Senior Software Development Engineer Jobs in Missouri

Senior Software Development Engineer jobs in Missouri are open across O'Fallon, St Louis, and St. Louis and other Missouri metros, with employers like Mastercard, Scale AI, and Affirm hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles22+
Top employerMastercard
Top cityO'Fallon, MO
Cities hiring5
Work type86% On-site
Top industryConsulting

Showing 5 of 22+ Senior Software Development Engineer jobs

Mastercard
Senior Software Engineer II
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Mastercard
Added 4d ago
Senior Software Engineer II
Mastercard
O'Fallon, Missouri
Software Engineering
Data Engineering
Data Science & Analytics
Data Science
Data Analytics
Backend Engineering
$115k - $184k/yr
On-Site
Bachelor's
10,000+

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Mastercard
Senior Software Engineer
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Mastercard
Added 1w ago
Senior Software Engineer
Mastercard
O'Fallon, Missouri
Software Engineering
Cloud & DevOps
Backend Engineering
DevOps
$115k - $184k/yr
On-Site
Bachelor's
10,000+

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Mastercard
Senior Software Engineer
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Mastercard
Added 1w ago
Senior Software Engineer
Mastercard
O'Fallon, Missouri
Software Engineering
Cloud & DevOps
Quality Assurance & Testing (QA Testing)
Backend Engineering
$115k - $212k/yr
On-Site
Bachelor's
10,000+

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Mastercard
Senior Software Engineer
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Mastercard
Added 2w ago
Senior Software Engineer
Mastercard
O'Fallon, Missouri
Software Engineering
Cloud & DevOps
Quality Assurance & Testing (QA Testing)
Backend Engineering
Cloud Engineering
$115k - $184k/yr
On-Site
Bachelor's
10,000+

Have you applied for this role?

Federal Reserve Bank Of New York
FedNow Senior Software Engineer
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Federal Reserve Bank Of New York
Added 3w ago
FedNow Senior Software Engineer
Federal Reserve Bank Of New York
St. Louis, Missouri
Software Engineering
Cloud & DevOps
Cloud Engineering
DevOps
Backend Engineering
$150k - $187k/yr
On-Site
Associate's

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See All 22 Senior Software Development Engineer Jobs in Missouri

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Senior Software Development Engineer Jobs by City in Missouri

Where Missouri roles are concentrated, by current openings.

O'Fallon
10 jobs
St Louis
5 jobs
St. Louis
4 jobs
Kansas City
2 jobs
Clayton
1 jobs

Senior Software Development Engineer Job Market in Missouri

A snapshot from current Missouri openings, updated as new roles post.

Who's Hiring

  • Mastercard
    Mastercard10
  • Scale AI
    Scale AI2
  • Affirm
    Affirm1
  • Centene
    Centene1
  • Cigna-Evernorth Services
    Cigna-Evernorth Services1

Top Industries Hiring

  • Consulting & Professional Services7
  • Technology & Software7
  • Banking & Financial Services2
  • Insurance2
  • Construction & Real Estate1

What Missouri Employers Look For

The qualifications that appear most often in senior software development engineer jobs across Missouri.

  • 5+ years of professional software development experience in production environments
  • Proficiency in at least one of Java, Python, C++, Go, or similar languages
  • Experience designing and building distributed systems or large-scale microservices architectures
  • Strong command of cloud platforms such as AWS, Azure, or Google Cloud
  • Ability to lead technical design reviews and mentor junior and mid-level engineers
  • Bachelor's degree in Computer Science, Software Engineering, or a related technical field

Senior Software Development Engineer Jobs in Missouri: Frequently Asked Questions

How many senior software development engineer jobs are there in Missouri?

There are 22+ senior software development engineer openings in Missouri on Migrate Mate as of June 2026, with the most roles in O'Fallon, St Louis, and St. Louis. New positions post regularly as employers across Missouri hire.

How much do senior software development engineers make in Missouri?

Senior software development engineers in Missouri earn a median of about $126,120 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $72,570 for the lowest 10% to over $169,340 for the top 10%. Pay rises with experience, specialty, and employer.

Which Missouri cities have the most senior software development engineer jobs?

O'Fallon, St Louis, and St. Louis have the most senior software development engineer openings in Missouri right now, with additional roles spread across smaller metros statewide.

Which companies hire senior software development engineers in Missouri?

Employers hiring senior software development engineers in Missouri include Mastercard, Scale AI, and Affirm, based on current listings on Migrate Mate as of June 2026.

Are there remote senior software development engineer jobs in Missouri?

Yes. About 14% of senior software development engineer openings tied to Missouri are remote or hybrid as of June 2026. The rest are on-site roles based in Missouri metros.

How do I apply for senior software development engineer jobs in Missouri?

You can apply to senior software development engineer jobs in Missouri directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Missouri location, then apply to each one that fits.

See All 22 Senior Software Development Engineer Jobs in Missouri

Find roles in Missouri that match your experience and apply in just a few clicks.

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