Registered Nurse Jobs in Greenville, SC
Registered Nurse jobs in Greenville, South Carolina are concentrated around the Haywood Road medical corridor, downtown Greenville, and the Eastside, with strong demand across hospital systems, outpatient clinics, and long-term care. Employers actively hiring include Prisma Health, Bon Secours, and BAYADA Home Health Care. Scan the live roles below and apply to whichever ones fit.
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Inspire health. Serve with compassion. Be the difference.
Job Summary
Provides clinical direction for all aspects of patient care in an outpatient setting. Demonstrates clinical competency utilizing evidence-based practices/research in all areas of the nursing process: assessment, planning, implementation, evaluation and outcomes. Incorporates knowledge of safety protocols, cost containment and quality improvement throughout the nursing process. Identifies patient, unit, and organizational priorities and incorporates into the nursing process. Adheres to all compliance and policy and procedure requirements of the organization including, but not limited to licensure renewal, assigned training, employee health screenings, time and attendance policy, dress code policy, patient confidentiality, infection control, medication administration. Demonstrates knowledge of regulatory agency requirements (JCAHO, DHEC). Provides care within the scope of the SC Nursing Practice Act. The outpatient setting usually does not require staff to be scheduled for a significant amount of shift, weekend, holiday, and on-call work.Essential Functions
All team members are expected to be knowledgeable and compliant with Prisma Health's purpose: Inspire health. Serve with compassion. Be the difference.
Collects data and completes nursing assessment utilizing appropriate area and/or age specific standards/policies and tools. Completes appropriate forms. Assesses and recognizes subtle or actual changes in patients' status and patient response to intervention. Identifies nursing priorities for patient plan of care based on nursing assessment (and other data as appropriate). Validates these priorities with healthcare team members and documents appropriately.
Develops an individual plan of care based on the age and assessed needs of the patient. Develops the plan in collaboration with the patient and/or family, the physician, and other members of the interdisciplinary health care team. Updates the plan based on changes in the patient's condition and communicates changes in the plan to other members of the team. Identifies realistic and measurable goals and outcomes to be attained prior to discharge. Validates these with the patient and/or family. Demonstrates respect for the patient's/family's cultural, spiritual, and belief system in planning for care. Includes planning for discharge to assure continuity of care and a smooth transition post discharge from one level of care to another (to include appropriate referrals).
Provides direct care to assigned patients consistent with the established nursing plan. Performs specific tasks based on organizational, departmental and/or unit policies and procedures within the RN scope of practice. Delegates nursing tasks as appropriate to members of the healthcare team, developing written assignments (if appropriate) and ensures completion of assigned tasks. Monitors quality of care delivered on a continual basis; ensures appropriate surveillance of assigned patients. Provides care based on patient and unit priorities, coordinating and organizing tasks as appropriate, utilizing known resources internal and external to the unit. Incorporates cost containment principles into nursing care. Assumes responsibility for patient safety by maintaining a safe environment to include awareness of safety procedures, protocols and adherence to patient care standards. Utilizes appropriate technology in daily practice. Utilizes performance indicators to collect data, monitor quality and effectiveness while providing nursing care. Completes assigned hospital/unit performance improvement monitoring (audits).
Evaluates nursing plan of care for effectiveness and determines progress toward expected outcomes. Revises diagnosis, outcomes and plan of care based on evaluation of data. Reports changes in patient status and refers unresolved problems to appropriate health team members. Discusses outcomes with peers via shift-to-shift report and with other healthcare team members as appropriate. Evaluates opportunities for quality improvement and based upon evaluation, incorporates PI recommendation into nursing plan of care as appropriate.
Identifies/assesses patient/family learning needs and teaches accordingly by using language and terminology that the patient/family is familiar with providing examples to clarify ideas, implementing and evaluating teaching plan (encourages patient/family, involvement/participation)
Communicates the patient/family's need for education/teaching to others in the healthcare continuum.
Evaluates own nursing practice in relation to professional practice standard guidelines, state statutes, family policies, procedures, rules and regulations and current specific knowledge. Maintains competency through education and professional activities. Reflects on identified areas of strength that offer opportunity for improvement.
Performs other duties as assigned.
Supervisory/Management Responsibilities
This is a non-management job that will report to a supervisor, manager, director or executive.
Minimum Requirements
Education - Associate degree in Nursing. Bachelor's degree in Nursing preferred.
Experience - One (1) year experience as a registered nurse.
In Lieu Of
In lieu of 1 year of registered nurse experience, will accept successful completion of the Prisma Health Nurse Residency Program or successful completion of a comparable residency from another organization.
In lieu of one (1) year of registered nurse experience, will accept 1 year of licensed practical nurse (LPN) experience for internal candidates within the same service line.
In lieu of Associate degree in nursing, will accept nursing diploma with licensure to practice as a registered nurse.
Required Certifications, Registrations, Licenses
Holds a current RN compact/multistate license recognized by the NCSBN Compact State or is licensed to practice as an RN in the state the team member is working.
Knowledge, Skills and Abilities
Basic computer skills
Mathematical skills
Working knowledge of Patient Equip (vitals, suction, defib)
Work Shift
Day (United States of America)Location
Centennial Way PracticesFacility
1008 Greenville Memorial HospitalDepartment
12086163 Recovery - CentennialShare your talent with us! Our vision is simple: to transform healthcare for the benefits of the communities we serve. The transformation of healthcare requires talented individuals in every role here at Prisma Health.
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Find Registered Nurse JobsRegistered Nurse Job Market in Greenville
Who's Hiring
- Prisma Health152

- Bon Secours34

- BAYADA Home Health Care5

- Gentiva3

- PruittHealth3

Top Industries Hiring
- Healthcare & Medical Services167
- Consulting & Professional Services6
Registered Nurse Jobs in Greenville: Frequently Asked Questions
How do I get a registered nurse job in Greenville?
The strongest path in Greenville is targeting its large health system campuses and the growing network of outpatient surgery centers and specialty clinics along the Haywood Road corridor and Eastside. Acute care units, emergency departments, and oncology floors at the major medical centers hire steadily. Candidates with experience in high-acuity settings or specialty certifications such as CCRN or CEN move to the front of the line in this market.
Which companies hire registered nurses in Greenville?
Companies currently hiring registered nurses in Greenville include Prisma Health, Bon Secours, and BAYADA Home Health Care, per current listings on Migrate Mate as of July 2026. Greenville's employer mix leans heavily toward large hospital systems and affiliated physician practice groups, with a growing presence of ambulatory care and rehabilitation facilities.
Are there remote registered nurse jobs in Greenville?
Yes, though remote opportunities are limited for registered nurses since most roles require hands-on patient care. About 3% of registered nurse openings tied to Greenville are remote or hybrid as of July 2026, concentrated in utilization review, case management, and telephonic triage positions. Health systems and insurance-affiliated employers in Greenville are the most likely sources of those remote roles.
How can I get a registered nurse job in Greenville with little or no experience?
The most realistic entry point in Greenville is a new graduate residency program at one of the major health system campuses, which provide structured clinical onboarding for nurses with limited post-licensure experience. Long-term care facilities, rehabilitation centers, and outpatient clinics across the Eastside and Simpsonville area also hire new nurses who may not yet qualify for acute care roles. A clinical rotation completed locally and any Greenville-area externship significantly improves your standing.
Which industries hire the most registered nurses in Greenville?
Greenville registered nurse roles concentrate in Healthcare & Medical Services and Consulting & Professional Services, based on current listings on Migrate Mate as of July 2026. Greenville's status as the Upstate's regional medical hub, anchored by major trauma and cancer care facilities, drives outsized demand relative to the city's overall size.
Related Jobs in South Carolina
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