Clinical Nurse Jobs in Indianapolis, IN
Clinical Nurse jobs in Indianapolis are in strong demand, concentrated in the Medical District on the near north side, Midtown, and the growing suburban corridors of Carmel and Fishers, across hospital systems, ambulatory care centers, and specialty clinics. Employers actively hiring include Ascension, Indiana University Health, and IQVIA. See the openings below and apply to the ones that match your experience.
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- You will provide advanced care, consultation, research, management and education in a specific clinical area.
- Provide advanced direct nursing care in accordance with established policies, procedures and protocols of the healthcare organization.
- Serve as an expert consultant for staff in areas of program development, clinical practice, and professional development. Contribute to defining, directing and evaluating the nursing care and functions of clinical staff.
- Manage clinical research projects in support of evidence-based practice and disseminate findings.
- Develop, implement and evaluate educational plans/programs and utilize methods, measurements and tools to evaluate achievement of learning goals.
- May assess the learning needs of patients and families and develop and/or implement teaching programs.
- BLS Provider obtained within 1 Month (30 days) of hire date or job transfer date required. American Heart Association or American Red Cross accepted.
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One or more of the following required:
- Clinical Nurse Specialist credentialed from the American Association of Critical Care Nurses (AACN) obtained within 12 Months (1 year) of hire date or job transfer date.
- Clinical Nurse Specialist credentialed from the American Nurses Credentialing Center (ANCC) obtained within 12 Months (1 year) of hire date or job transfer date.
- Registered Nurse credentialed from the American Nurses Credentialing Center (ANCC) obtained prior to hire date or job transfer date.
- Registered Nurse credentialed from the Indiana Board of Nursing obtained prior to hire date or job transfer date.
- Diploma from an accredited school/college of nursing required and Master's degree required.
- 3 - 5 years of experience as a Registered Nurse in Progressive Care
- Teaching/Education experience
- Leadership experience
- Need to be flexible on shift (support staff development – days, nights, and weekends)
Equal employment opportunity employer
Ascension provides Equal Employment Opportunities (EEO) to all associates and applicants for employment without regard to race, color, religion, sex/gender, sexual orientation, gender identity or expression, pregnancy, childbirth, and related medical conditions, lactation, breastfeeding, national origin, citizenship, age, disability, genetic information, veteran status, marital status, all as defined by applicable law, and any other legally protected status or characteristic in accordance with applicable federal, state and local laws. For further information, view the EEO Know Your Rights (English) poster or EEO Know Your Rights (Spanish) poster.
Fraud prevention notice
Prospective applicants should be vigilant against fraudulent job offers and interview requests. Scammers may use sophisticated tactics to impersonate Ascension employees. To ensure your safety, please remember: Ascension will never ask for payment or to provide banking or financial information as part of the job application or hiring process. Our legitimate email communications will always come from an @ascension.org email address; do not trust other domains, and an official offer will only be extended to candidates who have completed a job application through our authorized applicant tracking system.
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Benefits:
Various health insurance options & wellness plans
Retirement benefits including employer match plans
Long-term & short-term disability
Employee assistance programs (EAP)
Parental leave & adoption assistance
Tuition reimbursement
Ways to give back to your community
Benefit options and eligibility vary by position. Compensation varies based on factors including, but not limited to, experience, skills, education, performance, location and salary range at the time of the offer.
See All 41 Clinical Nurse Jobs in Indianapolis
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Find Clinical Nurse JobsClinical Nurse Job Market in Indianapolis
Who's Hiring
- Ascension14

- Indiana University Health9

- IQVIA5

- Eskenazi Health2

- Franciscan Health2

Top Industries Hiring
- Healthcare & Medical Services
Clinical Nurse Jobs in Indianapolis: Frequently Asked Questions
How do I get a clinical nurse job in Indianapolis?
Indianapolis hiring concentrates in its Medical District hospital systems, large ambulatory surgery networks, and the growing network of outpatient specialty clinics in Carmel and Fishers. Candidates with acute care or perioperative experience move fastest through hiring here. Tailoring your application to the specific service line, whether cardiac, oncology, or pediatrics, gives you a clear edge over generalist resumes in this market.
Which companies hire clinical nurses in Indianapolis?
Employers hiring clinical nurses in Indianapolis right now include Ascension, Indiana University Health, and IQVIA, based on current listings on Migrate Mate as of September 2026. Indianapolis's employer mix runs heavily toward large integrated health systems and regional specialty groups, with a growing presence from outpatient and urgent care operators expanding across the metro.
Are there remote clinical nurse jobs in Indianapolis?
Yes, but only for a narrow slice of the role. Clinical nursing is largely hands-on, so fully remote positions are limited to care management, utilization review, telephonic triage, and case coordination functions. About 0% of clinical nurse openings tied to Indianapolis are remote or hybrid as of September 2026, with most of those concentrated in insurance and managed care employers headquartered in the metro.
How can I get a clinical nurse job in Indianapolis with little or no experience?
The most realistic entry path in Indianapolis is through a new graduate residency program at one of the Medical District hospital systems, which accept candidates with a nursing license and no prior acute care experience. Indianapolis-area long-term care facilities and rehabilitation centers also hire new nurses for direct care roles. Volunteering or completing a clinical rotation at a local employer before applying strengthens your candidacy significantly.
Which industries hire the most clinical nurses in Indianapolis?
The sectors hiring the most clinical nurses in Indianapolis are Healthcare & Medical Services, based on current listings on Migrate Mate as of September 2026. Indianapolis functions as a regional healthcare hub for central Indiana, which keeps hospital, ambulatory, and specialty clinic demand consistently high relative to other metros of similar size.
See All 41 Clinical Nurse Jobs in Indianapolis
Find roles in Indianapolis that match your experience and apply in just a few clicks.
Find Clinical Nurse Jobs