Nurse Practitioner Jobs in Durham, NC

Nurse Practitioner jobs in Durham, North Carolina are concentrated in Research Triangle Park, Duke University's Medical Center area, and the Northgate corridor, with strong demand across academic medical centers, community health networks, and specialty clinics. Employers hiring right now include Duke Health, Thriveworks, and Crossover Health. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles168+
Top employerDuke Health
Work type75% Hybrid
Top credentialBLS Certification
Companies hiring5

Showing 5 of 168+ Nurse Practitioner jobs

Duke Health
Nurse Practitioner or Physician Assistant - Triangle Heart Associates
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Duke Health
New 13h ago
Nurse Practitioner or Physician Assistant - Triangle Heart Associates
Duke Health
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
BLS Certification
10,000+

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Duke Health
Nurse Practitioner or Physician Assistant- Duke Center for Onco-Primary Care Program
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Duke Health
Added 1d ago
Nurse Practitioner or Physician Assistant- Duke Center for Onco-Primary Care Program
Duke Health
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Hybrid
Acute Care Nurse Practitioner Certification - Adult Gerontology
10,000+

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Duke Health
Nurse Practitioner or Physician Assistant- Medical Oncology
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Duke Health
Added 1d ago
Nurse Practitioner or Physician Assistant- Medical Oncology
Duke Health
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Acute Care Nurse Practitioner Certification - Adult Gerontology
10,000+

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Duke Health
Nurse Practitioner or Physician Assistant - Hematologic Malignancy and Cellular Therapy (HMCT)
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Duke Health
Added 1d ago
Nurse Practitioner or Physician Assistant - Hematologic Malignancy and Cellular Therapy (HMCT)
Duke Health
Durham, North Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Acute Care Nurse Practitioner Certification - Adult Gerontology
10,000+

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Crossover Health
Nurse Practitioner As Needed @ Durham Fidelity
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Crossover Health
Added 2d ago
Nurse Practitioner As Needed @ Durham Fidelity
Crossover Health
Durham, North Carolina
Customer Service
Customer Success
Customer Support
BLS Certification
1,001-5,000

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See All 168+ Nurse Practitioner Jobs in Durham

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Nurse Practitioner Job Market in Durham

Who's Hiring

  • Duke Health
    Duke Health92
  • Thriveworks
    Thriveworks31
  • Crossover Health
    Crossover Health15
  • L
    LiveWell Homecare Agency15
  • Advanced Medaesthetic Partners
    Advanced Medaesthetic Partners15

Nurse Practitioner Jobs in Durham: Frequently Asked Questions

How do I get a nurse practitioner job in Durham?

Focus your search on Durham's two dominant hiring corridors: Duke Health's medical campus and the federally qualified health centers and community clinics serving the Walltown, Bragtown, and Southpoint corridors. Academic medical systems, private specialty practices, and urgent care groups all hire actively here. Candidates with experience in primary care, cardiology, or oncology have a clear edge in Durham's market, and bilingual skills in Spanish are a practical differentiator at community health sites.

Which companies hire nurse practitioners in Durham?

Employers hiring nurse practitioners in Durham right now include Duke Health, Thriveworks, and Crossover Health, based on current listings on Migrate Mate as of September 2026. Durham's employer mix leans heavily toward large academic health systems, multi-specialty physician groups, and federally funded community health organizations serving the Research Triangle region.

Are there remote nurse practitioner jobs in Durham?

Yes, though remote opportunities are limited by nature for nurse practitioners, since most roles require hands-on patient care. About 100% of nurse practitioner openings tied to Durham are remote or hybrid as of September 2026, concentrated in telehealth triage and chronic disease management programs. Durham's health systems have expanded telehealth panels, particularly for behavioral health and post-discharge follow-up care.

How can I get a nurse practitioner job in Durham with little or no experience?

The most realistic entry path in Durham is a new-graduate residency or fellowship at one of the area's academic health systems, which structure supervised clinical rotations for newly licensed NPs. Durham's federally qualified health centers and community clinics also hire new graduates more readily than private specialty practices. Completing clinical hours in Durham itself during your program builds direct relationships with hiring managers, which consistently outweighs a polished resume at the entry level.

See All 168+ Nurse Practitioner Jobs in Durham

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