Green Card Infrastructure And Operations Jobs
Infrastructure and operations roles in cloud infrastructure, network engineering, and systems administration qualify for EB-2 and EB-3 green card sponsorship through PERM labor certification. Employers file on your behalf, permanently sponsoring your U.S. residency rather than cycling you through temporary visa renewals. Priority dates and country of birth determine your actual wait.
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Get Access To All JobsINTRODUCTION
Karyopharm is seeking a Manager/Senior Manager, IT Infrastructure & Operations to serve as a senior individual contributor owning the architecture, reliability, and evolution of the company’s infrastructure environment, reporting to the VP, Information Technology. This is a hands-on role operating with a high degree of autonomy, partnering across IT, Security, and the business to design and run scalable, secure infrastructure across a mix of cloud and legacy systems in a regulated environment. This individual will lead complex initiatives end-to-end, drive modernization, and improve operational maturity across cloud and on-prem environments. Operating within a lean IT team, the role requires strong ownership, hands-on execution, and the ability to mentor others and influence infrastructure strategy without direct people management.
KEY RESPONSIBILITIES
Technical Leadership & Execution
- Serve as the senior technical lead for infrastructure design, architecture, and operations.
- Own and execute complex infrastructure initiatives end-to-end (design → build → optimize).
- Act as an escalation point for critical incidents and complex system issues.
- Lead by example through hands-on engineering, troubleshooting, and implementation work.
- Mentor and guide engineers through technical challenges, design reviews, and best practices (without direct management responsibility).
- Collaborate with IT Business Partners to identify and align solutions that balance meeting business needs and technical complexity.
Infrastructure Strategy & Modernization
- Drive cloud-first and hybrid infrastructure strategy, including migration from legacy systems.
- Design and implement scalable solutions across AWS/Azure, on-prem systems, and networking layers.
- Partner with IT leadership to shape long-term infrastructure roadmaps and technical standards.
- Evaluate emerging technologies and recommend adoption aligned with business needs.
Operational Excellence & Reliability
- Design and enhance monitoring, alerting, and observability frameworks.
- Improve system reliability through proactive engineering (capacity planning, performance tuning, resilience design).
- Lead root cause analysis (RCA) and implement long-term fixes to reduce incident recurrence.
- Optimize operational workflows, including ticket triage, escalation paths, and service ownership.
- Define and monitor KPIs, SLAs, and SLOs to ensure service health and performance.
Security, Compliance & Risk Management
- Partner closely with Cybersecurity to ensure infrastructure aligns with SOX, GxP, and enterprise security standards.
- Implement secure architecture patterns (identity, access, network segmentation, encryption).
- Support audit readiness through strong documentation, system configuration visibility, and asset management.
- Lead infrastructure contributions to disaster recovery (DR) and business continuity planning (BCP).
Cross-Functional Collaboration & Influence
- Work across teams (Applications, Data, Security, PMO) to deliver infrastructure solutions that support business initiatives.
- Act as a trusted advisor to leadership on infrastructure capabilities, risks, and trade-offs.
- Collaborate with vendors and partners to evaluate and implement solutions.
- Drive alignment and adoption of infrastructure standards without formal authority.
BASIC QUALIFICATIONS
Candidate Profile & Requirements:
- Bachelor’s degree in Computer Science, Information Technology, or equivalent experience.
- 8–10+ years of deep, hands-on IT infrastructure experience.
- Proven ability to operate independently and lead large technical initiatives without direct reports.
- Strong expertise in:
- Microsoft ecosystem (Windows Server, Active Directory, Azure AD, O365)
- Cloud platforms (AWS and/or Azure)
- Networking (firewalls, routing, VPNs, VLANs, subnets), specifically Fortinet
- Virtualization (VMware, Hyper-V)
- Experience with automation (scripting, Terraform/CloudFormation, etc.)
- Strong troubleshooting and systems thinking skills across complex environments.
- Experience working in regulated environments (SOX, GxP) preferred.
- Excellent communication skills with ability to translate technical concepts to non-technical stakeholders.
PREFERRED QUALIFICATIONS
- AWS Certified Solutions Architect or SysOps Administrator
- Microsoft Azure Administrator/Architect
- ITIL Foundation (or strong operational process experience)
COMPENSATION
- The anticipated base salary range for this position is $130 K - $175 K USD.
At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work.
OUR VALUE PROPOSITION
This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs. Our lead therapy, XPOVIO ® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor. As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.
INTRODUCTION
Karyopharm is seeking a Manager/Senior Manager, IT Infrastructure & Operations to serve as a senior individual contributor owning the architecture, reliability, and evolution of the company’s infrastructure environment, reporting to the VP, Information Technology. This is a hands-on role operating with a high degree of autonomy, partnering across IT, Security, and the business to design and run scalable, secure infrastructure across a mix of cloud and legacy systems in a regulated environment. This individual will lead complex initiatives end-to-end, drive modernization, and improve operational maturity across cloud and on-prem environments. Operating within a lean IT team, the role requires strong ownership, hands-on execution, and the ability to mentor others and influence infrastructure strategy without direct people management.
KEY RESPONSIBILITIES
Technical Leadership & Execution
- Serve as the senior technical lead for infrastructure design, architecture, and operations.
- Own and execute complex infrastructure initiatives end-to-end (design → build → optimize).
- Act as an escalation point for critical incidents and complex system issues.
- Lead by example through hands-on engineering, troubleshooting, and implementation work.
- Mentor and guide engineers through technical challenges, design reviews, and best practices (without direct management responsibility).
- Collaborate with IT Business Partners to identify and align solutions that balance meeting business needs and technical complexity.
Infrastructure Strategy & Modernization
- Drive cloud-first and hybrid infrastructure strategy, including migration from legacy systems.
- Design and implement scalable solutions across AWS/Azure, on-prem systems, and networking layers.
- Partner with IT leadership to shape long-term infrastructure roadmaps and technical standards.
- Evaluate emerging technologies and recommend adoption aligned with business needs.
Operational Excellence & Reliability
- Design and enhance monitoring, alerting, and observability frameworks.
- Improve system reliability through proactive engineering (capacity planning, performance tuning, resilience design).
- Lead root cause analysis (RCA) and implement long-term fixes to reduce incident recurrence.
- Optimize operational workflows, including ticket triage, escalation paths, and service ownership.
- Define and monitor KPIs, SLAs, and SLOs to ensure service health and performance.
Security, Compliance & Risk Management
- Partner closely with Cybersecurity to ensure infrastructure aligns with SOX, GxP, and enterprise security standards.
- Implement secure architecture patterns (identity, access, network segmentation, encryption).
- Support audit readiness through strong documentation, system configuration visibility, and asset management.
- Lead infrastructure contributions to disaster recovery (DR) and business continuity planning (BCP).
Cross-Functional Collaboration & Influence
- Work across teams (Applications, Data, Security, PMO) to deliver infrastructure solutions that support business initiatives.
- Act as a trusted advisor to leadership on infrastructure capabilities, risks, and trade-offs.
- Collaborate with vendors and partners to evaluate and implement solutions.
- Drive alignment and adoption of infrastructure standards without formal authority.
BASIC QUALIFICATIONS
Candidate Profile & Requirements:
- Bachelor’s degree in Computer Science, Information Technology, or equivalent experience.
- 8–10+ years of deep, hands-on IT infrastructure experience.
- Proven ability to operate independently and lead large technical initiatives without direct reports.
- Strong expertise in:
- Microsoft ecosystem (Windows Server, Active Directory, Azure AD, O365)
- Cloud platforms (AWS and/or Azure)
- Networking (firewalls, routing, VPNs, VLANs, subnets), specifically Fortinet
- Virtualization (VMware, Hyper-V)
- Experience with automation (scripting, Terraform/CloudFormation, etc.)
- Strong troubleshooting and systems thinking skills across complex environments.
- Experience working in regulated environments (SOX, GxP) preferred.
- Excellent communication skills with ability to translate technical concepts to non-technical stakeholders.
PREFERRED QUALIFICATIONS
- AWS Certified Solutions Architect or SysOps Administrator
- Microsoft Azure Administrator/Architect
- ITIL Foundation (or strong operational process experience)
COMPENSATION
- The anticipated base salary range for this position is $130 K - $175 K USD.
At Karyopharm, base pay is one part of a competitive total rewards package that includes comprehensive benefits (medical, dental, vision, 401(k), and more), equity and the potential to receive annual target bonuses. Actual pay is based on factors such as location, experience, skills, education, and internal equity. We maintain broad salary ranges to reflect market conditions and the specialized nature of our work.
OUR VALUE PROPOSITION
This is a uniquely exciting time to join Karyopharm Therapeutics where we are pioneering the science of nuclear export inhibition to develop differentiated therapies for patients with cancer. We are building upon an established commercial foundation in multiple myeloma while advancing the potential of selinexor across additional hematologic and solid tumor cancers including myelofibrosis and TP53 wild-type endometrial cancer, areas where patients continue to face significant unmet needs. Our lead therapy, XPOVIO ® (selinexor), is a first-in-class inhibitor of exportin 1 (XPO1) and is approved in the U.S. for adults with relapsed or refractory multiple myeloma, with approvals in more than 50 countries and territories outside the U.S. We are also exploring opportunities to evaluate XPO1 inhibition across myeloproliferative neoplasms and TP53 wild-type driven solid tumors using next-generation compounds, including eltanexor. As we prepare for our next phase of growth, we are continuing to invest in critical capabilities across the organization to support future opportunities and deepen our impact in oncology. We are looking for talented people who are motivated by meaningful work, energized by growth and momentum, and excited by the opportunity to help shape what comes next in a collaborative, fast-moving environment where individual contributions are visible and valued.
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Get Access To All JobsTips for Finding Green Card Sponsorship in Infrastructure And Operations
Document your technical stack for PERM
PERM job requirements must match your actual background. List every technology, platform, and certification you use daily so your employer can write requirements you satisfy without appearing tailored to you, which triggers DOL audits.
Distinguish EB-2 from EB-3 eligibility early
Infrastructure roles with a strict advanced-degree requirement qualify for EB-2. Roles requiring a bachelor's degree plus two years of experience typically land in EB-3. Your job description wording, not your credentials alone, determines the category.
Search employers with active PERM filing history
Use Migrate Mate to filter infrastructure and operations roles by employers who have completed PERM filings for similar positions. Past sponsorship activity is the most reliable signal that a hiring team will sponsor again.
Target employers already enrolled in E-Verify
PERM-sponsoring employers must be able to verify your work authorization after green card approval. Companies already using E-Verify have cleared the infrastructure for this step, which reduces delays when your I-485 or immigrant visa is approved.
Time your job offer around prevailing wage levels
PERM requires your offered salary to meet the DOL prevailing wage for your specific job zone and location. Look up your role's wage level using the OFLC Wage Search before negotiating an offer so you can confirm the employer's range qualifies.
Understand the I-140 to I-485 filing gap
After your employer's I-140 is approved by USCIS, you can only file the I-485 adjustment of status when your priority date is current. For infrastructure roles filed under EB-3, applicants born in India or China face multi-year waits at this stage.
Green Card Infrastructure And Operations: Frequently Asked Questions
Do infrastructure and operations roles qualify for EB-2 or EB-3 green card sponsorship?
Both categories apply depending on how the role is defined. Network engineers, cloud architects, and systems engineers whose positions require a master's degree or an advanced specialty can qualify under EB-2. Roles requiring a bachelor's degree and at least two years of experience typically qualify under EB-3. The PERM job description, not just your credentials, determines which category your employer files under.
How does the PERM green card process differ from H-1B sponsorship for infrastructure roles?
H-1B visa is a temporary nonimmigrant status with a three-year initial period and subject to annual lottery selection for most applicants. PERM-based green card sponsorship is permanent residency with no annual lottery at the EB-3 level, though priority date backlogs affect applicants born in India and China. PERM also requires the employer to conduct a formal domestic recruitment test and file a prevailing wage determination with DOL before petitioning USCIS.
How do I find employers who will sponsor a green card for infrastructure and operations positions?
Migrate Mate lets you search infrastructure and operations job listings filtered by employers with verified PERM and I-140 filing history, so you can prioritize roles where sponsorship is already established practice rather than something you'd need to negotiate from scratch.
Can my employer start PERM sponsorship while I'm on H-1B status?
Yes. Employers commonly begin PERM labor certification while you're working in H-1B status. Filing before your sixth H-1B year is particularly strategic because an approved I-140 petition allows H-1B extensions beyond the standard six-year cap under AC21 portability rules. Infrastructure roles with ongoing project continuity make this concurrent filing approach common at larger technology and enterprise employers.
What documentation should I prepare before an employer files PERM for an infrastructure role?
You'll need educational credentials evaluated by a NACES-member agency if your degree is from outside the U.S., employment verification letters covering any experience the PERM job description relies on, and copies of certifications relevant to the role such as AWS, Azure, or CISSP. USCIS and DOL both review whether your background genuinely meets the minimum requirements stated in the PERM application, and gaps or mismatches are a leading cause of RFEs and audits.