Nurse Practitioner Jobs in Columbia, SC
Nurse Practitioner jobs in Columbia, South Carolina are in strong demand, concentrated in the Midlands Medical Corridor near Palmetto Health Richland, the Harbison and Irmo corridor to the west, and the Fort Jackson adjacent communities to the east, across primary care, urgent care, and behavioral health. Employers hiring right now include Prisma Health, Prisma Health Urgent Care, and Lexington Health. Scan the live roles below and apply to whichever ones fit.
Find Nurse Practitioner JobsOverview
Showing 5 of 56+ Nurse Practitioner jobs
We offer Nurse Practitioners:
- Competitive earnings package with uncapped potential
- Compensation range: $142,000-$190,000, compensation model based on productivity
- W2 employed position with flexible hybrid work schedules
- Collaborative work environment with unmatched support
- Sign-on bonus!
- Care Access and Quality Incentive: Annual cash bonus program
- Comprehensive benefit package
- 401k with up to 4% match
- CME reimbursement
- Strong work/life balance
Nurse Practitioners are a critical part of our clinical team. We’re seeking NPs that are:
- Local to and fully licensed (PMHNP) in South Carolina.
- Beyond 6 months of employed outpatient experience.
- Board Certified with full prescribing ability.
- Experienced in both medication management and therapy.
- Experienced with adolescent and adult populations, ages 15+.
Location and Schedule:
- Conveniently located in St Andrews area, at I-20 and I-26/St Andrews Rd
- Start in September
- Beautifully designed offices that are thoughtfully laid out
- Full-time, Monday-Friday with evenings/weekends optional
- Flexible hybrid schedule to accommodate work/life balance
About LifeStance Health
We offer Nurse Practitioners:
- Competitive earnings package with uncapped potential
- Compensation range: $142,000-$190,000, compensation model based on productivity
- W2 employed position with flexible hybrid work schedules
- Collaborative work environment with unmatched support
- Sign-on bonus!
- Care Access and Quality Incentive: Annual cash bonus program
- Comprehensive benefit package
- 401k with up to 4% match
- CME reimbursement
- Strong work/life balance
Nurse Practitioners are a critical part of our clinical team. We’re seeking NPs that are:
- Local to and fully licensed (PMHNP) in South Carolina.
- Beyond 6 months of employed outpatient experience.
- Board Certified with full prescribing ability.
- Experienced in both medication management and therapy.
- Experienced with adolescent and adult populations, ages 15+.
Location and Schedule:
- Conveniently located in St Andrews area, at I-20 and I-26/St Andrews Rd
- Start in September
- Beautifully designed offices that are thoughtfully laid out
- Full-time, Monday-Friday with evenings/weekends optional
- Flexible hybrid schedule to accommodate work/life balance
About LifeStance Health
See All 56 Nurse Practitioner Jobs in Columbia
Find roles in Columbia that match your experience and apply in just a few clicks.
Find Nurse Practitioner JobsNurse Practitioner Job Market in Columbia
Who's Hiring
- Prisma Health24
- Prisma Health Urgent Care4
- Lexington Health3
- Optum2
- Curana Health2
Top Industries Hiring
- Healthcare & Medical Services
- Consulting & Professional Services
Nurse Practitioner Jobs in Columbia: Frequently Asked Questions
How do I get a nurse practitioner job in Columbia?
The strongest hiring in Columbia is concentrated in large health systems anchored near downtown, federally qualified health centers serving underserved communities, and the military-adjacent care network around Fort Jackson. Candidates with a primary care or psychiatric-mental health specialty tend to move fastest in this market. Tailoring your application to the specific patient population of each employer, whether that is a community health center or a hospital-based specialty clinic, gives you a clear edge.
Which companies hire nurse practitioners in Columbia?
Employers hiring nurse practitioners in Columbia right now include Prisma Health, Prisma Health Urgent Care, and Lexington Health, based on current listings on Migrate Mate as of July 2026. Columbia's market is anchored by large regional health systems, federally qualified health centers, and private multi-specialty practices serving both the general population and active-duty military families.
Are there remote nurse practitioner jobs in Columbia?
Yes, though remote opportunities are limited by the hands-on nature of most nurse practitioner roles. About 22% of nurse practitioner openings tied to Columbia are remote or hybrid as of July 2026, with those positions most often found in telehealth triage, psychiatric-mental health consultation, and care management roles with Columbia-based health systems.
How can I get a nurse practitioner job in Columbia with little or no experience?
The most realistic entry path in Columbia is joining a federally qualified health center or a large health system's new-graduate NP residency or fellowship program, several of which operate in the Midlands region. Community health centers serving Columbia's underserved zip codes frequently hire newer graduates and provide structured mentorship. Completing clinical rotations at Columbia-area facilities and networking through the South Carolina Nurses Association chapter also opens doors with local employers before you even apply.
Which industries hire the most nurse practitioners in Columbia?
The sectors hiring the most nurse practitioners in Columbia are Healthcare & Medical Services and Consulting & Professional Services, based on current listings on Migrate Mate as of July 2026. Columbia's role as the state capital and home to a major military installation drives consistent demand from government-affiliated healthcare facilities, large academic health networks, and community-focused primary care organizations.
Related Jobs in South Carolina
See All 56 Nurse Practitioner Jobs in Columbia
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