Senior Fullstack Software Engineer Jobs in Missouri
Senior Fullstack Software Engineer jobs in Missouri are in steady demand, concentrated in financial technology, healthcare software, and enterprise platforms across Kansas City, St. Louis, and Columbia. Established employers like Cerner (now Oracle Health), Edward Jones, and Mastercard's Kansas City operations consistently seek engineers at the senior level who can own both frontend and backend architecture. The most in-demand specialties are React and Node.js full-stack development, cloud-native application engineering, and API platform work. Find a role that fits below and apply directly.
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Showing 5 of 6+ Senior Fullstack Software Engineer jobs
#LI-Remote
- Lead the design and delivery of secure, high-performance Java microservices and cloud-native applications on Google Cloud Platform to power critical patient care experiences.
- Build modern, responsive front-end user interfaces using Next.js, React, and TypeScript to ensure intuitive digital journeys for clinicians and patients.
- Design, deploy, and manage scalable RESTful APIs and distributed systems following strict test-driven development and architectural best practices.
- Conduct thorough code reviews and enforce automated unit testing to guarantee platform security, high availability, and code quality.
- Mentor junior engineers through paired programming and design discussions to foster technical growth and engineering excellence across the team.
- High school diploma/GED with 2 years of experience, or Associate's degree, or Bachelor's degree required.
- 1 year of experience required.
- 4 years of experience preferred.
- 2 years of leadership or management experience preferred.
- 5 years of professional fullstack software development experience building cloud-native applications in an Agile environment.
- Expert-level proficiency in Java and Spring Boot paired with strong hands-on experience in Next.js or React.js, JavaScript, and TypeScript.
- Documented experience building microservices and managing cloud infrastructure within Google Cloud Platform (GCP).
Equal employment opportunity employer
Ascension provides Equal Employment Opportunities (EEO) to all associates and applicants for employment without regard to race, color, religion, sex/gender, sexual orientation, gender identity or expression, pregnancy, childbirth, and related medical conditions, lactation, breastfeeding, national origin, citizenship, age, disability, genetic information, veteran status, marital status, all as defined by applicable law, and any other legally protected status or characteristic in accordance with applicable federal, state and local laws. For further information, view the EEO Know Your Rights (English) poster or EEO Know Your Rights (Spanish) poster.
Fraud prevention notice
Prospective applicants should be vigilant against fraudulent job offers and interview requests. Scammers may use sophisticated tactics to impersonate Ascension employees. To ensure your safety, please remember: Ascension will never ask for payment or to provide banking or financial information as part of the job application or hiring process. Our legitimate email communications will always come from an @ascension.org email address; do not trust other domains, and an official offer will only be extended to candidates who have completed a job application through our authorized applicant tracking system.
E-Verify statement
Benefits:
Various health insurance options & wellness plans
Retirement benefits including employer match plans
Long-term & short-term disability
Employee assistance programs (EAP)
Parental leave & adoption assistance
Tuition reimbursement
Ways to give back to your community
Benefit options and eligibility vary by position. Compensation varies based on factors including, but not limited to, experience, skills, education, performance, location and salary range at the time of the offer.
#LI-Remote
- Lead the design and delivery of secure, high-performance Java microservices and cloud-native applications on Google Cloud Platform to power critical patient care experiences.
- Build modern, responsive front-end user interfaces using Next.js, React, and TypeScript to ensure intuitive digital journeys for clinicians and patients.
- Design, deploy, and manage scalable RESTful APIs and distributed systems following strict test-driven development and architectural best practices.
- Conduct thorough code reviews and enforce automated unit testing to guarantee platform security, high availability, and code quality.
- Mentor junior engineers through paired programming and design discussions to foster technical growth and engineering excellence across the team.
- High school diploma/GED with 2 years of experience, or Associate's degree, or Bachelor's degree required.
- 1 year of experience required.
- 4 years of experience preferred.
- 2 years of leadership or management experience preferred.
- 5 years of professional fullstack software development experience building cloud-native applications in an Agile environment.
- Expert-level proficiency in Java and Spring Boot paired with strong hands-on experience in Next.js or React.js, JavaScript, and TypeScript.
- Documented experience building microservices and managing cloud infrastructure within Google Cloud Platform (GCP).
Equal employment opportunity employer
Ascension provides Equal Employment Opportunities (EEO) to all associates and applicants for employment without regard to race, color, religion, sex/gender, sexual orientation, gender identity or expression, pregnancy, childbirth, and related medical conditions, lactation, breastfeeding, national origin, citizenship, age, disability, genetic information, veteran status, marital status, all as defined by applicable law, and any other legally protected status or characteristic in accordance with applicable federal, state and local laws. For further information, view the EEO Know Your Rights (English) poster or EEO Know Your Rights (Spanish) poster.
Fraud prevention notice
Prospective applicants should be vigilant against fraudulent job offers and interview requests. Scammers may use sophisticated tactics to impersonate Ascension employees. To ensure your safety, please remember: Ascension will never ask for payment or to provide banking or financial information as part of the job application or hiring process. Our legitimate email communications will always come from an @ascension.org email address; do not trust other domains, and an official offer will only be extended to candidates who have completed a job application through our authorized applicant tracking system.
E-Verify statement
Benefits:
Various health insurance options & wellness plans
Retirement benefits including employer match plans
Long-term & short-term disability
Employee assistance programs (EAP)
Parental leave & adoption assistance
Tuition reimbursement
Ways to give back to your community
Benefit options and eligibility vary by position. Compensation varies based on factors including, but not limited to, experience, skills, education, performance, location and salary range at the time of the offer.
See All 6 Senior Fullstack Software Engineer Jobs in Missouri
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Find JobsSenior Fullstack Software Engineer Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Senior Fullstack Software Engineer Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Consulting & Professional Services
What Missouri Employers Look For
The qualifications that appear most often in senior fullstack software engineer jobs across Missouri.
- Five or more years of professional fullstack development experience with modern frameworks
- Proficiency in at least one frontend framework such as React, Angular, or Vue
- Strong backend skills in Node.js, Java, Python, or a comparable server-side language
- Experience designing and consuming RESTful or GraphQL APIs in production environments
- Demonstrated ability to mentor junior engineers and lead code reviews independently
- Familiarity with cloud platforms such as AWS, Azure, or Google Cloud and CI/CD pipelines
Senior Fullstack Software Engineer Jobs in Missouri: Frequently Asked Questions
How do you become a senior fullstack software engineer in Missouri?
Senior fullstack software engineers in Missouri do not require a state-issued license, so the path runs through demonstrated technical depth rather than a credentialing board. Most employers expect a bachelor's degree in computer science, software engineering, or a closely related field, or equivalent experience. From there, candidates typically spend several years in fullstack or specialized roles before moving into senior positions. Building a portfolio of end-to-end projects and contributing to production-grade systems at Missouri-based tech companies or corporate engineering teams accelerates that progression.
How much do senior fullstack software engineers make in Missouri?
Senior fullstack software engineers in Missouri earn a median of about $126,120 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $72,570 for the lowest 10% to over $169,340 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire senior fullstack software engineers in Missouri?
Companies currently hiring senior fullstack software engineers in Missouri include Ascension, Mastercard, and InSequence, per current listings on Migrate Mate as of August 2026. Missouri's mix of large financial services headquarters, healthcare IT firms, and growing startup ecosystems in Kansas City and St. Louis creates consistent demand for senior fullstack talent across multiple industries.
Which Missouri cities have the most senior fullstack software engineer jobs?
St. Louis, O'Fallon, and Kansas City account for the largest share of senior fullstack software engineer openings in Missouri. Kansas City leads because of its dense concentration of financial technology companies and corporate engineering centers, while St. Louis draws significant volume from healthcare IT, defense contractors, and enterprise software firms headquartered or with major operations in the metro.
Are there remote senior fullstack software engineer jobs in Missouri?
Yes, and more than most fields. Fullstack software engineering is among the most remote-compatible disciplines in the job market because the work is entirely digital. About 75% of senior fullstack software engineer openings tied to Missouri are remote or hybrid as of August 2026, reflecting how broadly employers have accepted distributed engineering teams. Frontend-heavy and API-focused roles tend to be the most consistently offered as fully remote positions.
How can I get hired as a senior fullstack software engineer in Missouri with little or no experience?
The most realistic entry path is through an associate or junior software engineer role at a Missouri employer that runs structured development programs. Oracle Health in Kansas City and companies within the St. Louis technology corridor regularly onboard new graduates into engineering rotations or entry-level fullstack positions. Candidates from adjacent roles such as frontend developer, backend developer, or QA engineer can move laterally once they build out the opposite stack. A deployed portfolio with end-to-end projects and any cloud certification gives candidates a concrete edge in early screening.
Where can I find and apply to senior fullstack software engineer jobs in Missouri?
You can find and apply to senior fullstack software engineer jobs in Missouri on Migrate Mate, which lists current Missouri openings updated regularly. Find roles that match your experience and stack, then apply directly to the ones that fit. No profile creation is needed to search or apply.
See All 6 Senior Fullstack Software Engineer Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
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