Entry Level Principal Scientist Jobs
New grad principal scientist jobs welcome recent graduates and entry level candidates with zero to two years of experience, where strong internship work or a focused research portfolio can matter more than a long resume. Most openings are Science & Research, Banking & Financial Services, and Biotechnology & Pharmaceuticals roles across on-site, remote, and hybrid settings, with employers like Capital One, Novartis, and Genentech hiring at this level now.
Find JobsOverview
Showing 5 of 6+ Entry Level Principal Scientist jobs
Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.
Position Overview
The Principal Scientist, Clinical Pharmacology and Pharmacometrics will bring extensive experience in oncology quantitative pharmacology, clinical pharmacology strategy, and oncology drug development.
Responsibilities
- Formulate and deliver CP&MS strategy for late-stage and early preclinical/clinical development assets.
- Apply pharmacokinetic/pharmacodynamics (PK/PD), physiologic based PK (PBPK) and pharmacometric modeling & simulation (M&S) approaches to characterize drug absorption and disposition and assess the dynamics of drug effect to inform dose selection and go/no-go decisions.
- Work with preclinical and clinical CROs and company scientists to conduct and monitor clinical pharmacology studies, maintain study records and ensure study completion along program timelines.
- Contribute and drive program strategy, study design, protocol preparation, study execution, data review/analysis, report preparation and regulatory document preparation.
Qualifications
- Ph.D. or PharmD in a relevant scientific discipline (clinical pharmacology, pharmacometrics or closely related scientific discipline)
- 2-5 years' experience in pharmaceutical/biotechnology industry in a regulated bioanalytical environment, preferably with multiple modalities, including small molecule, large molecule and ADC experience.
- Experience in noncompartmental and PBPK analyses and pharmacometric modeling and simulation oversight including use of WINNONLIN, NONMEM, MONOLIX or similar statistical modeling software
- Knowledge of R, R-shiny, SAS, MATLAB, NONMEM, MONOLIX, PBPK (gastroplus or Simcyp) or similar modeling software and substantial experience integrating quantitative clinical pharmacology with oncology drug development strategy
- Familiarity with current global clinical pharmacology and pharmacometrics regulatory guidance.
- Experience in development of anti-cancer agents, preferably ADCs and/or RLTs.
Knowledge And Skills
- Excellent written/oral communication, interpersonal and problem-solving skills.
- Experience in oncology drug development with small and large molecule clinical pharmacology strategy. Experience in translational aspects of drug discovery and development is strongly preferred.
- Ability to deliver integrated clinical pharmacology roadmap to registration and new product label.
- Can manage multiple project related workstreams simultaneously under tight timelines collaboratively.
- Experience managing clinical pharmacology related data transfers, analysis, reporting, and related timelines.
- Experience interacting with global health authorities on optimal dosage design and clinical pharmacology strategy. Effective forms of written and spoken communication is essential (eg clinical pharmacology protocols, pharmacokinetic/pharmacometric reports and regulatory submissions and performing quality control).
- Knowledge of regulatory requirements governing drug development.
- Resourcefulness, pragmatism, creativity, and an independent work ethic.
Washington State Pay Range
$186,120 - $211,797 USD
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
E-Verify
Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).
Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.
Position Overview
The Principal Scientist, Clinical Pharmacology and Pharmacometrics will bring extensive experience in oncology quantitative pharmacology, clinical pharmacology strategy, and oncology drug development.
Responsibilities
- Formulate and deliver CP&MS strategy for late-stage and early preclinical/clinical development assets.
- Apply pharmacokinetic/pharmacodynamics (PK/PD), physiologic based PK (PBPK) and pharmacometric modeling & simulation (M&S) approaches to characterize drug absorption and disposition and assess the dynamics of drug effect to inform dose selection and go/no-go decisions.
- Work with preclinical and clinical CROs and company scientists to conduct and monitor clinical pharmacology studies, maintain study records and ensure study completion along program timelines.
- Contribute and drive program strategy, study design, protocol preparation, study execution, data review/analysis, report preparation and regulatory document preparation.
Qualifications
- Ph.D. or PharmD in a relevant scientific discipline (clinical pharmacology, pharmacometrics or closely related scientific discipline)
- 2-5 years' experience in pharmaceutical/biotechnology industry in a regulated bioanalytical environment, preferably with multiple modalities, including small molecule, large molecule and ADC experience.
- Experience in noncompartmental and PBPK analyses and pharmacometric modeling and simulation oversight including use of WINNONLIN, NONMEM, MONOLIX or similar statistical modeling software
- Knowledge of R, R-shiny, SAS, MATLAB, NONMEM, MONOLIX, PBPK (gastroplus or Simcyp) or similar modeling software and substantial experience integrating quantitative clinical pharmacology with oncology drug development strategy
- Familiarity with current global clinical pharmacology and pharmacometrics regulatory guidance.
- Experience in development of anti-cancer agents, preferably ADCs and/or RLTs.
Knowledge And Skills
- Excellent written/oral communication, interpersonal and problem-solving skills.
- Experience in oncology drug development with small and large molecule clinical pharmacology strategy. Experience in translational aspects of drug discovery and development is strongly preferred.
- Ability to deliver integrated clinical pharmacology roadmap to registration and new product label.
- Can manage multiple project related workstreams simultaneously under tight timelines collaboratively.
- Experience managing clinical pharmacology related data transfers, analysis, reporting, and related timelines.
- Experience interacting with global health authorities on optimal dosage design and clinical pharmacology strategy. Effective forms of written and spoken communication is essential (eg clinical pharmacology protocols, pharmacokinetic/pharmacometric reports and regulatory submissions and performing quality control).
- Knowledge of regulatory requirements governing drug development.
- Resourcefulness, pragmatism, creativity, and an independent work ethic.
Washington State Pay Range
$186,120 - $211,797 USD
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
E-Verify
Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).
See All 6 Entry Level Principal Scientist Jobs
Find roles that match your experience and apply in just a few clicks.
Find JobsEntry Level Principal Scientist Job Market
Who's Hiring
Top Industries Hiring
- Science & Research
- Banking & Financial Services
- Biotechnology & Pharmaceuticals
- Medical Devices
Entry Level Principal Scientist Jobs: Frequently Asked Questions
How do I get an entry level principal scientist job?
Focus on research experience from coursework, internships, or independent projects that demonstrate scientific rigor and problem-solving. Employers at this level look for candidates who can design experiments, analyze data, and communicate findings clearly. Tailoring your application to the employer's core research area and highlighting any published work, conference presentations, or lab contributions gives you a meaningful edge over candidates with a generic resume.
Which companies hire entry level principal scientists?
Companies hiring entry level principal scientists right now include Capital One, Novartis, and Genentech, based on current listings on Migrate Mate as of September 2026. Hiring at this level comes from a mix of pharmaceutical and biotech firms, technology companies running applied research divisions, and government-adjacent research organizations actively building out junior scientific talent.
Are there remote entry level principal scientist jobs?
Yes, though many roles at this stage are on-site given the lab and collaboration demands of scientific work. About 33% of entry level principal scientist openings are remote or hybrid as of September 2026, with remote-friendly positions more common in data-heavy or computational research disciplines than in bench science or experimental roles.
Are these new grad principal scientist jobs?
Yes, these listings include new grad, recent graduate, and junior principal scientist roles. A posting is new-grad friendly when it explicitly welcomes zero to two years of experience, counts internships or co-ops toward that requirement, or lists a strong academic research portfolio as an acceptable substitute for full-time work history. Searching for junior or new grad alongside the role title surfaces those openings.
Which industries hire the most entry level principal scientists?
Entry Level principal scientist roles concentrate in Science & Research, Banking & Financial Services, and Biotechnology & Pharmaceuticals, based on current listings on Migrate Mate as of September 2026. Those sectors drive hiring at this level because they run large-scale research programs that need junior scientists to support experimental pipelines, data analysis, and product development work alongside senior staff.