Systems Programmer Jobs in South Carolina
Systems Programmer jobs in South Carolina are open across Columbia, Charleston, and Clemson and other South Carolina metros, with employers like Alrek Business Solutions, Infojini, and Avani Technology Solutions hiring at every experience level. Find a role that fits below and apply directly.
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Job Description Summary
The DCU is looking for a computer programmer who can work with the Unit’s Information Systems team to develop and maintain the Unit’s clinical trials management system referred to as WebDCU™. This includes participating in web-based information management application validation and documentation, working with the study teams (clients) to ensure users’ needs are met, and assisting in the development, maintenance and upgrade of the Unit’s clinical trials management software. This WebDCU™ system supports all project and data management activities of the clinical trials managed by the DCU.
Job Duties:
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25% Independently execute the analysis and implementation of various modules housed within WebDCU™. Coordinates with team leaders on system development, documentation and testing. Completes milestones within required time frames.
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25% Plans, designs and implements individual projects within the WebDCU system, including data transfers in and out of the system. Provides ongoing support and maintenance through the entire life of the project. Independently process and implement database change requests from end users.
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25% Participate in conducting and documenting computerized system validation activities according to standard operating procedures. Determines end user needs by participating as an active member at internal and external study team meetings. Performs demonstrations of newly developed tools and functions to internal and external users.
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25% Helps with the design and development of database architectures. Creates stored procedures, triggers, views, etc. to perform project tasks. Reviews and validates work that has been completed by other team members. Test, validate and debug new installations.
BASIC QUALIFICATIONS
A high school diploma and three years work experience in the modification and maintenance of system programs, the design and development of system software, or the testing and debugging of system software. An associate's degree or a bachelor's degree in a related field may be substituted for the required work experience.
Physical Requirements:
(Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift)
- Ability to perform job functions in an upright position. (Frequent)
- Ability to perform job functions in a seated position. (Frequent)
- Ability to perform job functions while walking/mobile. (Frequent)
- Ability to work indoors. (Continuous)
- Ability to work in confined/cramped spaces. (Infrequent)
- Ability to bend at the waist. (Frequent)
- Ability to fully use both hands/arms. (Continuous)
- Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent)
- Ability to reach in all directions. (Frequent)
- Possess good finger dexterity. (Continuous)
- Ability to maintain tactile sensory functions. (Continuous)
- Ability to lift, lower, push or pull objects 15 lbs. or more, unassisted. (Infrequent)
- Ability to maintain 20/40 vision, corrected. (Continuous)
- Ability to see and recognize objects close at hand. (Continuous)
- Ability to see and recognize objects at a distance. (Continuous)
- Ability to match or discriminate between colors. (Continuous)
- Ability to determine distance/relationship between objects; depth perception. (Continuous)
- Good peripheral vision capabilities. (Continuous)
- Ability to hear and/or understand conversations. (Continuous)
- Ability to perform gross motor functions with frequent fine motor movements. (Continuous)
- Ability to work in dusty areas. (Infrequent)
If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees
LOCATION
Charleston, South Carolina
WORKER TYPE
Employee
WORKER SUB-TYPE
Research Grant
COST CENTER
CC001038 COM PHS Operations CC
PAY RATE TYPE
Salary
PAY GRADE
University-06
PAY RANGE
47,588.00 - 67,817.00 - 88,047.00
SCHEDULED WEEKLY HOURS
40
WORK SHIFT
See All 10 Systems Programmer Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Systems Programmer JobsSystems Programmer Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Systems Programmer Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Alrek Business Solutions4

- Infojini2

- Avani Technology Solutions1

- DatamanUSA1

- Medical University of South Carolina1

Top Industries Hiring
- Technology & Software5
- Consulting & Professional Services4
- Education1
What South Carolina Employers Look For
The qualifications that appear most often in systems programmer jobs across South Carolina.
- Proficiency in C or C++ for systems-level development and performance-critical code
- Experience with operating system internals such as memory management, scheduling, or device drivers
- Familiarity with assembly language and low-level debugging tools like GDB or JTAG
- Bachelor's degree in computer science, computer engineering, or a closely related field
- Experience with real-time operating systems or embedded platforms such as VxWorks or FreeRTOS
- Knowledge of version control, build systems, and continuous integration pipelines in Linux environments
Systems Programmer Jobs in South Carolina: Frequently Asked Questions
How many systems programmer jobs are there in South Carolina?
There are 10+ systems programmer openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Charleston, and Clemson. New positions post regularly as employers across South Carolina hire.
How much do systems programmers make in South Carolina?
Systems programmers in South Carolina earn a median of about $99,740 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $63,130 for the lowest 10% to over $135,250 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Carolina cities have the most systems programmer jobs?
Columbia, Charleston, and Clemson have the most systems programmer openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire systems programmers in South Carolina?
Employers hiring systems programmers in South Carolina include Alrek Business Solutions, Infojini, and Avani Technology Solutions, based on current listings on Migrate Mate as of June 2026.
Are there remote systems programmer jobs in South Carolina?
Yes. About 20% of systems programmer openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for systems programmer jobs in South Carolina?
You can apply to systems programmer jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 10 Systems Programmer Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Systems Programmer Jobs