Nurse Practitioner Jobs in Greenville, SC

Nurse Practitioner jobs in Greenville, South Carolina are concentrated in the Medical District along Grove Road, in the expanding Verdae corridor, and across downtown Greenville's growing network of outpatient and specialty clinics, with strong demand in primary care, urgent care, and family medicine. Employers actively hiring include Prisma Health, Prisma Health Urgent Care, and CVS Health. Find a role that fits below and apply directly.

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Overview

Open roles39
Top employerPrisma Health
Work type92% On-site
Top credentialMaster's
Companies hiring20

Showing 5 of 39+ Nurse Practitioner jobs

Curana Health
Nurse Practitioner - Psychiatric
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Curana Health
Added 1w ago
Nurse Practitioner - Psychiatric
Curana Health
Greenville, South Carolina
Business Analysis
Data Analytics
Project Management
BLS Certification
1,001-5,000

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HarmonyCares
PRN Nurse Practitioner Per Visit in Greenville, SC
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HarmonyCares
Added 1w ago
PRN Nurse Practitioner Per Visit in Greenville, SC
HarmonyCares
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Remote (US)
BLS Certification
1,001-5,000

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Comprehensive Rehab Consultants
Nurse Practitioner
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Comprehensive Rehab Consultants
Added 1w ago
Nurse Practitioner
Comprehensive Rehab Consultants
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$112k - $132k/yr
51-200

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Prisma Health
Nurse Practitioner –Geriatrics PACE Greenville – PRN
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Prisma Health
Added 2w ago
Nurse Practitioner –Geriatrics PACE Greenville – PRN
Prisma Health
Greenville, South Carolina
Allied Health
Healthcare Administration
Nursing
Master's degree in nursing
10,000+

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Carolinas Fertility Institute
Advanced Practice Provider
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Carolinas Fertility Institute
Added 2w ago
Advanced Practice Provider
Carolinas Fertility Institute
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$100k - $115k/yr
On-Site
Master's degree
51-200

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See All 39 Nurse Practitioner Jobs in Greenville

Find roles in Greenville that match your experience and apply in just a few clicks.

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Nurse Practitioner Job Market in Greenville

Who's Hiring

  • Prisma Health
    Prisma Health19
  • Prisma Health Urgent Care
    Prisma Health Urgent Care2
  • CVS Health
    CVS Health1
  • Crossroads
    Crossroads1
  • DOCS Health
    DOCS Health1

Top Industries Hiring

  • Healthcare & Medical Services
  • Consulting & Professional Services

Nurse Practitioner Jobs in Greenville: Frequently Asked Questions

How do I get a nurse practitioner job in Greenville?

Focus your search on Greenville's Medical District, where large health systems and specialty practices cluster along Grove Road and Patewood Drive, then expand to urgent care groups and federally qualified health centers serving underserved communities in and around the city. Candidates with primary care or family practice experience have the strongest footing here. Bilingual skills and experience with Medicaid or underinsured populations give applicants a real edge in Greenville's growing community health sector.

Which companies hire nurse practitioners in Greenville?

Companies currently hiring nurse practitioners in Greenville include Prisma Health, Prisma Health Urgent Care, and CVS Health, per current listings on MigrateАте as of July 2026. Greenville's employer mix ranges from large regional health systems and hospital-affiliated multispecialty groups to independent urgent care chains and community health organizations expanding their mid-level provider teams.

Are there remote nurse practitioner jobs in Greenville?

Yes, though remote opportunities are limited by the hands-on nature of most nurse practitioner roles. About 8% of nurse practitioner openings tied to Greenville are remote or hybrid as of July 2026, with the bulk of those positions concentrated in telehealth triage, chronic disease management, and behavioral health consulting rather than primary or acute care.

How can I get a nurse practitioner job in Greenville with little or no experience?

The most realistic entry path in Greenville is through large health system residency or transition-to-practice programs, which give new graduates supervised clinical hours and a structured ramp into independent practice. Community health centers serving the West Greenville and downtown corridors frequently hire new graduates willing to work in underserved settings. Urgent care groups across the Verdae and Woodruff Road corridors also hire new NPs for supervised roles, especially those with strong emergency or acute care RN backgrounds.

Which industries hire the most nurse practitioners in Greenville?

Most nurse practitioner openings in Greenville sit in Healthcare & Medical Services and Consulting & Professional Services, per current listings on Migrate Mate as of July 2026. Greenville's rapid population growth and the continued expansion of hospital-affiliated outpatient campuses in the Patewood and Verdae areas have made ambulatory and multispecialty care the dominant drivers of local NP hiring.

See All 39 Nurse Practitioner Jobs in Greenville

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