Nurse Practitioner Jobs in Columbia, SC

Nurse Practitioner jobs in Columbia, South Carolina are in strong demand, concentrated in the Midlands Medical Corridor near Palmetto Health Richland, the Harbison and Irmo corridor to the west, and the Fort Jackson adjacent communities to the east, across primary care, urgent care, and behavioral health. Employers hiring right now include Prisma Health, Concentra, and TeamHealth. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles75
Top employerPrisma Health
Work type50% Remote
Top credentialMaster's degree in nursing
Companies hiring9

Showing 5 of 75+ Nurse Practitioner jobs

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Remote Virtual Nurse Practitioner
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R
Added 1d ago
Remote Virtual Nurse Practitioner
Remote Care Partners
Columbia, South Carolina
Allied Health
Healthcare Administration
Nursing
$95k - $115k/yr
Remote (US)

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TeamHealth
Emergency Medicine Advanced Practice Clinician In Columbia, SC
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TeamHealth
Added 1d ago
Emergency Medicine Advanced Practice Clinician In Columbia, SC
TeamHealth
Columbia, South Carolina
Allied Health
Healthcare Administration
Nursing
PALS Certification
10,000+

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Advanced Correctional Healthcare
Psychiatric Nurse Practitioner
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Advanced Correctional Healthcare
Added 2d ago
Psychiatric Nurse Practitioner
Advanced Correctional Healthcare
Columbia, South Carolina
Business Development
Customer Success
Sales
$90 - $175/hr
Managed care
1,001-5,000

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M
Nurse Practitioner
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M
Added 2d ago
Nurse Practitioner
Midlands Neurology and Pain Associates
Columbia, South Carolina
Allied Health
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling

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US Department of Veterans Affairs
Primary Care Nurse Practitioner
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US Department of Veterans Affairs
Added 2d ago
Primary Care Nurse Practitioner
US Department of Veterans Affairs
Columbia, South Carolina
Content Marketing
Copywriting & Editorial
Marketing
$104k - $173k/yr
On-Site
Post-Master's Certificate (Nursing)
10,000+

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See All 75 Nurse Practitioner Jobs in Columbia

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Nurse Practitioner Job Market in Columbia

Who's Hiring

  • Prisma Health
    Prisma Health15
  • Concentra
    Concentra8
  • TeamHealth
    TeamHealth8
  • Agape Care
    Agape Care8
  • R
    Remote Care Partners8

Nurse Practitioner Jobs in Columbia: Frequently Asked Questions

How do I get a nurse practitioner job in Columbia?

The strongest hiring in Columbia is concentrated in large health systems anchored near downtown, federally qualified health centers serving underserved communities, and the military-adjacent care network around Fort Jackson. Candidates with a primary care or psychiatric-mental health specialty tend to move fastest in this market. Tailoring your application to the specific patient population of each employer, whether that is a community health center or a hospital-based specialty clinic, gives you a clear edge.

Which companies hire nurse practitioners in Columbia?

Employers hiring nurse practitioners in Columbia right now include Prisma Health, Concentra, and TeamHealth, based on current listings on Migrate Mate as of August 2026. Columbia's market is anchored by large regional health systems, federally qualified health centers, and private multi-specialty practices serving both the general population and active-duty military families.

Are there remote nurse practitioner jobs in Columbia?

Yes, though remote opportunities are limited by the hands-on nature of most nurse practitioner roles. About 50% of nurse practitioner openings tied to Columbia are remote or hybrid as of August 2026, with those positions most often found in telehealth triage, psychiatric-mental health consultation, and care management roles with Columbia-based health systems.

How can I get a nurse practitioner job in Columbia with little or no experience?

The most realistic entry path in Columbia is joining a federally qualified health center or a large health system's new-graduate NP residency or fellowship program, several of which operate in the Midlands region. Community health centers serving Columbia's underserved zip codes frequently hire newer graduates and provide structured mentorship. Completing clinical rotations at Columbia-area facilities and networking through the South Carolina Nurses Association chapter also opens doors with local employers before you even apply.

See All 75 Nurse Practitioner Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find Nurse Practitioner Jobs