Registered Nurse Jobs in Greenville, SC

Registered Nurse jobs in Greenville, South Carolina are concentrated around the Haywood Road medical corridor, downtown Greenville, and the Eastside, with strong demand across hospital systems, outpatient clinics, and long-term care. Employers actively hiring include Prisma Health, Bon Secours, and BAYADA Home Health Care. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles228+
Top employerPrisma Health
Work type97% On-site
Top credentialNursing Diploma
Companies hiring28

Showing 5 of 228+ Registered Nurse jobs

Prisma Health
Registered Nurse (RN)- Outpatient, Recovery Room- Centennial Surgery Center, PT, Day
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Prisma Health
New 1m ago
Registered Nurse (RN)- Outpatient, Recovery Room- Centennial Surgery Center, PT, Day
Prisma Health
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Nursing Diploma
10,000+

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Prisma Health
Registered Nurse (RN) - Acute Care, General Medicine, FT, Days
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Prisma Health
New 1m ago
Registered Nurse (RN) - Acute Care, General Medicine, FT, Days
Prisma Health
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Nursing Diploma
10,000+

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Prisma Health
Registered Nurse (RN)-Acute Care, Recovery Room (PACU), FT, Day
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Prisma Health
New 1m ago
Registered Nurse (RN)-Acute Care, Recovery Room (PACU), FT, Day
Prisma Health
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Nursing Diploma
10,000+

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Shriners Children's
Operating Room/PACU RN
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Shriners Children's
New 1m ago
Operating Room/PACU RN
Shriners Children's
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
PALS Certification
5,001-10,000

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Bon Secours
Registered Nurse (RN) - Operating Room (OR) - St. Francis Downtown
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Bon Secours
New 1m ago
Registered Nurse (RN) - Operating Room (OR) - St. Francis Downtown
Bon Secours
Greenville, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
PALS Certification
10,000+

Have you applied for this role?

See All 228+ Registered Nurse Jobs in Greenville

Find roles in Greenville that match your experience and apply in just a few clicks.

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Registered Nurse Job Market in Greenville

Who's Hiring

  • Prisma Health
    Prisma Health152
  • Bon Secours
    Bon Secours34
  • BAYADA Home Health Care
    BAYADA Home Health Care5
  • Gentiva
    Gentiva3
  • PruittHealth
    PruittHealth3

Top Industries Hiring

  • Healthcare & Medical Services167
  • Consulting & Professional Services6

Registered Nurse Jobs in Greenville: Frequently Asked Questions

How do I get a registered nurse job in Greenville?

The strongest path in Greenville is targeting its large health system campuses and the growing network of outpatient surgery centers and specialty clinics along the Haywood Road corridor and Eastside. Acute care units, emergency departments, and oncology floors at the major medical centers hire steadily. Candidates with experience in high-acuity settings or specialty certifications such as CCRN or CEN move to the front of the line in this market.

Which companies hire registered nurses in Greenville?

Companies currently hiring registered nurses in Greenville include Prisma Health, Bon Secours, and BAYADA Home Health Care, per current listings on Migrate Mate as of July 2026. Greenville's employer mix leans heavily toward large hospital systems and affiliated physician practice groups, with a growing presence of ambulatory care and rehabilitation facilities.

Are there remote registered nurse jobs in Greenville?

Yes, though remote opportunities are limited for registered nurses since most roles require hands-on patient care. About 3% of registered nurse openings tied to Greenville are remote or hybrid as of July 2026, concentrated in utilization review, case management, and telephonic triage positions. Health systems and insurance-affiliated employers in Greenville are the most likely sources of those remote roles.

How can I get a registered nurse job in Greenville with little or no experience?

The most realistic entry point in Greenville is a new graduate residency program at one of the major health system campuses, which provide structured clinical onboarding for nurses with limited post-licensure experience. Long-term care facilities, rehabilitation centers, and outpatient clinics across the Eastside and Simpsonville area also hire new nurses who may not yet qualify for acute care roles. A clinical rotation completed locally and any Greenville-area externship significantly improves your standing.

Which industries hire the most registered nurses in Greenville?

Greenville registered nurse roles concentrate in Healthcare & Medical Services and Consulting & Professional Services, based on current listings on Migrate Mate as of July 2026. Greenville's status as the Upstate's regional medical hub, anchored by major trauma and cancer care facilities, drives outsized demand relative to the city's overall size.

See All 228+ Registered Nurse Jobs in Greenville

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