Systems Development Engineer Jobs in St. Louis, MO

Systems Development Engineer jobs in St. Louis are in strong demand, concentrated in Clayton, Cortex Innovation Community, and downtown's tech corridor across defense contracting, healthcare IT, and financial services. Employers hiring right now include Washington University in St. Louis, Peraton, and Enterprise Mobility. Find a role that fits below and apply directly.

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Overview

Open roles46
Top employerWashington University in St. Louis
Work type45% On-site
Top credentialBachelor's degree in management information systems
Companies hiring33

Showing 5 of 46+ Systems Development Engineer jobs

General Dynamics Information Technology
Mobile Device Systems Administrator Senior
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General Dynamics Information Technology
Added 2d ago
Mobile Device Systems Administrator Senior
General Dynamics Information Technology
St. Louis, Missouri
Cloud & DevOps
Cloud Engineering
IT Support
Systems Administration
$130k - $138k/yr
On-Site
Bachelor's degree
10,000+

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Core & Main
Dynamics F&O -Business Systems Analyst
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Core & Main
Added 2d ago
Dynamics F&O -Business Systems Analyst
Core & Main
St. Louis, Missouri
Business Analysis
Business Analyst
Data Analytics
Bachelor of Science
5,001-10,000

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Enterprise Mobility
Principal Engineer - Systems
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Enterprise Mobility
Added 2d ago
Principal Engineer - Systems
Enterprise Mobility
St. Louis, Missouri
Account Management
Customer Success
Sales
Remote (US)
Bachelor's degree in management information systems
10,000+

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Graymatter
Control Systems Engineer
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Graymatter
Added 3d ago
Control Systems Engineer
Graymatter
St. Louis, Missouri
Customer Support
Solutions Engineering & Architecture
Technical Product & Program Management
Technical Program Management
Bachelor's degree in electrical engineering
2-10

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Serco
New Construction Senior Systems Engineer
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Serco
Added 3d ago
New Construction Senior Systems Engineer
Serco
St. Louis, Missouri
Compliance & Legal
Compliance & Risk
Consulting & Professional Services
$150k.22 - $260k.81/yr
Bachelor's degree in Physics
10,000+

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See All 46 Systems Development Engineer Jobs in St. Louis

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Systems Development Engineer Job Market in St. Louis

Who's Hiring

Washington University in St. Louis
Washington University in St. Louis4 open roles
Peraton
Peraton3 open roles
Enterprise Mobility
Enterprise Mobility3 open roles

Top Industries Hiring

  • Education
  • Aerospace & Defense
  • Technology & Software

Systems Development Engineer Jobs in St. Louis: Frequently Asked Questions

How do I get a systems development engineer job in St. Louis?

Target St. Louis's strongest hiring sectors first: defense and aerospace contractors in the metro area, healthcare IT firms anchored near the medical corridor, and financial technology companies based in Clayton. Hands-on experience with automation tooling, CI/CD pipelines, and cloud infrastructure stands out locally. Attending St. Louis tech meetups and connecting with hiring managers at Cortex-area companies gives candidates a concrete edge over remote applicants.

Which companies hire systems development engineers in St. Louis?

Companies currently hiring systems development engineers in St. Louis include Washington University in St. Louis, Peraton, and Enterprise Mobility, per current listings on Migrate Mate as of July 2026. St. Louis draws a mix of large defense primes, regional health systems, and mid-size fintech firms, all of which maintain dedicated engineering teams for internal platform development.

Are there remote systems development engineer jobs in St. Louis?

Yes, though availability depends on the role: infrastructure and platform-focused systems development engineer positions often support remote work, while roles tied to classified defense contracts or on-site hardware typically require in-person presence. About 55% of systems development engineer openings tied to St. Louis are remote or hybrid as of July 2026, with cloud and DevOps-oriented roles being the most likely to offer schedule flexibility.

How can I get a systems development engineer job in St. Louis with little or no experience?

The most realistic entry path in St. Louis is through associate software engineer or DevOps support roles at regional healthcare IT companies or mid-size defense subcontractors, many of which hire candidates with strong internship backgrounds. Washington University and Saint Louis University produce graduates that local employers actively recruit, so campus-connected internships carry real weight. Building projects around automation scripts, AWS basics, or Linux administration helps entry-level candidates compete for these openings.

Which industries hire the most systems development engineers in St. Louis?

Most systems development engineer openings in St. Louis sit in Education, Aerospace & Defense, and Technology & Software, per current listings on Migrate Mate as of July 2026. St. Louis's concentration of defense contractors, large regional health systems, and established financial services firms creates sustained demand for engineers who build and maintain internal platforms and development tooling.

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