Clinical Lead Jobs in Minnesota
Clinical Lead jobs in Minnesota concentrate in health systems, behavioral health, and ambulatory care networks, with demand at both the senior clinician and program oversight levels. The Twin Cities metro anchors most hiring, followed by Rochester and Duluth, where employers like Mayo Clinic, M Health Fairview, and Allina Health sustain consistent openings. The most active specialties are behavioral health, care coordination, and primary care quality improvement. Scan the live roles below and apply to whichever ones fit.
Find Clinical Lead JobsOverview
Showing 5 of 7+ Clinical Lead jobs








- A mobile app that helps Medicare patients (65+) complete simple, guided check ins, and
- A desktop app that helps care teams know which patients need them most — and act.
The next 6 months are about proving product-market fit with real clinical evidence in a category where fewer than 4% of eligible U.S. patients are currently receiving the care they are entitled to.
This is a Full Time Remote opportunity based in Canada or the United States.
THE OPPORTUNITY
Aetonix is looking for a hands-on clinical informatics leader to shape the clinical backbone of our multi-condition, respiratory-native care management platform. In this role, you'll own the critical translation of clinical best practice into the structured, computable logic that powers everything we build — converting established clinical guidelines into versioned digital care pathways, defining our clinical data model and terminology standards, and running the governance processes that keep our clinical content safe, evidence-based, and aligned with an evolving regulatory landscape.
You'll also define the clinical ground truth that underpins and constrains our AI capabilities, ensuring that as the platform grows more intelligent, it stays grounded in sound clinical reasoning. This is a high-impact, cross-functional role: you'll report directly to the Chief Technology Officer, maintain a close working relationship with clinical leadership, and collaborate daily with product and engineering teams to bring clinical rigor directly into the heart of the platform.
If you're energized by working at the intersection of clinical practice, data structure, and emerging AI technology — and want your expertise to directly shape a platform used in real-world respiratory care — we'd love to hear from you.
WHAT YOU'LL OWN
- Care pathway engineering. Translate clinical best-practice guidelines into structured, parameterized digital care pathways — starting with respiratory conditions like COPD and asthma and extending to common comorbidities (heart failure, hypertension, diabetes) as layered protocols on a shared engine, including patient goals, symptom checks, vitals, PROs, and educational content.
- Parameter & data-capture design. Determine the optimal clinical parameters and alerting thresholds for each condition, and decide how each is best captured — self-reported, acoustic, rPPG, or via connected devices — balancing clinical value, patient burden, and data reliability, while designing how information flows to care teams so they can practice "top of license."
- Clinical content governance. Own the clinical content lifecycle end-to-end: authoring standards, versioning, change control, and the review-and-approval workflow through which clinical leadership signs off before content reaches patients — keeping everything audit-ready and traceable.
- Regulatory-aware architecture. Stay attuned to how pathway and knowledge-engineering decisions affect regulatory classification, supporting a modular architecture that isolates predictive/interpretive (SaMD) capabilities from non-diagnostic ones.
- Clinical data model & terminology. Define and maintain the platform's canonical clinical data model and govern the standardized vocabularies (ICD-10-CM, SNOMED CT, LOINC, RxNorm, CPT/HCPCS) that keep data consistent, comparable, and shareable — including how it's structured for exchange via HL7 FHIR and USCDI in preparation for EHR integration.
- AI clinical grounding. Define the clinical ground truth, acceptance criteria, and human-review checkpoints that keep AI features — care plan extraction, alerting, patient-facing content — clinically sound, safe, and appropriately gated, while serving as the clinical authority on release readiness and ongoing model monitoring.
- Quality measures & evidence. Ensure the platform captures the data needed for HRRP, HEDIS, eCQMs, and UDS reporting, and structure clinical data to support the company's evidence program — validated endpoints, outcomes analysis, and study-grade data for formal HTA frameworks.
- Embedded clinical partnership. Act as the clinical-domain partner to patient, care-team, and AI squads — translating clinical intent into engineering-ready requirements and surfacing technical constraints back to clinical stakeholders.
- A builder — most energized when you are defining something new, not optimizing something established.
- Mission-driven — you care about patients and want your work to have a real impact on how chronic disease is managed.
- Humble enough to learn from a care coordinator, confident enough to push back on an engineering constraint, and clear enough to explain both to a President.
- Genuinely curious about AI — you read about how models are trained and evaluated, experiment on your own time, and treat AI/ML as a craft to develop, not a capability to delegate.
- Graduate degree in health, clinical, or biomedical informatics — or equivalent formal certification (e.g., nursing informatics board certification, clinical informatics subspecialty certification).
- 7+ years of progressive experience in clinical informatics, digital health, or health information technology.
- Direct, hands-on experience translating clinical guidelines or protocols into structured, computable artifacts — care pathways, order sets, clinical decision support rules, or equivalent.
- Working command of core clinical terminologies and standards, including ICD-10-CM, SNOMED CT, LOINC, and RxNorm.
- Strong working knowledge of chronic disease management, particularly respiratory conditions such as COPD and asthma, along with common comorbidities (heart failure, hypertension, diabetes).
- Practical familiarity with HL7 FHIR and experience supporting or preparing for EHR interoperability/integration work.
- We recognize this field is moving fast and that deep AI/ML expertise in a clinical context is rare. If you are not quite there yet but are actively putting in the reps — reading about evals, building things outside of work, treating AI as a serious area of craft development — we want to hear from you. That orientation matters as much as the credential.
- An agile, dynamic and motivated team working together in a fast-growing company that is changing the future of virtual care
- The ability to make a real difference in people’s lives
- Health insurance including medical, dental, vision and life
As part of our recruitment process, we may use AI tools to screen applicants and assist in evaluating candidate qualifications. All final hiring decisions are made by our recruitment team.
We are an equal opportunity employer and it is important to our Company that all its employees, including those with disabilities, find our workplace to be welcoming and supportive. If you are a candidate with a disability who requires accommodations during the recruitment process, please let us know.
See All 7 Clinical Lead Jobs in Minnesota
Find roles in Minnesota that match your experience and apply in just a few clicks.
Find Clinical Lead JobsClinical Lead Jobs by City in Minnesota
Where Minnesota roles are concentrated, by current openings.
Clinical Lead Job Market in Minnesota
A snapshot from current Minnesota openings, updated as new roles post.
Who's Hiring


What Minnesota Employers Look For
The qualifications that appear most often in clinical lead jobs across Minnesota.
- Active Minnesota license in a clinical discipline such as RN, LCSW, or LP
- Bachelor's degree in nursing, social work, or a related clinical field required
- Minimum three to five years of direct clinical practice in a relevant specialty
- Demonstrated experience leading, mentoring, or supervising clinical team members
- Proficiency with electronic health record systems such as Epic or Cerner
- Strong knowledge of quality improvement processes and regulatory compliance standards
Clinical Lead Jobs in Minnesota: Frequently Asked Questions
How do you become a clinical lead in Minnesota?
The path depends on your clinical discipline, but most clinical lead roles in Minnesota require an active state license from the Minnesota Board of Nursing, the Minnesota Board of Social Work, or another relevant board, combined with a bachelor's or master's degree in your field. Employers typically expect several years of direct practice before moving into a lead role. Certification in your specialty, such as a board certification in case management or behavioral health, strengthens your candidacy considerably.
Which companies hire clinical leads in Minnesota?
Employers hiring clinical leads in Minnesota right now include Abbott, Sevita, and Aetonix, based on current listings on Migrate Mate as of August 2026. Minnesota's large integrated health systems and regional behavioral health networks generate the most consistent volume of clinical lead openings across the state.
Which Minnesota cities have the most clinical lead jobs?
Minneapolis, Minnesota, and Plymouth account for the largest share of clinical lead openings in Minnesota. The Twin Cities drive the bulk of demand through their concentration of major health systems, academic medical centers, and managed care organizations, while Rochester's market is shaped heavily by Mayo Clinic and its affiliated network, and Duluth draws openings from Essentia Health and Lake Superior-area providers.
Are there remote clinical lead jobs in Minnesota?
Yes, but they're rare. Clinical lead work is largely tied to direct oversight of patient care teams and on-site clinical operations, which limits full remote arrangements. About 100% of clinical lead openings tied to Minnesota are remote or hybrid as of August 2026, and those positions tend to concentrate in utilization management, telehealth program coordination, and quality improvement rather than hands-on clinical supervision.
How can I get hired as a clinical lead in Minnesota with little or no experience?
The most realistic entry path is building clinical hours in a direct-care role first, then moving laterally into a charge nurse, lead therapist, or senior coordinator position before stepping into a formal clinical lead title. Large Minnesota employers like Allina Health and M Health Fairview run new-graduate residency programs that accelerate clinical development. Completing a specialty certification and volunteering for quality improvement projects or preceptor duties within your current role signals leadership readiness to Minnesota hiring managers.
Where can I find and apply to clinical lead jobs in Minnesota?
You can find and apply to clinical lead jobs in Minnesota on Migrate Mate, which lists current openings from employers across the state. Search the listings, find roles that match your experience and specialty, and apply directly to the ones that fit.
See All 7 Clinical Lead Jobs in Minnesota
Find roles in Minnesota that match your experience and apply in just a few clicks.
Find Clinical Lead Jobs