Human Resources Assistant Jobs in St. Louis, MO
Human Resources Assistant jobs in St. Louis are concentrated in Clayton, the Central Business District, and the Cortex Innovation Community, with strong demand from healthcare systems, financial services firms, and large universities employing CRB, Sonesta, and Stepful. Hiring is active across these sectors year-round. Find a role that fits below and apply directly.
Find JobsOverview
Showing 5 of 86+ Human Resources Assistant jobs









CRB's nearly 1,200 expert professionals drive innovative, life-changing and life-saving solutions for manufacturers in the life sciences and food and beverage industries. Our mission, vision and core values put client satisfaction and employee experience at the center of everything we do. See us at crbgroup.com.
Job Description
As member of our HR leadership team and under the direction of the Chief People Officer, the Director, People Operations will lead our HR Operations and Total Rewards function and be both hands-on and strategic: refining our total rewards philosophy; scaling our compensation and benefits programs; building a strong HR infrastructure; and refining HR delivery model to enable self-service with support. Managing and coaching a high-performing team creating programs that meet employees where they are today and build a strong foundation for tomorrow while reinforcing our company values.
As a thought leader and partner to HR and business leaders you will consult with key stakeholders to manage, drive, and influence the development and execution of global rewards, benefits, employee programs, and processes while balancing the financial goals of the company. You will work with the business leaders to translate the business strategy and objectives into a comprehensive Total Rewards & Operations strategy to meet our business needs today and, in the future, as we scale.
The position will work cross-functionally to deliver value-add support to the people team and be viewed as a subject matter expert with the ability to interact with all levels of the organization.
This position can be based in any of the following cities: Kansas City; St Louis; Raleigh; Denver; Philly; Boston; San Diego; Dallas
Responsibilities include:
Creating, administering, and evolving our Total Rewards strategy inclusive of compensation, benefits, wellbeing, and aligned with our DEI strategy.
Direct the annual merit and bonus processes
Leading our HR Operations team focused on building tools and processes that scale and support people activities across the company.
Partnering with the business leaders to drive recommendations for executive compensation and other analyses as requested by the Executive Leadership.
Leading, mentoring, coaching, and developing direct reports; develop the Total Rewards acumen of the broader HR team.
Staying up-to-date on current benefit & compensation-related legislation to ensure compliance with applicable employment-related federal and state statutory requirements.
Benchmark activities across all areas of rewards and operations to elevate our understanding of our competitiveness globally and evolve it over time to meet the changing landscape of Total Rewards & Operations.
Educating the organization, particularly our people managers, on topics related to Total Rewards.
Assist in the implementation, rollout, and adoption of CRB’s HRIS system and vendor relationship, ensuring a high level of data integrity
Oversee and manage HR compliance function including leading HR audits, documentation, and testing of key controls, and ensuring internal policies and processes support compliance requirements
Advise and consult with the Human Capitol and Executive Compensation Board of Directors committees on matters related to Total Rewards.
Qualifications
Bachelor’s degree requiredMinimum 10 years’ experience in human resources with a focus on total rewards and/or operations
Leadership experience in implementation and administration of total rewards and HR operational processes and programs.
Intermediate/Advanced Excel with strong data analytics skill set
Track record of working cross-functionally and collaboratively at all levels
Compensation or benefits subject matter expert
Agile and high degree of initiative; effectively handles multiple demands in a fast-paced environment.
Attention to detail, ability to juggle competing priorities during heavy total rewards cycles/processes.
Able to quickly establish trust and credibility across human resources and the business.
Additional Information
All your information will be kept confidential according to EEO guidelines. #LI-Remote
CRB is committed to hiring and retaining a diverse workforce. We are proud to be an Equal Opportunity Employer and it is our policy to provide equal opportunity to all people without regard to race, color, religion, national origin, ancestry, marital status, veteran status, age, disability, pregnancy, genetic information, citizenship status, sex, sexual orientation, gender identity or any other legally protected category. Employment is contingent on background screening.
CRB does not accept unsolicited resumes from search firms or agencies. Any resume submitted to any employee of CRB without a prior written search agreement will be considered unsolicited and the property of CRB. Please, no phone calls or emails.
CRB offers a complete and competitive benefit package designed to meet individual and family needs.
If you are unable to complete this application due to a disability, contact this employer to ask for an accommodation or an alternative application process.
See All 86 Human Resources Assistant Jobs in St. Louis
Find roles in St. Louis that match your experience and apply in just a few clicks.
Find JobsHuman Resources Assistant Job Market in St. Louis
Who's Hiring



Human Resources Assistant Jobs in St. Louis: Frequently Asked Questions
How do I get a human resources assistant job in St. Louis?
St. Louis hiring concentrates in healthcare networks, financial services companies, and large educational institutions in Clayton and the Central Business District, so targeting those employer types gives you a real edge. Candidates who have hands-on experience with HRIS software, onboarding coordination, or benefits administration stand out. Applying directly through employer career portals and building familiarity with Missouri-specific employment paperwork also moves your application forward faster in this market.
Which companies hire human resources assistants in St. Louis?
Companies currently hiring human resources assistants in St. Louis include CRB, Sonesta, and Stepful, per current listings on Migrate Mate as of August 2026. St. Louis draws a broad mix of large healthcare systems, regional banks, insurance companies, and manufacturing firms, all of which maintain active HR departments that hire at the assistant level on a rolling basis.
Are there remote human resources assistant jobs in St. Louis?
Yes, though remote availability is moderate since human resources assistant work often involves in-person onboarding, file management, and employee interactions that require an office presence. About 50% of human resources assistant openings tied to St. Louis are remote or hybrid as of August 2026, with hybrid schedules most common. Roles focused on data entry, HRIS administration, and benefits coordination tend to offer the most schedule flexibility in the St. Louis market.
How can I get a human resources assistant job in St. Louis with little or no experience?
The most realistic entry path in St. Louis is through administrative or receptionist roles at healthcare systems or universities, which regularly promote internally into HR assistant positions. St. Louis employers such as large hospital networks and regional insurers also hire entry-level HR coordinators who complete onboarding support tasks before moving into full assistant duties. A working knowledge of Microsoft Office, attention to detail on employee records, and any coursework in business or HR management will help your application stand out locally.
Related Jobs in Missouri
See All 86 Human Resources Assistant Jobs in St. Louis
Find roles in St. Louis that match your experience and apply in just a few clicks.
Find Jobs