H-1B1 Singapore Visa COO Jobs
COO roles qualify for H-1B1 Singapore visa sponsorship when the position requires a specialty occupation degree and your employer files a Labor Condition Application with the DOL. With no lottery and a 5,400-visa annual cap that routinely goes unfilled, Singaporean executives can secure consulate approval without competing against the H-1B visa pool.
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As an Associate Director of Clinical Operations, the qualified candidate will be excited about and capable of planning and executing early stage clinical trials. The candidate will interface with internal and external stakeholders to plan, execute and problem solve before and during the life of clinical trials with an initial focus on Oncology programs. The candidate will focus on site- and Contract Research Organization (CRO)-facing interactions to ensure smooth execution of studies, including start-up, drug and budget forecasting, and acquisition of detailed, high-quality clinical (including safety and efficacy) and translational data to support evaluation of the drugs under study. The candidate will be clear and efficient in communicating with cross-functional team members to achieve these goals. The candidate will serve as the clinical operations program lead for at least one program and any studies associated, in addition to leading a team of operations staff.
Here's how you will contribute:
- Develop clinical operations strategy for respective program in development, either directly or by leading study staff depending on the stage of the agent
- Cross-functional collaboration to develop needed outputs such as protocols, annual safety reports and investigator brochure, clinical study reports, presentations, regulatory submissions and publications
- Evaluate external collaborators including Contract Research Organizations (CROs) and sites and select the best candidates for each needed function. Develop vendor scope of work, contract, quality, monitoring and budget.
- Develop and manage standard operating procedures (SOPs) for the organization and its external collaborators. Ensure GCP compliance.
- Continuously evaluate performance of external collaborators and vendors, troubleshoot and recommend a path forward when challenges are encountered
- Develop and manage study timelines, working with internal partners (including but not limited to clinical development, clinical pharmacology and other quantitative functions, data management, biomarkers and translational, CMC, regulatory affairs and project management)
- Attend and, where appropriate, present at study site initiation meetings and study calls
- Patient recruitment planning and forecasting
- Manage or Mentor Clinical Operations team members on the program
The Ideal Candidate will have:
- Minimum 8 years of experience in clinical operations across at least 2 therapeutics areas, including oncology
- Experience managing CROs and vendors both in the US and in international clinical trials
- Experience in site initiation visits, site management, data cuts for publication and regulatory requirements
- Understanding of the drug development process from IND to NDA
- Dedication to collaborative work in a fast-paced environment; open-mindedness to shifting strategy in a data-guided manner
- Ability to communicate effectively and efficiently and willingness to train other team members within and outside of Clinical Operations
- Experience in large Pharma and biotech and with biomarker-selected studies preferred but not required
- Experience with at least one report is preferred, but a strong candidate with hands-on experience and a growth mindset will be considered
About Generate: Biomedicines
We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.
Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.
At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.
Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.
The Role:
As an Associate Director of Clinical Operations, the qualified candidate will be excited about and capable of planning and executing early stage clinical trials. The candidate will interface with internal and external stakeholders to plan, execute and problem solve before and during the life of clinical trials with an initial focus on Oncology programs. The candidate will focus on site- and Contract Research Organization (CRO)-facing interactions to ensure smooth execution of studies, including start-up, drug and budget forecasting, and acquisition of detailed, high-quality clinical (including safety and efficacy) and translational data to support evaluation of the drugs under study. The candidate will be clear and efficient in communicating with cross-functional team members to achieve these goals. The candidate will serve as the clinical operations program lead for at least one program and any studies associated, in addition to leading a team of operations staff.
Here's how you will contribute:
- Develop clinical operations strategy for respective program in development, either directly or by leading study staff depending on the stage of the agent
- Cross-functional collaboration to develop needed outputs such as protocols, annual safety reports and investigator brochure, clinical study reports, presentations, regulatory submissions and publications
- Evaluate external collaborators including Contract Research Organizations (CROs) and sites and select the best candidates for each needed function. Develop vendor scope of work, contract, quality, monitoring and budget.
- Develop and manage standard operating procedures (SOPs) for the organization and its external collaborators. Ensure GCP compliance.
- Continuously evaluate performance of external collaborators and vendors, troubleshoot and recommend a path forward when challenges are encountered
- Develop and manage study timelines, working with internal partners (including but not limited to clinical development, clinical pharmacology and other quantitative functions, data management, biomarkers and translational, CMC, regulatory affairs and project management)
- Attend and, where appropriate, present at study site initiation meetings and study calls
- Patient recruitment planning and forecasting
- Manage or Mentor Clinical Operations team members on the program
The Ideal Candidate will have:
- Minimum 8 years of experience in clinical operations across at least 2 therapeutics areas, including oncology
- Experience managing CROs and vendors both in the US and in international clinical trials
- Experience in site initiation visits, site management, data cuts for publication and regulatory requirements
- Understanding of the drug development process from IND to NDA
- Dedication to collaborative work in a fast-paced environment; open-mindedness to shifting strategy in a data-guided manner
- Ability to communicate effectively and efficiently and willingness to train other team members within and outside of Clinical Operations
- Experience in large Pharma and biotech and with biomarker-selected studies preferred but not required
- Experience with at least one report is preferred, but a strong candidate with hands-on experience and a growth mindset will be considered
About Generate: Biomedicines
We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.
Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.
At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.
Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.
See all 767+ H-1B1 Singapore Visa COO Jobs
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Get Access To All JobsTips for Finding COO Jobs
Verify your COO role qualifies
Check your target job description against the O*NET profile for Chief Executives to confirm the role requires a specific bachelor's degree or higher. Generalist executive titles without a defined specialty-degree requirement can trigger LCA complications.
Pull prevailing wage data before negotiating
Use the OFLC Wage Search to find the prevailing wage for your target SOC code and metro area before you enter salary discussions. Your offer must meet or exceed that wage level, and the LCA locks it in before consulate filing.
Target employers with active LCA filing history
Use Migrate Mate to filter COO-level roles by employers who have filed LCAs for executive positions. This cuts prospecting time by surfacing companies already familiar with H-1B1 Singapore sponsorship mechanics rather than those encountering it for the first time.
Clarify E-Verify enrollment before your offer
Ask your prospective employer whether they're enrolled in E-Verify before you receive a written offer. USCIS requires H-1B1 visa employers to verify employment eligibility, and unenrolled companies face delays that can push your start date back by weeks.
Prepare a specialty occupation memo for the interview
COO positions attract more consular scrutiny than narrower technical roles. Bring a written memo from your employer explaining how the position requires a specific field of study, not just any business degree, to satisfy the specialty occupation standard.
Request a two-year petition to maximize your runway
The H-1B1 Singapore visa is approved in one-year increments at the consulate, but your employer can file for two years on the LCA. Confirm your offer letter and LCA both reflect a two-year period so you're not renewing within months of starting.
Frequently Asked Questions
Does a COO role qualify as a specialty occupation for H-1B1 Singapore purposes?
A COO position qualifies if the role normally requires a specific bachelor's degree or higher in a directly related field, such as business administration, finance, or operations management. Roles described as requiring any bachelor's degree, regardless of field, often fail the specialty occupation test. Your employer's job description and internal requirements documentation carry significant weight when the consular officer evaluates the petition.
How does the H-1B1 Singapore visa compare to the H-1B for a COO seeking U.S. employment?
The H-1B1 Singapore visa has no lottery, meaning a qualified COO can apply any time of year rather than waiting for the annual April registration window. The 5,400-visa annual cap has never been exhausted, so availability isn't a practical constraint. Processing happens at the U.S. consulate in Singapore rather than through USCIS, which typically runs faster. The trade-off is that H-1B1 doesn't confer dual intent, so demonstrating nonimmigrant intent at your interview matters.
How do I find employers actively willing to sponsor H-1B1 Singapore visas for executive roles?
Migrate Mate lets you search for COO-level roles filtered by employers with documented LCA filing history, so you're targeting companies that have already navigated the sponsorship process rather than those learning about it during your negotiation. Approaching employers with prior executive-level sponsorship experience shortens the offer-to-filing timeline considerably.
What documentation should I gather before approaching U.S. employers for COO roles?
Assemble your academic transcripts with certified translations if issued in a language other than English, your passport valid for at least six months beyond your intended entry date, and any professional credentials relevant to your industry. For COO applications, evidence of progressive executive responsibility, such as board resolutions, org charts, or prior employment contracts, strengthens your specialty occupation case at the consular interview.
Can I switch U.S. employers after starting work on an H-1B1 Singapore visa as a COO?
Yes, but the H-1B1 visa doesn't carry H-1B portability protections, so you can't begin work with a new employer the moment you file a transfer petition. Your new employer must complete a fresh LCA with DOL and you'll need a new consular stamp before starting. Plan for a gap between your last day with the current employer and your first day in the new role.