H-1B Visa Senior Cloud Infrastructure Engineer Jobs
Senior Cloud Infrastructure Engineers rank among the most consistently sponsored H-1B visa roles, with strong demand across hyperscaler partners, fintech, and enterprise SaaS. Employers filing LCAs for this title typically classify it under SOC 15-1299, triggering prevailing wage requirements that reflect senior-level compensation in your target metro.
Find H-1B Visa Senior Cloud Infrastructure Engineer JobsOverview
Showing 5 of 158+ Senior Cloud Infrastructure Engineer jobs
See all 158+ Senior Cloud Infrastructure Engineer Jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Senior Cloud Infrastructure Engineer roles.
Get Access To All JobsINTRODUCTION
Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California.
SUMMARY
We are seeking a highly skilled Senior Cloud Infrastructure Engineer to architect, implement, and support cloud-first infrastructure platforms across AWS, Azure, and hybrid environments. This role will be responsible for designing scalable, secure, and highly available cloud infrastructure, managing containerized platforms, automating infrastructure deployments, and supporting critical enterprise and laboratory systems.
The ideal candidate has deep expertise in cloud technologies, Kubernetes, Docker, Infrastructure as Code (IaC), DevOps practices, and cloud security. This individual will work closely with software engineering, bioinformatics, security, laboratory operations, and compliance teams to ensure reliable and compliant infrastructure services supporting business-critical applications.
ONSITE: Monday, Tuesday, and Thursday
Responsibilities:
- Design, deploy, and manage enterprise cloud infrastructure primarily within AWS and/or Azure environments.
- Architect highly available, scalable, secure, and cost-effective cloud solutions.
- Implement cloud networking, identity management, storage, compute, monitoring, and security services.
- Support integration between cloud and on-premises infrastructure environments.
- Manage hybrid networking, VPNs, Direct Connect, ExpressRoute, and secure connectivity solutions.
- Support virtualization platforms and legacy infrastructure during cloud transformation initiatives.
- Design, deploy, and manage Kubernetes clusters in cloud and hybrid environments.
- Administer container orchestration platforms including Amazon EKS, Azure AKS, or self-managed Kubernetes environments.
- Build and maintain containerized application platforms using Docker.
- Automate infrastructure provisioning, configuration management, and deployment processes.
- Support and optimize CI/CD pipelines using GitHub Actions, GitLab CI, Azure DevOps, Jenkins, or similar platforms.
- Implement automated monitoring, alerting, scaling, backup, and recovery solutions.
- Partner with Security and Compliance teams to support HIPAA/CLIA/CAP/FDA requirements, where applicable.
- Ensure secure management of Protected Health Information (PHI) and sensitive business data.
- Partner with software engineering teams to optimize cloud-native application architectures.
REQUIRED QUALIFICATIONS:
- Bachelor's degree in Computer Science, Information Technology, Engineering, or related field.
- 7+ years of infrastructure engineering experience.
- 5+ years of hands-on cloud engineering experience in AWS, Azure, or GCP.
- 3+ years of Kubernetes administration and container platform management experience.
- Strong experience with Docker and containerized application deployment.
- Experience implementing Infrastructure as Code using Terraform or equivalent tools.
- Experience with Linux systems administration and cloud networking.
- Strong scripting and automation skills using Python, PowerShell, Bash, or similar languages.
- Experience supporting production-critical environments with high availability requirements.
TECHNICAL SKILLS:
- AWS (EC2, EKS, RDS, S3, IAM, VPC, Route53, CloudWatch, Lambda)
- Azure (AKS, Virtual Networks, Azure AD, Storage, Monitor, Key Vault)
- Multi-cloud and hybrid-cloud architectures
- Kubernetes, Docker, Helm, EKS, Terraform, Ansible and other adjacent cloud services
- Monitoring services like Splunk, Datadog or other cloud-native monitoring tools
KEY COMPETENCIES:
- Cloud Architecture & Engineering
- Kubernetes Administration
- Docker & Container Platforms
- Infrastructure Automation
- DevOps & CI/CD
- Cloud Security & Compliance
- Site Reliability Engineering (SRE)
- Disaster Recovery & Business Continuity
- Technical Leadership
- Problem Solving & Incident Management
SUCCESS METRICS:
- Cloud platform availability and reliability.
- Kubernetes cluster health and operational efficiency.
- Infrastructure automation coverage and deployment success rates.
- Compliance with HIPAA, CLIA, CAP, and security requirements.
- Cloud cost optimization and resource utilization.
- Incident response and recovery performance.
- Successful delivery of cloud modernization initiatives.
- Security and audit readiness.
The hiring range for this position is $150,000 to $180,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.
Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.
Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.
Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)
INTRODUCTION
Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California.
SUMMARY
We are seeking a highly skilled Senior Cloud Infrastructure Engineer to architect, implement, and support cloud-first infrastructure platforms across AWS, Azure, and hybrid environments. This role will be responsible for designing scalable, secure, and highly available cloud infrastructure, managing containerized platforms, automating infrastructure deployments, and supporting critical enterprise and laboratory systems.
The ideal candidate has deep expertise in cloud technologies, Kubernetes, Docker, Infrastructure as Code (IaC), DevOps practices, and cloud security. This individual will work closely with software engineering, bioinformatics, security, laboratory operations, and compliance teams to ensure reliable and compliant infrastructure services supporting business-critical applications.
ONSITE: Monday, Tuesday, and Thursday
Responsibilities:
- Design, deploy, and manage enterprise cloud infrastructure primarily within AWS and/or Azure environments.
- Architect highly available, scalable, secure, and cost-effective cloud solutions.
- Implement cloud networking, identity management, storage, compute, monitoring, and security services.
- Support integration between cloud and on-premises infrastructure environments.
- Manage hybrid networking, VPNs, Direct Connect, ExpressRoute, and secure connectivity solutions.
- Support virtualization platforms and legacy infrastructure during cloud transformation initiatives.
- Design, deploy, and manage Kubernetes clusters in cloud and hybrid environments.
- Administer container orchestration platforms including Amazon EKS, Azure AKS, or self-managed Kubernetes environments.
- Build and maintain containerized application platforms using Docker.
- Automate infrastructure provisioning, configuration management, and deployment processes.
- Support and optimize CI/CD pipelines using GitHub Actions, GitLab CI, Azure DevOps, Jenkins, or similar platforms.
- Implement automated monitoring, alerting, scaling, backup, and recovery solutions.
- Partner with Security and Compliance teams to support HIPAA/CLIA/CAP/FDA requirements, where applicable.
- Ensure secure management of Protected Health Information (PHI) and sensitive business data.
- Partner with software engineering teams to optimize cloud-native application architectures.
REQUIRED QUALIFICATIONS:
- Bachelor's degree in Computer Science, Information Technology, Engineering, or related field.
- 7+ years of infrastructure engineering experience.
- 5+ years of hands-on cloud engineering experience in AWS, Azure, or GCP.
- 3+ years of Kubernetes administration and container platform management experience.
- Strong experience with Docker and containerized application deployment.
- Experience implementing Infrastructure as Code using Terraform or equivalent tools.
- Experience with Linux systems administration and cloud networking.
- Strong scripting and automation skills using Python, PowerShell, Bash, or similar languages.
- Experience supporting production-critical environments with high availability requirements.
TECHNICAL SKILLS:
- AWS (EC2, EKS, RDS, S3, IAM, VPC, Route53, CloudWatch, Lambda)
- Azure (AKS, Virtual Networks, Azure AD, Storage, Monitor, Key Vault)
- Multi-cloud and hybrid-cloud architectures
- Kubernetes, Docker, Helm, EKS, Terraform, Ansible and other adjacent cloud services
- Monitoring services like Splunk, Datadog or other cloud-native monitoring tools
KEY COMPETENCIES:
- Cloud Architecture & Engineering
- Kubernetes Administration
- Docker & Container Platforms
- Infrastructure Automation
- DevOps & CI/CD
- Cloud Security & Compliance
- Site Reliability Engineering (SRE)
- Disaster Recovery & Business Continuity
- Technical Leadership
- Problem Solving & Incident Management
SUCCESS METRICS:
- Cloud platform availability and reliability.
- Kubernetes cluster health and operational efficiency.
- Infrastructure automation coverage and deployment success rates.
- Compliance with HIPAA, CLIA, CAP, and security requirements.
- Cloud cost optimization and resource utilization.
- Incident response and recovery performance.
- Successful delivery of cloud modernization initiatives.
- Security and audit readiness.
The hiring range for this position is $150,000 to $180,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.
Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.
Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.
Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)
See all 158+ H-1B Visa Senior Cloud Infrastructure Engineer Jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new H-1B Visa Senior Cloud Infrastructure Engineer Jobs.
Get Access To All JobsTips for Finding H-1B Visa Sponsorship as a Senior Cloud Infrastructure Engineer
Align your credentials to SOC codes
Your resume and degree must map cleanly to the SOC code your employer uses on the LCA. For cloud infrastructure roles, mismatches between your listed specialization and the filed SOC code are a common RFE trigger. Review the O*NET profile for SOC 15-1299 before applying.
Target employers with active LCA filings
Search the OFLC Wage Search to confirm a company has filed LCAs for cloud infrastructure titles in your target metro. Past filings signal an established H-1B process, legal counsel on staff, and familiarity with prevailing wage compliance, all of which reduce your sponsorship risk.
Use Migrate Mate to filter verified sponsors
On Migrate Mate, filter Senior Cloud Infrastructure Engineer roles by employers with documented H-1B filing history. This lets you skip companies that list sponsorship as possible but have no LCA track record, saving you weeks of applications that stall at the offer stage.
Negotiate offer timing around the cap deadline
H-1B cap petitions must be filed by early April for an October 1 start. If your offer comes in February or March, confirm your employer can prepare the I-129 in time. A delayed filing means waiting a full year for the next cap cycle.
Clarify cloud platform scope with your employer early
USCIS scrutinizes specialty occupation claims for broad titles. Before your employer files, confirm the job description specifies the required platform expertise, such as AWS, Azure, or GCP architecture at a senior level, so the LCA and I-129 reflect a clearly defined specialty.
Document your infrastructure certifications for the petition
Certifications like AWS Solutions Architect Professional or Google Cloud Professional Cloud Architect strengthen the specialty occupation argument in your I-129 packet. Gather official certificate PDFs and any continuing education records before your employer's legal team prepares the petition.
H-1B Visa Senior Cloud Infrastructure Engineer: Frequently Asked Questions
Do Senior Cloud Infrastructure Engineer roles qualify as H-1B specialty occupations?
Yes. USCIS recognizes senior-level cloud infrastructure roles as specialty occupations because they typically require at least a bachelor's degree in computer science, information systems, or a directly related engineering field. The employer must document that the position demands theoretical and practical application of highly specialized knowledge, which senior infrastructure roles generally satisfy through platform architecture responsibilities.
How do I find employers actively sponsoring H-1B visas for this role?
Search Migrate Mate to browse Senior Cloud Infrastructure Engineer positions filtered by employers with verified H-1B filing history. You can also cross-reference company names in the OFLC Wage Search to confirm active LCA filings for cloud infrastructure job titles in your target city before investing time in the application process.
Which SOC code applies to Senior Cloud Infrastructure Engineer positions?
Most employers file LCAs for this title under SOC 15-1299, which covers software and computer applications engineers not elsewhere classified, or occasionally under SOC 15-1244 for network and computer systems administrators depending on how the role is scoped. The SOC code determines the prevailing wage tier USCIS requires your employer to meet, so confirm which code your employer intends to use before accepting an offer.
Can I transfer my H-1B to a new employer if I'm already working as a cloud infrastructure engineer?
Yes. Under H-1B portability rules, you can begin working for a new employer as soon as they file an I-129 transfer petition, without waiting for USCIS approval, provided you're in valid H-1B status and have no unauthorized gaps. Your new employer files a new LCA for the role, and your job duties and title must still meet specialty occupation standards.
Does cloud infrastructure experience on OPT or STEM OPT help my H-1B petition?
It strengthens your specialty occupation argument by demonstrating that you've been performing the role in a professional capacity, which gives your employer concrete evidence of your qualifications beyond your degree. Employers should document your OPT-period responsibilities in the I-129 support letter. If your OPT employer sponsors you directly, the continuity of employment in the same role also simplifies the specialty occupation analysis.