Nurse Practitioner Jobs in Durham, NC
Nurse Practitioner jobs in Durham, North Carolina are concentrated in Research Triangle Park, Duke University's Medical Center area, and the Northgate corridor, with strong demand across academic medical centers, community health networks, and specialty clinics. Employers hiring right now include Duke Health, Thriveworks, and Crossover Health. Scan the live roles below and apply to whichever ones fit.
Find Nurse Practitioner JobsOverview
Showing 5 of 168+ Nurse Practitioner jobs











As a part of Duke Health’s outpatient clinic network, you will enjoy competitive compensation, comprehensive benefits plans, convenient work hours, and many opportunities for career advancement. Become a part of a team that values and invests in you.
Duke Advanced Practice Highlights:
- The nation’s first Physician Assistant Program was created at Duke in 1965 and is consistently ranked No. 1 in the country.
- The Duke School of Nursing is consistently ranked as one of the top nursing schools and their MSN and DNP programs offers eight advanced practice registered nurse majors and specialty certifications, as well as post master’s certificates and certification alignment programs.
- Commitment to ongoing learning for APPs through annual CME funding and access to high-quality Duke CME offerings including APP Grand Rounds and a professional advancement program. APPs are leaders in multiple arenas within Duke.
- Duke offers APPs opportunities to practice within team based integrative care in a tremendous variety of specialties. APPs are expected to work to top of scope in order to contribute to Duke’s missions which include clinical practice, education, and research.
- Practice locations can include Duke Health’s three hospitals or over 140 primary care and specialty care clinics throughout North Carolina.
Job Location
Job Summary
- Take patient histories, conduct physical examinations, and record data in patient’s record; write progress notes; prepare patient workups and summaries noting pertinent positive and negative findings; obtain psychosocial history relevant to patient care, and assume responsibility for developing therapeutic relationships with patients.
- Perform diagnostic and therapeutic procedures to assist physician in diagnosing medical problems and prescribing necessary treatment and services for quality patient care; record the normal and abnormal data for review by the physician.
- Order laboratory studies and diagnostic procedures; explain the necessity, preparation, nature and anticipated effects of scheduled diagnostic and therapeutic procedures to the patient.
- Carry out therapeutic procedures as necessary; monitor progress of patients, report progress to supervising physician, and maintain record of each patient's progress.
- May make work assignments for assigned nursing and technical personnel; review the work of other staff; train new personnel.
- Participate in teaching physician assistant students in techniques and procedures, which are unique to Cardiology.
Job Eligibility Requirements
Education
- Nurse Practitioners: Work requires completion of an accredited Nurse Practitioner program, with a Master's degree in Nursing.
- Physician Assistants: Completion of an accredited Physician Assistant program. A Bachelor's degree required; Master's degree strongly preferred.
Certification
- ACLS required.
- BLS required.
License
- Nurse Practitioners: Must have current or compact RN licensure in the state of North Carolina. National certification as a NP required prior to employment. Must be board certified from a national certifying board in the appropriate patient foci.
- Physician Assistants: Must be licensed in the state of NC and be certified as a Physician Assistant by the National Commission on Certification of Physician Assistants.
- Both: DEA licensure with prescriptive authority required.
Experience
- 1+ years of cardiology APP experience strongly preferred.
Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, (including pregnancy and pregnancy related conditions), sexual orientation, or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
See All 168+ Nurse Practitioner Jobs in Durham
Find roles in Durham that match your experience and apply in just a few clicks.
Find Nurse Practitioner JobsNurse Practitioner Job Market in Durham
Who's Hiring
- Duke Health92

- Thriveworks31

- Crossover Health15

- LiveWell Homecare Agency15L
- Advanced Medaesthetic Partners15

Nurse Practitioner Jobs in Durham: Frequently Asked Questions
How do I get a nurse practitioner job in Durham?
Focus your search on Durham's two dominant hiring corridors: Duke Health's medical campus and the federally qualified health centers and community clinics serving the Walltown, Bragtown, and Southpoint corridors. Academic medical systems, private specialty practices, and urgent care groups all hire actively here. Candidates with experience in primary care, cardiology, or oncology have a clear edge in Durham's market, and bilingual skills in Spanish are a practical differentiator at community health sites.
Which companies hire nurse practitioners in Durham?
Employers hiring nurse practitioners in Durham right now include Duke Health, Thriveworks, and Crossover Health, based on current listings on Migrate Mate as of September 2026. Durham's employer mix leans heavily toward large academic health systems, multi-specialty physician groups, and federally funded community health organizations serving the Research Triangle region.
Are there remote nurse practitioner jobs in Durham?
Yes, though remote opportunities are limited by nature for nurse practitioners, since most roles require hands-on patient care. About 100% of nurse practitioner openings tied to Durham are remote or hybrid as of September 2026, concentrated in telehealth triage and chronic disease management programs. Durham's health systems have expanded telehealth panels, particularly for behavioral health and post-discharge follow-up care.
How can I get a nurse practitioner job in Durham with little or no experience?
The most realistic entry path in Durham is a new-graduate residency or fellowship at one of the area's academic health systems, which structure supervised clinical rotations for newly licensed NPs. Durham's federally qualified health centers and community clinics also hire new graduates more readily than private specialty practices. Completing clinical hours in Durham itself during your program builds direct relationships with hiring managers, which consistently outweighs a polished resume at the entry level.
Related Jobs in North Carolina
See All 168+ Nurse Practitioner Jobs in Durham
Find roles in Durham that match your experience and apply in just a few clicks.
Find Nurse Practitioner Jobs