Registered Nurse Jobs in South Carolina
Registered Nurse jobs in South Carolina are open across Columbia, Charleston, and Greenville and other South Carolina metros, with employers like Medical University of South Carolina, Prisma Health, and McLeod Health hiring at every experience level. Find a role that fits below and apply directly.
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Job Type: Full time
Job Title: RN Case Manager | OneWell Health Care
Location: South Carolina
Introduction and Mission:
OneWell Health Care is a person-centered healthcare organization dedicated to empowering individuals with developmental disabilities and other barriers to independence. Through compassion, consistency, and quality service delivery, we help participants achieve meaningful goals and live more self-sufficient, fulfilling lives within their communities.
Position Summary:
The RN Case Manager: is responsible for coordinating and managing the nursing care of individuals with Intellectual and Developmental Disabilities (IDD) in the home setting. This role involves comprehensive case management, including assessing individuals’ needs, developing care plans, and ensuring coordination among interdisciplinary teams to ensure quality care for individuals with IDD.
The RN Case Manager will serve as the primary point of contact for individuals and their families, ensuring that all healthcare needs are met and that services are provided in a timely, efficient, and compassionate manner.
Key Responsibilities:
1. Care Coordination and Case Management:
- Assess the physical, emotional, and developmental needs of individuals with IDD in their home environment.
- Develop individualized care plans based on individual assessments, collaborating with Supports Coordinators, physicians, therapists, and other healthcare providers, as needed.
- Serve as the primary point of contact for individuals and their families, ensuring clear communication and coordination of services.
- Monitor individuals’ progress and make adjustments to care plans as needed, based on individual responses and evolving needs.
- Coordinate schedules for new and existing individuals to ensure staffing meets the appropriate level of care and the desired needs of the individual.
2. Referrals, Staffing Coordination and Onboarding:
- Referral Generation: Drive business by generating referrals from community partners for individuals with IDD with needed services and supports.
- Assess Staffing Needs: Work with RN Nursing manager and Nursing Business Operations manager to assess the staffing requirements for current and upcoming referral needs, ensuring the right balance of skills and expertise to meet service delivery needs for individuals with IDD.
- Referral Process Management: Oversee the referral process, ensuring that staffing referrals are timely, accurate, and aligned with individual needs and standards.
3. Collaboration and Communication:
- Communicate with the individual’s interdisciplinary care team, including Supports Coordinators, physicians, therapists, social workers, and caregivers, to ensure comprehensive, coordinated care.
- Educate individuals and families about the individual’s condition, care requirements, and strategies for managing health at home.
- Develop and implement strategies to address any concerns or barriers to effective care, ensuring individual and family satisfaction.
4. Compliance and Documentation:
- Monitoring and Oversight of Field based RNs and LPNs: Ensure that RNs and LPNs are submitting daily nursing notes that align with individual needs and outcomes.
- Staff Training: Provide training and guidance to field nurses, family members, and other team members on best practices in care delivery, person-centered planning, and internal policies.
- Maintain Documentation: Accurately document and maintain all required records, including ISP, assessments, nursing notes, and incident reports.
- Incident Reporting: Ensure that any incidents involving individuals with IDD are documented and reported according to regulatory requirements.
5. Health Education and Prevention:
- Provide education to individuals and their families on managing health conditions, medication administration, and preventive health measures.
- Offer guidance on healthy lifestyle choices, symptom management, and strategies for reducing the risk of health complications.
- Encourage and educate families on strategies for improving the individual’s quality of life and independence.
6. Quality Assurance and Safety:
- Ensure that all nursing care is delivered in accordance with best practices, individual safety protocols, and quality standards.
- Participate in regular case reviews and quality assurance initiatives to improve care delivery.
- Advocate for improvements in individual care and identify opportunities to enhance care quality and service delivery.
Qualifications:
Education: Bachelor’s Degree in Nursing (BSN or ADN) from an accredited nursing program.
Licensure: Valid Registered Nurse (RN) license in South Carolina.
Experience:
- At least 2 years of nursing experience, with a focus on home health or working with individuals with IDD preferred.
- Experience in case management, care coordination, or working in an interdisciplinary team is highly desirable.
Reports to: Regional RN Case Manager
Competency Requirements:
- Strong clinical skills and experience in performing nursing assessments and recertifications.
- Ability to develop and implement individualized care plans based on comprehensive individual assessments.
- Knowledge of IDD-related health conditions, treatment options, and individual care strategies.
- Strong communication skills to effectively interact with individuals, families, interdisciplinary teams, and external healthcare providers.
- Ability to work independently, manage a caseload, and prioritize tasks effectively.
- Cultural Competence: Sensitivity to and understanding of the diverse backgrounds and needs.
- Problem-Solving and Decision-Making: Strong analytical skills and the ability to make informed decisions based on data, individual needs, and organizational priorities.
Clearance Requirements:
- Criminal Background Check
- Motor Vehicle Record Check
- Child Abuse Clearance
- Authorization to work in the United States
Work Environment:
- The RN Case Manager will work in an office-based setting 08:30am-05:00pm Monday-Friday.
- The role requires travel to visit individuals in their homes, community settings, or healthcare facilities.
Benefits:
- Paid Orientation and Training
- Vacation and Sick Time Accrual
- Medical, Dental, Vision coverage
- 401K
- Life Insurance (Paid by OneWell Health Care)
- Daily Pay option
Legal Disclaimer:
This job description reflects the general nature and scope of the role and is not exhaustive. OneWell Health Care reserves the right to revise responsibilities, qualifications, or expectations at its discretion, consistent with applicable law. Employment is at-will and may be terminated by either party at any time, with or without cause or notice.
If you are passionate about making a meaningful difference in the lives of others and value a workplace that celebrates compassion, growth, and inclusion, we encourage you to apply today.
Join OneWell Health Care — where your work truly changes lives.
See All 1,289+ Registered Nurse Jobs in South Carolina
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Find Registered Nurse JobsRegistered Nurse Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Registered Nurse Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Medical University of South Carolina510

- Prisma Health361

- McLeod Health95

- Lexington Health69

- Self Regional Healthcare44

Top Industries Hiring
- Healthcare & Medical Services966
- Education321
- Consulting & Professional Services23
- Biotechnology & Pharmaceuticals22
- Insurance3
What South Carolina Employers Look For
The qualifications that appear most often in registered nurse jobs across South Carolina.
- Active RN license in the state of employment or a compact license
- Current BLS certification from an accredited provider
- Associate or bachelor's degree in nursing from an accredited program
- One or more years of acute care or specialty clinical experience
- ACLS certification for critical care, emergency, or telemetry roles
- Proficiency with electronic health record systems such as Epic or Cerner
Registered Nurse Jobs in South Carolina: Frequently Asked Questions
How many registered nurse jobs are there in South Carolina?
There are 1,289+ registered nurse openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Charleston, and Greenville. New positions post regularly as employers across South Carolina hire.
How much do registered nurses make in South Carolina?
Registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Carolina cities have the most registered nurse jobs?
Columbia, Charleston, and Greenville have the most registered nurse openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire registered nurses in South Carolina?
Employers hiring registered nurses in South Carolina include Medical University of South Carolina, Prisma Health, and McLeod Health, based on current listings on Migrate Mate as of June 2026.
Are there remote registered nurse jobs in South Carolina?
Yes. About 1% of registered nurse openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for registered nurse jobs in South Carolina?
You can apply to registered nurse jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 1,289+ Registered Nurse Jobs in South Carolina
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