Medical Assistant Jobs in Columbia, SC

Medical Assistant jobs in Columbia, South Carolina are concentrated across the Midlands health corridor, with strong demand in Forest Acres, Harbison, and the downtown medical district. Employers like Prisma Health, Lexington Health, and Medical University of South Carolina fill steady openings in primary care, urgent care, and specialty clinics. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles47
Top employerPrisma Health
Work type100% On-site
Top credentialCCMA Certification
Companies hiring11

Showing 5 of 47+ Medical Assistant jobs

Lexington Health
Certified Medical Assistant
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Lexington Health
New 1m ago
Certified Medical Assistant
Lexington Health
Columbia, South Carolina
Healthcare Administration
Patient Services & Wellbeing
Physicians
BLS Certification
5,001-10,000

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P
Medical Assistant (Columbia- Harbison)
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New 1m ago
Medical Assistant (Columbia- Harbison)
Prisma Health Urgent Care
Columbia, South Carolina
Clinical Support
Healthcare Administration
Medical Specialists
EMT Certification

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Medical University of South Carolina
Certified Medical Assistant (MCP)
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Medical University of South Carolina
New 1m ago
Certified Medical Assistant (MCP)
Medical University of South Carolina
Columbia, South Carolina
Healthcare Administration
Patient Services & Wellbeing
Social Work & Counseling
CPR Certification
10,000+

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Prisma Health
Certified Medical Assistant (CMA), Rheumatology, FT, Days
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Prisma Health
New 1m ago
Certified Medical Assistant (CMA), Rheumatology, FT, Days
Prisma Health
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
CCMA Certification
10,000+

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Medical Assistant (Columbia-Garners Ferry)
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P
New 1m ago
Medical Assistant (Columbia-Garners Ferry)
Prisma Health Urgent Care
Columbia, South Carolina
Clinical Support
Healthcare Administration
Medical Specialists
EMT Certification

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See All 47 Medical Assistant Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

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Medical Assistant Job Market in Columbia

Who's Hiring

  • Prisma Health
    Prisma Health19
  • Lexington Health
    Lexington Health9
  • Medical University of South Carolina
    Medical University of South Carolina6
  • P
    Prisma Health Urgent Care3
  • Doctors Care
    Doctors Care2

Top Industries Hiring

  • Healthcare & Medical Services29
  • Education1

Medical Assistant Jobs in Columbia: Frequently Asked Questions

How do I get a medical assistant job in Columbia?

Focus your search on Columbia's dense cluster of outpatient clinics, federally qualified health centers, and multi-specialty group practices anchored along the Midlands corridor and near the Palmetto Health and MUSC Health networks. Candidates with phlebotomy certification and electronic health record experience, especially Epic or NextGen, stand out most in this market. Applying directly through clinic system career portals, rather than waiting for listings to age, tends to move faster here.

Which companies hire medical assistants in Columbia?

Columbia medical assistant roles are posted by Prisma Health, Lexington Health, and Medical University of South Carolina and others right now, based on current listings on Migrate Mate as of July 2026. The Columbia market is anchored by large health system affiliates and independent specialty practices ranging from orthopedics to behavioral health.

Are there remote medical assistant jobs in Columbia?

Yes, though remote options are limited given that most medical assistant work is hands-on and clinic-based. About 0% of medical assistant openings tied to Columbia are remote or hybrid as of July 2026, covering roles such as prior authorization coordinators and telephonic care management. Those positions tend to sit within Columbia's larger health system administrative operations.

How can I get a medical assistant job in Columbia with little or no experience?

The most realistic entry path in Columbia is through externship-connected programs at Midlands Technical College, which feeds directly into local clinic hiring pipelines. Urgent care chains and federally qualified health centers in the Columbia area are notably more open to training new graduates than specialty practices. Highlighting a completed clinical rotation, even unpaid, and any patient-facing customer service experience gives entry-level candidates a concrete edge locally.

Which industries hire the most medical assistants in Columbia?

Columbia medical assistant roles concentrate in Healthcare & Medical Services and Education, based on current listings on Migrate Mate as of July 2026. Columbia's position as a state capital with a large insured government-employee population drives sustained demand across these sectors year-round.

See All 47 Medical Assistant Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find Medical Assistant Jobs