Green Card Business Process Optimization Jobs
Business Process Optimization roles qualify for EB-2 or EB-3 green card sponsorship when the position requires a bachelor's degree or higher in industrial engineering, operations management, or a related field. Employers file PERM labor certification with the DOL before sponsoring your I-140 petition, putting you on the path to permanent residency.
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Get Access To All JobsINTRODUCTION
Work Your Magic with us! Start your next chapter and join EMD Serono.
Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.
United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.
Your role:
This Principal Scientist role will join the Oligonucleotide Therapeutics team to lead the design, engineering and optimization of therapeutic mRNAs for protein replacement, immunomodulation, vaccines and gene editing applications.
-
Design and optimize mRNA constructs end-to-end: 5’ UTR, coding sequence, 3’ UTR, poly(A) tail and cap structure – including UTR library generation and high-throughput screening, codon optimization, miRNA and RNA-binding-protein site engineering, GC content and motif design, secondary structure/folding optimization and control of innate immune activation – to maximize protein expression, stability and translational efficiency.
-
Engineer tissue- and cell-type-specific expression through regulatory element design, base and nucleoside modification strategies (e.g. N1-methylpseudouridine), and cap/poly(A) optimization.
-
Establish and run in vitro transcription (IVT) for mRNA synthesis, purification and characterization workflows, and design experiments assessing integrity, purity, stability, translation, biological activity and critical quality attributes (capping efficiency, dsRNA, residual impurities).
-
Lead internal projects advancing mRNA cargo for our LNP platform, evaluating how sequence, length, charge, structure and chemical modifications influence encapsulation, biodistribution and translation, with a focus on immuno-oncology and immunology disease applications, including CAR and other engineered protein payloads.
-
Present data and study updates in cross-functional project meetings.
-
Collaborate internally with colleagues within the extended organization to build on strengths and generate effective partnerships.
Strategic Impact
-
Shape the next generation of Immunology and Oncology therapeutics by advancing mRNA design, and deliver internal pipeline projects on time and at high quality.
-
Build and own the mRNA design and optimization capability (design rules, screening platforms, data-driven sequence optimization) feeding LNP discovery and maturation workflows.
-
Act as Subject Matter Expert for mRNA design, optimization and manufacture of research-grade material, independently defining scientific strategy for the area.
Cooperation Internally Externally
-
Work closely with the LNP and RNA delivery team to optimize mRNA–delivery system interactions, and with biology, formulation and analytical teams supporting US and EU innovation projects.
-
Work closely with broader DDTech organization, including NBE, ADC Tech and Discovery Pharmacology teams.
-
Collaborate with Healthcare Research Units for advancing internal pipeline, including CAR and protein engineering programs.
-
Manage CRO/CDMO partnerships for mRNA cargo sourcing and IVT scale-up.
Qualifications
Minimum Qualifications
-
PhD in RNA Biology, Molecular Biology, Biochemistry, Bioengineering, Chemical Biology, Genetics, Biotechnology or a related discipline.
-
Typically 5+ years of relevant industry or academic experience in RNA/mRNA therapeutics, RNA engineering or a closely related field.
-
In-depth, hands-on expertise in mRNA design and sequence optimization (UTR libraries and screening, codon optimization, miRNA/RNA-binding protein site engineering, folding, enhancement of translation) with a strong understanding of mRNA architecture and the determinants of RNA stability and translation.
-
Demonstrated ability to lead multidisciplinary projects independently, define scientific strategy and solve complex technical problems, with strong scientific communication, technical writing and presentation skills.
Preferred Qualifications
-
Experience with tissue- and cell-specific expression optimization and modified nucleosides/base modification strategies.
-
Hands-on experience with in vitro transcription, mRNA synthesis, purification (e.g. chromatography, dsRNA removal), RNA characterization (CE, HPLC, LC-MS, capping and poly(A) analysis) and cellular protein-expression assays.
-
CAR design expertise and protein engineering knowledge (construct design, expression, functional characterization).
-
Experience working with LNP or other nucleic acid delivery systems and with therapeutic areas (immuno-oncology, immunology, neuroscience).
-
Highly organized, detail-oriented, creative, results-driven problem solver with demonstrated flexibility and collaborative working style.
Work Experience
- 5+ years of pharmaceutical or biotech industry experience strongly preferred.
Job specific Competencies & Skills
-
Awareness of nucleic acid drug development, mRNA design and delivery trends in the industry.
-
Familiarity with computational/in silico sequence design, folding prediction and sequence-activity data analysis.
-
Ability to translate therapeutic area needs into mRNA design strategies and advance internal innovation projects.
-
Ability to prioritize across parallel platform and pipeline projects.
LOCATION
Location: On-site Billerica MA
COMPENSATION
Pay Range for this position: $131,300 - $216,600
The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.
What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!
Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!
INTRODUCTION
Work Your Magic with us! Start your next chapter and join EMD Serono.
Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.
United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.
Your role:
This Principal Scientist role will join the Oligonucleotide Therapeutics team to lead the design, engineering and optimization of therapeutic mRNAs for protein replacement, immunomodulation, vaccines and gene editing applications.
-
Design and optimize mRNA constructs end-to-end: 5’ UTR, coding sequence, 3’ UTR, poly(A) tail and cap structure – including UTR library generation and high-throughput screening, codon optimization, miRNA and RNA-binding-protein site engineering, GC content and motif design, secondary structure/folding optimization and control of innate immune activation – to maximize protein expression, stability and translational efficiency.
-
Engineer tissue- and cell-type-specific expression through regulatory element design, base and nucleoside modification strategies (e.g. N1-methylpseudouridine), and cap/poly(A) optimization.
-
Establish and run in vitro transcription (IVT) for mRNA synthesis, purification and characterization workflows, and design experiments assessing integrity, purity, stability, translation, biological activity and critical quality attributes (capping efficiency, dsRNA, residual impurities).
-
Lead internal projects advancing mRNA cargo for our LNP platform, evaluating how sequence, length, charge, structure and chemical modifications influence encapsulation, biodistribution and translation, with a focus on immuno-oncology and immunology disease applications, including CAR and other engineered protein payloads.
-
Present data and study updates in cross-functional project meetings.
-
Collaborate internally with colleagues within the extended organization to build on strengths and generate effective partnerships.
Strategic Impact
-
Shape the next generation of Immunology and Oncology therapeutics by advancing mRNA design, and deliver internal pipeline projects on time and at high quality.
-
Build and own the mRNA design and optimization capability (design rules, screening platforms, data-driven sequence optimization) feeding LNP discovery and maturation workflows.
-
Act as Subject Matter Expert for mRNA design, optimization and manufacture of research-grade material, independently defining scientific strategy for the area.
Cooperation Internally Externally
-
Work closely with the LNP and RNA delivery team to optimize mRNA–delivery system interactions, and with biology, formulation and analytical teams supporting US and EU innovation projects.
-
Work closely with broader DDTech organization, including NBE, ADC Tech and Discovery Pharmacology teams.
-
Collaborate with Healthcare Research Units for advancing internal pipeline, including CAR and protein engineering programs.
-
Manage CRO/CDMO partnerships for mRNA cargo sourcing and IVT scale-up.
Qualifications
Minimum Qualifications
-
PhD in RNA Biology, Molecular Biology, Biochemistry, Bioengineering, Chemical Biology, Genetics, Biotechnology or a related discipline.
-
Typically 5+ years of relevant industry or academic experience in RNA/mRNA therapeutics, RNA engineering or a closely related field.
-
In-depth, hands-on expertise in mRNA design and sequence optimization (UTR libraries and screening, codon optimization, miRNA/RNA-binding protein site engineering, folding, enhancement of translation) with a strong understanding of mRNA architecture and the determinants of RNA stability and translation.
-
Demonstrated ability to lead multidisciplinary projects independently, define scientific strategy and solve complex technical problems, with strong scientific communication, technical writing and presentation skills.
Preferred Qualifications
-
Experience with tissue- and cell-specific expression optimization and modified nucleosides/base modification strategies.
-
Hands-on experience with in vitro transcription, mRNA synthesis, purification (e.g. chromatography, dsRNA removal), RNA characterization (CE, HPLC, LC-MS, capping and poly(A) analysis) and cellular protein-expression assays.
-
CAR design expertise and protein engineering knowledge (construct design, expression, functional characterization).
-
Experience working with LNP or other nucleic acid delivery systems and with therapeutic areas (immuno-oncology, immunology, neuroscience).
-
Highly organized, detail-oriented, creative, results-driven problem solver with demonstrated flexibility and collaborative working style.
Work Experience
- 5+ years of pharmaceutical or biotech industry experience strongly preferred.
Job specific Competencies & Skills
-
Awareness of nucleic acid drug development, mRNA design and delivery trends in the industry.
-
Familiarity with computational/in silico sequence design, folding prediction and sequence-activity data analysis.
-
Ability to translate therapeutic area needs into mRNA design strategies and advance internal innovation projects.
-
Ability to prioritize across parallel platform and pipeline projects.
LOCATION
Location: On-site Billerica MA
COMPENSATION
Pay Range for this position: $131,300 - $216,600
The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.
What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!
Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!
See all 187+ Green Card Business Process Optimization Jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Green Card Business Process Optimization Jobs.
Get Access To All JobsTips for Finding Green Card Sponsorship in Business Process Optimization
Align your credentials to PERM requirements
PERM requires your degree to match the specific role being sponsored. A business administration or industrial engineering degree maps cleanly to most BPO titles, but a general management degree may trigger an audit if the job description demands a specialized field.
Target employers with active PERM filing history
Large manufacturers, logistics firms, and consulting companies regularly file PERM for process roles. Use the OFLC Wage Search to verify an employer has submitted labor certifications in your target occupation before investing time in their application process.
Search green card roles using Migrate Mate
Migrate Mate filters job listings specifically by employment-based green card sponsorship, so you see Business Process Optimization openings where employers are already committed to PERM filing rather than companies still deciding whether to sponsor.
Document quantifiable process improvements for your I-140
EB-2 candidates with advanced degrees benefit from evidence of concrete outcomes: percentage reductions in cycle time, cost savings from Lean or Six Sigma projects, or headcount efficiencies. USCIS adjudicators respond to measurable proof of specialized expertise, not job titles alone.
Clarify the employer's PERM timeline before accepting an offer
PERM labor certification averages over a year from filing to certification, and that clock starts only after your employer submits. Confirm whether the company has begun the prevailing wage determination with DOL before you give notice at a current role.
Use O*NET to confirm specialty occupation standing
The O*NET occupation profile for industrial engineers and management analysts shows that a bachelor's degree is the standard entry requirement, which supports PERM's specialty occupation threshold. Reference this when discussing your role definition with your employer's immigration counsel.
Green Card Business Process Optimization: Frequently Asked Questions
Does a Business Process Optimization role qualify for EB-2 or EB-3 sponsorship?
Most Business Process Optimization positions qualify for EB-3 when the employer requires a bachelor's degree in industrial engineering, operations management, or a related field. EB-2 applies when the role requires an advanced degree or when you have a combination of a bachelor's degree and at least five years of progressive specialized experience. Your employer defines the minimum requirements in the PERM application, so the job description language directly determines which category fits.
How does green card sponsorship differ from H-1B for this type of role?
H-1B visa is a temporary nonimmigrant status capped at 85,000 slots annually with a lottery, while EB-3 green card sponsorship has no annual lottery and leads to permanent residency. The tradeoff is time: PERM labor certification, I-140 petition, and adjustment of status together take two to four years for most countries, compared to H-1B processing that can run three to eight months. For nationals of India or China, EB-3 priority date backlogs can extend that timeline significantly.
What does the PERM labor certification process require from my employer?
Your employer must conduct a DOL-mandated recruitment process showing no qualified U.S. workers were available for the position, then file the ETA Form 9089 with DOL. The job description in that filing must accurately reflect the role you'll perform and the minimum qualifications required. Any mismatch between the PERM job description and your actual duties can create problems at the I-485 adjustment of status stage, so clarity at this step matters.
How do I find employers who are already open to PERM sponsorship for process roles?
Migrate Mate lets you search Business Process Optimization jobs filtered by employers with employment-based green card sponsorship history, so you're not cold-applying to companies that have never navigated PERM. Consulting firms with dedicated process improvement practices, large manufacturers, and supply chain companies are among the most consistent filers in this occupation category.
Can I change jobs after my employer files my PERM but before I get my green card?
Changing employers resets the PERM process because the labor certification is tied to a specific employer and role. Once your I-140 is approved and your priority date is current, portability rules under AC21 allow you to move to a similar job in the same occupational classification without losing your place in line, but only after 180 days of pending adjustment of status. Discuss timing with your employer's immigration counsel before making any move.