Senior Systems Administrator Jobs in Massachusetts
Senior Systems Administrator jobs in Massachusetts are open across Boston, Somerville, and Charlestown and other Massachusetts metros, with employers like Beth Israel Lahey Health, Boston College, and Cambridge Health Alliance hiring at every experience level. Find a role that fits below and apply directly.
Find JobsOverview
Showing 5 of 63+ Senior Systems Administrator jobs
Senior System Administrator
About Astellas
Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at Astellas.com.
Are you driven to make a real difference in the lives of patients?
We're seeking passionate individuals who thrive in dynamic environments, embrace new ideas, and aren't afraid to take intelligent risks. People who act with unwavering integrity and are deeply committed to making a tangible impact.
Purpose & Scope
The System Administrator supports the implementation, operation, and maintenance of digital and computerized systems within a cGMP manufacturing environment. Acting as the primary link between Operations and IT, this role manages system configuration, user access, and master data for core applications such as SAP. The position ensures ongoing data integrity and 21 CFR Part 11 compliance across manufacturing and laboratory systems.
Role and Responsibilities
- Administer and maintain site computerized systems, including configuration, access control, and master data management.
- Serve as first-line support for user issues and coordinate system troubleshooting, change control, and periodic maintenance.
- Develop and maintain documentation including URS, configuration guides, validation protocols, SOPs, and training materials.
- Partner with IT, QA, and system vendors to manage system qualification (IQ/OQ/PQ), updates, and change management activities.
- Ensure systems operate in compliance with cGMP and data integrity standards; support internal/external audits and inspections.
- Support onboarding and training for system users and monitor compliance metrics for continuous improvement. Develop and maintain validation templates, SOPs, and training programs.
Required Qualifications
- B.S. in biological sciences, chemistry, or related field with 5+ years (or M.S. with 3+ years) experience managing analytical or manufacturing computerized systems.
- Strong knowledge of GMP, 21 CFR Part 11, and data integrity principles.
- Experience with SAP system administration and validation.
- Familiarity with Windows environments, networks, and laboratory system integration.
- Excellent technical writing, communication, and troubleshooting skills.
- Demonstrated ability to work collaboratively and manage multiple priorities in a regulated setting.
Preferred Qualifications
- Experience in a fast-paced, high-growth biopharma or gene therapy environment.
- Experience with additional digital platforms (BMRAM, Labware LIMS, Tempo).
- Hands-on experience with instrument integration or data capture workflows.
Location and Working Environment
- This is an on-site role working in a cGMP regulated manufacturing facility. On occasion, this role may travel to other Astellas Gene Therapies manufacturing facilities (0-5%).
What awaits you at Astellas?
- Global collaboration: Become part of a connected global business of like-minded life science leaders, all dedicated to improving patients' lives worldwide.
- Real-world patient impact: Contribute to transformative therapies that reach patients around the world, knowing your work makes a difference every day.
- Relentless Innovation: Join a company at the forefront of scientific breakthroughs, where you'll have the opportunity to shape the future of healthcare.
- A Culture of Growth: Chart your own course within a supportive environment that values your contributions, champions your development, and empowers you to pursue your passions.
Our Organizational Values and Behaviors
Values: Innovation, Integrity and Impact sit at the heart of what we do.
Behaviors: We come together as ‘One Astellas,’ working with courage and a sense of urgency. We are outcome focused and consistently take accountability for our personal contribution.
Salary Range
$94,570 - $135,100 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations)
Benefits:
- Medical, Dental and Vision Insurance
- Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
- 401(k) match and annual company contribution
- Company paid life insurance
- Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
- Long Term Incentive Plan for eligible positions
- Company fleet vehicle for eligible positions
- Referral bonus program
Senior System Administrator
About Astellas
Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at Astellas.com.
Are you driven to make a real difference in the lives of patients?
We're seeking passionate individuals who thrive in dynamic environments, embrace new ideas, and aren't afraid to take intelligent risks. People who act with unwavering integrity and are deeply committed to making a tangible impact.
Purpose & Scope
The System Administrator supports the implementation, operation, and maintenance of digital and computerized systems within a cGMP manufacturing environment. Acting as the primary link between Operations and IT, this role manages system configuration, user access, and master data for core applications such as SAP. The position ensures ongoing data integrity and 21 CFR Part 11 compliance across manufacturing and laboratory systems.
Role and Responsibilities
- Administer and maintain site computerized systems, including configuration, access control, and master data management.
- Serve as first-line support for user issues and coordinate system troubleshooting, change control, and periodic maintenance.
- Develop and maintain documentation including URS, configuration guides, validation protocols, SOPs, and training materials.
- Partner with IT, QA, and system vendors to manage system qualification (IQ/OQ/PQ), updates, and change management activities.
- Ensure systems operate in compliance with cGMP and data integrity standards; support internal/external audits and inspections.
- Support onboarding and training for system users and monitor compliance metrics for continuous improvement. Develop and maintain validation templates, SOPs, and training programs.
Required Qualifications
- B.S. in biological sciences, chemistry, or related field with 5+ years (or M.S. with 3+ years) experience managing analytical or manufacturing computerized systems.
- Strong knowledge of GMP, 21 CFR Part 11, and data integrity principles.
- Experience with SAP system administration and validation.
- Familiarity with Windows environments, networks, and laboratory system integration.
- Excellent technical writing, communication, and troubleshooting skills.
- Demonstrated ability to work collaboratively and manage multiple priorities in a regulated setting.
Preferred Qualifications
- Experience in a fast-paced, high-growth biopharma or gene therapy environment.
- Experience with additional digital platforms (BMRAM, Labware LIMS, Tempo).
- Hands-on experience with instrument integration or data capture workflows.
Location and Working Environment
- This is an on-site role working in a cGMP regulated manufacturing facility. On occasion, this role may travel to other Astellas Gene Therapies manufacturing facilities (0-5%).
What awaits you at Astellas?
- Global collaboration: Become part of a connected global business of like-minded life science leaders, all dedicated to improving patients' lives worldwide.
- Real-world patient impact: Contribute to transformative therapies that reach patients around the world, knowing your work makes a difference every day.
- Relentless Innovation: Join a company at the forefront of scientific breakthroughs, where you'll have the opportunity to shape the future of healthcare.
- A Culture of Growth: Chart your own course within a supportive environment that values your contributions, champions your development, and empowers you to pursue your passions.
Our Organizational Values and Behaviors
Values: Innovation, Integrity and Impact sit at the heart of what we do.
Behaviors: We come together as ‘One Astellas,’ working with courage and a sense of urgency. We are outcome focused and consistently take accountability for our personal contribution.
Salary Range
$94,570 - $135,100 (Final compensation will be determined based on a variety of factors, including but not limited to skills, experience and organizational equity considerations)
Benefits:
- Medical, Dental and Vision Insurance
- Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down
- 401(k) match and annual company contribution
- Company paid life insurance
- Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
- Long Term Incentive Plan for eligible positions
- Company fleet vehicle for eligible positions
- Referral bonus program
See All 63 Senior Systems Administrator Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
Find JobsSenior Systems Administrator Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Senior Systems Administrator Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
- Beth Israel Lahey Health2
- Boston College2
- Cambridge Health Alliance2
- Dana-Farber Cancer Institute2
- Form Energy2
Top Industries Hiring
- Healthcare & Medical Services13
- Biotechnology & Pharmaceuticals9
- Technology & Software8
- Electronics & Hardware7
- Banking & Financial Services4
What Massachusetts Employers Look For
The qualifications that appear most often in senior systems administrator jobs across Massachusetts.
- Five or more years of hands-on systems administration experience in enterprise environments
- Proficiency with Windows Server and Active Directory administration and management
- Experience managing Linux systems including configuration, patching, and user administration
- Hands-on experience with virtualization platforms such as VMware vSphere or Hyper-V
- Familiarity with cloud platforms including AWS, Azure, or Google Cloud infrastructure services
- Bachelor's degree in computer science, information technology, or a related technical field
Senior Systems Administrator Jobs in Massachusetts: Frequently Asked Questions
How many senior systems administrator jobs are there in Massachusetts?
There are 63+ senior systems administrator openings in Massachusetts on Migrate Mate as of June 2026, with the most roles in Boston, Somerville, and Charlestown. New positions post regularly as employers across Massachusetts hire.
How much do senior systems administrators make in Massachusetts?
Senior systems administrators in Massachusetts earn a median of about $110,980 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $76,750 for the lowest 10% to over $168,910 for the top 10%. Pay rises with experience, specialty, and employer.
Which Massachusetts cities have the most senior systems administrator jobs?
Boston, Somerville, and Charlestown have the most senior systems administrator openings in Massachusetts right now, with additional roles spread across smaller metros statewide.
Which companies hire senior systems administrators in Massachusetts?
Employers hiring senior systems administrators in Massachusetts include Beth Israel Lahey Health, Boston College, and Cambridge Health Alliance, based on current listings on Migrate Mate as of June 2026.
Are there remote senior systems administrator jobs in Massachusetts?
Yes. About 30% of senior systems administrator openings tied to Massachusetts are remote or hybrid as of June 2026. The rest are on-site roles based in Massachusetts metros.
How do I apply for senior systems administrator jobs in Massachusetts?
You can apply to senior systems administrator jobs in Massachusetts directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Massachusetts location, then apply to each one that fits.
See All 63 Senior Systems Administrator Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
Find Jobs