Senior AI Software Engineer Jobs in Ohio

Senior AI Software Engineer jobs in Ohio are in strong and growing demand, concentrated in financial technology, healthcare informatics, defense contracting, and enterprise software, with openings at every level from mid-career engineers stepping into senior roles through principal and staff-level positions. Columbus, Cincinnati, and Cleveland are the primary hiring centers, anchored by employers such as JPMorgan Chase, Nationwide, and Lockheed Martin, all of which have substantial Ohio operations and ongoing AI engineering needs. The most sought-after specialties include large language model integration, MLOps infrastructure, and applied machine learning for regulated industries. Find a role that fits below and apply directly.

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Overview

Open roles276+
Top employerMedpace
Top cityColumbus, OH
Cities hiring53
Work type78% On-site
Top industryTechnology

Showing 5 of 276+ Senior AI Software Engineer jobs

First Student
AI Software Lead
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First Student
Added 2w ago
AI Software Lead
First Student
Cincinnati, Ohio
Software Engineering
Technical Product & Program Management
Product Management
AI (Artificial Intelligence)
Technical Program Management
On-Site
Bachelor's
10,000+

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Cleveland Clinic
AI Software Engineer
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Cleveland Clinic
Added 2w ago
AI Software Engineer
Cleveland Clinic
Cleveland, Ohio
Software Engineering
Cloud & DevOps
Technical Product & Program Management
AI (Artificial Intelligence)
ML (Machine Learning)
Backend Engineering
$112k - $171k/yr
On-Site
Bachelor's
10,000+

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McKesson
Senior AI Full stack Software Engineer
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McKesson
Added 1mo ago
Senior AI Full stack Software Engineer
McKesson
Columbus, Ohio
Software Engineering
Data Science & Analytics
Technical Product & Program Management
AI (Artificial Intelligence)
Full-stack Engineering
Backend Engineering
$131k - $218k/yr
On-Site
Bachelor's
10,000+

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Bitdeer (NASDAQ: BTDR)
AI & Cloud Infra Software Engineer
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Bitdeer (NASDAQ: BTDR)
Added 3mo ago
AI & Cloud Infra Software Engineer
Bitdeer (NASDAQ: BTDR)
Massillon, Ohio
Software Engineering
Cloud & DevOps
Cloud Engineering
AI (Artificial Intelligence)
DevOps
Backend Engineering
On-Site
Bachelor's

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Revel IT
Lead Machine Learning Engineer
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Revel IT
Added 3w ago
Lead Machine Learning Engineer
Revel IT
Columbus, Ohio
Software Engineering
Data Science & Analytics
Data Engineering
Cloud & DevOps
AI (Artificial Intelligence)
ML (Machine Learning)
Data Science
Remote (US)
Bachelor's

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Senior AI Software Engineer Jobs by City in Ohio

Where Ohio roles are concentrated, by current openings.

Columbus
78 jobs
Cincinnati
57 jobs
Cleveland
24 jobs
Mason
12 jobs
Dublin
12 jobs
Raymond
7 jobs
New Albany
6 jobs
Dayton
4 jobs
Mayfield
4 jobs

Senior AI Software Engineer Job Market in Ohio

A snapshot from current Ohio openings, updated as new roles post.

Who's Hiring

  • Medpace
    Medpace22
  • Tata Consultancy Services (TCS)
    Tata Consultancy Services (TCS)20
  • Huntington Bank
    Huntington Bank10
  • Revel IT
    Revel IT8
  • OCLC
    OCLC6

Top Industries Hiring

  • Technology & Software87
  • Consulting & Professional Services28
  • Science & Research18
  • Banking & Financial Services17
  • Biotechnology & Pharmaceuticals15

What Ohio Employers Look For

The qualifications that appear most often in senior AI software engineer jobs across Ohio.

  • Bachelor's or master's degree in computer science, AI, or a closely related engineering field
  • Five or more years of production-level experience building and deploying machine learning systems
  • Strong proficiency in Python and at least one deep learning framework such as PyTorch or TensorFlow
  • Demonstrated experience designing MLOps pipelines, model monitoring, and CI/CD workflows for AI systems
  • Experience working with cloud platforms such as AWS, Azure, or Google Cloud for model training and inference
  • Ability to lead technical design reviews and mentor junior engineers on AI best practices

Senior AI Software Engineer Jobs in Ohio: Frequently Asked Questions

How do you become a senior ai software engineer in Ohio?

Reaching a senior ai software engineer role in Ohio typically requires a bachelor's or master's degree in computer science, machine learning, or a related field, followed by several years of progressively complex engineering work. Ohio does not require a state-issued license for software engineering roles. Employers across Columbus, Cincinnati, and Cleveland consistently favor candidates who can show production-deployed AI systems, contributions to open-source ML projects, or certifications from major cloud platforms as concrete evidence of senior-level readiness.

How much do senior AI software engineers make in Ohio?

Senior AI software engineers in Ohio earn a median of about $114,090 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $77,790 for the lowest 10% to over $168,400 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire senior ai software engineers in Ohio?

Employers hiring senior ai software engineers in Ohio right now include Medpace, Tata Consultancy Services (TCS), and Huntington Bank, based on current listings on Migrate Mate as of June 2026. Ohio's concentration of Fortune 500 headquarters, large healthcare systems, and defense contractors means demand for senior AI engineering talent is distributed across industries rather than limited to pure technology firms.

Which Ohio cities have the most senior ai software engineer jobs?

Columbus, Cincinnati, and Cleveland have the most senior ai software engineer openings in Ohio. Columbus leads because of its dense cluster of insurance, financial services, and retail technology headquarters, while Cincinnati draws demand from consumer goods, healthcare, and logistics companies, and Cleveland's activity reflects its large hospital systems and advanced manufacturing sector, each of which is investing heavily in applied AI.

Are there remote senior ai software engineer jobs in Ohio?

Yes, and more than most fields. About 22% of senior ai software engineer openings tied to Ohio are remote or hybrid as of June 2026, reflecting how well the role's core work, including model development, code review, and system design, translates to distributed teams. The parts of the role most commonly offered remotely are research and prototyping work, while positions requiring on-site collaboration with hardware or regulated data infrastructure tend to require in-person presence.

How can I get hired as a senior ai software engineer in Ohio with little or no experience?

The most realistic entry path is securing a machine learning engineer or data scientist role first, then building toward senior AI work through demonstrated project ownership. Large Ohio employers such as Nationwide, Kroger, and Cleveland Clinic run structured associate engineer and rotational technology programs that accept candidates without extensive industry experience. Building a public portfolio of end-to-end ML projects, contributing to open-source repositories, and earning a cloud platform certification gives Ohio hiring managers the concrete evidence they need to consider a less-experienced candidate.

Where can I find and apply to senior ai software engineer jobs in Ohio?

You can find and apply to senior ai software engineer jobs in Ohio on Migrate Mate, which lists current Ohio openings across Columbus, Cincinnati, Cleveland, and surrounding areas. Search the listings for roles that match your experience and specialization, then apply directly to the ones that fit.

See All 276+ Senior AI Software Engineer Jobs in Ohio

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