Medical Assistant Jobs in South Carolina

Medical assistant jobs in South Carolina are in strong and consistent demand, with the bulk of openings concentrated in outpatient clinics, physician practices, and urgent care networks serving a fast-growing population. Columbia, Greenville, and Charleston are the primary hiring metros, anchored by large systems like Prisma Health, MUSC Health, and Novant Health. The most sought-after specialties are family medicine, pediatrics, and orthopedics, with entry-level through senior clinical roles all actively recruiting. Find a role that fits below and apply directly.

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Overview

Open roles57
Top employerPrisma Health
Top cityRock Hill, SC
Cities hiring24
Work type100% On-site
Top industryHealthcare

Showing 5 of 57+ Medical Assistant jobs

US Department of Veterans Affairs
Medical Support Assistant
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US Department of Veterans Affairs
Added 1d ago
Medical Support Assistant
US Department of Veterans Affairs
Charleston, South Carolina
Customer Service
Customer Support
Hospitality & Guest Services
$36k - $58k/yr
On-Site
High school
10,000+

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Prisma Health
Nurse Practitioner / Physician Assistant - Seneca Medical Associates
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Prisma Health
Added 1d ago
Nurse Practitioner / Physician Assistant - Seneca Medical Associates
Prisma Health
Seneca, South Carolina
Compliance & Risk
Project Management
Quality Assurance & Testing (QA Testing)
Master's degree in nursing
10,000+

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Doctors Care
Greer Certified Medical Assistant/ LPN PRN
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Doctors Care
Added 1d ago
Greer Certified Medical Assistant/ LPN PRN
Doctors Care
Greer, South Carolina
IT Support
Project Management
Technical Program Management
CPR Certification
1,001-5,000

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P
Clinical Services Rep. Medical Assistant (Gaffney)
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Added 1d ago
Clinical Services Rep. Medical Assistant (Gaffney)
Prisma Health Urgent Care
Gaffney, South Carolina
Administrative & Office Support
Customer Service
Human Resources
EMT Certification

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Clinical Services Rep. Medical Assistant (Anderson)
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Added 1d ago
Clinical Services Rep. Medical Assistant (Anderson)
Prisma Health Urgent Care
Anderson, South Carolina
Clinical Support
Healthcare Administration
Patient Services & Wellbeing
EMT Certification

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See All 57 Medical Assistant Jobs in South Carolina

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Medical Assistant Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Rock Hill
9 jobs
Greenville
7 jobs
Charleston
4 jobs
North Charleston
4 jobs
West Columbia
3 jobs
Mount Pleasant
3 jobs
Greer
2 jobs
Conway
2 jobs
Sumter
2 jobs

Medical Assistant Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

Prisma Health
Prisma Health7 open roles
Advocate Aurora Health
Advocate Aurora Health6 open roles
Roper St. Francis Healthcare
Roper St. Francis Healthcare6 open roles

Top Industries Hiring

  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in medical assistant jobs across South Carolina.

  • Completion of an accredited medical assistant program or equivalent education recognized in South Carolina
  • Certification as a CMA through AAMA or RMA through AMT preferred or required
  • Demonstrated proficiency in clinical skills including vital signs, phlebotomy, and EKG administration
  • Experience with electronic health records, commonly Epic or Athenahealth used by South Carolina systems
  • Strong communication skills for patient-facing roles in high-volume South Carolina clinic environments
  • CPR and Basic Life Support certification current and maintained throughout employment

Medical Assistant Jobs in South Carolina: Frequently Asked Questions

How do you become a medical assistant in South Carolina?

South Carolina does not require a state-issued license for medical assistants, so the path to employment runs through education and voluntary national certification. Most South Carolina employers expect candidates to have completed an accredited medical assistant program, typically offered at community colleges such as Trident Technical, Midlands Technical, and Greenville Technical. Earning a Certified Medical Assistant credential through the American Association of Medical Assistants or a Registered Medical Assistant credential through American Medical Technologists gives candidates a clear competitive advantage in local hiring.

How much do medical assistants make in South Carolina?

Medical assistants in South Carolina earn a median of about $41,160 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $34,730 for the lowest 10% to over $49,110 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire medical assistants in South Carolina?

Employers hiring medical assistants in South Carolina right now include Prisma Health, Advocate Aurora Health, and Roper St. Francis Healthcare, based on current listings on Migrate Mate as of August 2026. South Carolina's large integrated health systems, including Prisma Health and MUSC Health, consistently post the highest volume of openings across both urban and rural clinic locations.

Which South Carolina cities have the most medical assistant jobs?

Rock Hill, Greenville, and Charleston account for the largest share of medical assistant openings in South Carolina. Columbia leads because of its concentration of Prisma Health and MUSC-affiliated outpatient facilities, Greenville's growth reflects the expansion of Prisma Health Upstate and Bon Secours, and Charleston's position is driven by MUSC Health's flagship campus and the region's strong population growth attracting new specialty practices.

Are there remote medical assistant jobs in South Carolina?

Yes, but they're rare. Medical assisting is a hands-on clinical role built around direct patient contact, so the large majority of positions require an on-site presence in a clinic or practice. About 0% of medical assistant openings tied to South Carolina are remote or hybrid as of August 2026, and those positions are almost exclusively in administrative or telehealth triage functions rather than traditional clinical duties.

How can I get hired as a medical assistant in South Carolina with little or no experience?

The most realistic entry path is completing an accredited medical assistant program at a South Carolina community college, then applying directly to large health systems that routinely hire new graduates. Prisma Health and MUSC Health both employ medical assistants at the entry level across their ambulatory care networks and often onboard candidates with externship experience gained during their training programs. Moving into a medical assistant role from a patient care technician, phlebotomist, or certified nursing assistant position is also a common lateral step, and holding a current CMA or RMA credential strengthens any entry-level application.

Where can I find and apply to medical assistant jobs in South Carolina?

You can find and apply to medical assistant jobs in South Carolina on Migrate Mate, which lists current openings from employers hiring in the state right now. Search the available roles, find the ones that match your experience and location, and apply directly to each one.

See All 57 Medical Assistant Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Medical Assistant Jobs