Medical Assistant Jobs in South Carolina

Medical assistant jobs in South Carolina are in strong and consistent demand, with the bulk of openings concentrated in outpatient clinics, physician practices, and urgent care networks serving a fast-growing population. Columbia, Greenville, and Charleston are the primary hiring metros, anchored by large systems like Prisma Health, MUSC Health, and Novant Health. The most sought-after specialties are family medicine, pediatrics, and orthopedics, with entry-level through senior clinical roles all actively recruiting. Find a role that fits below and apply directly.

Find Medical Assistant Jobs

Overview

Open roles55
Top employerPrisma Health Urgent Care
Top cityMyrtle Beach, SC
Cities hiring27
Work type93% On-site
Top industryHealthcare

Showing 5 of 55+ Medical Assistant jobs

Medical Support Assistant (Advanced)
We won't show you this job again
New 2h ago
Medical Support Assistant (Advanced)
US Department of Veterans Affairs
Anderson, South Carolina
Allied Health
Healthcare Administration
Mental & Behavioral Health
Social Work & Counseling
$50k - $69k/yr
On-Site
High school diploma or GED
10,000+

Have you applied for this role?

Certified Medical Assistant
We won't show you this job again
New 4h ago
Certified Medical Assistant
Natasha Thomas MD
Myrtle Beach, South Carolina
Healthcare Administration
Medical Assistant
Patient Services & Wellbeing
$19 - $25/hr
On-Site

Have you applied for this role?

Certified Medical Assistant
We won't show you this job again
New 4h ago
Certified Medical Assistant
Caribbean Fusion Restaurant and Grocery
Simpsonville, South Carolina
Healthcare Administration
Medical Assistant
Patient Services & Wellbeing
$19 - $25/hr
On-Site
Associate's degree

Have you applied for this role?

Medical Assistant Certified (CMA) - Sweetgrass Endocrinology - Roper Medical Office Building
We won't show you this job again
New 4h ago
Medical Assistant Certified (CMA) - Sweetgrass Endocrinology - Roper Medical Office Building
Roper St. Francis Healthcare
Charleston, South Carolina
Business Operations
Program Management
Project Management
CCMA Certification
1,001-5,000

Have you applied for this role?

Medical Assistant
We won't show you this job again
New 14h ago
Medical Assistant
Summerville Women's Care
Summerville, South Carolina
Clinical Support
Healthcare Administration
Medical Specialists

Have you applied for this role?

See All 55 Medical Assistant Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Medical Assistant Jobs

Medical Assistant Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Myrtle Beach
7 jobs
Charleston
5 jobs
Greenville
4 jobs
North Charleston
4 jobs
Columbia
3 jobs
Spartanburg
3 jobs
Greer
2 jobs
Easley
2 jobs
Anderson
2 jobs

Medical Assistant Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

Prisma Health Urgent Care8 open roles
US Department of Veterans Affairs4 open roles
CareNow2 open roles

Top Industries Hiring

  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in medical assistant jobs across South Carolina.

  • Completion of an accredited medical assistant program or equivalent education recognized in South Carolina
  • Certification as a CMA through AAMA or RMA through AMT preferred or required
  • Demonstrated proficiency in clinical skills including vital signs, phlebotomy, and EKG administration
  • Experience with electronic health records, commonly Epic or Athenahealth used by South Carolina systems
  • Strong communication skills for patient-facing roles in high-volume South Carolina clinic environments
  • CPR and Basic Life Support certification current and maintained throughout employment

Medical Assistant Jobs in South Carolina: Frequently Asked Questions

How do you become a medical assistant in South Carolina?

South Carolina does not require a state-issued license for medical assistants, so the path to employment runs through education and voluntary national certification. Most South Carolina employers expect candidates to have completed an accredited medical assistant program, typically offered at community colleges such as Trident Technical, Midlands Technical, and Greenville Technical. Earning a Certified Medical Assistant credential through the American Association of Medical Assistants or a Registered Medical Assistant credential through American Medical Technologists gives candidates a clear competitive advantage in local hiring.

How much do medical assistants make in South Carolina?

Medical assistants in South Carolina earn a median of about $41,160 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $34,730 for the lowest 10% to over $49,110 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire medical assistants in South Carolina?

Employers hiring medical assistants in South Carolina right now include Prisma Health Urgent Care, US Department of Veterans Affairs, and CareNow, based on current listings on Migrate Mate as of October 2026. South Carolina's large integrated health systems, including Prisma Health and MUSC Health, consistently post the highest volume of openings across both urban and rural clinic locations.

Which South Carolina cities have the most medical assistant jobs?

Myrtle Beach, Charleston, and Greenville account for the largest share of medical assistant openings in South Carolina. Columbia leads because of its concentration of Prisma Health and MUSC-affiliated outpatient facilities, Greenville's growth reflects the expansion of Prisma Health Upstate and Bon Secours, and Charleston's position is driven by MUSC Health's flagship campus and the region's strong population growth attracting new specialty practices.

Are there remote medical assistant jobs in South Carolina?

Yes, but they're rare. Medical assisting is a hands-on clinical role built around direct patient contact, so the large majority of positions require an on-site presence in a clinic or practice. About 7% of medical assistant openings tied to South Carolina are remote or hybrid as of October 2026, and those positions are almost exclusively in administrative or telehealth triage functions rather than traditional clinical duties.

How can I get hired as a medical assistant in South Carolina with little or no experience?

The most realistic entry path is completing an accredited medical assistant program at a South Carolina community college, then applying directly to large health systems that routinely hire new graduates. Prisma Health and MUSC Health both employ medical assistants at the entry level across their ambulatory care networks and often onboard candidates with externship experience gained during their training programs. Moving into a medical assistant role from a patient care technician, phlebotomist, or certified nursing assistant position is also a common lateral step, and holding a current CMA or RMA credential strengthens any entry-level application.

Where can I find and apply to medical assistant jobs in South Carolina?

You can find and apply to medical assistant jobs in South Carolina on Migrate Mate, which lists current openings from employers hiring in the state right now. Search the available roles, find the ones that match your experience and location, and apply directly to each one.

See All 55 Medical Assistant Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Medical Assistant Jobs