
- Minimum of 5-8 years of relevant experience, preferably in the Life Sciences industry.
- Proven experience as an HCM functional owner, HCM manager, or super user – preferably with Workday HCM implementation experience.
- Workday Pro Certification, e.g. HCM, Payroll, etc., a plus.
- Strong understanding of HR and Payroll business processes and SOX, including segregation of duties (SoD) principles.
- Knowledge of user management and role-based access controls. Knowledge of Workday security a plus.
- Experience with Computer Software Assurance/GxP Computer System Validation.
- Experience managing external consultants and vendors.
- Experience collaborating with HR and Finance counterparts to prioritize support and enhancement requests.
- Experience with system integrations (APIs, data flows, connectors).
Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short- & long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.
Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.
Compensation Range: $150K - $226.1K
See all 95+ H-1B Visa Director of Information Systems Jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new H-1B Visa Director of Information Systems Jobs.
Get Access To All JobsTips for Finding H-1B Visa Sponsorship in Director of Information Systems
Align your credentials to specialty occupation standards
Pull the O*NET profile for this occupation and map your degree field directly to the listed knowledge requirements. USCIS scrutinizes whether your specific degree, not just any technical degree, relates to the director-level duties in the job offer.
Target employers with active LCA filing histories
Use Migrate Mate to browse Director of Information Systems roles at employers with verified H-1B LCA sponsorship history, searchable by city and industry. This cuts time spent on companies that have never navigated the process for this title.
Verify each worksite requires its own certified LCA
If your role involves multiple office locations or client sites, your employer must file a separate certified LCA for each worksite before you work there. Confirm this with your employer early so USCIS filing timelines don't create gaps in your authorization.
Request premium processing for director-level transitions
Director roles often come with start-date commitments tied to budget cycles or board approvals. USCIS premium processing gets your I-129 adjudicated within days rather than months, reducing the risk of a delayed start derailing the offer.
Document your specialty occupation case thoroughly upfront
USCIS issues Requests for Evidence more frequently on management-titled roles where the degree requirement isn't self-evident. Prepare a detailed job duty description tying every responsibility to degree-level information systems knowledge before the petition is filed.
Understand the cap and your timing options early
H-1B cap selection rules have changed recently. Knowing whether you're cap-exempt through a previous H-1B or eligible via an institution affects when your employer can file. Confirm your status category with your employer before accepting an offer timeline.
H-1B Visa Director of Information Systems: Frequently Asked Questions
Does a Director of Information Systems role qualify as an H-1B specialty occupation?
Yes, this role typically qualifies. USCIS defines a specialty occupation as one requiring at least a bachelor's degree in a directly related field. Director of Information Systems positions are grounded in information systems, computer science, or a closely related discipline, and the degree-to-duty connection is well-established for this title at most organizations.
What does the H-1B sponsorship process look like for this role?
Your employer files a Labor Condition Application with DOL first, certifying the prevailing wage and working conditions. Once certified, they file Form I-129 with USCIS. For new H-1B cap cases, selection rules have changed recently, so confirm your employer's filing timeline with them directly. Approval covers an initial three-year period, extendable to a six-year maximum.
How do I find employers who sponsor H-1B visas for Director of Information Systems jobs?
Migrate Mate lists employers with verified H-1B LCA sponsorship history for this role, searchable by location and industry. Looking at which companies have filed LCAs for director-level information systems positions shows you active sponsors, not just companies that mention visa sponsorship in job postings without a track record of following through.
What prevailing wage level applies to a Director of Information Systems on H-1B?
Director-level roles typically map to DOL wage Level III or Level IV, reflecting supervisory responsibility and advanced decision-making. Your employer must pay at least the certified prevailing wage for the specific worksite location. Use the OFLC Wage Search to look up the wage levels for this occupation code in your target city before negotiating your offer.
Can my H-1B transfer to a new employer if I change companies in this role?
Yes. Under H-1B portability rules, you can begin working for a new employer as soon as they file an H-1B transfer petition with USCIS, without waiting for approval, provided you've been maintaining valid H-1B status. The new employer must file a fresh LCA and I-129 specific to the new position and worksite before your start date.