Senior AI Software Engineer Jobs in Missouri
Senior AI Software Engineer jobs in Missouri are concentrated in St. Louis, Kansas City, and Columbia, where employers such as Boeing, Centene, and Edward Jones maintain large technology organizations actively building out machine learning and generative AI capabilities. Demand is strongest in healthcare AI, financial services automation, and defense-related systems engineering, reflecting Missouri's anchor industries. Roles range from principal-level individual contributors to AI platform leads overseeing production model pipelines. Find a role that fits below and apply directly.
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Showing 5 of 6+ Senior AI Software Engineer jobs
H&R Block AI Platforms Team is looking for an experienced Sr. Software Engineer to join a high-powered team to build AI platforms and solutions. You will be joining an elite team of engineers charged with developing transformative GenAI capabilities to power the next generation of customer experiences. As a Software Engineer on this team, you will be responsible for designing, developing, and deploying services on this platform.
- Use business and functional requirements to produce technical specifications and platform requirements
- Use tools, languages, coding standards and best practices to develop new product features and continually enhance product functionality
- Create and execute unit tests and address identified defects
- Work closely with other team members to ensure consistent understanding of requirements and approach
- Build features to support scalability, usability, resiliency and better performance
- Assist in technical design and code reviews for new enhancements and maintenance work delivered by the development team
- Bachelor’s degree in a related field or the equivalent through a combination of education and related work experience.
- 5+ years of experience building software products & solutions.
- 3-5 year of hands on experience working with: .NET, REST APIs, Cosmos/SQL server, Azure.
- Experience working with agile methodologies (SCRUM and/or Kanban).
- Experience with Azure DevOps platform including source control management systems and continuous integration/deployment environments.
- Experience developing engineering solutions to meet functional & non-functional requirements.
- Strong communication skills and problem-solving skills.
- 1+ year of experience building AI products & solutions
- Experience with the following Azure SignalR service and Azure AI Services
Specific benefits may vary based on your role. For detailed eligibility requirements and benefits information, visit blockbenefits.com.
Equal Opportunity Employer: H&R Block does not tolerate discrimination based on a person’s race, color, religion, ancestry, age, sex/gender (including pregnancy, childbirth, related medical conditions and sex-based stereotypes and transgender status), sexual orientation, gender identity or expression, service in the Armed Forces, national origin, physical or mental disability, genetic information, citizenship status or any other status protected by law. Pay Range Information: The pay range for this position is listed below. Local minimum wage laws apply. This information is posted pursuant to local requirements to provide applicants with information about what they might be eligible to receive. Individual pay decisions will depend on job-related factors such as experience, education, skill, performance, and geographic location where work will be performed. Successful candidates may be able to participate in one or more incentive compensation or short-term incentive plans, which could generate additional earnings in accordance with the terms of each plan. Qualifying associates can enroll themselves and/or their eligible dependents in medical and prescription drug coverage; can participate in the H&R Block Retirement Savings Plan (401(k) Plan), the Employee Assistance Program, (virtual) fitness center programs, and the associate discount program; are automatically enrolled in Business Travel Accident Insurance; and receive Associate Tax Prep benefit. Pay Range: $101,200.00 - $161,900.00/Yr. Sponsored Job: #LI-SH1 #LI-REMOTE
H&R Block AI Platforms Team is looking for an experienced Sr. Software Engineer to join a high-powered team to build AI platforms and solutions. You will be joining an elite team of engineers charged with developing transformative GenAI capabilities to power the next generation of customer experiences. As a Software Engineer on this team, you will be responsible for designing, developing, and deploying services on this platform.
- Use business and functional requirements to produce technical specifications and platform requirements
- Use tools, languages, coding standards and best practices to develop new product features and continually enhance product functionality
- Create and execute unit tests and address identified defects
- Work closely with other team members to ensure consistent understanding of requirements and approach
- Build features to support scalability, usability, resiliency and better performance
- Assist in technical design and code reviews for new enhancements and maintenance work delivered by the development team
- Bachelor’s degree in a related field or the equivalent through a combination of education and related work experience.
- 5+ years of experience building software products & solutions.
- 3-5 year of hands on experience working with: .NET, REST APIs, Cosmos/SQL server, Azure.
- Experience working with agile methodologies (SCRUM and/or Kanban).
- Experience with Azure DevOps platform including source control management systems and continuous integration/deployment environments.
- Experience developing engineering solutions to meet functional & non-functional requirements.
- Strong communication skills and problem-solving skills.
- 1+ year of experience building AI products & solutions
- Experience with the following Azure SignalR service and Azure AI Services
Specific benefits may vary based on your role. For detailed eligibility requirements and benefits information, visit blockbenefits.com.
Equal Opportunity Employer: H&R Block does not tolerate discrimination based on a person’s race, color, religion, ancestry, age, sex/gender (including pregnancy, childbirth, related medical conditions and sex-based stereotypes and transgender status), sexual orientation, gender identity or expression, service in the Armed Forces, national origin, physical or mental disability, genetic information, citizenship status or any other status protected by law. Pay Range Information: The pay range for this position is listed below. Local minimum wage laws apply. This information is posted pursuant to local requirements to provide applicants with information about what they might be eligible to receive. Individual pay decisions will depend on job-related factors such as experience, education, skill, performance, and geographic location where work will be performed. Successful candidates may be able to participate in one or more incentive compensation or short-term incentive plans, which could generate additional earnings in accordance with the terms of each plan. Qualifying associates can enroll themselves and/or their eligible dependents in medical and prescription drug coverage; can participate in the H&R Block Retirement Savings Plan (401(k) Plan), the Employee Assistance Program, (virtual) fitness center programs, and the associate discount program; are automatically enrolled in Business Travel Accident Insurance; and receive Associate Tax Prep benefit. Pay Range: $101,200.00 - $161,900.00/Yr. Sponsored Job: #LI-SH1 #LI-REMOTE
See All 6 Senior AI Software Engineer Jobs in Missouri
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Find JobsSenior AI Software Engineer Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Senior AI Software Engineer Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Healthcare & Medical Services
What Missouri Employers Look For
The qualifications that appear most often in senior AI software engineer jobs across Missouri.
- Bachelor's or master's degree in computer science, AI, or a closely related engineering field
- Seven or more years of software engineering experience with at least three in applied machine learning
- Proficiency in Python and deep learning frameworks such as PyTorch or TensorFlow
- Experience designing and deploying large language models or generative AI systems in production
- Demonstrated ability to lead technical architecture decisions across cross-functional engineering teams
- Familiarity with cloud infrastructure on AWS, Azure, or GCP including MLOps tooling and pipelines
Senior AI Software Engineer Jobs in Missouri: Frequently Asked Questions
How do you become a senior ai software engineer in Missouri?
Senior ai software engineer roles in Missouri require no state-issued license, so the path runs through education and demonstrated experience. Most employers expect a bachelor's degree in computer science, data science, or a related field, though a master's degree is increasingly common among competitive candidates. From there, engineers typically spend several years building production ML systems before reaching the senior level. Missouri employers in healthcare and financial services also value domain knowledge alongside technical depth.
How much do senior AI software engineers make in Missouri?
Senior AI software engineers in Missouri earn a median of about $126,120 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $72,570 for the lowest 10% to over $169,340 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire senior ai software engineers in Missouri?
Missouri senior ai software engineer roles are posted by H&R Block, CVS Health, and ALLO Communications and others right now, based on current listings on Migrate Mate as of August 2026. Missouri's mix of large healthcare systems, defense contractors, and financial services firms creates consistent demand for senior AI engineers across multiple industries in the state.
Which Missouri cities have the most senior ai software engineer jobs?
Missouri, Kansas City, and Springfield account for the largest share of senior ai software engineer openings in Missouri. St. Louis drives the most volume, anchored by Boeing's defense technology operations, Centene's healthcare IT division, and a growing corridor of fintech and health-tech startups, while Kansas City's strong financial services and logistics sectors generate steady AI engineering demand and Columbia benefits from University of Missouri research activity attracting technology employers to the region.
Are there remote senior ai software engineer jobs in Missouri?
Yes, and more than most fields. About 83% of senior ai software engineer openings tied to Missouri are remote or hybrid as of August 2026, reflecting the desk-based and highly portable nature of AI and software engineering work. Model development, research engineering, and MLOps roles tend to be the most consistently remote, while positions involving on-site infrastructure, classified defense systems, or embedded hardware integration are more likely to require in-person presence.
How can I get hired as a senior ai software engineer in Missouri with little or no experience?
The most realistic entry path is an associate or junior machine learning engineer role that lets you build production experience before moving into senior positions. Missouri employers such as Boeing, Cerner, and Mastercard's Kansas City operations run internship and new-graduate programs that place candidates into AI-adjacent engineering teams. Starting in data engineering, backend software development, or analytics engineering at a Missouri company and transitioning internally is equally common. A strong GitHub portfolio demonstrating applied ML projects and a relevant cloud certification give candidates without formal experience a concrete edge.
Where can I find and apply to senior ai software engineer jobs in Missouri?
You can find and apply to senior ai software engineer jobs in Missouri on Migrate Mate, which lists current Missouri openings across St. Louis, Kansas City, Columbia, and beyond. Search for roles that match your specialization and experience level, then apply directly to the ones that fit.
See All 6 Senior AI Software Engineer Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
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