H-1B Visa Real World Evidence Jobs
Real World Evidence roles sit squarely within H-1B visa specialty occupation territory, requiring at least a bachelor's degree in epidemiology, biostatistics, health economics, or a closely related field. Pharma, biotech, and health technology employers sponsor H-1B visas for RWE analysts, scientists, and directors across study design, claims data analysis, and outcomes research functions.
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General Summary:
The Real World Evidence Manager is an integral member of the RWE team who leverages expertise in epidemiology, real world data, and other relevant disciplines to assess the natural history and real world outcomes for Vertex’s pipeline and portfolio products. The position will support cross-functional global observational research by providing methodological and analytical support for internal stakeholders, including Clinical Development, Global Medical Affairs, Global Patient Safety, and Government Affairs and Public Policy. The Manager will also execute on tactics related to the collection and/or analysis of real world data to inform relevant stakeholders such as regulatory affairs and clinical development.
Key Duties and Responsibilities:
- Support focused/targeted epidemiologic research in support of Vertex’s pipeline and established portfolios, including Natural History (NH) of disease and systematic literature reviews
- Ensure scientific rigor for real world data analyses
- Conduct feasibility assessment of relevant data sources for disease areas and research questions
- Provide insights and experience to design and defend fit-for-purpose epidemiologic observational research; Identify appropriate analytic methods aligned to research needs
- Collaborate with and manage vendors, to ensure meeting project timelines and goals
- Support Study Execution Teams for observational studies
- Contribute to development of performance metrics and dashboards for RWE projects
- Able to balance multiple projects in a fast-paced environment
- Utilize strong oral and visual communication skills and understanding of Vertex strategies to promote and translate value of RWD/RWE methods and studies across the company
- Excellent communication skills (oral and written) with internal and external audiences
- Contribute to company publications strategy via development of conference abstracts, presentations, peer-reviewed manuscripts based on the findings of RWE studies
Knowledge and Skills:
- Working knowledge of relevant RWE regulatory agency guidance and position papers and the opportunities to use RWE to inform regulatory decision making
- Demonstrated ability to design and execute observational research
- Strong interpersonal communication and study management skills
- Ability to take detailed observational study results and communicate them in a clear, non-technical manner to internal cross-functional teams, using language that resonates with the teams, while maintaining the integrity of key findings
- Ability to work collaboratively in a constantly changing, diverse, and matrix environment
Education and Experience:
- PhD (preferred) or MS/MPH in epidemiology, biostatistics, health economics and outcomes research, or similar required
- Formal graduate training in Epidemiology/Health Services Research required
- Minimum 2 years of experience working in observational research within the life sciences industry or relevant academic, government, or consulting environment
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$132,100 - $198,100
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
LI-Hybrid
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
Job Description
General Summary:
The Real World Evidence Manager is an integral member of the RWE team who leverages expertise in epidemiology, real world data, and other relevant disciplines to assess the natural history and real world outcomes for Vertex’s pipeline and portfolio products. The position will support cross-functional global observational research by providing methodological and analytical support for internal stakeholders, including Clinical Development, Global Medical Affairs, Global Patient Safety, and Government Affairs and Public Policy. The Manager will also execute on tactics related to the collection and/or analysis of real world data to inform relevant stakeholders such as regulatory affairs and clinical development.
Key Duties and Responsibilities:
- Support focused/targeted epidemiologic research in support of Vertex’s pipeline and established portfolios, including Natural History (NH) of disease and systematic literature reviews
- Ensure scientific rigor for real world data analyses
- Conduct feasibility assessment of relevant data sources for disease areas and research questions
- Provide insights and experience to design and defend fit-for-purpose epidemiologic observational research; Identify appropriate analytic methods aligned to research needs
- Collaborate with and manage vendors, to ensure meeting project timelines and goals
- Support Study Execution Teams for observational studies
- Contribute to development of performance metrics and dashboards for RWE projects
- Able to balance multiple projects in a fast-paced environment
- Utilize strong oral and visual communication skills and understanding of Vertex strategies to promote and translate value of RWD/RWE methods and studies across the company
- Excellent communication skills (oral and written) with internal and external audiences
- Contribute to company publications strategy via development of conference abstracts, presentations, peer-reviewed manuscripts based on the findings of RWE studies
Knowledge and Skills:
- Working knowledge of relevant RWE regulatory agency guidance and position papers and the opportunities to use RWE to inform regulatory decision making
- Demonstrated ability to design and execute observational research
- Strong interpersonal communication and study management skills
- Ability to take detailed observational study results and communicate them in a clear, non-technical manner to internal cross-functional teams, using language that resonates with the teams, while maintaining the integrity of key findings
- Ability to work collaboratively in a constantly changing, diverse, and matrix environment
Education and Experience:
- PhD (preferred) or MS/MPH in epidemiology, biostatistics, health economics and outcomes research, or similar required
- Formal graduate training in Epidemiology/Health Services Research required
- Minimum 2 years of experience working in observational research within the life sciences industry or relevant academic, government, or consulting environment
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$132,100 - $198,100
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
LI-Hybrid
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
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Get Access To All JobsTips for Finding H-1B Visa Sponsorship in Real World Evidence
Match your degree to the RWE role
USCIS scrutinizes whether your degree field directly relates to the position. An epidemiology or biostatistics degree maps cleanly to RWE scientist roles; a general biology degree may trigger an RFE if the job description emphasizes statistical modeling or health economics.
Use OFLC Wage Search before negotiating
RWE roles span multiple SOC codes depending on whether your work is classified as epidemiology, medical science, or operations research. Pull prevailing wage levels for each applicable code using OFLC Wage Search so you can evaluate whether an offer meets Level I through Level IV thresholds before signing.
Target sponsors in pharma and health tech
Pharma manufacturers, contract research organizations, and health data companies file the highest volume of H-1B LCAs for RWE functions. Search Migrate Mate to filter employers by verified H-1B filing history specifically for outcomes research and epidemiology job titles.
Confirm E-Verify enrollment for STEM OPT transitions
If you're extending OPT before your H-1B starts, the employer must be enrolled in E-Verify. RWE roles at smaller biotech startups sometimes lack enrollment, which blocks your STEM OPT extension even if the H-1B petition is already approved.
Distinguish contract versus full-time sponsorship early
Many RWE positions are staffed through CROs or consulting firms on a contract basis. The H-1B petitioner must be your direct employer of record, not the end client. Clarify which entity will file your I-129 and control your day-to-day work before accepting a contract offer.
Request premium processing at the offer stage
RWE project timelines are often tied to drug development milestones, so a delayed H-1B approval can push your start date past a critical study phase. Ask during negotiations whether the employer will elect premium processing, which USCIS currently adjudicates within 15 business days.
H-1B Visa Real World Evidence: Frequently Asked Questions
Does a Real World Evidence role qualify as an H-1B specialty occupation?
Yes, RWE positions qualify when the job requires at least a bachelor's degree in a specific field such as epidemiology, biostatistics, health economics, or pharmacoepidemiology. The key is that a theoretical and practical body of specialized knowledge must be required to perform the job. Roles that accept any bachelor's degree, regardless of field, are more vulnerable to USCIS specialty occupation challenges during adjudication.
Which employers sponsor H-1B visas for RWE jobs?
Pharmaceutical companies, contract research organizations, health data analytics firms, and medical device manufacturers are the primary H-1B sponsors for RWE functions. You can browse employers with verified H-1B filing history for outcomes research and epidemiology roles on Migrate Mate, which surfaces DOL Labor Condition Application data by employer and job title.
How does the H-1B cap lottery affect RWE job seekers?
Most RWE roles are with cap-subject employers, meaning your petition enters the annual H-1B lottery limited to 85,000 slots. Registrations are accepted each March for an October 1 start date. If your employer is a university, nonprofit research institution, or government research entity, the cap-exempt category may apply and your petition can be filed at any time.
What SOC code typically applies to Real World Evidence roles?
RWE job titles map to several SOC codes depending on the core function. Epidemiologists, medical scientists, operations research analysts, and statisticians each have distinct classifications under DOL's occupational system. Your employer's LCA must list the SOC code that best reflects your actual duties, which directly determines the prevailing wage level used to set your minimum salary. Checking O*NET for your specific role description helps confirm the correct classification.
Can I transfer my H-1B to a new RWE employer mid-project?
Yes, H-1B portability lets you start working for a new employer as soon as the new petition is filed, without waiting for approval, as long as you've been in valid H-1B status for at least 180 days. RWE professionals switching between a pharma sponsor and a CRO, or moving from a research role to a consulting firm, commonly use this mechanism to avoid gaps in authorized work status.