Registered Nurse Jobs in South Carolina

Registered Nurse jobs in South Carolina are open across Columbia, Charleston, and Greenville and other South Carolina metros, with employers like Medical University of South Carolina, Prisma Health, and McLeod Health hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles1,289+
Top cityColumbia, SC
Cities hiring73
Work type99% On-site
Top industryHealthcare

Showing 5 of 1,289+ Registered Nurse jobs

OneWell Health Care
RN Case Manager
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OneWell Health Care
New 45m ago
RN Case Manager
OneWell Health Care
Conway, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
Caregiving & Elderly Support
$37 - $41/hr
On-Site
Bachelor's
1,001-5,000

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McLeod Health
RN Case Manager
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McLeod Health
New 1h ago
RN Case Manager
McLeod Health
Loris, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
Caregiving & Elderly Support
On-Site
None
10,000+

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Prisma Health
Registered Nurse
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Prisma Health
New 2h ago
Registered Nurse
Prisma Health
Columbia, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's
10,000+

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Prisma Health
Registered Nurse
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Prisma Health
New 3h ago
Registered Nurse
Prisma Health
Columbia, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's
10,000+

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Prisma Health
Registered Nurse
We won't show you this job again
Prisma Health
New 3h ago
Registered Nurse
Prisma Health
Columbia, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's
10,000+

Have you applied for this role?

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Find roles in South Carolina that match your experience and apply in just a few clicks.

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Registered Nurse Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
258 jobs
Charleston
202 jobs
Greenville
153 jobs
Florence
137 jobs
West Columbia
53 jobs
Greenwood
37 jobs
Camden
28 jobs
Sumter
25 jobs
Seneca
20 jobs

Registered Nurse Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Medical University of South Carolina
    Medical University of South Carolina510
  • Prisma Health
    Prisma Health361
  • McLeod Health
    McLeod Health95
  • Lexington Health
    Lexington Health69
  • Self Regional Healthcare
    Self Regional Healthcare44

Top Industries Hiring

  • Healthcare & Medical Services966
  • Education321
  • Consulting & Professional Services23
  • Biotechnology & Pharmaceuticals22
  • Insurance3

What South Carolina Employers Look For

The qualifications that appear most often in registered nurse jobs across South Carolina.

  • Active RN license in the state of employment or a compact license
  • Current BLS certification from an accredited provider
  • Associate or bachelor's degree in nursing from an accredited program
  • One or more years of acute care or specialty clinical experience
  • ACLS certification for critical care, emergency, or telemetry roles
  • Proficiency with electronic health record systems such as Epic or Cerner

Registered Nurse Jobs in South Carolina: Frequently Asked Questions

How many registered nurse jobs are there in South Carolina?

There are 1,289+ registered nurse openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Charleston, and Greenville. New positions post regularly as employers across South Carolina hire.

How much do registered nurses make in South Carolina?

Registered nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Carolina cities have the most registered nurse jobs?

Columbia, Charleston, and Greenville have the most registered nurse openings in South Carolina right now, with additional roles spread across smaller metros statewide.

Which companies hire registered nurses in South Carolina?

Employers hiring registered nurses in South Carolina include Medical University of South Carolina, Prisma Health, and McLeod Health, based on current listings on Migrate Mate as of June 2026.

Are there remote registered nurse jobs in South Carolina?

Yes. About 1% of registered nurse openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.

How do I apply for registered nurse jobs in South Carolina?

You can apply to registered nurse jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.

See All 1,289+ Registered Nurse Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Registered Nurse Jobs