H-1B Visa Systems Manager Jobs
Systems Manager jobs at H-1B visa sponsoring employers put you in charge of enterprise infrastructure, IT operations, and cross-functional technology teams. The role typically qualifies as a specialty occupation under H-1B, requiring a bachelor's degree in computer science, information systems, or a related field. Employers file an I-129 petition with USCIS and a certified LCA with DOL before you start.
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Get Access To All JobsINTRODUCTION
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.
The Quality Systems Manager is responsible for managing day-to-day GxP document control processes, ensuring controlled documents and quality records are compliant with regulatory requirements, internal standards, and company procedures.
This role reports to the Senior Manager of Quality Systems and acts as a subject matter expert and collaborates with cross-functional teams to support the document lifecycle, drive process improvements, maintain inspection readiness, and promote compliance with quality system requirements.
Responsibilities
- Manage day-to-day document control operations and ensure controlled documents are maintained throughout their lifecycle in the electronic document management system (e.g., SOPs, Policies, Work Instructions, Forms) in compliance with Business Process and GxP requirements.
- Serve as a subject matter expert for the electronic document management system, including document workflows, user support, testing, and implementation of system enhancements as applicable.
- Partner with document authors, reviewers, approvers, and cross-functional stakeholders to facilitate timely document review, approval, issuance, periodic review, and retirement activities.
- Support the development, maintenance, and continuous improvement of document control procedures, standards, templates, and best practices to support an effective Quality Management System.
- Provide guidance and training to document authors, collaborators, reviewers, and approvers on GxP documentation practices, document management processes, and electronic document management system functionality.
- Demonstrated ability to develop, deliver, and facilitate end-user training for Electronic Document Management Systems (EDMS), including creating training materials and user guides.
- Monitor and report document control metrics, identify trends, and recommend process improvements to enhance efficiency, compliance, and document quality.
- Support change controls, CAPAs, deviations, and continuous improvement initiatives related to document control processes.
- Support internal audits, external audits, and regulatory inspections by providing documentation, records, and subject matter expertise related to document control systems.
- Ensure document control processes remain inspection-ready and compliant with applicable FDA, EMA, ICH, and other GxP regulatory requirements.
- Provide Training coverage as needed.
SKILLS & QUALIFICATIONS
- Bachelor's degree in Life Sciences, Quality, Business, or a related discipline, or equivalent combination of education and experience.
- 6+ years of experience in Document Control and Quality Systems within a regulated GxP environment.
- Demonstrated experience managing document control processes and electronic document management systems.
- 2+ years of recent experience administering Veeva Vault QualityDocs and Vault Training.
- Strong knowledge of FDA, EMA, ICH, and applicable GxP regulations governing quality documentation.
- Experience supporting regulatory inspections, customer audits, and internal audits.
- Advanced proficiency in Microsoft Office Suite, particularly Microsoft Word for document formatting and template management.
- Excellent organizational skills with strong attention to detail and the ability to manage multiple priorities in a fast-paced environment.
- Strong written, verbal, and interpersonal communication skills with a collaborative, customer-focused approach.
- Experience with quality metrics, process improvement, and inspection readiness preferred.
Pay Range:
Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.
Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.
Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.
Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers
Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process.
Here are some ways to check for authenticity:
- We do not conduct job interviews through non-standard text messaging applications.
- We will never request personal information such as banking details until after an official offer has been accepted and verified.
- We will never request that you purchase equipment or other items when interviewing or hiring.
- If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com.
Cytokinetics is an Equal Opportunity Employer
INTRODUCTION
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.
The Quality Systems Manager is responsible for managing day-to-day GxP document control processes, ensuring controlled documents and quality records are compliant with regulatory requirements, internal standards, and company procedures.
This role reports to the Senior Manager of Quality Systems and acts as a subject matter expert and collaborates with cross-functional teams to support the document lifecycle, drive process improvements, maintain inspection readiness, and promote compliance with quality system requirements.
Responsibilities
- Manage day-to-day document control operations and ensure controlled documents are maintained throughout their lifecycle in the electronic document management system (e.g., SOPs, Policies, Work Instructions, Forms) in compliance with Business Process and GxP requirements.
- Serve as a subject matter expert for the electronic document management system, including document workflows, user support, testing, and implementation of system enhancements as applicable.
- Partner with document authors, reviewers, approvers, and cross-functional stakeholders to facilitate timely document review, approval, issuance, periodic review, and retirement activities.
- Support the development, maintenance, and continuous improvement of document control procedures, standards, templates, and best practices to support an effective Quality Management System.
- Provide guidance and training to document authors, collaborators, reviewers, and approvers on GxP documentation practices, document management processes, and electronic document management system functionality.
- Demonstrated ability to develop, deliver, and facilitate end-user training for Electronic Document Management Systems (EDMS), including creating training materials and user guides.
- Monitor and report document control metrics, identify trends, and recommend process improvements to enhance efficiency, compliance, and document quality.
- Support change controls, CAPAs, deviations, and continuous improvement initiatives related to document control processes.
- Support internal audits, external audits, and regulatory inspections by providing documentation, records, and subject matter expertise related to document control systems.
- Ensure document control processes remain inspection-ready and compliant with applicable FDA, EMA, ICH, and other GxP regulatory requirements.
- Provide Training coverage as needed.
SKILLS & QUALIFICATIONS
- Bachelor's degree in Life Sciences, Quality, Business, or a related discipline, or equivalent combination of education and experience.
- 6+ years of experience in Document Control and Quality Systems within a regulated GxP environment.
- Demonstrated experience managing document control processes and electronic document management systems.
- 2+ years of recent experience administering Veeva Vault QualityDocs and Vault Training.
- Strong knowledge of FDA, EMA, ICH, and applicable GxP regulations governing quality documentation.
- Experience supporting regulatory inspections, customer audits, and internal audits.
- Advanced proficiency in Microsoft Office Suite, particularly Microsoft Word for document formatting and template management.
- Excellent organizational skills with strong attention to detail and the ability to manage multiple priorities in a fast-paced environment.
- Strong written, verbal, and interpersonal communication skills with a collaborative, customer-focused approach.
- Experience with quality metrics, process improvement, and inspection readiness preferred.
Pay Range:
Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.
Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.
Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.
Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers
Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process.
Here are some ways to check for authenticity:
- We do not conduct job interviews through non-standard text messaging applications.
- We will never request personal information such as banking details until after an official offer has been accepted and verified.
- We will never request that you purchase equipment or other items when interviewing or hiring.
- If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at talentacquisition@cytokinetics.com.
Cytokinetics is an Equal Opportunity Employer
See all 738+ H-1B Visa Systems Manager Jobs
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Get Access To All JobsTips for Finding H-1B Visa Sponsorship as a Systems Manager
Align your degree to your job title
USCIS expects a direct connection between your bachelor's degree field and the Systems Manager duties in your offer letter. A degree in information systems, computer science, or engineering management gives you the strongest specialty occupation argument. A general business degree alone may trigger an RFE.
Look up prevailing wages before negotiating
Your employer's LCA must certify a wage at or above the DOL prevailing wage for your SOC code and work location. Use the OFLC Wage Search to check Level I through Level IV wages for your metro area before you receive an offer, so you can spot underpayment risk early.
Find sponsors with active LCA filing history
Target employers who have already certified LCAs for Systems Manager or related IT management roles. Migrate Mate shows verified LCA filing history by employer and role, so you can identify companies that have sponsored this position before rather than guessing from job postings.
Confirm each worksite has its own certified LCA
If your Systems Manager role spans multiple office locations or data centers, your employer must file a separate certified LCA for each worksite before you work there. Raise this with HR during the offer stage, especially if you'll oversee distributed infrastructure across different metro areas.
Get the job description to reflect degree-level duties
USCIS scrutinizes whether a Systems Manager role truly requires a specialized degree or could be filled by someone without one. Work with your employer to ensure the job description explicitly lists duties like enterprise architecture design, vendor contract analysis, or security compliance rather than generic team supervision.
Plan your timeline around cap selection changes
H-1B cap selection rules have changed recently, and the annual registration window is narrow. Your employer needs to file your I-129 petition with USCIS well before your intended start date. Build at least six months of lead time into your job search to avoid gaps between offers and petition approval.
H-1B Visa Systems Manager: Frequently Asked Questions
Does a Systems Manager role qualify as a specialty occupation for H-1B?
Yes, in most cases. USCIS looks for a direct relationship between the job duties and a specific bachelor's degree field. Systems Manager roles that require a degree in computer science, information systems, or engineering management typically qualify. Where denials occur, it's usually because the job description emphasizes general supervision over technical duties. A well-drafted offer letter that details infrastructure and architecture responsibilities strengthens the case.
Which employers sponsor H-1B visas for Systems Manager positions?
Employers in technology, financial services, healthcare, and government contracting sponsor H-1B visas for Systems Manager roles most frequently. These are organizations with established immigration infrastructure and recurring needs for IT leadership. Migrate Mate lists employers with verified LCA filing history for systems and IT management roles, so you can focus your search on companies that have sponsored this position before.
How does the prevailing wage requirement affect Systems Manager H-1B petitions?
Your employer's certified LCA must commit to paying at least the DOL prevailing wage for your SOC code, experience level, and work location. Systems Manager wages vary significantly by metro area, and the DOL assigns four wage levels tied to your seniority and job complexity. Use the OFLC Wage Search to verify which wage level applies to your role before accepting an offer.
Can my employer transfer my H-1B status if I move into a Systems Manager role from a different IT position?
Yes, but it's treated as an amendment, not a simple transfer. If your job duties change materially from the original approved petition, your employer must file an amended I-129 petition with USCIS before or at the time of the role change. A new LCA certified for the Systems Manager position and worksite is also required. You can begin the new role under portability rules once the amendment is filed, not just submitted.
What happens to my H-1B status if my employer is acquired or restructures my Systems Manager role?
A corporate acquisition may allow you to continue working under the successor employer without a new petition if the terms of employment remain substantially the same and the new employer assumes the original petition obligations. However, if your Systems Manager duties, location, or salary change materially during the restructuring, an amended petition with a new certified LCA is required. Confirm the succession status with your HR or immigration counsel promptly after any merger closes.