Head of Clinical Operations Jobs
Head of Clinical Operations jobs are open across pharma, biotech, medical devices, and contract research organizations, from senior director to executive VP, with specializations in trial management, regulatory affairs, and site operations. Find a role that fits below and apply directly.
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Showing 5 of 9+ Head of Clinical Operations jobs
San Francisco
About the company
Braintrust is the agent observability platform. By actively applying intelligence to agent traces and automatically surfacing the most critical patterns, Braintrust gives teams the visibility to understand how agents behave in production and the tools to improve them.
Teams at Notion, Stripe, Box, OpenAI, and Cloudflare use Braintrust to trace their agents, find the issues in their observability data, and run evals that tell them how to improve.
We’re hiring a Head of GTM Ops to own Sales Ops and CS Ops at Braintrust. You’ll be a business partner to both teams, combining strong analytical skills and resourcefulness with deep knowledge of enterprise sales and customer success.
What you’ll own
Business partnership and analysis
Partner with Sales and CS leaders on business decisions, from where to invest and how to structure coverage to which problems need attention first.
Dig into pipeline, conversion, sales productivity, customer usage, retention, and expansion. Explain what’s happening, what’s behind it, and what we should do next.
Build models, compare options, and take recommendations through execution. Work across teams to solve the problem and check whether the change helped.
Billing and Finance
Own the GTM side of the handoff from signed contract to billing. Make sure pricing, SKUs, commitments, credits, and billing schedules are captured accurately.
Work with Billing and Finance to resolve gaps between contracts, Salesforce, and billing records, including amendments, credits, and customer billing questions.
Give Sales and CS visibility into usage against customer commitments and upcoming charges. Provide reliable bookings, renewal, and usage inputs for Finance’s planning and revenue forecast.
Systems and process improvements
Define business requirements and priorities for Salesforce, CPQ, and CS workflows. Work with GTM Engineering, Systems, and Data on implementation.
Make new products and pricing changes ready for the field, from quoting tools and Salesforce to billing handoffs and team training.
Partner with GTM Engineering on the product management work for our internal agents. GTM Engineering owns the agents; you bring Sales and CS needs, help define requirements and success criteria, and prioritize improvements together.
Test agents with Sales and CS, give GTM Engineering actionable feedback, and drive training and adoption. Measure whether the agents are improving the work and use that feedback to shape the next iteration together.
What we’re looking for
You’ve owned Sales Ops or Revenue Ops at a growing B2B software company and worked deeply with CS. You understand enterprise selling, customer onboarding, adoption, renewals, and expansion.
You’re highly analytical. You can take an ambiguous question, work through the data yourself, build a model, challenge your assumptions, and explain what the business should do next.
You have range. You can move between a planning model, a complicated deal, and the details of a broken process, then work across teams to get the fix in place.
You’re AI pilled and use agents in your own work. You can show us how you’ve used them to change how the work gets done.
You bring good product judgment to operations. You can turn a messy operational problem into clear requirements, help decide what’s worth building, and weigh the benefit against the complexity and upkeep.
You understand usage-based business models and can work through commitments, credits, variable usage, and their impact on pricing and billing.
You’re comfortable in Salesforce, spreadsheets, and the details of a quote or contract. You’ve worked with CPQ, forecasting, and commercial approval workflows.
Benefits include
Medical, dental, and vision insurance
Daily lunch, snacks, and beverages
Flexible time off
Competitive salary and equity
Wifi & cellphone stipend
Equal opportunity
Braintrust is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
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Find JobsHead of Clinical Operations Job Market
Who's Hiring
Top Industries Hiring
- Medical Devices
What Employers Look For
The qualifications that appear most often in head of clinical operations jobs.
- Ten or more years of clinical operations experience with at least three in a senior leadership role
- Demonstrated oversight of Phase I through Phase III clinical trials across multiple therapeutic areas
- Deep knowledge of ICH-GCP guidelines, FDA regulations, and international regulatory requirements
- Experience managing CROs, site relationships, and clinical operations budgets at a program level
- Proficiency with clinical trial management systems such as Veeva Vault or Medidata Rave
- Bachelor's degree in a life sciences field required, with advanced degree or PMP certification preferred
Tips for Your Head of Clinical Operations Job Search
Quantify trial portfolio scale on your resume
Hiring managers for head of clinical operations roles want to see the number of concurrent trials you've overseen, therapeutic areas managed, and budget size. Replace vague scope language with concrete metrics that reflect the complexity you've handled.
Apply early to roles that fit
Migrate Mate lists head of clinical operations openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Tailor your credentials to the organization type
A CRO wants execution efficiency and vendor management depth. A biotech startup wants someone who can build infrastructure from scratch. Read each job description carefully and lead with the experience that matches that specific environment before anything else.
Highlight cross-functional leadership in interviews
Interviewers at the head of clinical operations level routinely probe how you've aligned clinical, regulatory, and data teams under a single operating model. Prepare two or three concrete examples where you resolved cross-functional conflict or redesigned a process to reduce cycle time.
Target postings that match your therapeutic area depth
Oncology, rare disease, and CNS programs each carry distinct protocol complexity and regulatory expectations. When you filter openings by therapeutic area, you'll compete against a narrower, more relevant candidate pool and demonstrate clearer fit from the first screening call.
Negotiate scope alongside compensation at offer stage
At the head of clinical operations level, what you're responsible for matters as much as pay. Before accepting, clarify headcount, budget authority, and reporting structure so your title reflects actual decision-making power, not just a senior individual contributor role rebranded.
Head of Clinical Operations Jobs: Frequently Asked Questions
Which companies are hiring the most head of clinical operationss?
Florida State University, Moderna, and Workwhile are hiring the most head of clinical operationss right now, with openings concentrated in California, Florida, and Massachusetts, based on current listings on Migrate Mate as of November 2026. Activity is highest at mid-size biotechs and large CROs actively running late-stage programs.
How many head of clinical operations jobs are remote?
About 100% of head of clinical operations openings are fully remote or hybrid as of November 2026, reflecting the administrative and strategic weight of the role. Sub-functions like vendor oversight, budget management, and SOP development are most likely to be performed remotely, while roles tied to active site oversight or executive team collaboration tend to require on-site presence.
How do you become a head of clinical operations?
Start in a clinical research associate or clinical trial manager role and build hands-on trial execution experience across at least two therapeutic areas. Move into a director-level position overseeing a team and a full program budget. Develop fluency with regulatory submissions, CRO governance, and cross-functional leadership. Most candidates also complete GCP training and earn a certification such as the ACRP CCRA or PMP to demonstrate operational rigor before stepping into the head role.
Can you get a head of clinical operations job without direct senior leadership experience?
It's uncommon but possible at smaller biotechs or startups building their clinical function for the first time. If you're making this transition, emphasize any experience where you owned a full program budget, led a team through a regulatory milestone, or stood up a clinical operations function without inherited infrastructure. Smaller organizations value breadth and initiative over pedigree when they're hiring their first clinical operations leader.
What does the head of clinical operations interview process look like?
Most hiring processes include an initial screening with HR or a talent partner, followed by a technical interview with the CMO or VP of clinical development focused on your trial oversight philosophy and regulatory experience. A presentation round is common, often asking you to outline how you'd build or improve the clinical operations function. Final rounds typically involve cross-functional stakeholders from regulatory, data management, and finance before an offer is extended.
Where can I find and apply to head of clinical operations jobs?
You can find and apply to head of clinical operations jobs on Migrate Mate, which lists current openings from across the United States. Find roles that match your experience in pharma, biotech, medical devices, or CROs, and apply directly to each listing without being redirected to a third-party site.
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