Senior Fullstack Software Engineer Jobs in Ohio
Senior Fullstack Software Engineer jobs in Ohio are open across Columbus, Cleveland, and Blue Ash and other Ohio metros, with employers like Arrow International, Aditi Consulting, and Ampcus hiring at every experience level. Find a role that fits below and apply directly.
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Success Profile
What makes a successful Senior AI Full Stack Software Engineer? Here are the top traits.
- Conceptual
- Proactive
- Problem-Solver
- Strategic
- Technologically Savvy
- Visual Thinker
Culture
Accomplish
Make a meaningful impact by using your problem-solving skills to push the boundaries of innovation in healthcare, while maintaining a healthy work-life balance.
Innovate
Foster a digital mindset to drive IT transformation across McKesson through our evolving data and technology tools.
Grow
Join a supportive environment where you can advance your career and develop both personally and professionally.
Benefits
Coverage you can rely on
- Medical, Dental, and Vision
- Health Spending Accounts
- Flexible Spending Accounts
Benefits that go beyond your base pay
- 401(k) (U.S.)
- Pension (Canada)
- Employee Stock Purchase Plan
Support for total well-being
- Mental Health Programs
- Flexible Schedules
- Paid Time Off
- Wellness Program
- Education Reimbursement
- Volunteer Opportunities
- Flexible Work Environment
A culture powered by belonging
By fostering a culture of belonging, we advance our goal of being the best place to work in healthcare—connecting the right talent to the right roles to solve our most critical challenges.
Responsibility
McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care.
What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.
We are seeking a highly skilled and experienced Senior AI Full Stack Software Engineer to join our innovative team at CMM. This role involves designing, developing, and deploying end-to-end AI-powered solutions, from robust backend services to intuitive user interfaces, to enhance our healthcare and decision-making platforms.
Key Responsibilities
- Lead AI-Driven Healthcare Solutions: Design and deploy AI applications that support decision-making, patient engagement, and operational efficiency.
- Integrate AI into EHRs and Clinical Systems: Build scalable systems that incorporate LLMs, voice/image recognition, and document parsing into existing healthcare IT infrastructure.
- Develop and Optimize Data Pipelines: Ensure secure, HIPAA-compliant data pipelines for training and deploying AI models using structured and unstructured healthcare data (e.g., clinical notes, imaging, lab results).
- Model Evaluation and Compliance: Apply rigorous evaluation metrics (e.g., sensitivity, specificity, AUC-ROC) and ensure models meet regulatory and ethical standards.
- Mentor and Lead: Guide junior engineers and contribute to the strategic direction of AI initiatives within the organization.
- Rapid AI prototyping and iteration with product representatives to vet multiple concepts.
Minimum Qualifications
- 10+ years of software engineering experience, with 4+ years in AI/ML development.
- B.S. degree in Computer Science or related engineering discipline, or equivalent experience.
Critical Skills
- 2+ years of experience building AI solutions in healthcare or life sciences.
- Deep understanding of healthcare data standards (e.g., HL7, FHIR) and compliance frameworks (e.g., HIPAA, GDPR).
- Healthcare AI Expertise: Proven ability to build AI models for clinical NLP, medical imaging, patient risk stratification, and care personalization.
- LLM & RAG Systems: Skilled in building retrieval-augmented generation systems using tools like Pydantic, Semantic Kernel, LangChain, LlamaIndex, and vector databases.
- Experienced in creating custom AI agents or spec-driven tools.
- Experience writing skills for Claude, Copilot, Codex etc.
- Prompt Engineering & Optimization: Advanced techniques for prompt tuning, caching, and benchmarking.
- Full Stack Development: Proficiency in Python, Node.js, and modern web frameworks.
Preferred Skills
- Cloud & DevOps: Experience with secure cloud environments (AWS/GCP/Azure), containerization (Docker, Kubernetes), and CI/CD pipelines.
- AI Tooling: Familiarity with OpenAI, Hugging Face, PyDanticAI, TensorFlow, PyTorch, and healthcare-specific AI libraries.
- Communication & Leadership: Ability to communicate complex AI concepts to clinical and executive stakeholders and lead cross-functional teams.
- Experience mentoring and developing juniors in development and AI concepts/best practices.
We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered.
Our Base Pay Range for this position
$131,000 - $218,300
McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson’s (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind:
McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application.
McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates.
McKesson job postings are posted on our career site: careers.mckesson.com.
McKesson is an Equal Opportunity Employer
McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.
McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) Disability_Accommodation@McKesson.com or (Canada) Accessibility@mckesson.ca. Resumes or CVs submitted to this email box will not be accepted.
Join us at McKesson!
See All 8 Senior Fullstack Software Engineer Jobs in Ohio
Find roles in Ohio that match your experience and apply in just a few clicks.
Find JobsSenior Fullstack Software Engineer Jobs by City in Ohio
Where Ohio roles are concentrated, by current openings.
Senior Fullstack Software Engineer Job Market in Ohio
A snapshot from current Ohio openings, updated as new roles post.
Who's Hiring
- Arrow International2

- Aditi Consulting1

- Ampcus1

- Cardinal Health1

- Children'S Surgical Associates, Corp. At Nationwide Children'S Hospital1

Top Industries Hiring
- Technology & Software3
- Healthcare & Medical Services2
- Consulting & Professional Services1
- Distribution & Wholesale1
- Medical Devices1
What Ohio Employers Look For
The qualifications that appear most often in senior fullstack software engineer jobs across Ohio.
- 5 or more years of professional fullstack development experience
- Proficiency in at least one modern frontend framework such as React, Vue, or Angular
- Strong backend experience with Node.js, Python, Java, Go, or a comparable language
- Experience designing and consuming RESTful or GraphQL APIs at production scale
- Familiarity with cloud platforms such as AWS, Google Cloud, or Azure
- Experience with relational and non-relational databases including PostgreSQL and MongoDB
Senior Fullstack Software Engineer Jobs in Ohio: Frequently Asked Questions
How many senior fullstack software engineer jobs are there in Ohio?
There are 8+ senior fullstack software engineer openings in Ohio on Migrate Mate as of June 2026, with the most roles in Columbus, Cleveland, and Blue Ash. New positions post regularly as employers across Ohio hire.
How much do senior fullstack software engineers make in Ohio?
Senior fullstack software engineers in Ohio earn a median of about $114,090 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $77,790 for the lowest 10% to over $168,400 for the top 10%. Pay rises with experience, specialty, and employer.
Which Ohio cities have the most senior fullstack software engineer jobs?
Columbus, Cleveland, and Blue Ash have the most senior fullstack software engineer openings in Ohio right now, with additional roles spread across smaller metros statewide.
Which companies hire senior fullstack software engineers in Ohio?
Employers hiring senior fullstack software engineers in Ohio include Arrow International, Aditi Consulting, and Ampcus, based on current listings on Migrate Mate as of June 2026.
Are there remote senior fullstack software engineer jobs in Ohio?
Yes. About 0% of senior fullstack software engineer openings tied to Ohio are remote or hybrid as of June 2026. The rest are on-site roles based in Ohio metros.
How do I apply for senior fullstack software engineer jobs in Ohio?
You can apply to senior fullstack software engineer jobs in Ohio directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Ohio location, then apply to each one that fits.
See All 8 Senior Fullstack Software Engineer Jobs in Ohio
Find roles in Ohio that match your experience and apply in just a few clicks.
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