Technical Sales Manager Jobs in San Francisco, CA
Technical Sales Manager jobs in San Francisco are concentrated in SoMa, the Financial District, and Mission Bay, driven by demand from enterprise software, cloud infrastructure, and life sciences employers. Companies hiring right now include Johnson Controls, Ecolab, and Biotage. Scan the live roles below and apply to whichever ones fit.
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Senior Sales Specialist – High-Plex Sequencing
Location: Field-Based / Flexible with location.
We have 2 new exciting opportunities, one for the East Coast and one for the West coast.
Position Overview:
Applied Biosystems has a long and proud history in DNA sequencing. From laying the backbone with Sanger sequencing to advancing current next-generation sequencing workflows, our brand is built on science and trusted performance. Now, as we accelerate our growth in NGS library preparation and expand our footprint into High-Plex Sequencing, we are looking for a key player to help shape the future of this business with us.
This is not a traditional sales role. As our High-Plex Sequencing Sales Specialist, you will serve as a foundational pillar for our NGS strategy. You will work with us to develop end-to-end workflows, and market strategy, acting as both a technical authority and a growth catalyst across key market segments. If you know the NGS landscape inside and out, understand the nuances of library prep chemistry, and want to help build and guide a high-growth portfolio, this is where you can make a lasting impact.
Requirements:
BS degree required, preferred field of study in the Life Sciences
8 plus years of technical sales experience in life sciences is strongly preferred
How You Will Make an Impact:
- Shape the Strategy & Market Growth: Partner directly with research and clinical customers to expand our High-Plex Sequencing footprint. You will help drive market adoption of our NGS library prep solutions, identifying emerging trends, customer needs, and workflow gaps to influence our commercial approach.
- Serve as the High-Plex Expert: Translate complex chemistry, assays, and sequencing workflows into consultative solutions. Whether guiding a lab through library preparation optimization or presenting at industry conferences, you will be the trusted technical authority for our scientific community and internal partners.
- Drive Strategic Customer Success: Build deep, lasting relationships with key opinion leaders, sequencing core facilities, and commercial accounts. You will manage complex, consultative sales cycles from initial engagement through technical demonstration and final implementation.
- Collaborate Across the Business: Work in close partnership with field application scientists, product management, and regional sales teams in a matrixed environment to ensure seamless customer onboarding, robust pipeline execution, and sustained revenue growth.
What You Bring to the Team:
- Deep NGS Expertise: You have a thorough, hands-on understanding of next-generation sequencing chemistry, high-plex target enrichment, sample prep, and end-to-end library preparation workflows. You know the players, the platforms, and the commercial landscape.
- Proven Commercial Success: You hold a Bachelor’s degree in Life Sciences, Chemistry, Genetics, or a related field, combined with at least 5 years of successful technical sales or field application experience in life science research instruments and reagents.
- Consultative Problem Solver: You excel at navigating complex sales cycles, leading technical discussions with principal investigators and lab directors, and tailoring solutions to specific market segments.
- Strategic Vision & Execution: You have a track record of territory planning, market analysis, and cross-functional leadership, with the organizational skill to manage high-touch customer relationships alongside internal strategic initiatives.
- Mobility & Engagement: You are comfortable traveling up to 50 to 75 percent within the assigned territory to meet customers in their labs, present at conferences, and host targeted workflow sessions. Bilingual communication skills are a welcome advantage.
Compensation and Benefits
This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
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Find Technical Sales Manager JobsTechnical Sales Manager Job Market in San Francisco
Who's Hiring
- Johnson Controls18

- Ecolab9

- Biotage9

- galliot9G
- Altinity9

Top Industries Hiring
- Science & Research
Technical Sales Manager Jobs in San Francisco: Frequently Asked Questions
How do I get a technical sales manager job in San Francisco?
Focus your search on San Francisco's enterprise software, cybersecurity, and cloud infrastructure sectors, where demand for technical sales managers is highest. Roles concentrate in SoMa, Mission Bay, and the Financial District, with many employers expecting familiarity with complex B2B sales cycles and technical product knowledge. Candidates who can demonstrate quota attainment in a SaaS or hardware environment, and who already have relationships within the Bay Area tech ecosystem, move to the top of shortlists fastest.
Which companies hire technical sales managers in San Francisco?
Employers hiring technical sales managers in San Francisco right now include Johnson Controls, Ecolab, and Biotage, based on current listings on Migrate Mate as of November 2026. The local market skews toward growth-stage and enterprise tech companies, with a smaller but steady presence from medtech and fintech firms headquartered in or near the city.
Are there remote technical sales manager jobs in San Francisco?
Yes, though partially: technical sales manager roles often require in-person client meetings and territory coverage, so fully remote positions are less common than in purely analytical roles. About 100% of technical sales manager openings tied to San Francisco are remote or hybrid as of November 2026, reflecting a market that values flexibility for internal work but expects presence for key accounts. Strategic and forecasting responsibilities tend to be the most remote-friendly portion of the role locally.
How can I get a technical sales manager job in San Francisco with little or no experience?
The most realistic entry path in San Francisco is moving up from a sales development representative or account executive role at a SoMa or Mission Bay software company, where internal promotions into technical sales management are common. Early-stage startups often promote high performers faster than larger enterprise firms and are more open to candidates who pair strong sales instincts with technical self-study. Familiarity with the tools and products common in the Bay Area tech stack, such as cloud platforms or developer tooling, gives candidates a clear edge over generalists.
Which industries hire the most technical sales managers in San Francisco?
San Francisco technical sales manager roles concentrate in Science & Research, based on current listings on Migrate Mate as of November 2026. San Francisco's density of venture-backed software and infrastructure companies, combined with a strong biotech presence in Mission Bay, keeps demand for technical sales leadership consistently high across those sectors.
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