Nursing Jobs in St. Louis, MO
Nursing jobs in St. Louis draw strong demand from health systems and specialty clinics concentrated in the Central West End, Cortex Innovation District, and South Grand corridor, with the city's academic medical centers and long-term care networks among the most active employers. Employers hiring right now include Mercy, SSM Health, and Luxor Healthcare. See the openings below and apply to the ones that match your experience.
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It's more than a career, it's a calling
MO-SSM Health Mission HillWorker Type:
Job Highlights:
Named 150 Top Places to Work in Healthcare 2025 - Becker's Healthcare
Named One of the World’s Happiest Workplace 2025 – WorkL
Named One of America's Best In-State Employers 2025 - Forbes
Named One of America's Greatest Workplaces for Women 2025 – Newsweek
Named One of America’s Greatest Workplaces for Culture, Belonging & Community 2026 – Newsweek
SSM Health is a Catholic, not-for-profit health system serving the comprehensive health needs of communities across the Midwest through a robust and fully integrated health care delivery system. The organization’s 40,000 team members and more than 13,900+ providers are committed to providing exceptional health care services and revealing God’s healing presence to everyone they serve.
With care delivery sites in Illinois, Missouri, Oklahoma, and Wisconsin, SSM Health includes 23 hospitals, more than 300 physician offices and other outpatient and virtual care services, 12 post-acute facilities, comprehensive home care and hospice services, a pharmacy benefit company, a health insurance company and an accountable care organization. It is one of the largest employers in every community it serves.
This position will be responsible for the St. Louis and Southern IL regions and will be based at our regional offices in St. Louis, MO. This role is NOT remote work eligible and will require relocation upon acceptance of the position.
To request additional information, confidentially submit your interest, or nominate a fellow colleague, please contact:
Angela Jones
Executive Talent Partner
Angela.Jones1@ssmhealth.com
Job Summary:
Develops short- and long-term Nursing goals and plans ensuring alignment with broader organization priorities. Utilizes metrics and organization vision to lead and direct strategic nursing practice and standards, patient safety, clinical outcomes and patient, employee and physician satisfaction. Develops and implements nursing practice standards and guidelines across organization to ensure the safe provision of quality patient care.Job Responsibilities and Requirements:
PRIMARY RESPONSIBILITIES
- Serves as a member of the leadership team providing strategic direction on Nursing related issues. Works effectively as a team member in a dynamic executive environment in a matrix organization, and promotes teamwork within and across the organization by maintaining positive relationships and utilizing effective problem solving skills.
- Regularly displays and encourages ethical behavior in the areas of business ethics, legal compliance, confidentiality, conflicts of interest, vendor relationships and the reporting of questionable activities. Serves as a role model and mentor to nursing leaders.
- Identifies common opportunities for standardizing processes to achieve a consistent experience for all served. Develops strategies to ensure premier patient satisfaction. Leads development of nursing practice standards to facilitate effective utlization of the electronic health record.
- Establishes and implements key quality metrics to evaluate the quality of patient care. Participates in ongoing continuous quality improvement education and training.
- Oversees human resource management for the assigned area creating a culture of employee engagement. Ensures HR policies are administered consistently across function. Organizes nursing through appropriate structure and delegation of functions using staffing models/tools to achieve productivity and optimize the delivery of patient care. Identifies succession planning needs within the nursing team.
- Promotes team building and collaboration. Motivates, encourages and empowers staff to achieve personal, organizational and team goals. Recognizes accomplishment. Encourages and provides opportunity for staff input and feedback regarding improvement opportunities. Advocates for patients and the nursing profession.
- Maintains knowledge and achieves compliance with federal, state and local regulatory requirements, licensure, accreditation requirements, record procedures and internal controls. Regularly informs and updates staff on organizational and industry issues.
- Reviews pending legislation on local, state and national levels for impact on health care; and when appropriate, enlists support to influence effective legislation.
- Monitors nursing practice, clinical outcomes and process improvement initiatives to achieve value based outcome metrics. Assumes fiscal responsibility through budgetary planning and implementation.
- Partners across the organization to support smooth transition of care for patients across care settings to ensure optimal setting of care to address patient needs.
- Works in a constant state of alertness and safe manner.
- Performs other duties as assigned.
EDUCATION
- Master's degree
EXPERIENCE
- Fifteen years' experience, with seven years' in leadership
REQUIRED PROFESSIONAL LICENSE AND/OR CERTIFICATIONS
State of Work Location: Missouri
- Registered Nurse (RN) Issued by Compact State
- Or
- Registered Nurse (RN) - Missouri Division of Professional Registration
Work Shift:
Day Shift (United States of America)Job Type:
Department:
Benefits:
SSM Health values our exceptional employees by offering a comprehensive benefits package to fit their needs.
Paid Parental Leave: we offer eligible team members one week of paid parental leave for newborns or newly adopted children (pro-rated based on FTE).
Flexible Payment Options: our voluntary benefit offered through DailyPay offers eligible hourly team members instant access to their earned, unpaid base pay (fees may apply) before payday.
Upfront Tuition Coverage: we provide upfront tuition coverage through FlexPath Funded for eligible team members.
Explore All Benefits
SSM Health is an equal opportunity employer. SSM Health does not discriminate on the basis of race, color, religion, national origin, age, disability, sex, sexual orientation, gender identity, pregnancy, veteran status, or any other characteristic protected by applicable law. Click here to learn more.
See All 38 Nursing Jobs in St. Louis
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Find Nursing JobsNursing Job Market in St. Louis
Who's Hiring
- Mercy11

- SSM Health4

- Luxor Healthcare4

- Reliant Care Management Company4
- Kindred Hospitals2

Top Industries Hiring
- Healthcare & Medical Services14
- Education1
Nursing Jobs in St. Louis: Frequently Asked Questions
How do I get a nursing job in St. Louis?
Start by targeting St. Louis's largest hiring sectors: academic medical centers, large regional health systems, and the growing network of outpatient specialty clinics in the Central West End and Midtown corridors. Candidates with experience in critical care, med-surg, or oncology have a consistent edge given the concentration of cancer and cardiac programs here. Applying directly to health system career portals and following up through unit nurse managers tends to move faster than applying through general boards.
Which companies hire nursings in St. Louis?
Employers hiring nursings in St. Louis right now include Mercy, SSM Health, and Luxor Healthcare, based on current listings on Migrate Mate as of July 2026. St. Louis draws hiring from a mix of large nonprofit health systems, for-profit hospital groups, and specialty ambulatory surgery centers spread across the metro.
Are there remote nursing jobs in St. Louis?
Yes, though remote nursing roles are limited by nature since most positions require direct patient care. About 22% of nursing openings tied to St. Louis are remote or hybrid as of July 2026, covering roles where this is feasible. In St. Louis, remote opportunities concentrate in utilization review, case management, telehealth triage, and insurance authorization roles connected to the city's large managed care and payer organizations.
How can I get a nursing job in St. Louis with little or no experience?
The most realistic entry path in St. Louis is a new graduate residency program offered by the city's major health systems, which provide structured clinical mentorship for RNs entering their first role. Entry-level candidates also find traction in long-term care facilities and skilled nursing communities across South City and the inner suburbs, where hiring volume is high and competition is lower than in acute care. Completing a clinical rotation at a local facility and converting that relationship into an offer is a proven route here.
Which industries hire the most nursings in St. Louis?
Most nursing openings in St. Louis sit in Healthcare & Medical Services and Education, per current listings on Migrate Mate as of July 2026. St. Louis's identity as a regional medical hub, anchored by its cluster of academic hospitals, rehabilitation centers, and specialty research institutions, drives consistent demand across those sectors year-round.
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