Security Operations Engineer Jobs in San Francisco, CA
Security Operations Engineer jobs in San Francisco are concentrated in the Financial District, SoMa, and Mission Bay, across fintech, enterprise software, cloud infrastructure, and cybersecurity firms. Employers hiring right now include DoorDash, OpenAI, and Airwallex. Scan the live roles below and apply to whichever ones fit.
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The Position
The Program Operations Compliance Manager will play a critical role on the HCO team at Genentech. This role is responsible for operational elements and compliance guidance and reviews for external funding requests (e.g., grants, exhibits, sponsorships, corporate memberships), Advisory Boards, fair market value (FMV), and other areas of business need as assigned, including ensuring adherence to and oversight of applicable Genentech processes and guidelines. The role requires an individual with strong subject matter expertise on state and federal laws on interactions with healthcare professionals, a strong operational mindset to redesign workflows, eliminate bottlenecks, and actively implement cutting-edge technologies—including AI and automation—and ability to develop an in-depth understanding of Genentech’s policies, requirements, processes, and procedures.
The Opportunity
- Serve as a business owner for Funding Operations and/or Advisory Board Operations systems; navigation within these systems and compliance review of funding requests may be up to 80% of the role for an extended period.
- Perform compliance review and approval and appropriately process external funding requests based on relevant Genentech processes, guidelines, and SOPs.
- Broadly understand relevant healthcare fraud and abuse regulations and maintain ability to adapt to changes, both active and pending, that will impact or influence the work of Genentech.
- Ensure consistency with and adherence to Genentech standards, laws, regulations, and policies that govern the conduct of the Genentech activities in the remit of this role.
- Lead operational governance across Program Operations’ areas of accountability, providing ongoing guidance to internal stakeholders.
- Provide customer service and guidance to external organizations regarding the grant application process and pending grant requests.
- Drive co-ownership of operational elements and compliance with cross-functional internal stakeholders for the processes in Program Operations’ areas of accountability.
- Working with the end-user in mind, drive modernization of operational processes by evaluating current workflows, designing streamlined alternatives, and partnering with technology teams to successfully implement tools, including automation and AI solutions.
- Actively pursue continuous professional growth and the development of new skills through formal education, hands-on experience, or other acceptable means, utilizing Genentech's provided resources for education and professional development.
- Comply with all laws, regulations, policies and procedures that govern the conduct of Genentech activities.
- Supporting other duties and projects in functional areas such as operations, monitoring, auditing, investigations, policy, training, iHCP, FMV and transparency, as needed.
Competencies/Skills
- Impeccable ethics. Demonstrates, or has proven abilities to demonstrate, Roche Values and Leadership Commitments.
- Adept at identifying operational friction and leveraging modern technology—including automation and AI—to redesign workflows, eliminate bottlenecks, and drive organizational efficiency.
- Strong verbal and written business communication skills: highly adept at synthesizing and summarizing complex and/or voluminous content into clear, concise and actionable communications, including balancing use of AI tools and human confirmation.
- Works well within teams.
- Effectively identifies, develops and implements scalable/sustainable process and other continuous improvements to achieve organizational efficiencies and increase effectiveness.
- Experience building and cultivating relationships with key partners and stakeholders across organizational levels.
- Thinks “outside of the box” for solutions. Applies creative problem-solving and develops appropriate business solutions to effectively address compliance risk.
- Brings strong operational expertise and program management skills to HCO, with a proven ability to prioritize multiple tasks, projects, and goals. Demonstrates complete, end-to-end ownership of initiatives to ensure the timely, on-target, and within-budget delivery of outcomes, while continually identifying and implementing process improvements.
- Demonstrates ability to gain a deep understanding of business operations, including proven ability to connect operational changes to the broader organizational strategy and anticipate downstream impacts. Consistently leverages strong organizational navigation skills to guide complex initiatives to successful completion.
- Demonstrates ability to identify appropriate resources. Exercises good judgment in terms of when to leverage internal resources, including approved artificial intelligence tools.
- Can effectively drive discussions and decisions toward desired end-results.
Who You Are
- Bachelor's Degree (life sciences, law, public policy, marketing, business, education, finance/accounting or related discipline preferred).
- 3 or more years of work experience gained in the pharmaceutical, biotechnology, management consulting, or other regulated industry.
- Healthcare Compliance Certification (before or w/in 6 months of start date).
- Familiarity with funding related preventative and detective controls in the pharmaceutical industry (preferred).
- Experience serving as an advisor on or developer of key operational practices, processes, or procedures (preferred).
- Must demonstrate in-depth knowledge of the bio/pharma industry (compliance, legal, medical affairs, sales, and product marketing).
- Must demonstrate in-depth knowledge of the legal and regulatory environment, as it relates to healthcare compliance in the bio/pharma industry (includes anti-kickback statutes, healthcare fraud & abuse, off-label promotion, PhRMA Code, etc.).
- Experience in compliance disciplines (privacy, healthcare auditing and monitoring, transparency) a plus.
LOCATION
This position is based on-site in South San Francisco. A remote option is not available.
Relocation benefits are not available for this position.
COMPENSATION
- The expected salary range for this position based on the primary location of California is $111,790 to $207,610. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
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Find JobsSecurity Operations Engineer Job Market in San Francisco
Who's Hiring
- DoorDash9

- OpenAI8

- Airwallex7

- Lyft6

- Amazon6

Top Industries Hiring
- Technology & Software113
- Banking & Financial Services18
- Retail15
- Healthcare & Medical Services11
- Science & Research9
Security Operations Engineer Jobs in San Francisco: Frequently Asked Questions
How do I get a security operations engineer job in San Francisco?
The strongest path into San Francisco's security operations market runs through fintech, cloud infrastructure, and enterprise SaaS companies concentrated in SoMa, the Financial District, and Mission Bay. Candidates with hands-on SIEM experience, incident response practice, and familiarity with cloud-native environments stand out most. Certifications like CompTIA Security+, CEH, or CISSP signal readiness to the employer types that dominate local hiring.
Which companies hire security operations engineers in San Francisco?
Employers hiring security operations engineers in San Francisco right now include DoorDash, OpenAI, and Airwallex, based on current listings on Migrate Mate as of June 2026. San Francisco's employer mix skews toward high-growth technology companies, large financial institutions, and cybersecurity-focused firms, many of which run mature security operations centers requiring dedicated engineering staff.
Are there remote security operations engineer jobs in San Francisco?
Yes, though availability depends on the role's focus: analytical and detection-engineering work tends toward remote, while positions tied to physical infrastructure or on-site SOC operations typically require in-person presence. About 38% of security operations engineer openings tied to San Francisco are remote or hybrid as of June 2026, with threat intelligence and cloud security roles leading the remote share locally.
How can I get a security operations engineer job in San Francisco with little or no experience?
The most realistic entry point in San Francisco is a SOC analyst or IT security analyst role at one of the city's mid-size fintech or SaaS companies, where smaller security teams often cross-train junior staff into engineering work. Internships at cloud and cybersecurity firms in SoMa and Mission Bay also convert regularly into full-time roles. Building hands-on lab skills and earning an entry-level certification before applying puts candidates ahead of the field here.
Which industries hire the most security operations engineers in San Francisco?
The sectors hiring the most security operations engineers in San Francisco are Technology & Software, Banking & Financial Services, and Retail, based on current listings on Migrate Mate as of June 2026. San Francisco's density of venture-backed technology companies and regulated financial services firms creates consistent baseline demand, with cybersecurity-specific companies in SoMa adding a layer of specialized hiring that sets the city apart from other California markets.
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