Program Manager Jobs in St. Louis, MO
Program Manager jobs in St. Louis are concentrated in the Central West End, Clayton, and downtown's Midtown Corridor, with strong demand across healthcare, defense contracting, and financial services. Employers hiring right now include Washington University in St. Louis, BJC HealthCare, and World Wide Technology. Scan the live roles below and apply to whichever ones fit.
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Job Description
As part of the Thermo Fisher Scientific team, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every day by enabling our customers to make the world healthier, cleaner, and safer. We provide our global teams with the resources needed to achieve individual career goals while helping take science a step beyond through solutions that address some of the world’s toughest challenges, including helping bring life-changing therapies to patients.
Description
Join Thermo Fisher Scientific as a Project Management Manager supporting the process development organization within the BIO network. In this role, you will lead project management activities across a portfolio of client programs, partnering closely with technical, analytical, manufacturing, quality, regulatory, business, and client-facing teams to enable successful execution from early development through technology transfer and manufacturing readiness.
The Project Management Manager will provide leadership, structure, and oversight for BioProcess Sciences project execution, ensuring alignment of scope, timelines, resources, risks, dependencies, and deliverables. This role is responsible for driving cross-functional execution, strengthening communication across internal teams, supporting client commitments, and enabling timely progression of programs toward key development and clinical manufacturing milestones.
The successful candidate will bring strong project management discipline, people leadership, stakeholder management, and technical understanding of biologics process development. This individual will help establish and continuously improve project management processes, support team prioritization, proactively identify and escalate risks, and ensure project teams are equipped to deliver high-quality outcomes in a dynamic CDMO environment.
Education
- Advanced degree plus 6 years of relevant experience, or Bachelor’s degree plus 8 years of relevant experience in project/program management, process development, manufacturing, or related industry settings
- Preferred fields of study: Life Sciences, Biology, Biochemistry, Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Business, or related field
- Professional certifications preferred, such as PMP, Lean Six Sigma, Agile, or other project/program management certifications
- Experience in biologics, bioprocess development, CDMO operations, GMP/GxP environments, or pharmaceutical development strongly preferred
Key Responsibilities
- Lead and manage project management activities for BIO BPS process development programs, including project planning, execution, monitoring, risk management, escalation, and delivery of key milestones
- Oversee a portfolio of biologics process development projects, ensuring alignment of scope, timelines, resources, dependencies, deliverables, and client commitments
- Partner closely with analytical development, upstream and downstream process development, quality, business management, supply chain, and manufacturing sites to drive integrated program execution
- Manage, coach, and develop project managers and/or project coordinators supporting BPS programs, including prioritization guidance, performance feedback, workload management, and professional development
- Establish and maintain clear project governance, meeting cadence, action tracking, escalation pathways, decision-making forums, and communication expectations across cross-functional teams
- Drive proactive identification, communication, and mitigation of project risks, issues, scope changes, timeline impacts, and resource constraints
- Support client-facing project teams by ensuring accurate, timely, and transparent updates related to process development progress, risks, mitigation plans, and deliverables
- Facilitate alignment across drug substance process development, analytical development, manufacturing, quality, and technology transfer teams to support successful program progression
- Ensure project plans are integrated with key development milestones, including process development, scale-up, material generation, process characterization, technology transfer, GMP readiness, and IND-enabling activities, as applicable
- Monitor project performance against timelines, deliverables, budget, and resource assumptions; identify gaps and escalate to appropriate leadership to support timely resolution
- Develop, maintain, and improve project management tools, dashboards, templates, reporting mechanisms, and best practices for the BIO BPS organization
- Support continuous improvement initiatives to enhance project execution, cross-functional communication, client experience, operational efficiency, and portfolio visibility
- Promote a culture of accountability, collaboration, transparency, scientific excellence, and client-focused delivery across project teams
Knowledge, Skills, and Abilities
- Strong understanding of biologics process development, including upstream and/or downstream development, analytical interfaces, scale-up, technology transfer, and manufacturing readiness
- Experience working in a CDMO, biopharmaceutical development, GMP/GxP, or regulated life sciences environment
- Demonstrated success leading complex, cross-functional development programs with multiple internal and external stakeholders
- Strong project management expertise, including schedule development, critical path management, risk management, action tracking, resource planning, stakeholder communication, and governance
- Ability to manage multiple programs, competing priorities, and shifting business needs in a fast-paced, matrixed environment
- Strong people leadership skills with the ability to coach, develop, and guide project management professionals
- Excellent communication, facilitation, and presentation skills across technical teams, business stakeholders, senior leadership, and client-facing teams
- Demonstrated ability to influence without direct authority and drive accountability across cross-functional teams
- Strong analytical, problem-solving, and decision-making skills
- Ability to translate technical project details into clear business, operational, leadership, and client-facing communications
- Knowledge of project management tools and systems such as Smartsheet, MS Project, SharePoint, Power BI, JIRA, or similar platforms
- Strong organizational skills and attention to detail, with the ability to maintain project discipline while adapting to changing business and technical priorities
- Customer-focused mindset with a commitment to quality, partnership, transparency, and delivery excellence
- Understanding of regulatory expectations, quality systems, and documentation practices relevant to biologics development and GMP manufacturing preferred
Compensation and Benefits
The salary range estimated for this position based in Missouri is $103,100.00–$154,700.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
See All 38 Program Manager Jobs in St. Louis
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Find Program Manager JobsProgram Manager Job Market in St. Louis
Who's Hiring
- Washington University in St. Louis7

- BJC HealthCare4

- World Wide Technology4

- SSM Health2

- sse1S
Top Industries Hiring
- Education8
- Technology & Software5
- Healthcare & Medical Services2
- Food & Beverage1
- Distribution & Wholesale1
Program Manager Jobs in St. Louis: Frequently Asked Questions
How do I get a program manager job in St. Louis?
Your strongest entry point is the healthcare and life sciences cluster anchored in the BJC HealthCare and Washington University medical corridor, followed by defense and government contracting firms based in the St. Louis Metro East and Hazelwood areas. Employers here weight PMP certification, experience managing cross-functional stakeholders, and familiarity with federal or clinical compliance frameworks. Networking through the St. Louis chapter of PMI gives you direct access to hiring managers in those concentrations.
Which companies hire program managers in St. Louis?
Companies currently hiring program managers in St. Louis include Washington University in St. Louis, BJC HealthCare, and World Wide Technology, per current listings on Migrate Mate as of July 2026. St. Louis draws a mix of large health systems, aerospace and defense contractors, and regional financial institutions, all of which maintain ongoing program management needs across multi-year initiatives.
Are there remote program manager jobs in St. Louis?
Yes, though availability depends heavily on the sector. About 75% of program manager openings tied to St. Louis are remote or hybrid as of July 2026, skewing toward roles in software, consulting, and financial operations rather than defense or clinical settings that require on-site presence. Hybrid schedules anchored to Clayton or downtown offices are the most common arrangement.
How can I get a program manager job in St. Louis with little or no experience?
The most realistic path in St. Louis is starting as a project coordinator or associate project manager inside a large health system, a regional bank, or a defense contractor, then building toward a full program manager title. Employers like those in the BJC or SSM Health networks regularly hire coordinators who can demonstrate process ownership. A CAPM certification and volunteer leadership with a St. Louis nonprofit portfolio round out an entry-level application effectively.
Which industries hire the most program managers in St. Louis?
The sectors hiring the most program managers in St. Louis are Education, Technology & Software, and Healthcare & Medical Services, based on current listings on Migrate Mate as of July 2026. St. Louis's concentration of major hospital networks, legacy aerospace and defense firms, and a growing fintech presence makes these sectors the consistent drivers of local program management demand.
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