RN Staff Nurse Jobs in South Carolina
RN Staff Nurse jobs in South Carolina are open across Florence, Charleston, and Edgefield and other South Carolina metros, with employers like McLeod Health, Medical University of South Carolina, and Self Regional Healthcare hiring at every experience level. Find a role that fits below and apply directly.
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Showing 5 of 8+ RN Staff Nurse jobs
Staff Nurse - Neuro Endovascular
- $25,000 Sign On Bonus Available
Essential Functions
Assesses needs of patients as assigned based on data collected through history, observation, physical examination, and analysis of diagnostic data. Provides appropriate nursing interventions, consistent with the Plan of Care and standards of practice, incorporating the Physician’s prescribed medical plans of care. Using service excellence standards, conducts Hourly Rounds. Fosters an environment that demonstrates caring, compassion, and respect for all patients, families, and visitors. Contributes to the department growth and performance through hospital-system initiatives cultivating nursing involved Evidence Based Practices. Demonstrates continued professional growth through setting goals and participating in educational offerings.
Schedule: Full time; 80 hours biweekly; Monday - Friday 7:00am - 3:30pm with call
Required Education/Experience
- Graduate from an accredited registered nursing program
- Must possess a valid South Carolina or compact (multi-state) RN license.
- This position requires an active Basic Life Support certification, as well as additional certifications per unit requirements.
- Experience in Neuro-interventional procedures, OR, interventional radiology, ICU required.
If you would enjoy working in a dynamic environment and are looking for an opportunity to become part of a stellar team of professionals, we invite you to apply online today. We are an equal opportunity employer.
Founded in 1906, McLeod Health is a locally owned and managed, not for profit organization supported by the strength of more than 900 members on its medical staff and more than 2,900 licensed nurses. McLeod Health is also composed of approximately 15,000 team members and more than 90 physician practices throughout its 18-county service area. With seven hospitals, McLeod Health operates three Health and Fitness Centers, a Sports Medicine and Outpatient Rehabilitation Center, Hospice and Home Health Services. The system currently has 988 licensed beds, including Hospice and Behavioral Health. The hospitals within McLeod Health include: McLeod Regional Medical Center, McLeod Health Dillon, McLeod Health Loris, McLeod Health Seacoast, McLeod Health Cheraw, McLeod Health Clarendon and McLeod Behavioral Health.
Staff Nurse - Neuro Endovascular
- $25,000 Sign On Bonus Available
Essential Functions
Assesses needs of patients as assigned based on data collected through history, observation, physical examination, and analysis of diagnostic data. Provides appropriate nursing interventions, consistent with the Plan of Care and standards of practice, incorporating the Physician’s prescribed medical plans of care. Using service excellence standards, conducts Hourly Rounds. Fosters an environment that demonstrates caring, compassion, and respect for all patients, families, and visitors. Contributes to the department growth and performance through hospital-system initiatives cultivating nursing involved Evidence Based Practices. Demonstrates continued professional growth through setting goals and participating in educational offerings.
Schedule: Full time; 80 hours biweekly; Monday - Friday 7:00am - 3:30pm with call
Required Education/Experience
- Graduate from an accredited registered nursing program
- Must possess a valid South Carolina or compact (multi-state) RN license.
- This position requires an active Basic Life Support certification, as well as additional certifications per unit requirements.
- Experience in Neuro-interventional procedures, OR, interventional radiology, ICU required.
If you would enjoy working in a dynamic environment and are looking for an opportunity to become part of a stellar team of professionals, we invite you to apply online today. We are an equal opportunity employer.
Founded in 1906, McLeod Health is a locally owned and managed, not for profit organization supported by the strength of more than 900 members on its medical staff and more than 2,900 licensed nurses. McLeod Health is also composed of approximately 15,000 team members and more than 90 physician practices throughout its 18-county service area. With seven hospitals, McLeod Health operates three Health and Fitness Centers, a Sports Medicine and Outpatient Rehabilitation Center, Hospice and Home Health Services. The system currently has 988 licensed beds, including Hospice and Behavioral Health. The hospitals within McLeod Health include: McLeod Regional Medical Center, McLeod Health Dillon, McLeod Health Loris, McLeod Health Seacoast, McLeod Health Cheraw, McLeod Health Clarendon and McLeod Behavioral Health.
See All 8 RN Staff Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find RN Staff Nurse JobsRN Staff Nurse Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
RN Staff Nurse Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- McLeod Health4
- Medical University of South Carolina2
- Self Regional Healthcare2
Top Industries Hiring
- Healthcare & Medical Services7
- Education1
What South Carolina Employers Look For
The qualifications that appear most often in RN staff nurse jobs across South Carolina.
- Active RN license in the state of employment or a compact multistate license
- Current BLS certification required, ACLS often required for acute care settings
- Associate or Bachelor of Science in Nursing from an accredited program
- Minimum one to two years of clinical experience in a relevant care setting
- Proficiency with electronic health record systems such as Epic or Cerner
- Ability to assess, plan, implement, and evaluate patient care in fast-paced environments
RN Staff Nurse Jobs in South Carolina: Frequently Asked Questions
How many RN staff nurse jobs are there in South Carolina?
There are 8+ RN staff nurse openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Florence, Charleston, and Edgefield. New positions post regularly as employers across South Carolina hire.
How much do RN staff nurses make in South Carolina?
RN staff nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Carolina cities have the most RN staff nurse jobs?
Florence, Charleston, and Edgefield have the most RN staff nurse openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire RN staff nurses in South Carolina?
Employers hiring RN staff nurses in South Carolina include McLeod Health, Medical University of South Carolina, and Self Regional Healthcare, based on current listings on Migrate Mate as of June 2026.
Are there remote RN staff nurse jobs in South Carolina?
Yes. About 0% of RN staff nurse openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for RN staff nurse jobs in South Carolina?
You can apply to RN staff nurse jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 8 RN Staff Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find RN Staff Nurse Jobs