Geneticist Visa Sponsorship Jobs in Minnesota
Minnesota's geneticist jobs are concentrated at major research institutions and healthcare systems including Mayo Clinic, the University of Minnesota, and Fairview Health Services, with Twin Cities metro and Rochester as the primary hiring hubs. Employers in clinical genetics, agricultural biotech, and genomics research have an established track record of H-1B visa and O-1 visa sponsorship for qualified candidates.
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Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights
- Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
Responsibilities
The Cousin Lab at Mayo Clinic is seeking a postdoctoral fellow who will contribute to a growing rare disease therapeutics program with an initial emphasis on POLR2A-related disorders. This work will also support broader efforts in the lab, including genetic forms of ALS and other monogenic neurologic conditions. Projects may include iPSC-derived neural models, variant-mechanism studies, RNA-targeted therapies, genome editing, sequencing-based biomarkers, and collaboration with Mayo Clinic precision medicine and N-of-1 therapeutic programs, core facilities, and external academic partners.
The Cousin Lab at Mayo Clinic develops mechanism-guided, gene-targeted therapeutic strategies for rare neurogenetic diseases. Our work integrates clinical genetics, patient-derived biospecimens, functional genomics, iPSC-based disease modeling, preclinical therapeutic testing, and clinical translation.
Position Overview
The fellow will lead experimental and analytical components of translational rare disease projects. The role includes developing and characterizing patient-derived and engineered cell models; defining variant effects and disease mechanisms; designing and evaluating RNA-targeted and gene-editing therapeutic strategies; and integrating functional, genomic, and clinical data to prioritize treatment approaches. The position involves substantial wet-lab research, quantitative data analysis, manuscript and grant preparation, and cross-disciplinary collaboration.
The fellow will join a collaborative Mayo Clinic environment with access to clinical expertise, core facilities, genomic and sequencing resources, translational infrastructure, and multi-institutional rare disease networks. This position offers the opportunity to develop an independent research niche at the interface of rare disease biology, human neural modeling, and targeted therapeutic development; publish first-author manuscripts; present at national and international meetings; and pursue external fellowship or career-development funding.
Key Responsibilities
- Disease Modeling & Assay Development: Develop and characterize patient-derived and engineered disease models, including fibroblasts, iPSCs, isogenic controls, iPSC-derived neural cell types, and organoid or multicellular systems.
- Mechanistic & Functional Studies: Design and execute molecular, cellular, imaging, electrophysiologic, and functional genomics assays to define variant effects, disease mechanisms, cellular phenotypes, biomarkers, and therapeutic response.
- Therapeutic Development: Develop and evaluate RNA-targeted and gene-editing strategies, including ASO/siRNA, allele-selective or splice-modifying approaches, CRISPR/base-editing platforms, delivery systems, and target-engagement or rescue assays.
- Genomic Data Integration: Integrate variant interpretation, sequencing data, and functional readouts to prioritize therapeutic strategies and evaluate loss-of-function, dominant-negative, allele-specific, and related mechanisms.
- Collaboration & Translation: Coordinate with the PI, clinicians, partners, core facilities, biobanks, and external collaborators to align patient samples, disease models, assays, and preclinical workflows.
- Scientific Communication & Mentorship: Manage projects with rigor and reproducibility; prepare figures, reports, manuscripts, presentations, and grant/fellowship applications; and contribute to mentoring junior team members.
Qualifications
Education: Ph.D., M.D./Ph.D., or equivalent doctoral degree in neuroscience, genetics/genomics, molecular or cell biology, stem cell biology, biomedical engineering, pharmacology, RNA biology, bioengineering, or a related field.
- Research Expertise: Demonstrated productivity in cell-based disease modeling, molecular biology, functional genomics, therapeutic development, neurogenetics, or rare disease biology.
- Technical Skills: Strong wet-lab skills in aseptic cell culture, molecular biology, assay development, sequencing workflows, microscopy/imaging, and experimental documentation.
- Quantitative & Analytical Skills: Ability to analyze, interpret, and communicate complex data; familiarity with Prism, R, Python, or related statistical and visualization tools is helpful.
- Professional Skills: Excellent organization, independence, attention to detail, and communication skills, with the ability to thrive in a collaborative translational research environment.
Experience in one or more of the following areas is preferred:
- iPSC & Neural Models: Experience with human iPSC culture, genome-edited/isogenic lines, neural differentiation, neurons, glia, organoids, or related iPSC-derived neural models.
- Therapeutic Platforms: Experience with RNA-targeted therapeutic development, genome engineering, or delivery platforms, including ASOs, siRNA, CRISPR/Cas, base or prime editing, AAV, or LNPs.
- Rare Disease Translation: Experience with rare genetic, neurodevelopmental, or neuromuscular disease models; patient-derived biospecimens; variant interpretation; genotype-phenotype analysis; or individualized/N-of-1 therapeutic approaches.
- Genomics & Biomarkers: Experience with RNA-seq, long-read sequencing, phasing/haplotype analysis, single-cell or multi-omic workflows, biomarker discovery, bioinformatics, or high-content/high-throughput screening.
- Scientific Leadership: Experience in translational or preclinical research, collaborative project management, manuscript preparation, grant writing, and mentoring.
Candidates should submit a CV, a brief cover letter describing research interests and relevant experience, and contact information for 2-3 references.
Exemption Status
Exempt
Compensation Detail
$67,282 - $78,711 / year; Education, experience and tenure may be considered along with internal equity when job offers are extended.
Benefits Eligible
Yes
Schedule
Full Time
Hours/Pay Period
80
Schedule Details
Varies
International Assignment
No
Site Description
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.
Equal Opportunity
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.
Recruiter
Amy Hoffman
Geneticist Job Roles in Minnesota
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Search Geneticist Jobs in MinnesotaGeneticist Jobs in Minnesota: Frequently Asked Questions
Which companies sponsor visas for geneticists in Minnesota?
Mayo Clinic in Rochester is among the most active sponsors for clinical and research geneticist roles in Minnesota, alongside the University of Minnesota, which regularly sponsors H-1B positions through its medical and biological sciences departments. Agricultural biotech firms in the Twin Cities corridor, including those in the plant genomics sector, also have documented sponsorship histories. Hospital systems such as M Health Fairview and Allina Health have sponsored genetics specialists as demand for clinical genomics has grown.
Which visa types are most common for geneticist roles in Minnesota?
The H-1B is the most frequently used visa for geneticist positions in Minnesota because the role meets USCIS specialty occupation standards, requiring at minimum a bachelor's degree in genetics, molecular biology, or a closely related field. Researchers with exceptional recognition in the field may qualify for the O-1A. Academic and nonprofit research positions at institutions like the University of Minnesota can also qualify for cap-exempt H-1B filings, which bypass the annual lottery.
How to find geneticist visa sponsorship jobs in Minnesota?
Migrate Mate filters geneticist openings specifically to Minnesota employers with verified visa sponsorship history, which saves significant time compared to manually reviewing job postings. Because sponsorship willingness is not always stated in a listing, Migrate Mate surfaces employers whose prior H-1B or O-1 visa filings indicate they sponsor geneticist roles. Focusing your search on Rochester and the Twin Cities metro will return the highest concentration of relevant opportunities in the state.
Which cities in Minnesota have the most geneticist sponsorship jobs?
Rochester leads for clinical and translational genetics roles due to Mayo Clinic's scale as both a research and healthcare employer. The Twin Cities metro, particularly Minneapolis and Saint Paul, concentrates university-affiliated research positions, biotech company roles, and hospital genetics department openings. Smaller clusters exist around University of Minnesota extension campuses and agricultural research stations, but for sponsored positions the Rochester and Twin Cities markets account for the large majority of activity.
Are there state-specific considerations for geneticists seeking visa sponsorship in Minnesota?
Minnesota's concentration of nonprofit and academic employers is relevant because these organizations are often exempt from the H-1B cap, meaning they can file petitions outside the annual lottery cycle and at any time of year. Clinical genetics roles typically require board certification or eligibility through the American Board of Medical Genetics and Genomics, which employers factor into their prevailing wage and job duty filings with DOL. The OFLC Wage Search tool lists Minnesota-specific prevailing wages by SOC code, which governs the minimum salary an H-1B employer must pay a sponsored geneticist in the state.
What is the prevailing wage for sponsored geneticist jobs in Minnesota?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.