COO Jobs in Philadelphia, PA
COO jobs in Philadelphia are concentrated in Center City, University City, and the Navy Yard, with strong demand across healthcare, financial services, and professional services. Employers hiring right now include Penn Medicine, Community Veterinary Partners, and MasTec. See the openings below and apply to the ones that match your experience.
Find COO JobsOverview
Showing 5 of 149+ COO jobs
About the Position
The Senior Director, HR Operations is a strategic and execution focused leader responsible for building and scaling a modern, data driven HR infrastructure that enables organizational growth, operational excellence, and an exceptional employee experience.
Reporting into the CHRO, this role will lead HR technology, global HR operations, compliance, and people analytics, while also serving as a trusted HR Business Partner for a few key business leaders. The role will partner closely with Finance, Legal, and Business leadership to ensure that HR processes, systems, and insights are efficient, scalable, compliant, and aligned to business priorities, particularly in a dynamic, high growth environment.
The ideal candidate brings a track record of implementing HR systems, automating operations, leveraging analytics for decision making, and partnering with executive leadership, along with experience supporting compensation and benefits programs.
Responsibilities Include
HR Operations and Technology
- Lead and optimize global HR operations across employee lifecycle processes (hire to retire), ensuring efficiency, scalability, and a strong employee experience.
- Design and implement standardized workflows, policies, and service delivery models to support growth while driving continuous improvement, reducing manual processes, and increasing operational effectiveness.
- Own the implementation and optimization of HR systems (HCM, ATS, performance management tools, etc.), including integration and migration from a legacy PEO.
- Partner with IT and business stakeholders to deliver scalable, user-centric solutions.
- Drive adoption of new systems, processes, and programs with high engagement and minimal disruption.
- Leverage AI, automation, and digital tools to enhance HR service delivery, insights, and employee engagement.
People Analytics and Insights
- Establish and track metrics such as time to fill, productivity, retention, and diversity goals, providing real-time visibility into headcount, attrition, engagement, performance, and hiring metrics.
- Translate data into actionable insights that inform workforce planning, organizational design, and business decisions.
- Support compensation planning cycles (merit, bonus, equity) and market benchmarking and job architecture.
- Contribute to the design and administration of competitive, scalable benefits programs.
HR Business Partnering
- Serve as an HR partner to designated business leaders, providing guidance on organizational design, workforce planning, and talent and performance management.
- Support leaders with data-driven insights and pragmatic solutions that balance speed, quality, and culture.
- Act as a trusted advisor during periods of growth, transformation, or change, and lead operational readiness for rapid growth and organizational changes.
- Support culture evolution through scalable HR practices that reinforce company values and performance expectations.
Required Qualifications
- Bachelor’s degree required; advanced degree (MHRM, MBA, or related) preferred.
- 15+ years of progressive HR experience, with a focus in HR Operations and people analytics.
- Demonstrated success leading HR technology implementations and transformations.
- Experience building or scaling HR infrastructure in high-growth or dynamic environments (biotech, tech, or similar industries preferred).
- Strong working knowledge of global HR compliance and employment practices.
- Experience supporting compensation processes and benefits programs.
- Track record of partnering with executive leaders and influencing decisions.
- High level of judgment, adaptability, and resilience in fast-paced environments.
- Exceptional communication and stakeholder management skills.
- Ability to operate effectively in a fast-paced, collaborative, and evolving environment.
How to Apply
Please click the link at the bottom of the posting to submit an application.
Benefits
Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.
Equal Opportunity Employer
Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.
About the Position
The Senior Director, HR Operations is a strategic and execution focused leader responsible for building and scaling a modern, data driven HR infrastructure that enables organizational growth, operational excellence, and an exceptional employee experience.
Reporting into the CHRO, this role will lead HR technology, global HR operations, compliance, and people analytics, while also serving as a trusted HR Business Partner for a few key business leaders. The role will partner closely with Finance, Legal, and Business leadership to ensure that HR processes, systems, and insights are efficient, scalable, compliant, and aligned to business priorities, particularly in a dynamic, high growth environment.
The ideal candidate brings a track record of implementing HR systems, automating operations, leveraging analytics for decision making, and partnering with executive leadership, along with experience supporting compensation and benefits programs.
Responsibilities Include
HR Operations and Technology
- Lead and optimize global HR operations across employee lifecycle processes (hire to retire), ensuring efficiency, scalability, and a strong employee experience.
- Design and implement standardized workflows, policies, and service delivery models to support growth while driving continuous improvement, reducing manual processes, and increasing operational effectiveness.
- Own the implementation and optimization of HR systems (HCM, ATS, performance management tools, etc.), including integration and migration from a legacy PEO.
- Partner with IT and business stakeholders to deliver scalable, user-centric solutions.
- Drive adoption of new systems, processes, and programs with high engagement and minimal disruption.
- Leverage AI, automation, and digital tools to enhance HR service delivery, insights, and employee engagement.
People Analytics and Insights
- Establish and track metrics such as time to fill, productivity, retention, and diversity goals, providing real-time visibility into headcount, attrition, engagement, performance, and hiring metrics.
- Translate data into actionable insights that inform workforce planning, organizational design, and business decisions.
- Support compensation planning cycles (merit, bonus, equity) and market benchmarking and job architecture.
- Contribute to the design and administration of competitive, scalable benefits programs.
HR Business Partnering
- Serve as an HR partner to designated business leaders, providing guidance on organizational design, workforce planning, and talent and performance management.
- Support leaders with data-driven insights and pragmatic solutions that balance speed, quality, and culture.
- Act as a trusted advisor during periods of growth, transformation, or change, and lead operational readiness for rapid growth and organizational changes.
- Support culture evolution through scalable HR practices that reinforce company values and performance expectations.
Required Qualifications
- Bachelor’s degree required; advanced degree (MHRM, MBA, or related) preferred.
- 15+ years of progressive HR experience, with a focus in HR Operations and people analytics.
- Demonstrated success leading HR technology implementations and transformations.
- Experience building or scaling HR infrastructure in high-growth or dynamic environments (biotech, tech, or similar industries preferred).
- Strong working knowledge of global HR compliance and employment practices.
- Experience supporting compensation processes and benefits programs.
- Track record of partnering with executive leaders and influencing decisions.
- High level of judgment, adaptability, and resilience in fast-paced environments.
- Exceptional communication and stakeholder management skills.
- Ability to operate effectively in a fast-paced, collaborative, and evolving environment.
How to Apply
Please click the link at the bottom of the posting to submit an application.
Benefits
Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.
Equal Opportunity Employer
Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.
See All 149+ COO Jobs in Philadelphia
Find roles in Philadelphia that match your experience and apply in just a few clicks.
Find COO JobsCOO Job Market in Philadelphia
Who's Hiring
- Penn Medicine18
- Community Veterinary Partners11
- MasTec7
- The Archdiocese of Philadelphia7
- Thomas Jefferson University & Jefferson Health7
Top Industries Hiring
- Healthcare & Medical Services11
- Education4
- Human Resources4
- Agriculture & Farming4
- Staffing & Recruiting4
COO Jobs in Philadelphia: Frequently Asked Questions
How do I get a coo job in Philadelphia?
The strongest path to a coo role in Philadelphia runs through its healthcare networks, regional banks, and professional services firms, which consistently hire at the executive level. Candidates who have led operations through growth or restructuring stand out in this market. Networking through local business associations and board-level connections in Center City and University City opens doors that posted listings often don't.
Which companies hire coos in Philadelphia?
Employers hiring coos in Philadelphia right now include Penn Medicine, Community Veterinary Partners, and MasTec, based on current listings on Migrate Mate as of August 2026. Philadelphia's hiring mix tends to feature large health systems, regional financial institutions, and mid-size professional services firms alongside emerging life sciences companies anchored in the University City Science Center corridor.
Are there remote coo jobs in Philadelphia?
Yes, though coo roles are rarely fully remote given the hands-on leadership and cross-functional oversight they require. About 33% of coo openings tied to Philadelphia are remote or hybrid as of August 2026, reflecting flexibility in scheduling rather than fully location-independent work. Strategy, investor relations, and board-facing responsibilities are the functions most commonly handled off-site in Philadelphia-based organizations.
How can I get a coo job in Philadelphia with little or no experience?
The most realistic entry path is moving into an operations director or VP of operations role at a mid-size Philadelphia company, then building toward the coo title. Philadelphia's dense nonprofit sector, health systems like Penn Medicine and Jefferson Health, and growing life sciences firms in University City regularly hire operations managers who advance quickly. Demonstrating P&L responsibility and cross-department leadership in those settings builds the profile Philadelphia employers look for at the coo level.
Which industries hire the most coos in Philadelphia?
The sectors hiring the most coos in Philadelphia are Healthcare & Medical Services, Education, and Human Resources, based on current listings on Migrate Mate as of August 2026. Philadelphia's role as a regional hub for healthcare delivery, financial services, and life sciences research drives consistent executive-level operations hiring that outpaces most comparable mid-Atlantic metros.
Related Jobs in Pennsylvania
See All 149+ COO Jobs in Philadelphia
Find roles in Philadelphia that match your experience and apply in just a few clicks.
Find COO Jobs