Principal Jobs in Waltham, MA

Principal jobs in Waltham, Massachusetts are concentrated along Route 128's tech corridor, in Waltham's Moody Street business district, and in the Waltham Woods and Bear Hill office parks, with strong demand from ZoomInfo, Boston Scientific, and SS&C across life sciences, enterprise software, and professional services. See the openings below and apply to the ones that match your experience.

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Overview

Open roles207+
Top employerZoomInfo
Work type75% Hybrid
Top credentialBachelor's degree in engineering
Companies hiring7

Showing 5 of 207+ Principal jobs

SS&C
Principal Data Engineer
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SS&C
Added 1d ago
Principal Data Engineer
SS&C
Waltham, Massachusetts
AI (Artificial Intelligence)
Data Science
$160k - $170k/yr
Bachelor's degree in engineering
10,000+

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Pegasystems
Principal Technical Support Engineer
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Pegasystems
Added 2d ago
Principal Technical Support Engineer
Pegasystems
Waltham, Massachusetts
AI (Artificial Intelligence)
Data Science
$101k - $154k/yr
Bachelor's degree in engineering
1,001-5,000

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Alkermes, Inc.
Principal Engineer, Platform Engineering & AI Enablement
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Alkermes, Inc.
Added 2d ago
Principal Engineer, Platform Engineering & AI Enablement
Alkermes, Inc.
Waltham, Massachusetts
Business Development
Events & Tourism
Executive Leadership & C-Suite
Project Management
Hybrid
Bachelor's degree
1,001-5,000

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ZoomInfo
Principal Procurement Manager
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ZoomInfo
Added 1w ago
Principal Procurement Manager
ZoomInfo
Waltham, Massachusetts
IT Support & Systems Administration
Program Management
Project & Program Management
Technical Product & Program Management
$117k - $184k/yr
Master's degree in business administration
1,001-5,000

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Boston Scientific
Principal Software Engineer - Electrophysiology
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Boston Scientific
Added 1w ago
Principal Software Engineer - Electrophysiology
Boston Scientific
Waltham, Massachusetts
Business Operations
Compensation & Benefits
Human Resources (HR) — Generalist
$107k - $203k/yr
Master's degree
10,000+

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See All 207+ Principal Jobs in Waltham

Find roles in Waltham that match your experience and apply in just a few clicks.

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Principal Job Market in Waltham

Who's Hiring

  • ZoomInfo
    ZoomInfo46
  • Boston Scientific
    Boston Scientific46
  • SS&C
    SS&C23
  • Sanofi
    Sanofi23
  • Pegasystems
    Pegasystems23

Top Industries Hiring

  • Biotechnology & Pharmaceuticals

Principal Jobs in Waltham: Frequently Asked Questions

How do I get a principal job in Waltham?

Focus on Waltham's Route 128 tech corridor and its dense concentration of life sciences firms, enterprise software companies, and professional services consultancies. Candidates who combine deep domain expertise with cross-functional leadership stand out locally. Networking through Waltham-area industry events and targeting employers in the Waltham Woods and Bear Hill office parks gives you the most direct access to open principal roles.

Which companies hire principals in Waltham?

Employers hiring principals in Waltham right now include ZoomInfo, Boston Scientific, and SS&C, based on current listings on Migrate Mate as of September 2026. Waltham's employer base skews toward mid-size and enterprise technology, biopharma, and professional services firms that routinely hire at the principal level across engineering, science, and consulting functions.

Are there remote principal jobs in Waltham?

Yes, though availability depends heavily on the discipline. About 75% of principal openings tied to Waltham are remote or hybrid as of September 2026, with the share highest for software, data, and strategy-focused roles. Lab-based and client-facing principal positions at Waltham's life sciences and professional services employers tend to require on-site presence most consistently.

How can I get a principal job in Waltham with little or no experience?

The most realistic entry path in Waltham is moving up from a senior individual contributor role at one of the corridor's many mid-size tech or biopharma companies, where internal promotions to principal are common. Look for roles titled senior engineer, senior scientist, or senior consultant at growing Waltham employers, build visibility on high-impact projects, and position yourself for the step-up within that same organization before targeting principal titles externally.

Which industries hire the most principals in Waltham?

The sectors hiring the most principals in Waltham are Biotechnology & Pharmaceuticals, based on current listings on Migrate Mate as of September 2026. Waltham's position as a Route 128 anchor drives outsized demand from companies in those sectors that have built significant R&D, engineering, and consulting operations locally.

See All 207+ Principal Jobs in Waltham

Find roles in Waltham that match your experience and apply in just a few clicks.

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