Green Card Executive Management Jobs
Executive Management roles at the director, VP, and C-suite level regularly qualify for EB-2 and EB-3 green card sponsorship through the PERM labor certification process. Employers document recruitment efforts, file an I-140 petition, and sponsor you for permanent residency, not just a temporary work authorization.
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The Executive Director, Portfolio & Program Management is a global leadership role within the Program and Portfolio Management (PPM) organization. The role is accountable for all program management efforts across the drug development lifecycle and commercialization, including Disease Area Strategy Teams (DST), Program Teams (PT), and research PTs, ensuring end-to-end integration with DST strategy for a subset of Vertex’s portfolio diseases. This role drives organizational design, strategic growth, and operational excellence, with expanded scope to lead multiple disease areas and mentor senior program managers.
This position is based in our Boston, MA location (Seaport area) and requires a hybrid work schedule with 3 days in office / 2 days remote on a weekly basis.
Key Duties & Responsibilities:
- Provide strategic and operational leadership to multiple cross-functional teams, spanning research, clinical, and marketed products.
- Lead and mentor Senior Directors and PPM staff across at least one additional disease area (“player/coach” model).
- Drive synergies and scalability across disease areas, optimizing resource allocation to deliver on Vertex portfolio priorities.
- Set strategy and oversee decision-making for high-priority and complex programs, ensuring alignment with corporate objectives.
- Champion organizational design principles to enable agile, scalable teams and career development opportunities.
- Represent PPM on governance forums and with senior leaders, influencing strategic direction and portfolio growth.
- Propose and implement innovative approaches and process improvements to maximize operational excellence.
- Oversee financial and human resource accountability for expanded teams (direct and indirect reports).
- Ensure integration of research, development and commercialization of program management efforts with DST strategy.
Basic Requirements
- Bachelor’s degree in Life Sciences or a relevant field.
- Typically requires 15+ years of experience, including 7+ years of management experience, or the equivalent combination of education and experience.
- Demonstrated experience leading large, complex teams and programs at a global level.
Knowledge and Skills:
- Deep expertise in portfolio and program management, strategic planning, risk management and resource management across multiple disease areas.
- Proven ability to lead and mentor senior program managers and high-level professionals.
- Advanced business management and financial acumen to drive value creation.
- Exceptional communication and collaboration skills with internal and external stakeholders.
- Strong organizational skills and ability to manage multiple priorities in a dynamic environment.
- Pharmaceutical drug discovery and development expertise across disciplines.
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$260,800 - $391,200
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
LI-Hybrid
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
Job Description
The Executive Director, Portfolio & Program Management is a global leadership role within the Program and Portfolio Management (PPM) organization. The role is accountable for all program management efforts across the drug development lifecycle and commercialization, including Disease Area Strategy Teams (DST), Program Teams (PT), and research PTs, ensuring end-to-end integration with DST strategy for a subset of Vertex’s portfolio diseases. This role drives organizational design, strategic growth, and operational excellence, with expanded scope to lead multiple disease areas and mentor senior program managers.
This position is based in our Boston, MA location (Seaport area) and requires a hybrid work schedule with 3 days in office / 2 days remote on a weekly basis.
Key Duties & Responsibilities:
- Provide strategic and operational leadership to multiple cross-functional teams, spanning research, clinical, and marketed products.
- Lead and mentor Senior Directors and PPM staff across at least one additional disease area (“player/coach” model).
- Drive synergies and scalability across disease areas, optimizing resource allocation to deliver on Vertex portfolio priorities.
- Set strategy and oversee decision-making for high-priority and complex programs, ensuring alignment with corporate objectives.
- Champion organizational design principles to enable agile, scalable teams and career development opportunities.
- Represent PPM on governance forums and with senior leaders, influencing strategic direction and portfolio growth.
- Propose and implement innovative approaches and process improvements to maximize operational excellence.
- Oversee financial and human resource accountability for expanded teams (direct and indirect reports).
- Ensure integration of research, development and commercialization of program management efforts with DST strategy.
Basic Requirements
- Bachelor’s degree in Life Sciences or a relevant field.
- Typically requires 15+ years of experience, including 7+ years of management experience, or the equivalent combination of education and experience.
- Demonstrated experience leading large, complex teams and programs at a global level.
Knowledge and Skills:
- Deep expertise in portfolio and program management, strategic planning, risk management and resource management across multiple disease areas.
- Proven ability to lead and mentor senior program managers and high-level professionals.
- Advanced business management and financial acumen to drive value creation.
- Exceptional communication and collaboration skills with internal and external stakeholders.
- Strong organizational skills and ability to manage multiple priorities in a dynamic environment.
- Pharmaceutical drug discovery and development expertise across disciplines.
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$260,800 - $391,200
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
LI-Hybrid
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
See all 44+ Green Card Executive Management Jobs
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Get Access To All JobsTips for Finding Green Card Sponsorship in Executive Management
Document your leadership scope before applying
PERM requires your employer to define the role's minimum requirements precisely. Gather evidence of your P&L responsibility, team size, and strategic decision-making authority now, so your credentials align cleanly with the job description USCIS will scrutinize.
Target companies with active PERM filing history
Not every corporation sponsors green cards for executive roles. Use Migrate Mate to filter employers by EB-2 and EB-3 filing activity, so you're applying to organizations that have already navigated PERM for management-level positions, not starting that conversation from scratch.
Verify your role meets specialty occupation standards
Senior management positions sometimes face USCIS scrutiny over whether they genuinely require an advanced degree versus broad business experience. Review the O*NET profile for your specific executive title to confirm the education and specialization requirements that support an EB-2 classification.
Ask employers about their PERM recruitment timeline early
PERM requires the employer to complete a mandatory recruitment period before DOL will certify the labor condition. For executive roles, this process often runs six to twelve months before the I-140 can even be filed, so clarify the employer's readiness before accepting an offer.
Check prevailing wage for your management tier
DOL sets prevailing wages by occupation and geography. Use the OFLC Wage Search to confirm your offered salary meets the Level III or Level IV threshold for executive roles in your metro area before your employer files, since a wage shortfall can delay or derail PERM certification.
Understand how your country affects green card timing
EB-2 and EB-3 priority dates vary significantly by country of birth. Nationals of India and China face multi-year backlogs even after I-140 approval, while applicants from most other countries see much shorter waits. Factor this into your negotiations around starting date and employment agreement terms.
Green Card Executive Management: Frequently Asked Questions
Do Executive Management roles qualify for EB-2 or EB-3 green card sponsorship?
Most executive and senior management positions qualify under EB-2 when the role requires an advanced degree or equivalent specialized experience. Roles with a standard bachelor's degree requirement can qualify under EB-3. The key factor is how the employer defines the minimum education and experience requirements in the PERM job description, which USCIS and DOL both review.
How does green card sponsorship differ from H-1B for Executive Management roles?
Green card sponsorship through PERM leads to permanent residency, not a temporary work authorization with a fixed expiration. There's no annual cap lottery for EB-2 or EB-3 petitions the way there is for H-1B visa. The process takes longer upfront because PERM requires a documented recruitment period, but the outcome is lawful permanent residence rather than status you must renew or extend every few years.
What makes an employer willing to sponsor a green card for an executive hire?
Employers who sponsor executive roles through PERM have typically concluded the role requires specialized qualifications they can't readily fill domestically. Large corporations with HR infrastructure and experienced immigration counsel are more likely to have an established PERM process. Asking about a company's prior green card filing history during late-stage interviews is a practical way to gauge their readiness before you commit.
How can I find Executive Management jobs where the employer actively sponsors green cards?
Migrate Mate lets you search for Executive Management roles filtered by employers with active EB-2 and EB-3 filing history, so you're not spending time on companies that have never sponsored a PERM-based green card. Filtering by role level and sponsorship track record significantly narrows your search to realistic opportunities from the start.
Can I negotiate my employment offer while a PERM application is pending?
You can negotiate salary above the prevailing wage DOL certifies, since PERM sets a floor, not a ceiling. What you can't do is change the job duties or title materially after PERM certification without restarting the process. Get offer terms in writing before PERM is filed and confirm that any future promotion or title change won't invalidate the underlying labor certification.