Senior Software Development Engineer Jobs in South Carolina
Senior Software Development Engineer jobs in South Carolina are concentrated in Columbia, Charleston, and Greenville, where established employers like Booz Allen Hamilton, Benefitfocus, and SCANA Corporation hire senior engineers across cloud architecture, full-stack development, and DevSecOps. The state's growing defense contracting corridor and insurance technology sector keep demand steady for engineers with system design and distributed systems expertise. Find a role that fits below and apply directly.
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Showing 5 of 25+ Senior Software Development Engineer jobs
Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
We are seeking a Senior Staff Software Engineer to help architect and build the data platform and backend services for our healthcare SaaS solutions. This is a hands-on technical leadership role requiring deep expertise in database and data architecture, cloud-native backend development, scalability, security, and healthcare interoperability.
The ideal candidate combines strong software engineering skills with the ability to design secure, high-performance data architectures for large-scale, multi-tenant applications handling sensitive healthcare data.
Key Responsibilities
- Architect and develop scalable backend services and data platforms for multi-tenant SaaS applications.
- Design and optimize relational and non-relational database architectures, data models, and storage strategies.
- Build scalable data ingestion, integration, and processing capabilities for large and complex healthcare datasets.
- Design cloud-native data architectures incorporating databases, data lakes/lakehouses, and distributed data platforms.
- Develop APIs and integration capabilities supporting healthcare interoperability, including HL7 and FHIR.
- Ensure appropriate architecture for security, encryption, access control, auditability, data governance, retention, and regulatory compliance.
- Design for high availability, disaster recovery, performance, and scalability.
- Provide technical leadership and architectural guidance while remaining hands-on with design and development.
- Collaborate with Software Engineering, Product, Security, Quality, and Regulatory teams.
Required Qualifications
- Bachelor’s or Master’s degree in Computer Science, Engineering, Information Systems, or related field.
- 10+ years of software engineering experience, including significant backend and data-platform development.
- Deep experience designing and optimizing relational databases such as PostgreSQL, SQL Server, or MySQL.
- Experience with NoSQL technologies such as MongoDB, Cosmos DB, or equivalent.
- Strong experience with cloud platforms (Azure, AWS, or GCP) and cloud-native architectures.
- Experience with modern data pipelines, ingestion frameworks, data lakes/lakehouses, and distributed data architectures.
- Strong understanding of multi-tenant SaaS architecture, APIs, scalability, security, and data governance.
- Experience designing systems that handle sensitive or regulated data.
Preferred Qualifications
- Healthcare software or regulated-industry experience.
- Experience with HL7, FHIR, EHR/EMR integration, or healthcare interoperability.
- Experience with Databricks, Azure Data Factory, Kafka, Spark, or similar technologies.
- Experience with containerized environments such as Docker and Kubernetes.
Compensation and Benefits
The salary range estimated for this position based in Indiana is $135,800.00–$203,750.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
We are seeking a Senior Staff Software Engineer to help architect and build the data platform and backend services for our healthcare SaaS solutions. This is a hands-on technical leadership role requiring deep expertise in database and data architecture, cloud-native backend development, scalability, security, and healthcare interoperability.
The ideal candidate combines strong software engineering skills with the ability to design secure, high-performance data architectures for large-scale, multi-tenant applications handling sensitive healthcare data.
Key Responsibilities
- Architect and develop scalable backend services and data platforms for multi-tenant SaaS applications.
- Design and optimize relational and non-relational database architectures, data models, and storage strategies.
- Build scalable data ingestion, integration, and processing capabilities for large and complex healthcare datasets.
- Design cloud-native data architectures incorporating databases, data lakes/lakehouses, and distributed data platforms.
- Develop APIs and integration capabilities supporting healthcare interoperability, including HL7 and FHIR.
- Ensure appropriate architecture for security, encryption, access control, auditability, data governance, retention, and regulatory compliance.
- Design for high availability, disaster recovery, performance, and scalability.
- Provide technical leadership and architectural guidance while remaining hands-on with design and development.
- Collaborate with Software Engineering, Product, Security, Quality, and Regulatory teams.
Required Qualifications
- Bachelor’s or Master’s degree in Computer Science, Engineering, Information Systems, or related field.
- 10+ years of software engineering experience, including significant backend and data-platform development.
- Deep experience designing and optimizing relational databases such as PostgreSQL, SQL Server, or MySQL.
- Experience with NoSQL technologies such as MongoDB, Cosmos DB, or equivalent.
- Strong experience with cloud platforms (Azure, AWS, or GCP) and cloud-native architectures.
- Experience with modern data pipelines, ingestion frameworks, data lakes/lakehouses, and distributed data architectures.
- Strong understanding of multi-tenant SaaS architecture, APIs, scalability, security, and data governance.
- Experience designing systems that handle sensitive or regulated data.
Preferred Qualifications
- Healthcare software or regulated-industry experience.
- Experience with HL7, FHIR, EHR/EMR integration, or healthcare interoperability.
- Experience with Databricks, Azure Data Factory, Kafka, Spark, or similar technologies.
- Experience with containerized environments such as Docker and Kubernetes.
Compensation and Benefits
The salary range estimated for this position based in Indiana is $135,800.00–$203,750.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
See All 25 Senior Software Development Engineer Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find JobsSenior Software Development Engineer Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Senior Software Development Engineer Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Banking & Financial Services
What South Carolina Employers Look For
The qualifications that appear most often in senior software development engineer jobs across South Carolina.
- Bachelor's or master's degree in computer science, software engineering, or a closely related field
- Seven or more years of professional software development experience with demonstrated technical leadership
- Proficiency in one or more languages such as Java, Python, C++, or Go
- Experience designing and deploying scalable cloud solutions on AWS, Azure, or Google Cloud Platform
- Familiarity with Agile or SAFe methodologies and leading cross-functional engineering teams
- Strong background in CI/CD pipelines, automated testing, and secure software development practices
Senior Software Development Engineer Jobs in South Carolina: Frequently Asked Questions
How do you become a senior software development engineer in South Carolina?
Software development engineering is not a state-licensed profession in South Carolina, so there is no state board exam or registration required. Most senior roles expect a bachelor's degree in computer science or a related field plus several years of progressively responsible engineering experience. Building a portfolio that demonstrates system design, code quality, and technical leadership is the clearest path to senior-level hiring in South Carolina's technology and defense contracting sectors.
How much do senior software development engineers make in South Carolina?
Senior software development engineers in South Carolina earn a median of about $129,450 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $76,010 for the lowest 10% to over $212,460 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire senior software development engineers in South Carolina?
Employers hiring senior software development engineers in South Carolina right now include Booz Allen Hamilton, PEMCCO, and LPL Financial, based on current listings on Migrate Mate as of November 2026. South Carolina's defense contracting presence around Fort Jackson and Joint Base Charleston also drives consistent senior engineering demand from government technology contractors.
Which South Carolina cities have the most senior software development engineer jobs?
Fort Mill, Charleston, and Hanahan lead South Carolina for senior software development engineer openings. Columbia anchors the market through state government technology contracts, major insurance carriers, and the University of South Carolina's research programs, while Charleston's defense and aerospace corridor and Greenville's advanced manufacturing and financial services base generate strong secondary demand.
Are there remote senior software development engineer jobs in South Carolina?
Yes, and more than most fields. About 56% of senior software development engineer openings tied to South Carolina are remote or hybrid as of November 2026, reflecting how naturally suited desk-based engineering work is to distributed arrangements. Roles focused on cloud infrastructure, backend services, and software architecture tend to carry the highest share of fully remote options.
How can I get hired as a senior software development engineer in South Carolina with little or no experience?
The most realistic entry path is an associate or junior software engineer role at one of South Carolina's larger technology employers, followed by steady progression through code reviews, mentorship, and increasing system ownership. Employers like Booz Allen Hamilton and state government IT agencies in Columbia run rotational associate programs and entry-level contract positions that develop engineers toward senior responsibilities. Contributing to open-source projects, earning cloud certifications, and completing a degree in computer science or software engineering strengthens candidacy considerably.
Where can I find and apply to senior software development engineer jobs in South Carolina?
You can find and apply to senior software development engineer jobs in South Carolina on Migrate Mate, which lists current South Carolina openings updated regularly. Find roles that fit your experience and apply directly to each employer from the listing.
See All 25 Senior Software Development Engineer Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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