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Director and Head of roles are among the most actively sponsored positions in the U.S., companies routinely file H-1B visa, L-1A, and O-1 visa petitions for senior leadership hires. Most require a bachelor's degree plus substantial progressive experience, and many qualify for EB-1C or EB-2 green card pathways.
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Get Access To All JobsWhat if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
ABOUT PIONEERING MEDICINES
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
Position Summary
The Senior Director, Head of Toxicology will lead and build the toxicology function within Pioneering Medicines, defining and executing nonclinical safety strategies across a diverse and rapidly evolving portfolio. This role provides scientific and strategic leadership across both investigative and regulatory toxicology, supporting a broad range of therapeutic modalities.
Working in a dynamic venture creation environment, you will collaborate closely with multidisciplinary teams to optimize candidate selection, guide preclinical development, and ensure regulatory readiness. This is a high-impact role requiring strong analytical thinking, scientific rigor, and clear communication, influencing programs from discovery through early clinical development.
This role can be onsite at our Cambridge, MA site. Or if you are over 30 miles away remote with travel 3-4 days per month.
Key Responsibilities
Functional Leadership & Capability Building
- Lead, build, and scale the toxicology function, including internal team development and external partnerships
- Define fit-for-purpose operating models spanning investigative and regulatory toxicology
- Serve as the primary internal expert for nonclinical safety, ensuring quality, consistency, and scalability across the portfolio
Portfolio & Program Strategy
- Define and drive toxicology strategies across multiple programs and modalities
- Translate findings into clear risk assessments, mitigation strategies, and IND/CTA-enabling plans
- Enable transparent, data-driven decision-making by articulating risks, assumptions, and trade-offs to program teams
- Oversee the design, execution, and interpretation of non-GLP and GLP toxicology studies
- Partner cross-functionally (DMPK, pharmacology, CMC, clinical) to integrate safety into development strategy
- Support diligence and evaluation of new programs within Flagship's ecosystem
External Partnerships & Regulatory
- Build and manage a high-performing CRO and consultant network, ensuring quality, timelines, and cost efficiency
- Leverage and contribute to the Flagship ecosystem, fostering knowledge sharing and collaboration across platform companies
- Lead nonclinical regulatory strategy and documentation (INDs, IBs, briefing materials)
- Ensure regulatory readiness through clear and scientifically robust safety narratives
- Represent toxicology in regulatory interactions as appropriate
Qualifications
- PhD, DVM, or equivalent in Toxicology, Pathology, Pharmacology, or related field
- ~10-15+ years of experience in nonclinical safety in biotech/pharma
- Proven track record advancing programs through IND and into clinical development
- Experience across multiple modalities preferred
- Strong experience managing CROs and external collaborations
- Experience leading or building a toxicology function or team, including management of internal scientists and/or external partners, is a plus
Leadership Profile
- Enterprise mindset; able to operate across a portfolio in a fast-paced, collaborative environment
- Analytical and goal-oriented, with the ability to operate with urgency while maintaining high standards of scientific rigor and ethics
- Strong communicator who can translate complex toxicology into clear, audience-appropriate risk assessments, from early-stage teams to large pharma partners
About Flagship
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company's annual list of the World's Most Innovative Companies.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $228,000 - $310,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
ABOUT PIONEERING MEDICINES
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
Position Summary
The Senior Director, Head of Toxicology will lead and build the toxicology function within Pioneering Medicines, defining and executing nonclinical safety strategies across a diverse and rapidly evolving portfolio. This role provides scientific and strategic leadership across both investigative and regulatory toxicology, supporting a broad range of therapeutic modalities.
Working in a dynamic venture creation environment, you will collaborate closely with multidisciplinary teams to optimize candidate selection, guide preclinical development, and ensure regulatory readiness. This is a high-impact role requiring strong analytical thinking, scientific rigor, and clear communication, influencing programs from discovery through early clinical development.
This role can be onsite at our Cambridge, MA site. Or if you are over 30 miles away remote with travel 3-4 days per month.
Key Responsibilities
Functional Leadership & Capability Building
- Lead, build, and scale the toxicology function, including internal team development and external partnerships
- Define fit-for-purpose operating models spanning investigative and regulatory toxicology
- Serve as the primary internal expert for nonclinical safety, ensuring quality, consistency, and scalability across the portfolio
Portfolio & Program Strategy
- Define and drive toxicology strategies across multiple programs and modalities
- Translate findings into clear risk assessments, mitigation strategies, and IND/CTA-enabling plans
- Enable transparent, data-driven decision-making by articulating risks, assumptions, and trade-offs to program teams
- Oversee the design, execution, and interpretation of non-GLP and GLP toxicology studies
- Partner cross-functionally (DMPK, pharmacology, CMC, clinical) to integrate safety into development strategy
- Support diligence and evaluation of new programs within Flagship's ecosystem
External Partnerships & Regulatory
- Build and manage a high-performing CRO and consultant network, ensuring quality, timelines, and cost efficiency
- Leverage and contribute to the Flagship ecosystem, fostering knowledge sharing and collaboration across platform companies
- Lead nonclinical regulatory strategy and documentation (INDs, IBs, briefing materials)
- Ensure regulatory readiness through clear and scientifically robust safety narratives
- Represent toxicology in regulatory interactions as appropriate
Qualifications
- PhD, DVM, or equivalent in Toxicology, Pathology, Pharmacology, or related field
- ~10-15+ years of experience in nonclinical safety in biotech/pharma
- Proven track record advancing programs through IND and into clinical development
- Experience across multiple modalities preferred
- Strong experience managing CROs and external collaborations
- Experience leading or building a toxicology function or team, including management of internal scientists and/or external partners, is a plus
Leadership Profile
- Enterprise mindset; able to operate across a portfolio in a fast-paced, collaborative environment
- Analytical and goal-oriented, with the ability to operate with urgency while maintaining high standards of scientific rigor and ethics
- Strong communicator who can translate complex toxicology into clear, audience-appropriate risk assessments, from early-stage teams to large pharma partners
About Flagship
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company's annual list of the World's Most Innovative Companies.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $228,000 - $310,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
See all 59+ Director Head Of Jobs
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Get Access To All JobsTips for Finding Director Head Of Jobs
Lead with measurable impact
Visa petitions for director-level roles require evidence of organizational leadership. Quantify team size, budget authority, and revenue impact in your resume. USCIS and consular officers evaluate whether the role genuinely requires a director-caliber hire.
Understand the L-1A pathway
If you've managed a team at a related foreign entity for at least one year, the L-1A intracompany transfer is often faster than H-1B. It also creates a direct path to the EB-1C green card, bypassing PERM labor certification entirely.
Position yourself for EB-1C early
Many employers sponsoring directors will pursue the EB-1C immigrant visa. This requires managerial or executive capacity at the U.S. entity. Ensure your offer letter and job description explicitly reflect organizational authority and direct reporting relationships.
Target companies with active sponsorship history
Not every employer sponsors senior roles, even when budgets allow it. Filter specifically for companies with a documented H-1B or L-1 visa filing history in your industry. Migrate Mate surfaces these employers directly so you're not guessing.
Prepare for specialty occupation scrutiny
USCIS sometimes challenges whether a Director or Head of role constitutes a specialty occupation. A strong petition connects your specific degree field to the theoretical and practical requirements of the position, not just the seniority level.
Align your degree field to the function
A Director of Engineering petition is straightforward with a computer science degree. A Director of Marketing with a business degree requires a tighter connection. The petition must show your field of study directly applies to the managerial function you'll oversee.
Frequently Asked Questions
Can companies sponsor a Director or Head of role for an H-1B visa?
Yes. Director and Head of roles routinely qualify for H-1B visa sponsorship when the position requires at least a bachelor's degree in a specific specialty field. The key is demonstrating the role is a specialty occupation, not just a senior management title. Employers must show the duties require theoretical and practical application of specialized knowledge, which most functional director roles satisfy.
Do I need a specific degree to qualify for a Director-level H-1B petition?
You need a bachelor's degree or higher in a field directly related to the role's core function. A Director of Finance typically needs a degree in finance, accounting, or economics. A Director of Engineering needs a degree in an engineering discipline. If your degree field is adjacent rather than direct, your attorney will need to build a stronger connection through coursework or work experience equivalency.
How does the L-1A visa work for Director and Head of roles?
The L-1A is available if you've worked for a related foreign affiliate, subsidiary, or parent company in a managerial or executive capacity for at least one continuous year within the past three years. It has no lottery, no annual cap, and no prevailing wage requirement. It also creates a streamlined path to the EB-1C green card, making it the preferred route for multinationals hiring senior leadership from abroad.
Where can I find Director and Head of roles that offer visa sponsorship?
Most general job boards don't filter by sponsorship willingness, which means significant time wasted on roles that exclude visa holders. Migrate Mate is built specifically for this, listing Director and Head of roles from employers with confirmed sponsorship history. You can browse by function, industry, and visa type without filtering through hundreds of irrelevant postings.
Can a Director-level role lead directly to a green card?
Yes, and the path is often faster than for individual contributor roles. Directors who qualify under L-1A status can petition for the EB-1C green card without going through PERM labor certification. H-1B holders in director roles can pursue EB-2 or EB-1C depending on the employer's petition. The EB-1C route requires that the U.S. position itself involves managing an organization or a key function and overseeing other managers or professionals.
What is the prevailing wage requirement for sponsored Director Head Of jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.