Nurse Practitioner Jobs in San Antonio, TX

Nurse Practitioner jobs in San Antonio are in strong demand, with openings concentrated in the South Texas Medical Center, downtown, and the Stone Oak corridor across health systems, federally qualified health centers, and military-affiliated clinics. Employers hiring right now include Methodist Healthcare System, Next Level Urgent Care, and MatchNP. See the openings below and apply to the ones that match your experience.

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Overview

Open roles335+
Top employerMethodist Healthcare System
Work type50% On-site
Top credentialBLS Certification
Companies hiring18

Showing 4 of 335+ Nurse Practitioner jobs

Matrix Providers
Nurse Practitioner NP / Physician Assistant PA
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Matrix Providers
Added 1d ago
Nurse Practitioner NP / Physician Assistant PA
Matrix Providers
San Antonio, Texas
Healthcare Administration
Nursing
Patient Services & Wellbeing
$55 - $58.59/hr
501-1,000

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Commonwealth Medical Services
Nurse Practitioner - San Antonio, TX - Part-Time
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Commonwealth Medical Services
Added 1d ago
Nurse Practitioner - San Antonio, TX - Part-Time
Commonwealth Medical Services
San Antonio, Texas
Healthcare Administration
Nursing
Patient Services & Wellbeing
$450 - $550/hr
51-200

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Sanitas Medical Center
Nurse Practitioner
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Sanitas Medical Center
Added 1d ago
Nurse Practitioner
Sanitas Medical Center
San Antonio, Texas
Clinical Support
Healthcare Administration
Human Resources
BLS Certification
10,000+

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Methodist Healthcare System
Heart Failure & Transplant Acute Care Nurse Practitioner
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Methodist Healthcare System
Added 4d ago
Heart Failure & Transplant Acute Care Nurse Practitioner
Methodist Healthcare System
San Antonio, Texas
Healthcare Administration
Nursing
Patient Services & Wellbeing
5,001-10,000

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Nurse Practitioner Job Market in San Antonio

Who's Hiring

  • Methodist Healthcare System
    Methodist Healthcare System48
  • Next Level Urgent Care
    Next Level Urgent Care32
  • MatchNP
    MatchNP16
  • HARBOR HEALTH
    HARBOR HEALTH16
  • Legion Health
    Legion Health16

Top Industries Hiring

  • Healthcare & Medical Services

Nurse Practitioner Jobs in San Antonio: Frequently Asked Questions

How do I get a nurse practitioner job in San Antonio?

The strongest hiring in San Antonio comes from the South Texas Medical Center complex, large regional health systems, federally qualified health centers serving the city's underserved communities, and military-connected facilities near Joint Base San Antonio. Candidates with experience in primary care, family medicine, or psychiatry tend to move fastest. Bilingual Spanish proficiency is a genuine competitive advantage in a city where a large share of patients speak Spanish as their primary language.

Which companies hire nurse practitioners in San Antonio?

San Antonio nurse practitioner roles are posted by Methodist Healthcare System, Next Level Urgent Care, and MatchNP and others right now, based on current listings on Migrate Mate as of August 2026. The local market is anchored by large nonprofit health systems, federally qualified health centers, and military-affiliated healthcare organizations that collectively drive a consistent share of openings year-round.

Are there remote nurse practitioner jobs in San Antonio?

Yes, but only for a narrow slice of the role, since most nurse practitioner positions require direct patient care on-site. About 50% of nurse practitioner openings tied to San Antonio are remote or hybrid as of August 2026, and those positions tend to cluster in telehealth, utilization review, and case management functions where patient interaction happens through virtual platforms rather than in a clinic.

How can I get a nurse practitioner job in San Antonio with little or no experience?

The most realistic entry path in San Antonio is through federally qualified health centers and community health clinics, which regularly hire new graduates and often offer loan repayment incentives tied to underserved-area service. Military-affiliated facilities near Joint Base San Antonio also run structured onboarding programs suited to early-career NPs. Completing clinical rotations with San Antonio health systems beforehand builds familiarity with local protocols and gives hiring managers a reason to reach back out when a position opens.

Which industries hire the most nurse practitioners in San Antonio?

Most nurse practitioner openings in San Antonio sit in Healthcare & Medical Services, per current listings on Migrate Mate as of August 2026. San Antonio's concentration of military personnel, veterans, and a large uninsured population creates sustained demand across health systems, community clinics, and government-affiliated healthcare programs that other Texas cities don't replicate at the same scale.

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