Senior AI Software Engineer Jobs in Boston, MA

Senior AI Software Engineer jobs in Boston are in strong demand, concentrated in the Seaport Innovation District, Kendall Square, and the Back Bay across biotech, healthtech, fintech, and enterprise software. Employers actively hiring include Wayfair, Zoox, and Klaviyo. Find a role that fits below and apply directly.

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Overview

Open roles68
Top employerWayfair
Work type66% On-site
Top credentialBachelor's
Companies hiring34

Showing 5 of 68+ Senior AI Software Engineer jobs

State Street
Artificial Intelligence & Machine Learning, Vice President
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State Street
Added 1w ago
Artificial Intelligence & Machine Learning, Vice President
State Street
Boston, Massachusetts
Software Engineering
Solutions Engineering & Architecture
Technical Product & Program Management
AI (Artificial Intelligence)
ML (Machine Learning)
Technical Program Management
$120k - $203k/yr
Hybrid
Bachelor's
10,000+

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Klaviyo
Sr. Software Engineer, AI Enablement
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Klaviyo
Added 1w ago
Sr. Software Engineer, AI Enablement
Klaviyo
Boston, Massachusetts
Software Engineering
Backend Engineering
$148k - $222k/yr
1,001-5,000

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WilmerHale
Artificial Intelligence (AI) Engineer
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WilmerHale
Added 2w ago
Artificial Intelligence (AI) Engineer
WilmerHale
Boston, Massachusetts
Software Engineering
Cloud & DevOps
$135k - $169k/yr
Bachelor's

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Humana
Principal Software Engineer – ITSM Process Automation & AI
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Humana
Added 2w ago
Principal Software Engineer – ITSM Process Automation & AI
Humana
Boston, Massachusetts
Software Engineering
Cloud & DevOps
Backend Engineering
$157k - $215k/yr
Remote (US)
Bachelor's
10,000+

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Klaviyo
Senior Lead AI Software Engineer
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Klaviyo
Added 2w ago
Senior Lead AI Software Engineer
Klaviyo
Boston, Massachusetts
Software Engineering
Technical Product & Program Management
Cloud & DevOps
AI (Artificial Intelligence)
Technical Program Management
Cloud Engineering
Backend Engineering
$216k - $324k/yr
Bachelor's
1,001-5,000

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See All 68 Senior AI Software Engineer Jobs in Boston

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Senior AI Software Engineer Job Market in Boston

Who's Hiring

  • Wayfair
    Wayfair6
  • Zoox
    Zoox5
  • Klaviyo
    Klaviyo5
  • WHOOP
    WHOOP4
  • Chewy
    Chewy3

Top Industries Hiring

  • Technology & Software26
  • E-Commerce & Online Marketplaces8
  • Science & Research7
  • Healthcare & Medical Services6
  • Insurance5

Senior AI Software Engineer Jobs in Boston: Frequently Asked Questions

How do I get a senior ai software engineer job in Boston?

Boston's strongest hiring comes from biotech and healthtech companies in Kendall Square and the Seaport, along with fintech and enterprise software firms in the Back Bay and downtown Financial District. Candidates with experience in machine learning infrastructure, LLM integration, or AI-driven clinical or financial applications stand out locally. Building connections through Boston's dense research and startup ecosystem, including ties to MIT and Harvard spinouts, gives applicants a real edge.

Which companies hire senior ai software engineers in Boston?

Boston senior ai software engineer roles are posted by Wayfair, Zoox, and Klaviyo and others right now, based on current listings on Migrate Mate as of June 2026. Boston's hiring mix is broad, drawing from established biotech and pharmaceutical firms, fast-growing healthtech startups, and financial services companies with large technology divisions.

Are there remote senior ai software engineer jobs in Boston?

Yes, though many Boston roles at this seniority level prefer hybrid arrangements given the collaborative nature of AI research and engineering. About 34% of senior ai software engineer openings tied to Boston are remote or hybrid as of June 2026, with the strongest remote flexibility appearing in roles focused on model development, MLOps, and data pipeline work rather than embedded or lab-integrated positions.

How can I get a senior ai software engineer job in Boston with little or no experience?

The most realistic entry path in Boston is through junior or mid-level machine learning engineer or data scientist roles at one of the city's many healthtech or biotech startups in Kendall Square or the Seaport. Boston's university-affiliated research labs and AI accelerator programs also regularly hire associate engineers. Building a visible portfolio of applied AI projects and contributing to open-source tools commonly used in life sciences or fintech strengthens a local application considerably.

Which industries hire the most senior ai software engineers in Boston?

Most senior ai software engineer openings in Boston sit in Technology & Software, E-Commerce & Online Marketplaces, and Science & Research, per current listings on Migrate Mate as of June 2026. Boston's concentration of world-class research hospitals, pharmaceutical companies, and fintech firms creates sustained local demand for senior AI talent with domain-specific expertise.

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