H-1B Visa Executive Director of Operations Jobs
H-1B visa jobs for Executive Directors of Operations sit at the intersection of strategic leadership and operational oversight, roles that typically qualify as specialty occupations when grounded in business administration, industrial engineering, or a related degree field. Sponsoring employers file a certified LCA and I-129 petition with USCIS, covering an initial three-year status period.
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Get Access To All JobsINTRODUCTION
Fate Therapeutics is seeking an Executive Director, Clinical Operations to contribute to the strategy and lead execution of our global clinical operations across multiple cell therapy franchises. In this senior leadership role, you will drive the planning and delivery of studies built on a differentiated, off-the-shelf platform designed for broad patient access. Partnering closely with the executive team, clinical leadership, and cross-functional colleagues, you will shape portfolio priorities, ensure operational excellence in site start-up, enrollment, and data quality, and own the timelines and budgets that bring our pipeline to patients. If you are a strategic, hands-on leader who thrives on building high-performing teams and scalable processes, this is an opportunity to make a meaningful impact on the future of cell therapy in autoimmune disease.
Responsibilities
- Lead and drive successful execution of the company’s clinical operation strategies through establishing consistent and deliverable operational plans across multiple cell therapy franchises.
- Establish study planning models, oversee efficient site start-up across multiple countries and drive patient recruitment as part of a unique outpatient administration and on-demand available cell therapy platform for broad patient access.
- Partner with executive team to plan and drive corporate clinical initiatives, and to establish delivery strategies, portfolio priorities, and progress metrics.
- Partner with larger clinical organization to provide operational input into clinical protocol design, study endpoints, enrollment strategy, and trial timelines.
- Provide strategic oversight of global cell therapy studies to deliver on timelines and cost allocations; own variable and headcount costs for the assigned portfolio, including forecasting, resource allocation assumptions, change order review, and cost containment, in partnership with Finance.
- Develop and oversee patient enrollment, data and timeline completion risk mitigation plans, patient data quality, and completion timelines.
- Maintain integration and alignment of Clinical Operations with key cross-functional departments including Clinical Outsourcing, Program Management, R&D, Manufacturing, Biometrics, Regulatory, QA, Safety/Pharmacovigilance, Legal, Finance, and external partners to translate portfolio strategy into executable plans; lead partnerships with external partners, vendors and CROs.
- Establish performance metrics, dashboards and forecasting models (enrollment, site activation, protocol deviations, query rates, cycle times) to drive accountability; oversee site selection, feasibility, activation, and engagement, including patient recruitment and retention.
- Build relationships with key opinion leaders, investigators, and sites to support innovation into clinical operations practice; travel to sites and represent the company at investigator meetings, advisory boards, conferences, and patient advocacy events; contribute to corporate planning, investor updates, and partnering or due diligence activities as needed.
- Lead development and continuous improvement of scalable SOPs, processes, and tools, ensuring adherence to GCP and applicable regulations.
- Build a culture of ownership, transparency, continuous improvement, and shape organizational design and hiring to match pipeline growth, balancing internal headcount with flexible resources.
BASIC QUALIFICATIONS
- BS/BA or advanced degree with a minimum of 14 years of pharmaceutical and/or biotech experience in a clinical drug development setting.
- Strong leadership competencies and influencing skills with senior leaders and cross functional leaders.
- Extensive experience with clinical operations line management, performance management and staff coaching.
- Proven leadership of clinical operations functions and execution of clinical trials including successful study start-up, site selection, patient recruitment, and relationship building with investigators and CROs; intimate knowledge of study site selection and site start up in the oncology or autoimmunity space.
- Experience in clinical resource allocation and budget forecasting.
- Management experience including outsourcing to third-party organizations, e.g., CROs.
- Expert knowledge of FDA and GCP regulations and guidelines.
- Experience in the development of protocols, SOPs, clinical study reports, INDs, NDAs and other clinical, regulatory and safety documents required.
- Effective oral and written communication skills to influence, inform and guide the clinical operational team.
- Strong project management skills.
- Proven team building skills and ability to foster partnerships across projects and multidisciplinary teams.
- Experience in cell-based therapies is highly preferred.
- Excellent organizational, communication and people management skills required.
WORKING CONDITIONS & PHYSICAL REQUIREMENTS
- Travel may be required (up to 30%).
- Subject to extended periods of sitting and standing, vision to monitor, and moderate noise levels.
COMPENSATION
- The salary offer will be based on a variety of factors, including level, experience, qualifications, internal equity, and location.
- Fate offers a competitive employment package that includes an annual bonus, equity, and a generous benefits package.
- The anticipated salary range for this role is $280,000 - $300,000.
The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time.
Equal Employment Opportunity
Fate Therapeutics, Inc. is an equal opportunity employer. We value diversity and are committed to creating an inclusive environment for all employees.
Privacy Notice
To learn about how Fate collects and uses job application information, please visit Fate's online Privacy Notice.
About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to bringing a pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients. Using its proprietary iPSC product platform, the Company has established a leadership position in creating multiplexed-engineered master iPSC lines and in the manufacture and clinical development of off-the-shelf, iPSC-derived cell products. The Company’s pipeline includes iPSC-derived T-cell and natural killer (NK) cell product candidates, which are selectively designed, incorporate novel synthetic controls of cell function, and are intended to deliver multiple therapeutic mechanisms to patients. Fate Therapeutics is headquartered in San Diego, CA.
⚠️ Recruitment Fraud Alert
Recently, we have been made aware of unauthorized individuals falsely presenting themselves as Fate Therapeutics employees or recruiters as part of online scams or phishing attempts. Impersonators may use the Fate Therapeutics name and logo, as well as employee names and job titles, to gain a job seeker’s personal or banking information or to request payment as a condition of being considered for a position at the company. Fate Therapeutics and its employees are not involved in these scams. Here are a few things to be aware of to help identify recruitment fraud:
- Our Talent Acquisition team only corresponds from our @fatetherapeutics.com domain.
- At no stage in our hiring process will we require payment or ask you to make deposits in your bank account.
- We will only ask for personal information when applying for a position via our Careers page or thereafter.
- At no stage during our hiring process will we ask you to click a link to begin a one-way video interview.
- We do not use Google Hangouts, WhatsApp, or other third-party messaging platforms to recruit candidates or conduct interviews.
Please exercise caution. If something feels off about your interactions, we encourage you to contact us at [email protected] to confirm the authenticity of the message. Your security is important to us, and we appreciate your vigilance. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
INTRODUCTION
Fate Therapeutics is seeking an Executive Director, Clinical Operations to contribute to the strategy and lead execution of our global clinical operations across multiple cell therapy franchises. In this senior leadership role, you will drive the planning and delivery of studies built on a differentiated, off-the-shelf platform designed for broad patient access. Partnering closely with the executive team, clinical leadership, and cross-functional colleagues, you will shape portfolio priorities, ensure operational excellence in site start-up, enrollment, and data quality, and own the timelines and budgets that bring our pipeline to patients. If you are a strategic, hands-on leader who thrives on building high-performing teams and scalable processes, this is an opportunity to make a meaningful impact on the future of cell therapy in autoimmune disease.
Responsibilities
- Lead and drive successful execution of the company’s clinical operation strategies through establishing consistent and deliverable operational plans across multiple cell therapy franchises.
- Establish study planning models, oversee efficient site start-up across multiple countries and drive patient recruitment as part of a unique outpatient administration and on-demand available cell therapy platform for broad patient access.
- Partner with executive team to plan and drive corporate clinical initiatives, and to establish delivery strategies, portfolio priorities, and progress metrics.
- Partner with larger clinical organization to provide operational input into clinical protocol design, study endpoints, enrollment strategy, and trial timelines.
- Provide strategic oversight of global cell therapy studies to deliver on timelines and cost allocations; own variable and headcount costs for the assigned portfolio, including forecasting, resource allocation assumptions, change order review, and cost containment, in partnership with Finance.
- Develop and oversee patient enrollment, data and timeline completion risk mitigation plans, patient data quality, and completion timelines.
- Maintain integration and alignment of Clinical Operations with key cross-functional departments including Clinical Outsourcing, Program Management, R&D, Manufacturing, Biometrics, Regulatory, QA, Safety/Pharmacovigilance, Legal, Finance, and external partners to translate portfolio strategy into executable plans; lead partnerships with external partners, vendors and CROs.
- Establish performance metrics, dashboards and forecasting models (enrollment, site activation, protocol deviations, query rates, cycle times) to drive accountability; oversee site selection, feasibility, activation, and engagement, including patient recruitment and retention.
- Build relationships with key opinion leaders, investigators, and sites to support innovation into clinical operations practice; travel to sites and represent the company at investigator meetings, advisory boards, conferences, and patient advocacy events; contribute to corporate planning, investor updates, and partnering or due diligence activities as needed.
- Lead development and continuous improvement of scalable SOPs, processes, and tools, ensuring adherence to GCP and applicable regulations.
- Build a culture of ownership, transparency, continuous improvement, and shape organizational design and hiring to match pipeline growth, balancing internal headcount with flexible resources.
BASIC QUALIFICATIONS
- BS/BA or advanced degree with a minimum of 14 years of pharmaceutical and/or biotech experience in a clinical drug development setting.
- Strong leadership competencies and influencing skills with senior leaders and cross functional leaders.
- Extensive experience with clinical operations line management, performance management and staff coaching.
- Proven leadership of clinical operations functions and execution of clinical trials including successful study start-up, site selection, patient recruitment, and relationship building with investigators and CROs; intimate knowledge of study site selection and site start up in the oncology or autoimmunity space.
- Experience in clinical resource allocation and budget forecasting.
- Management experience including outsourcing to third-party organizations, e.g., CROs.
- Expert knowledge of FDA and GCP regulations and guidelines.
- Experience in the development of protocols, SOPs, clinical study reports, INDs, NDAs and other clinical, regulatory and safety documents required.
- Effective oral and written communication skills to influence, inform and guide the clinical operational team.
- Strong project management skills.
- Proven team building skills and ability to foster partnerships across projects and multidisciplinary teams.
- Experience in cell-based therapies is highly preferred.
- Excellent organizational, communication and people management skills required.
WORKING CONDITIONS & PHYSICAL REQUIREMENTS
- Travel may be required (up to 30%).
- Subject to extended periods of sitting and standing, vision to monitor, and moderate noise levels.
COMPENSATION
- The salary offer will be based on a variety of factors, including level, experience, qualifications, internal equity, and location.
- Fate offers a competitive employment package that includes an annual bonus, equity, and a generous benefits package.
- The anticipated salary range for this role is $280,000 - $300,000.
The preceding job description indicates the general nature and level of work performed by employees within this classification. Additional and incidental duties related to the primary duties may be required from time to time.
Equal Employment Opportunity
Fate Therapeutics, Inc. is an equal opportunity employer. We value diversity and are committed to creating an inclusive environment for all employees.
Privacy Notice
To learn about how Fate collects and uses job application information, please visit Fate's online Privacy Notice.
About Fate Therapeutics, Inc.
Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to bringing a pipeline of induced pluripotent stem cell (iPSC)-derived cellular immunotherapies to patients. Using its proprietary iPSC product platform, the Company has established a leadership position in creating multiplexed-engineered master iPSC lines and in the manufacture and clinical development of off-the-shelf, iPSC-derived cell products. The Company’s pipeline includes iPSC-derived T-cell and natural killer (NK) cell product candidates, which are selectively designed, incorporate novel synthetic controls of cell function, and are intended to deliver multiple therapeutic mechanisms to patients. Fate Therapeutics is headquartered in San Diego, CA.
⚠️ Recruitment Fraud Alert
Recently, we have been made aware of unauthorized individuals falsely presenting themselves as Fate Therapeutics employees or recruiters as part of online scams or phishing attempts. Impersonators may use the Fate Therapeutics name and logo, as well as employee names and job titles, to gain a job seeker’s personal or banking information or to request payment as a condition of being considered for a position at the company. Fate Therapeutics and its employees are not involved in these scams. Here are a few things to be aware of to help identify recruitment fraud:
- Our Talent Acquisition team only corresponds from our @fatetherapeutics.com domain.
- At no stage in our hiring process will we require payment or ask you to make deposits in your bank account.
- We will only ask for personal information when applying for a position via our Careers page or thereafter.
- At no stage during our hiring process will we ask you to click a link to begin a one-way video interview.
- We do not use Google Hangouts, WhatsApp, or other third-party messaging platforms to recruit candidates or conduct interviews.
Please exercise caution. If something feels off about your interactions, we encourage you to contact us at [email protected] to confirm the authenticity of the message. Your security is important to us, and we appreciate your vigilance. We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
See all 40+ H-1B Visa Executive Director of Operations Jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new H-1B Visa Executive Director of Operations Jobs.
Get Access To All JobsTips for Finding H-1B Visa Sponsorship in Executive Director of Operations
Align your degree to operational leadership
USCIS scrutinizes whether your degree directly relates to the role's duties. Frame your business administration, industrial engineering, or operations management credentials around specific functions you'll oversee, not just your title, when preparing your petition documentation.
Verify prevailing wage before accepting offers
Your employer's LCA must certify a wage at or above the DOL prevailing wage for your SOC code and work location. Run the OFLC Wage Search using the correct metropolitan area before negotiations so you know the floor, not just the offer.
Target employers with multi-site LCA experience
If the role involves oversight across multiple facilities, confirm each worksite is covered by its own certified LCA. Ask hiring managers directly whether their legal team has handled multi-location H-1B visa filings before you advance in the process.
Find sponsors through Migrate Mate's verified data
Filter your employer search to organizations with active H-1B LCA filings in operations and general management. Migrate Mate surfaces this DOL filing history by role and location, so you can target companies that have sponsored comparable positions before.
Request premium processing before your start date
Standard USCIS adjudication can take several months. If your offer has a firm start date, ask the employer to file for premium processing through USCIS so you receive a decision within a defined shorter window and avoid status gaps.
Review your O*NET profile to build specialty occupation evidence
The O*NET profile for Chief Executives and General and Operations Managers lists the degree requirements and core tasks USCIS expects to see reflected in your job description. Cross-reference your offer letter duties against those benchmarks before your petition is drafted.
H-1B Visa Executive Director of Operations: Frequently Asked Questions
Does an Executive Director of Operations role qualify as an H-1B specialty occupation?
Yes, when the position requires at least a bachelor's degree in a directly related field such as business administration, industrial engineering, supply chain management, or operations research. USCIS evaluates the actual duties, not just the title, so the job description must tie each core responsibility to degree-level knowledge. Employers sponsoring this role typically document the theoretical and analytical demands that distinguish it from general management.
What LCA requirements apply if the role involves multiple office locations?
Each fixed worksite where you'll perform duties for more than 40 hours in a 90-day period requires its own certified Labor Condition Application. Your employer must file a separate LCA with DOL for each location before you work there. Short-term placements have narrow exemptions, but ongoing multi-site responsibilities almost always trigger additional LCA obligations that your employer's legal team needs to plan for before the I-129 is filed.
How long does H-1B status last for this type of senior operations role?
USCIS grants H-1B status for an initial period of up to three years, with the option to extend for another three years, reaching a six-year maximum under standard rules. If your employer is sponsoring you for permanent residence and has an approved I-140 or a pending PERM labor certification, additional extensions beyond six years may be available. Those extensions depend on where your employer is in the green card process.
How can I find employers that actively sponsor H-1B visas for operations leadership roles?
Migrate Mate shows employers with verified H-1B LCA filing history searchable by role type and location, so you can focus on organizations that have already sponsored comparable positions. DOL discloses every certified LCA publicly, and reviewing that data for operations management SOC codes gives you a concrete list of active sponsors before you apply.
Can my employer sponsor me for a green card while I'm on H-1B in this role?
Yes. H-1B status allows dual intent, meaning you can pursue permanent residence without jeopardizing your nonimmigrant status. For an Executive Director of Operations, the most common pathways are EB-1C for multinational managers or executives, and EB-2 or EB-3 through PERM labor certification. Your employer initiates the PERM process with DOL, and the timeline depends heavily on your country of birth and the current visa bulletin priority dates.