Human Resources Assistant Jobs in St. Louis, MO
Human Resources Assistant jobs in St. Louis are concentrated in Clayton, the Central Business District, and the Cortex Innovation Community, with strong demand from healthcare systems, financial services firms, and large universities employing Webster University, Marriott International, and XPO. Hiring is active across these sectors year-round. Find a role that fits below and apply directly.
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Showing 5 of 93+ Human Resources Assistant jobs
- Bachelor’s degree or equivalent related work or military experience
- 1 year of experience as a Human Resources (HR) Generalist or an equivalent combination of education and experience
- Experience with basic business and customer service principles, including planning, organizing, resource management and leadership skills
- Experience with FMLA, LOA and other state and federal employment laws
- Experience supporting employee relations and strategic HR initiatives including handling sensitive, complex and confidential information
- Demonstrate functional knowledge of payroll software, HRIS programs and Microsoft Office
- A valid driver’s license
- Available to work a flexible schedule, including occasional weekend work; travel 25-50% of the time
Preferred qualifications:
- Bachelor’s degree in Human Resources
- PHR/SHRM certification
- Experience building solid partnerships with leadership
About the Human Resources Generalist job
What you’ll do on a typical day:
- Provide employee relations guidance to employees and management; identify and actively respond with sensitivity to the needs of employees and business unit leaders
- Oversee the day-to-day support of HR transactions in collaboration with a shared services team
- Ensure compliance with state and federal laws and regulations; assess, communicate, interpret and administer updated HR policies and procedures to assigned area
- Deliver benefits information to employees based on company handbook/policies and procedures; ensure fair, equitable and consistent application of all company policies and procedures
- Assist with investigating a variety of employee-related issues, incidents and complaints; resolve disputes and recommend appropriate remedial actions
- Support hiring managers and internal teams by interviewing, presenting offers, facilitating candidate logistics, scheduling onboarding and administering the training/orientation process
- Assist in the development and implementation of programs or information regarding HR policies, procedures or information
- Support a values-driven environment through consultation and service regarding employee engagement activities
XPO does not provide employment-based immigration sponsorship for employment in the United States for this role. Applicants must be authorized to work in the United States without current or future employer sponsorship.
About XPO
XPO is a top ten global provider of transportation services, with a highly integrated network of people, technology and physical assets. At XPO, we look for employees who like a challenge and can communicate effectively in all situations. We want to leverage your skills and years of experience to drive positive results while ensuring a bright future for yourself and XPO. If you’re looking for a growth opportunity, join us at XPO.
We are proud to be an Equal Opportunity employer. Qualified applicants will receive consideration for employment without regard to race, sex, disability, veteran or other protected status.
All applicants who receive a conditional offer of employment may be required to take and pass a pre-employment drug test.
The above statements are not an exhaustive list of all required responsibilities, duties and skills for this job classification.
Review XPO's candidate privacy statement here.
- Bachelor’s degree or equivalent related work or military experience
- 1 year of experience as a Human Resources (HR) Generalist or an equivalent combination of education and experience
- Experience with basic business and customer service principles, including planning, organizing, resource management and leadership skills
- Experience with FMLA, LOA and other state and federal employment laws
- Experience supporting employee relations and strategic HR initiatives including handling sensitive, complex and confidential information
- Demonstrate functional knowledge of payroll software, HRIS programs and Microsoft Office
- A valid driver’s license
- Available to work a flexible schedule, including occasional weekend work; travel 25-50% of the time
Preferred qualifications:
- Bachelor’s degree in Human Resources
- PHR/SHRM certification
- Experience building solid partnerships with leadership
About the Human Resources Generalist job
What you’ll do on a typical day:
- Provide employee relations guidance to employees and management; identify and actively respond with sensitivity to the needs of employees and business unit leaders
- Oversee the day-to-day support of HR transactions in collaboration with a shared services team
- Ensure compliance with state and federal laws and regulations; assess, communicate, interpret and administer updated HR policies and procedures to assigned area
- Deliver benefits information to employees based on company handbook/policies and procedures; ensure fair, equitable and consistent application of all company policies and procedures
- Assist with investigating a variety of employee-related issues, incidents and complaints; resolve disputes and recommend appropriate remedial actions
- Support hiring managers and internal teams by interviewing, presenting offers, facilitating candidate logistics, scheduling onboarding and administering the training/orientation process
- Assist in the development and implementation of programs or information regarding HR policies, procedures or information
- Support a values-driven environment through consultation and service regarding employee engagement activities
XPO does not provide employment-based immigration sponsorship for employment in the United States for this role. Applicants must be authorized to work in the United States without current or future employer sponsorship.
About XPO
XPO is a top ten global provider of transportation services, with a highly integrated network of people, technology and physical assets. At XPO, we look for employees who like a challenge and can communicate effectively in all situations. We want to leverage your skills and years of experience to drive positive results while ensuring a bright future for yourself and XPO. If you’re looking for a growth opportunity, join us at XPO.
We are proud to be an Equal Opportunity employer. Qualified applicants will receive consideration for employment without regard to race, sex, disability, veteran or other protected status.
All applicants who receive a conditional offer of employment may be required to take and pass a pre-employment drug test.
The above statements are not an exhaustive list of all required responsibilities, duties and skills for this job classification.
Review XPO's candidate privacy statement here.
See All 93 Human Resources Assistant Jobs in St. Louis
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Find JobsHuman Resources Assistant Job Market in St. Louis
Who's Hiring
Human Resources Assistant Jobs in St. Louis: Frequently Asked Questions
How do I get a human resources assistant job in St. Louis?
St. Louis hiring concentrates in healthcare networks, financial services companies, and large educational institutions in Clayton and the Central Business District, so targeting those employer types gives you a real edge. Candidates who have hands-on experience with HRIS software, onboarding coordination, or benefits administration stand out. Applying directly through employer career portals and building familiarity with Missouri-specific employment paperwork also moves your application forward faster in this market.
Which companies hire human resources assistants in St. Louis?
Companies currently hiring human resources assistants in St. Louis include Webster University, Marriott International, and XPO, per current listings on Migrate Mate as of November 2026. St. Louis draws a broad mix of large healthcare systems, regional banks, insurance companies, and manufacturing firms, all of which maintain active HR departments that hire at the assistant level on a rolling basis.
Are there remote human resources assistant jobs in St. Louis?
Yes, though remote availability is moderate since human resources assistant work often involves in-person onboarding, file management, and employee interactions that require an office presence. About 57% of human resources assistant openings tied to St. Louis are remote or hybrid as of November 2026, with hybrid schedules most common. Roles focused on data entry, HRIS administration, and benefits coordination tend to offer the most schedule flexibility in the St. Louis market.
How can I get a human resources assistant job in St. Louis with little or no experience?
The most realistic entry path in St. Louis is through administrative or receptionist roles at healthcare systems or universities, which regularly promote internally into HR assistant positions. St. Louis employers such as large hospital networks and regional insurers also hire entry-level HR coordinators who complete onboarding support tasks before moving into full assistant duties. A working knowledge of Microsoft Office, attention to detail on employee records, and any coursework in business or HR management will help your application stand out locally.
See All 93 Human Resources Assistant Jobs in St. Louis
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