Clinical Director Jobs in Cambridge, MA
Clinical Director jobs in Cambridge are in strong demand, concentrated in Kendall Square, East Cambridge, and the Harvard Square corridor across academic medical centers, biotech, and behavioral health. Employers hiring right now include Amylyx Pharmaceuticals, Takeda Pharmaceuticals, and AstraZeneca. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 169+ Clinical Director jobs
Why Sarepta? Why Now?
Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold a leadership position in Duchenne Muscular Dystrophy and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. Our next-generation siRNA platform is focused on chronically administered therapies for neurodegenerative and pulmonary diseases.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
Physical and Emotional Wellness
Financial Wellness
Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. Additionally, the candidate will work with early research and other stakeholders to build out the oversight model for Feasibility & Study Start-up. The candidate will drive the study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for 1) directing and overseeing the success of Sarepta’s clinical trial feasibility process, 2) leading the development of feasibility and start-up strategies including study-specific plans, 3) directing and overseeing the success of the Sarepta’s clinical trial start-up activities, 4) and working with both internal and external vendors.
This is a highly cross-functional position, collaborating with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
The Opportunity to Make a Difference
Primary Responsibilities Include:
- Develop and implement the feasibility and start-up strategies to support the success of Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study specific meeting series to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO. The candidate will report metrics to larger teams including senior management.
- Lead calls with Sarepta and the CRO to manage feasibility and study start-up activities and ensure the study timelines are achieved.
- Oversee study feasibility activities including country, site, and investigator selection for participation in Sarepta-lead studies.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentoring to junior members of the Study Start-up and Feasibility Team.
- Create reporting tools to measure ongoing activities and other key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations and CRO teams, and other key stakeholders to implement innovative feasibility efforts including collection of data within CTMS.
- Support and or lead the development of Charters or SOPs as it relates to Study Start-up and Feasibility.
- May have direct reports.
More about You
Desired Education and Skills:
- BA / BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs.
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
#LI-Hybrid This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time. The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
Why Sarepta? Why Now?
Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold a leadership position in Duchenne Muscular Dystrophy and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. Our next-generation siRNA platform is focused on chronically administered therapies for neurodegenerative and pulmonary diseases.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta Offers
At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:
Physical and Emotional Wellness
Financial Wellness
Support for Caregivers
For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
The Importance of the Role
The Associate Director, Clinical Operations Program Lead, Study Start-up and Feasibility will report to the Director, Patient Recruitment and Start-Up Strategy and lead a team to drive the strategy and implementation of country and site feasibility for our studies and support the internalization of country and site feasibility. Additionally, the candidate will work with early research and other stakeholders to build out the oversight model for Feasibility & Study Start-up. The candidate will drive the study start-up activities and be responsible for oversight of timelines and goals with respect to our clinical studies. The candidate will be responsible for 1) directing and overseeing the success of Sarepta’s clinical trial feasibility process, 2) leading the development of feasibility and start-up strategies including study-specific plans, 3) directing and overseeing the success of the Sarepta’s clinical trial start-up activities, 4) and working with both internal and external vendors.
This is a highly cross-functional position, collaborating with internal teams, CROs, and vendors. The candidate must be comfortable working directly with clinical trial sites.
The contribution of the candidate directly supports the goals of the Development Operations organization under R&D.
This is a great opportunity for an individual with an operational background and innovative mindset to help us accelerate study execution to support Sarepta’s goal of Patient’s First.
The Opportunity to Make a Difference
Primary Responsibilities Include:
- Develop and implement the feasibility and start-up strategies to support the success of Sarepta clinical studies.
- Gather cross-functional, country-level input to inform robust feasibility strategies.
- Develop and manage integrated feasibility and site start-up timelines, and report on progress, including plans to address potential timing risks or gaps.
- Establish study specific meeting series to review clinical trial feasibility data and start-up activities with study leads, MSLs, and the CRO. The candidate will report metrics to larger teams including senior management.
- Lead calls with Sarepta and the CRO to manage feasibility and study start-up activities and ensure the study timelines are achieved.
- Oversee study feasibility activities including country, site, and investigator selection for participation in Sarepta-lead studies.
- Foster a culture of innovation by developing new ideas and programs to advance feasibility and support departmental growth.
- Provide guidance and mentoring to junior members of the Study Start-up and Feasibility Team.
- Create reporting tools to measure ongoing activities and other key performance, quality, and effectiveness indicators.
- Partner with Clinical Operations and CRO teams, and other key stakeholders to implement innovative feasibility efforts including collection of data within CTMS.
- Support and or lead the development of Charters or SOPs as it relates to Study Start-up and Feasibility.
- May have direct reports.
More about You
Desired Education and Skills:
- BA / BS degree in a related field; 10+ years related experience in the pharmaceutical or biotech industry within a clinical operations or project management role or similar
- Experience in clinical study budget planning, and program implementation
- Experience with both direct line management and dotted line reporting
- Experience in developing feasibility questionnaires
- Experience with protocol and ICF development and review
- Experience in clinical study start-up
- Experience with rare disease / difficult to recruit populations a plus
- Experience identifying and managing multiple CROs, vendors, budgets, KPIs.
- Comprehensive regulatory knowledge, including ICH and GCPs
- Exceptional organizational skills and ability to deal with competing priorities
- Strong analytical reasoning and problem-solving ability
- Excellent PowerPoint slide development and presentation skills
- Ability to multi-task, work independently and as part of a multidisciplinary team, exercise sound judgement and escalate issues when necessary
What Now?
We’re always looking for solution-oriented, critical thinkers.
So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
#LI-Hybrid This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time. The targeted salary range for this position is $160,800 - $201,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
See All 169+ Clinical Director Jobs in Cambridge
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Find Clinical Director JobsClinical Director Job Market in Cambridge
Who's Hiring
- Amylyx Pharmaceuticals28
- Takeda Pharmaceuticals28
- AstraZeneca14
- Scholar Rock14
- IPSEN7
Top Industries Hiring
- Healthcare & Medical Services
- Biotechnology & Pharmaceuticals
Clinical Director Jobs in Cambridge: Frequently Asked Questions
How do I get a clinical director job in Cambridge?
Focus your search on Cambridge's three dominant hiring pockets: the Kendall Square biotech and life sciences corridor, the academic medical institutions clustered near Harvard and MIT, and the behavioral health and community health center networks in East Cambridge. Employers in these sectors prioritize candidates with direct program leadership experience, strong outcomes data, and familiarity with research-adjacent clinical environments. A background bridging clinical practice and operational management gives you a clear edge here.
Which companies hire clinical directors in Cambridge?
Companies currently hiring clinical directors in Cambridge include Amylyx Pharmaceuticals, Takeda Pharmaceuticals, and AstraZeneca, per current listings on Migrate Mate as of October 2026. Cambridge's employer mix leans heavily toward research hospitals, life sciences firms, and community health organizations, making it one of the more varied clinical director markets in New England.
Are there remote clinical director jobs in Cambridge?
Yes, though remote availability is limited by nature since most clinical director roles involve direct oversight of staff, facilities, or patient-facing programs. About 80% of clinical director openings tied to Cambridge are remote or hybrid as of October 2026, skewing toward roles in utilization management, clinical operations strategy, and health services research. Fully on-site roles remain the norm for positions at hospitals and community health centers.
How can I get a clinical director job in Cambridge with little or no experience?
The most realistic entry path in Cambridge is moving into a clinical program manager or clinical operations lead role at one of the city's community health centers or behavioral health organizations, which tend to promote from within more actively than large academic hospitals. Lateral moves from senior clinical specialist or charge clinician positions are common stepping stones. Demonstrating measurable outcomes in a team lead capacity, even informally, strengthens a Cambridge application considerably.
Which industries hire the most clinical directors in Cambridge?
Most clinical director openings in Cambridge sit in Healthcare & Medical Services and Biotechnology & Pharmaceuticals, per current listings on Migrate Mate as of October 2026. Cambridge's concentration of world-class research institutions, biotech firms, and federally funded community health programs creates unusually consistent demand for clinical leadership across all three sectors.
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