Registered Nurse Jobs in Columbia, SC

Registered Nurse jobs in Columbia, South Carolina are concentrated in the Midlands medical corridor, with demand running highest across hospital systems, long-term care, and outpatient clinics near the Harbison, Forest Acres, and downtown districts. Employers hiring right now include Prisma Health, Medical University of South Carolina, and Lexington Health. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles296+
Top employerPrisma Health
Work type99% On-site
Top credentialAssociate's
Companies hiring35

Showing 5 of 296+ Registered Nurse jobs

PruittHealth
RN Clinical Competency Coordinator HCC
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PruittHealth
New 1m ago
RN Clinical Competency Coordinator HCC
PruittHealth
Columbia, South Carolina
Clinical Support
Healthcare Administration
Human Resources
CPR Certification
10,000+

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Medical University of South Carolina
Registered Nurse II-Cath Lab
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Medical University of South Carolina
New 1m ago
Registered Nurse II-Cath Lab
Medical University of South Carolina
Columbia, South Carolina
Allied Health
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
CPR Certification
10,000+

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Medical University of South Carolina
RN II- OR - Northeast
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Medical University of South Carolina
New 1m ago
RN II- OR - Northeast
Medical University of South Carolina
Columbia, South Carolina
Allied Health
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
CPR Certification
10,000+

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Medical University of South Carolina
Registered Nurse II - Telemetry
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Medical University of South Carolina
New 1m ago
Registered Nurse II - Telemetry
Medical University of South Carolina
Columbia, South Carolina
Allied Health
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
CPR Certification
10,000+

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Prisma Health
Registered Nurse (RN) - Acute Care, Family Beginnings, FT, Nights
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Prisma Health
New 1m ago
Registered Nurse (RN) - Acute Care, Family Beginnings, FT, Nights
Prisma Health
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Nursing Diploma
10,000+

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Registered Nurse Job Market in Columbia

Who's Hiring

  • Prisma Health
    Prisma Health107
  • Medical University of South Carolina
    Medical University of South Carolina96
  • Lexington Health
    Lexington Health20
  • PruittHealth
    PruittHealth12
  • V
    Voyage Health12

Top Industries Hiring

  • Healthcare & Medical Services172
  • Education67
  • Consulting & Professional Services9
  • Biotechnology & Pharmaceuticals4
  • Insurance1

Registered Nurse Jobs in Columbia: Frequently Asked Questions

How do I get a registered nurse job in Columbia?

Columbia's strongest hiring comes from its major hospital campuses, VA healthcare facilities, and the cluster of outpatient and specialty clinics that ring the downtown and Harbison corridors. Candidates who have experience in med-surg, critical care, or emergency settings tend to move fastest here. Tailoring your application to the specific unit or care setting, and noting any familiarity with the Midlands patient population, gives you a concrete edge over generalist applicants.

Which companies hire registered nurses in Columbia?

Employers hiring registered nurses in Columbia right now include Prisma Health, Medical University of South Carolina, and Lexington Health, based on current listings on Migrate Mate as of July 2026. Columbia's hiring mix leans toward large academic medical centers, community hospital systems, and federally affiliated health facilities, reflecting the city's role as the state's primary healthcare hub.

Are there remote registered nurse jobs in Columbia?

Yes, though options are limited given how hands-on most registered nurse roles are by nature. About 1% of registered nurse openings tied to Columbia are remote or hybrid as of July 2026, concentrated in areas such as telehealth triage, case management, utilization review, and insurance care coordination rather than direct bedside or clinic roles.

How can I get a registered nurse job in Columbia with little or no experience?

The most realistic entry path in Columbia is through new-graduate residency programs offered by the city's larger hospital systems, which are structured specifically to bring BSN graduates into med-surg and general acute care units with supervised onboarding. Long-term care facilities and rehabilitation centers in the Midlands also hire entry-level RNs consistently. Completing a clinical rotation at a Columbia facility beforehand and applying directly to those units before graduation improves your odds substantially.

Which industries hire the most registered nurses in Columbia?

Most registered nurse openings in Columbia sit in Healthcare & Medical Services, Education, and Consulting & Professional Services, per current listings on Migrate Mate as of July 2026. Columbia's status as South Carolina's capital and largest inland city means it anchors a regional referral network that draws specialized clinical volume from across the Midlands, sustaining broad and consistent demand across those sectors.

See All 296+ Registered Nurse Jobs in Columbia

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