Director, Program Management Office Jobs
Director, Program Management Office jobs are open across technology, healthcare, financial services, and defense, at levels from senior manager to VP, with specializations in portfolio governance, enterprise transformation, and strategic planning. Find a role that fits below and apply directly.
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BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.
General Description:
The Associate Director, Global Medical Affairs Program Management Office (GMA PMO), will partner with the Director, GMA PMO to support the global solid tumor franchise. Serving as a Franchise Program Manager and strategic thought partner to global disease leads, this role helps shape priorities and leads the planning, coordination, and execution of key Medical Affairs initiatives.
Working closely with Global Hematology Medical Directors and Franchise Leadership, the Associate Director will drive major deliverables including advisory boards, integrated evidence plans, thought leader engagement strategies, and launch planning and budgets. This role also develops tracking tools and reporting to monitor progress and ensure alignment across cross-functional teams. This role will provide constructive challenge, surface risks and trade-offs, and develop tracking tools and reporting to monitor progress and ensure alignment across cross-functional teams.
As a core member of the PMO, the Associate Director will lead additional initiatives to enhance processes and improve operational efficiency across Global Medical Affairs.
The ideal candidate is a strategic, execution-focused leader who thrives in a complex, matrixed, and dynamic environment. They are a strong communicator and problem solver who can build trusted partnerships, manage competing priorities, synthesize complex information, and drive initiatives forward with a high level of ownership and initiative. Flexibility, adaptability, sound judgment, and comfort navigating ambiguity are essential.
This position will report to the Director, GMA PMO.
Essential Functions of the job:
- Lead cross-functional planning and execution of global solid tumor medical initiatives across disease areas and assets
- Drive development and tracking of integrated evidence plans and medical strategies
- Facilitate alignment across disease teams, franchise leadership, regions, and key cross-functional stakeholders; surface decisions, risks, dependencies, and trade-offs
- Develop and manage integrated project plans, including timelines, milestones, resources, dependencies, risks, and critical path activities
- Lead effective team meetings, including agenda development, documentation of decisions and action items, and tracking of follow-ups in accordance with project management best practices
- Synthesize complex information and develop clear, high-impact presentations that communicate medical strategy, recommendations, plans, progress, and decisions to stakeholders
- Drive continuous improvement within the PMO by identifying efficiencies, sharing best practices, and implementing fit-for-purpose processes and performance metrics across Global Medical Affairs; adapt approaches as franchise needs evolve
Required Experience
- Bachelor’s degree with 8+ years, or Master’s degree with 6+ years of relevant experience in drug development within academia, consulting, pharmaceutical or biotechnology industry.
- 5+ years of experience in project or program management
- Demonstrated understanding of the solid tumor oncology landscape and the medical affairs environment (preferred)
- Experience supporting Global Medical Affairs activities, including medical strategy and planning, advisory boards, integrated evidence planning, thought leader engagement, or launch readiness
- Strong proficiency in project and program management tools and systems (e.g., Smartsheet, MS Project, Excel, PowerPoint), including development of dashboards, trackers, and reporting
- Proven ability to lead complex, cross-functional initiatives
- Experience with integrated evidence generation planning highly desirable
Computer Skills:
Advanced proficiency in Microsoft Office (Outlook, Excel, Power Point, Word, Teams) is required. Proficiency (or familiarity with an ability to learn quickly) in Smartsheet is required.
Other Qualifications:
- PMP Certification a plus
Travel:
Work-related travel will be less than 10%. Over-time and weekend travel may be required on occasion.
Global Competencies
When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.
- Fosters Teamwork
- Provides and Solicits Honest and Actionable Feedback
- Self-Awareness
- Acts Inclusively
- Demonstrates Initiative
- Entrepreneurial Mindset
- Continuous Learning
- Embraces Change
- Results-Oriented
- Analytical Thinking/Data Analysis
- Financial Excellence
- Communicates with Clarity
BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.
We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact accommodationsus@beonemed.com.
BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.
General Description:
The Associate Director, Global Medical Affairs Program Management Office (GMA PMO), will partner with the Director, GMA PMO to support the global solid tumor franchise. Serving as a Franchise Program Manager and strategic thought partner to global disease leads, this role helps shape priorities and leads the planning, coordination, and execution of key Medical Affairs initiatives.
Working closely with Global Hematology Medical Directors and Franchise Leadership, the Associate Director will drive major deliverables including advisory boards, integrated evidence plans, thought leader engagement strategies, and launch planning and budgets. This role also develops tracking tools and reporting to monitor progress and ensure alignment across cross-functional teams. This role will provide constructive challenge, surface risks and trade-offs, and develop tracking tools and reporting to monitor progress and ensure alignment across cross-functional teams.
As a core member of the PMO, the Associate Director will lead additional initiatives to enhance processes and improve operational efficiency across Global Medical Affairs.
The ideal candidate is a strategic, execution-focused leader who thrives in a complex, matrixed, and dynamic environment. They are a strong communicator and problem solver who can build trusted partnerships, manage competing priorities, synthesize complex information, and drive initiatives forward with a high level of ownership and initiative. Flexibility, adaptability, sound judgment, and comfort navigating ambiguity are essential.
This position will report to the Director, GMA PMO.
Essential Functions of the job:
- Lead cross-functional planning and execution of global solid tumor medical initiatives across disease areas and assets
- Drive development and tracking of integrated evidence plans and medical strategies
- Facilitate alignment across disease teams, franchise leadership, regions, and key cross-functional stakeholders; surface decisions, risks, dependencies, and trade-offs
- Develop and manage integrated project plans, including timelines, milestones, resources, dependencies, risks, and critical path activities
- Lead effective team meetings, including agenda development, documentation of decisions and action items, and tracking of follow-ups in accordance with project management best practices
- Synthesize complex information and develop clear, high-impact presentations that communicate medical strategy, recommendations, plans, progress, and decisions to stakeholders
- Drive continuous improvement within the PMO by identifying efficiencies, sharing best practices, and implementing fit-for-purpose processes and performance metrics across Global Medical Affairs; adapt approaches as franchise needs evolve
Required Experience
- Bachelor’s degree with 8+ years, or Master’s degree with 6+ years of relevant experience in drug development within academia, consulting, pharmaceutical or biotechnology industry.
- 5+ years of experience in project or program management
- Demonstrated understanding of the solid tumor oncology landscape and the medical affairs environment (preferred)
- Experience supporting Global Medical Affairs activities, including medical strategy and planning, advisory boards, integrated evidence planning, thought leader engagement, or launch readiness
- Strong proficiency in project and program management tools and systems (e.g., Smartsheet, MS Project, Excel, PowerPoint), including development of dashboards, trackers, and reporting
- Proven ability to lead complex, cross-functional initiatives
- Experience with integrated evidence generation planning highly desirable
Computer Skills:
Advanced proficiency in Microsoft Office (Outlook, Excel, Power Point, Word, Teams) is required. Proficiency (or familiarity with an ability to learn quickly) in Smartsheet is required.
Other Qualifications:
- PMP Certification a plus
Travel:
Work-related travel will be less than 10%. Over-time and weekend travel may be required on occasion.
Global Competencies
When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.
- Fosters Teamwork
- Provides and Solicits Honest and Actionable Feedback
- Self-Awareness
- Acts Inclusively
- Demonstrates Initiative
- Entrepreneurial Mindset
- Continuous Learning
- Embraces Change
- Results-Oriented
- Analytical Thinking/Data Analysis
- Financial Excellence
- Communicates with Clarity
BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.
We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact accommodationsus@beonemed.com.
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Find JobsDirector, Program Management Office Job Market
Who's Hiring
What Employers Look For
The qualifications that appear most often in Director, program management office jobs.
- 10 or more years of program or project management experience, including at least 3 in a leadership role
- Proven experience establishing or maturing a PMO function within a complex organization
- PMP certification or equivalent credential required by the majority of postings
- Proficiency with enterprise project management tools such as Microsoft Project, Smartsheet, or Planview
- Strong executive stakeholder management and cross-functional communication skills
- Bachelor's degree in business, engineering, or a related field, with many roles preferring an MBA
Tips for Your Director, Program Management Office Job Search
Quantify portfolio governance achievements clearly
Your resume should show the scale of programs you've overseen: total budget managed, number of concurrent projects, and measurable outcomes like on-time delivery rate improvements or cost reductions. Hiring managers for PMO director roles scan for scope, not just titles.
Highlight your PMO maturity model experience
Many employers are building or scaling their PMOs from scratch. Calling out hands-on experience with maturity assessments, process standardization, or methodology implementation signals you can operate in ambiguous environments, not just manage an established function.
Align your certifications to the employer's methodology
A PMP signals foundational rigor, but if the job description mentions Agile at scale, SAFe, or PRINCE2, make sure any matching credentials appear prominently. Tailoring your credential emphasis to each listing increases your interview conversion rate meaningfully.
Apply early to roles that fit
Migrate Mate lists director, program management office openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare a PMO transformation case study
Interviewers for director-level PMO roles frequently ask you to walk through a PMO you built or restructured. Prepare one concise example covering the before state, your intervention, the governance model you introduced, and the measurable result. Practice delivering it in under four minutes.
Negotiate scope alongside compensation
When you receive an offer, clarify reporting lines, decision authority over project prioritization, and headcount before accepting. PMO director roles vary widely in real authority, and misaligned expectations are a leading reason directors leave within the first year.
Director, Program Management Office Jobs: Frequently Asked Questions
Which companies are hiring the most director, program management offices?
The most active employers for director, program management offices right now are Falcata, Alkermes, and BeOne Medicines, and the most openings are in Massachusetts, Utah, and Alabama, based on current listings on Migrate Mate as of November 2026. Demand tends to be strongest at large enterprises undergoing digital transformation or post-merger integration.
How many director, program management office jobs are remote?
About 100% of director, program management office openings are fully remote or hybrid as of November 2026, with remote availability concentrated in portfolio oversight, strategic planning, and reporting functions. Roles that require direct team leadership, executive presence in leadership reviews, or hands-on PMO build-outs are more likely to require on-site or hybrid arrangements.
How do you become a director, program management office?
Start by building deep delivery experience as a project or program manager across multiple business units, then move into PMO leadership roles such as PMO manager or program director. Earning a PMP credential strengthens your candidacy, and experience driving governance frameworks, portfolio reporting, or methodology standardization is what distinguishes director-level candidates from senior managers when applying.
Can you get hired as a director, program management office with little experience?
Candidates without a full PMO director background can break in by demonstrating ownership of a PMO build, a significant governance overhaul, or an enterprise-scale program with cross-functional complexity. Many hiring managers weigh demonstrated leadership of ambiguous, high-stakes programs over years in a formal PMO title, especially at organizations that are standing up their first PMO.
What does the director, program management office interview process look like?
The process typically starts with a recruiter screen focused on scope and leadership style, followed by a panel with the hiring executive and functional stakeholders. Expect a case study or presentation round where you are asked to assess a PMO's current state and recommend improvements. Final stages often include a conversation with the CHRO or CFO given the cross-functional budget authority the role carries.
Where can I find and apply to director, program management office jobs?
You can find and apply to director, program management office jobs on Migrate Mate, which lists current openings from across the United States. Search for roles that match your experience and seniority level, then apply directly to each listing that fits.
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