Outpatient Registered Nurse Jobs in South Carolina

Outpatient Registered Nurse jobs in South Carolina are concentrated in Columbia, Greenville, and Charleston, where large systems like Prisma Health, MUSC Health, and Bon Secours St. Francis have built substantial ambulatory care networks. Demand is strongest in primary care, oncology infusion, and orthopedic clinic settings, with openings at both entry and experienced levels. South Carolina's growing retiree population and expanding community health infrastructure keep outpatient hiring active year-round. Find a role that fits below and apply directly.

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Overview

Open roles31
Top employerPrisma Health
Top cityGreenville, SC
Cities hiring18
Work type100% On-site
Top industryHealthcare

Showing 5 of 31+ Outpatient Registered Nurse jobs

Outpatient Registered Nurse - RN
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Added 3d ago
Outpatient Registered Nurse - RN
Fresenius Medical Care
Darlington, South Carolina
Higher Education
K-12 Teaching
Teaching & Instruction
Managed Registered Nurses (RNs)
10,000+

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Outpatient Registered Nurse - RN
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Added 5d ago
Outpatient Registered Nurse - RN
Fresenius Medical Care
Fort Mill, South Carolina
Healthcare Administration
Human Resources
Nursing
Patient Services & Wellbeing
Managed Registered Nurses (RNs)
10,000+

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Outpatient Wound Care Supervisor - RN License Required
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Added 2w ago
Outpatient Wound Care Supervisor - RN License Required
Healogics
Beaufort, South Carolina
Clinical Support
Healthcare Administration
Human Resources
$71k - $95k/yr
Managed Registered Nurses (RNs)
1,001-5,000

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Outpatient Registered Nurse - RN
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Added 2w ago
Outpatient Registered Nurse - RN
Fresenius Medical Care
Charleston, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Managed Registered Nurses (RNs)
10,000+

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Part-Time Outpatient Registered Dietitian
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Added 3w ago
Part-Time Outpatient Registered Dietitian
HHS
Greenville, South Carolina
Healthcare Administration
Patient Services & Wellbeing
Master's degree
10,000+

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Outpatient Registered Nurse Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Greenville
8 jobs
Columbia
4 jobs
Sumter
2 jobs
Charleston
2 jobs
Boiling Springs
2 jobs
Aiken
1 job
Dillon
1 job
Bamberg
1 job
Anderson
1 job

Outpatient Registered Nurse Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Prisma Health13
  • Fresenius Medical Care12
  • HHS1
  • Healogics1
  • Vibra Travels1

Top Industries Hiring

  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in outpatient registered nurse jobs across South Carolina.

  • Active South Carolina RN license or a Compact license recognized in South Carolina
  • Associate or Bachelor of Science in Nursing from an accredited nursing program
  • Current BLS certification required prior to first day of patient care
  • Minimum one year of clinical nursing experience in an ambulatory or acute care setting
  • Proficiency with electronic health record systems such as Epic or Cerner
  • Strong patient education and chronic disease management skills preferred by hiring managers

Outpatient Registered Nurse Jobs in South Carolina: Frequently Asked Questions

How do you become a outpatient registered nurse in South Carolina?

You become an outpatient registered nurse in South Carolina by earning an Associate or Bachelor of Science in Nursing, passing the NCLEX-RN, and obtaining an active RN license through the South Carolina Board of Nursing. South Carolina also participates in the Nurse Licensure Compact, so nurses licensed in other Compact states may practice without applying for a separate South Carolina license. Outpatient roles typically prefer candidates with some clinical experience, though new-grad positions exist in larger ambulatory care networks.

How much do outpatient registered nurses make in South Carolina?

Outpatient registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire outpatient registered nurses in South Carolina?

Companies currently hiring outpatient registered nurses in South Carolina include Prisma Health, Fresenius Medical Care, and HHS, per current listings on Migrate Mate as of October 2026. Prisma Health and MUSC Health are among the most consistent sources of outpatient RN openings given the scale of their physician practice and specialty clinic operations across the state.

Which South Carolina cities have the most outpatient registered nurse jobs?

Greenville, Columbia, and Sumter have the most outpatient registered nurse openings in South Carolina. Columbia and Greenville lead because Prisma Health operates major ambulatory care campuses in both cities, while Charleston's concentration of MUSC Health clinics and private specialty practices drives strong demand there as well.

Are there remote outpatient registered nurse jobs in South Carolina?

Yes, but they're rare. About 0% of outpatient registered nurse openings tied to South Carolina are remote or hybrid as of October 2026, reflecting the hands-on nature of most clinic-based patient care. The outpatient RN tasks most likely to be performed remotely are telephone triage, care coordination, and chronic disease management coaching.

How can I get hired as a outpatient registered nurse in South Carolina with little or no experience?

The most realistic entry path is a new-graduate residency program, and both Prisma Health and MUSC Health run structured ambulatory or primary care residencies that accept candidates without prior outpatient experience. Applying for med-surg or telemetry floor roles first and then transferring into a clinic setting after months is a common lateral move. Holding an active South Carolina RN license, BLS certification, and a completed preceptorship in an outpatient setting significantly strengthens applications at community health centers and federally qualified health clinics across the state.

Where can I find and apply to outpatient registered nurse jobs in South Carolina?

You can find and apply to outpatient registered nurse jobs in South Carolina on Migrate Mate, which lists current South Carolina openings. Search the roles above, find the positions that fit your experience and location, and apply directly to each employer.

See All 31 Outpatient Registered Nurse Jobs in South Carolina

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