Outpatient Registered Nurse Jobs in South Carolina
Outpatient Registered Nurse jobs in South Carolina are concentrated in Columbia, Greenville, and Charleston, where large systems like Prisma Health, MUSC Health, and Bon Secours St. Francis have built substantial ambulatory care networks. Demand is strongest in primary care, oncology infusion, and orthopedic clinic settings, with openings at both entry and experienced levels. South Carolina's growing retiree population and expanding community health infrastructure keep outpatient hiring active year-round. Find a role that fits below and apply directly.
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Showing 5 of 33+ Outpatient Registered Nurse jobs
Inspire health. Serve with compassion. Be the difference.
Job Summary
Provides therapies in the oncology setting, which includes, but is not limited to chemotherapy, immunotherapy, monoclonal antibody therapy, blood product transfusions, radiation therapy, and bone marrow transplant. Demonstrates clinical competency utilizing evidence-based practices/research in all areas of the nursing process: assessment, planning, implementation, evaluation, and outcomes. Incorporates knowledge of safety protocols, cost containment and quality improvement throughout the nursing process. Identifies patient, unit, and organizational priorities and incorporates the nursing process. Adheres to all compliance and policy and procedure requirements of the organization including, but not limited to licensure renewal, assigned training, employee health screenings, time and attendance policy, dress code policy, patient confidentiality, infection control, and medication administration. This job may require additional training and certifications such as ACLS, PALS, chemotherapy/biotherapy, and transplant/cellular therapy curriculum. Demonstrates knowledge of regulatory agency requirements (JCAHO, DHEC). Provides care within the scope of the SC Nursing Practice Act. This setting may require staff to be scheduled for shift, weekend, holiday, and on-call work.Essential Functions
All team members are expected to be knowledgeable and compliant with Prisma Health's purpose: Inspire health. Serve with compassion. Be the difference.
Assists physicians with examinations, procedures and other activities related to direct patient care.
Arranges for patient appointments for diagnostic testing, consults, referrals and admission to the hospital.
Monitors and maintains stock of medical supplies and proper functioning of equipment.
Documents patients' vital statistics and other encounter data into patient chart and ensures that all required records are in the chart. Obtains brief medical history and chief complaint from patients.
Calls in prescriptions for patients according to physician order.
Prepares exam rooms with appropriate instruments, supplies, and equipment. Cleans exam rooms between procedures and exams.
Receives and returns clinically related telephone calls, screening and forwarding those requiring physician action.
Completes medical/physical history forms and other related information for insurance companies.
Informs physician of changes in schedule.
Uses advanced level nursing skills and telephone triage guidelines to assess and prioritize different types of conditions and symptoms including when to call 911.
Performs other duties as assigned.
Supervisory/Management Responsibilities
This is a non-management job that will report to a supervisor, manager, director or executive.
Minimum Requirements
Education - Associate' degree in Nursing. Bachelor's degree in Nursing preferred.
Experience - One (1) year experience as a registered nurse.
In Lieu Of
In lieu of one (1) year of registered nurse experience, will accept successful completion of the Prisma Health Nurse Residency Program or successful completion of a comparable residency from another organization.
In lieu of one (1) year of registered nurse experience, will accept 1 year of licensed practical nurse (LPN) experience.
Required Certifications, Registrations, Licenses
Holds a current RN compact/multistate license recognized by the NCSBN Compact State or is licensed to practice as an RN in the state the team member is working.
Knowledge, Skills and Abilities
Working knowledge of Patient Equip (vitals, suction, defib)
Work Shift
Day (United States of America)Location
Greer Medical CampusFacility
Greenville Memorial HospitalDepartment
Ambulatory Infusion Center-CIGreerShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
Inspire health. Serve with compassion. Be the difference.
Job Summary
Provides therapies in the oncology setting, which includes, but is not limited to chemotherapy, immunotherapy, monoclonal antibody therapy, blood product transfusions, radiation therapy, and bone marrow transplant. Demonstrates clinical competency utilizing evidence-based practices/research in all areas of the nursing process: assessment, planning, implementation, evaluation, and outcomes. Incorporates knowledge of safety protocols, cost containment and quality improvement throughout the nursing process. Identifies patient, unit, and organizational priorities and incorporates the nursing process. Adheres to all compliance and policy and procedure requirements of the organization including, but not limited to licensure renewal, assigned training, employee health screenings, time and attendance policy, dress code policy, patient confidentiality, infection control, and medication administration. This job may require additional training and certifications such as ACLS, PALS, chemotherapy/biotherapy, and transplant/cellular therapy curriculum. Demonstrates knowledge of regulatory agency requirements (JCAHO, DHEC). Provides care within the scope of the SC Nursing Practice Act. This setting may require staff to be scheduled for shift, weekend, holiday, and on-call work.Essential Functions
All team members are expected to be knowledgeable and compliant with Prisma Health's purpose: Inspire health. Serve with compassion. Be the difference.
Assists physicians with examinations, procedures and other activities related to direct patient care.
Arranges for patient appointments for diagnostic testing, consults, referrals and admission to the hospital.
Monitors and maintains stock of medical supplies and proper functioning of equipment.
Documents patients' vital statistics and other encounter data into patient chart and ensures that all required records are in the chart. Obtains brief medical history and chief complaint from patients.
Calls in prescriptions for patients according to physician order.
Prepares exam rooms with appropriate instruments, supplies, and equipment. Cleans exam rooms between procedures and exams.
Receives and returns clinically related telephone calls, screening and forwarding those requiring physician action.
Completes medical/physical history forms and other related information for insurance companies.
Informs physician of changes in schedule.
Uses advanced level nursing skills and telephone triage guidelines to assess and prioritize different types of conditions and symptoms including when to call 911.
Performs other duties as assigned.
Supervisory/Management Responsibilities
This is a non-management job that will report to a supervisor, manager, director or executive.
Minimum Requirements
Education - Associate' degree in Nursing. Bachelor's degree in Nursing preferred.
Experience - One (1) year experience as a registered nurse.
In Lieu Of
In lieu of one (1) year of registered nurse experience, will accept successful completion of the Prisma Health Nurse Residency Program or successful completion of a comparable residency from another organization.
In lieu of one (1) year of registered nurse experience, will accept 1 year of licensed practical nurse (LPN) experience.
Required Certifications, Registrations, Licenses
Holds a current RN compact/multistate license recognized by the NCSBN Compact State or is licensed to practice as an RN in the state the team member is working.
Knowledge, Skills and Abilities
Working knowledge of Patient Equip (vitals, suction, defib)
Work Shift
Day (United States of America)Location
Greer Medical CampusFacility
Greenville Memorial HospitalDepartment
Ambulatory Infusion Center-CIGreerShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
See All 33 Outpatient Registered Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find JobsOutpatient Registered Nurse Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Outpatient Registered Nurse Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Fresenius Medical Care17
- Prisma Health7
- Aiken Regional Medical Centers3
- HHS1
- Atrium Health1
Top Industries Hiring
- Healthcare & Medical Services
What South Carolina Employers Look For
The qualifications that appear most often in outpatient registered nurse jobs across South Carolina.
- Active South Carolina RN license or a Compact license recognized in South Carolina
- Associate or Bachelor of Science in Nursing from an accredited nursing program
- Current BLS certification required prior to first day of patient care
- Minimum one year of clinical nursing experience in an ambulatory or acute care setting
- Proficiency with electronic health record systems such as Epic or Cerner
- Strong patient education and chronic disease management skills preferred by hiring managers
Outpatient Registered Nurse Jobs in South Carolina: Frequently Asked Questions
How do you become a outpatient registered nurse in South Carolina?
You become an outpatient registered nurse in South Carolina by earning an Associate or Bachelor of Science in Nursing, passing the NCLEX-RN, and obtaining an active RN license through the South Carolina Board of Nursing. South Carolina also participates in the Nurse Licensure Compact, so nurses licensed in other Compact states may practice without applying for a separate South Carolina license. Outpatient roles typically prefer candidates with some clinical experience, though new-grad positions exist in larger ambulatory care networks.
How much do outpatient registered nurses make in South Carolina?
Outpatient registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire outpatient registered nurses in South Carolina?
Companies currently hiring outpatient registered nurses in South Carolina include Fresenius Medical Care, Prisma Health, and Aiken Regional Medical Centers, per current listings on Migrate Mate as of August 2026. Prisma Health and MUSC Health are among the most consistent sources of outpatient RN openings given the scale of their physician practice and specialty clinic operations across the state.
Which South Carolina cities have the most outpatient registered nurse jobs?
Greenville, Aiken, and Spartanburg have the most outpatient registered nurse openings in South Carolina. Columbia and Greenville lead because Prisma Health operates major ambulatory care campuses in both cities, while Charleston's concentration of MUSC Health clinics and private specialty practices drives strong demand there as well.
Are there remote outpatient registered nurse jobs in South Carolina?
Yes, but they're rare. About 8% of outpatient registered nurse openings tied to South Carolina are remote or hybrid as of August 2026, reflecting the hands-on nature of most clinic-based patient care. The outpatient RN tasks most likely to be performed remotely are telephone triage, care coordination, and chronic disease management coaching.
How can I get hired as a outpatient registered nurse in South Carolina with little or no experience?
The most realistic entry path is a new-graduate residency program, and both Prisma Health and MUSC Health run structured ambulatory or primary care residencies that accept candidates without prior outpatient experience. Applying for med-surg or telemetry floor roles first and then transferring into a clinic setting after months is a common lateral move. Holding an active South Carolina RN license, BLS certification, and a completed preceptorship in an outpatient setting significantly strengthens applications at community health centers and federally qualified health clinics across the state.
Where can I find and apply to outpatient registered nurse jobs in South Carolina?
You can find and apply to outpatient registered nurse jobs in South Carolina on Migrate Mate, which lists current South Carolina openings. Search the roles above, find the positions that fit your experience and location, and apply directly to each employer.
See All 33 Outpatient Registered Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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