Medical Director Jobs in Cambridge, MA
Medical Director jobs in Cambridge, Massachusetts are in strong demand, concentrated in Kendall Square, East Cambridge, and the Longwood Medical Area corridor, with openings across biopharmaceuticals, academic medicine, and health technology. Employers hiring right now include Takeda Pharmaceuticals, Biogen, and AstraZeneca. Find a role that fits below and apply directly.
Find Medical Director JobsOverview
Showing 5 of 200+ Medical Director jobs
Job Title: Global Development Senior Medical Director, Hematology Oncology
Hybrid Working: In the office a minimum of 3 days per week
Location: This Senior Medical Director role is posted in Boston, although we are willing to consider candidates in these Hematology locations: Gaithersburg, South San Francisco, California; Barcelona, Spain.
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. We are more than one of the world’s leading pharmaceutical companies.
AstraZeneca has a multifaceted environment that cultivates collaboration and innovation. We attract top minds, and we nurture and build talent.
Within Hematology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs
The Senior Global Development Medical Director is an important part of the Clinical Project Team (CPT), and Global Study Team (GST) working synergistically and cross functionally (in a matrix environment) with other CPT, GST and GPT members, Site Management & Monitoring (SMM), field-based liaisons, and site personnel. The Senior Global Development Medical Director and counterpart Global Development Scientist work collaboratively in the clinical aspects underpinning a product. Accountabilities include clinical support for the development and implementation of early and/or late phase AstraZeneca sponsored clinical program strategies, including providing scientific input into design & implementation of clinical trial(s), their delivery, clinical data review, interpretation of results, reporting successfully on time, and activities required for worldwide registration of the product (i.e. clinical input to (s)NDA/(s)BLA).
The Senior Global Development Medical Director plays a critical role in the medical monitoring of a clinical study ensuring safety to patients. They share responsibility with Clinical Operations team members in the planning, execution and closure of a clinical study. The Senior Global Development Medical Director may also provide expert input or lead functional process improvement initiatives and provide contributions to cross-asset, cross-indication working groups depending on the level of experience.
This position demands strong collaborative communication skills, including the ability to engage with and influence a diverse range of stakeholders both within and external to AstraZeneca. The individual will operate according to the highest ethical standards in compliance with internal SOPs, local regulations, laws and adhere to Good Clinical Practice and regulatory requirements.
Depending upon experience level, the role will mentor the development of less experienced members of the clinical team, and may involve direct line management of other physicians or scientists.
- Responsible for the ensuring the risk-benefit of a clinical study, ensuring that all clinical studies operate to the highest ethical and safety standards and in compliance FDA, EMEA, ICH and GCP guidelines as well as AZ SOPs regarding safety
- Work cross-functionally and lead all aspects of the design and implementation of clinical hemato-oncology projects, as leader of our Clinical Product Team (CPT) and member of the Clinical Sub-Team (CST). Ensure that the overall scientific and medical content of all clinical programs is scientifically and clinically rigorous.
- Significant contributor to the development of program strategy for assigned compound(s)/programs and work with GPT/CPT members to develop a compelling business case for governance approval
- Provide expert clinical input to influence the study design via collaboration with primary investigators, key external experts (KEE), study sites, team members, and internal stakeholders, such that it reflects clinical practice, evolving landscape, regulatory and reimbursement requirements, and meets the strategic program objectives.
- Participate or lead as needed the review and assessment of new opportunities and ESRs.
- Accountable for the relevance and accuracy of clinical science underpinning of clinical study based on detailed scientific review and consultation, for the clinical and scientific leadership and integrity of protocols and/or components of clinical plans and for the delivery of final protocol and its governance approval.
- Provides expert input into/lead the development of the protocol and related documents and the development and delivery of the clinical study report
- Full responsibility for the planning, implementation and daily operation of assigned drug development projects in hemato-oncology.
- Supports or leads interactions with global medical affairs, marketing companies, commercial, in collaboration with GCH/GCPL to ensure cross functional input into protocols.
- Responsible for timely responses to investigational study sites for local ICF changes, protocol & EC/IRB questions/requests. Contribute to development and delivery of face to face or virtual investigator and monitor training.
- Support the development of clinical components of regulatory and EC/IRB submission documents for instances where marketing approval is warranted
- Prepare clinical development plans that integrate pre-clinical and early clinical findings while working to ensure cross-functional alignment on an ongoing basis throughout the early phases of clinical development.
- Present and defend protocols and clinical development plans at internal governance forums.
- Serve as Medical Monitor, responsible for the safety monitoring of clinical trials, and as medical expert for Phase I/II or Phase III studies, innovating the process from protocol development thorough individual study report and coordinated regulatory documentation.
- Prepare various official and regulatory documents for Regulatory and other agencies, such as Dossiers, BLAs, INDs, Safety and Annual reports, handling of responses to regulatory agencies regarding questions about complex clinical development issues (e.g., safety or efficacy).
- Implement clinical R&D policies, SOPs and related directives.
- Review potential in-licensing candidates and present recommendations to Senior Management groups.
- Support any needed due diligence and prepare/present medically sound strategy and plans associated with advanced opportunities.
- Contribute and support Department/Clinical initiatives to improve the quality and content of all clinical programs as well as the cross functional/organization processes designed to effectively deliver our R&D portfolio.
- Serve as mentor of less experienced staff that may include physicians or scientists
Minimum Requirements:
- MD or international equivalent is required
- Medical hemato-oncology clinical training is required
- Minimum of 4 years of relevant experience
- Board Certification is preferred
- Significant clinical research experience (in industry, academic or CRO environment) related to drug development, design and/or conduct of clinical studies in oncology and/or malignant hematology is required.
- Possesses detailed knowledge of Good Clinical Practice (GCP) and other regulations governing clinical research.
- Possesses general knowledge of 1) medical monitoring; 2) Regulatory approval process in relevant countries; 3) pharmaceutical industry/R&D operations; 4) marketing and commercial fundamentals.
- Drug Development/Clinical Development Planning: Demonstrates a proven ability to both independently complete, and lead peers in completion in components of complex plans, related documents, appropriate methodologies, measures, analytical plans and evaluation tools.
- Strong communication & presentation skills to clearly communicate scientific concepts /data to leadership committees both internally or externally
Working at AstraZeneca
Here you’ll have the chance to create a substantial difference to patients’ lives! With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and crafting the patient ecosystem.
Next Steps? !
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
The annual base pay ranges from $288,059.20 - 432,088.80 Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Find out more and follow AstraZeneca on:
LinkedIn https://www.linkedin.com/company/1603/
Facebook https://www.facebook.com/astrazenecacareers/
Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
Date Posted
22-Oct-2026Closing Date
30-Oct-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
Job Title: Global Development Senior Medical Director, Hematology Oncology
Hybrid Working: In the office a minimum of 3 days per week
Location: This Senior Medical Director role is posted in Boston, although we are willing to consider candidates in these Hematology locations: Gaithersburg, South San Francisco, California; Barcelona, Spain.
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. We are more than one of the world’s leading pharmaceutical companies.
AstraZeneca has a multifaceted environment that cultivates collaboration and innovation. We attract top minds, and we nurture and build talent.
Within Hematology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs
The Senior Global Development Medical Director is an important part of the Clinical Project Team (CPT), and Global Study Team (GST) working synergistically and cross functionally (in a matrix environment) with other CPT, GST and GPT members, Site Management & Monitoring (SMM), field-based liaisons, and site personnel. The Senior Global Development Medical Director and counterpart Global Development Scientist work collaboratively in the clinical aspects underpinning a product. Accountabilities include clinical support for the development and implementation of early and/or late phase AstraZeneca sponsored clinical program strategies, including providing scientific input into design & implementation of clinical trial(s), their delivery, clinical data review, interpretation of results, reporting successfully on time, and activities required for worldwide registration of the product (i.e. clinical input to (s)NDA/(s)BLA).
The Senior Global Development Medical Director plays a critical role in the medical monitoring of a clinical study ensuring safety to patients. They share responsibility with Clinical Operations team members in the planning, execution and closure of a clinical study. The Senior Global Development Medical Director may also provide expert input or lead functional process improvement initiatives and provide contributions to cross-asset, cross-indication working groups depending on the level of experience.
This position demands strong collaborative communication skills, including the ability to engage with and influence a diverse range of stakeholders both within and external to AstraZeneca. The individual will operate according to the highest ethical standards in compliance with internal SOPs, local regulations, laws and adhere to Good Clinical Practice and regulatory requirements.
Depending upon experience level, the role will mentor the development of less experienced members of the clinical team, and may involve direct line management of other physicians or scientists.
- Responsible for the ensuring the risk-benefit of a clinical study, ensuring that all clinical studies operate to the highest ethical and safety standards and in compliance FDA, EMEA, ICH and GCP guidelines as well as AZ SOPs regarding safety
- Work cross-functionally and lead all aspects of the design and implementation of clinical hemato-oncology projects, as leader of our Clinical Product Team (CPT) and member of the Clinical Sub-Team (CST). Ensure that the overall scientific and medical content of all clinical programs is scientifically and clinically rigorous.
- Significant contributor to the development of program strategy for assigned compound(s)/programs and work with GPT/CPT members to develop a compelling business case for governance approval
- Provide expert clinical input to influence the study design via collaboration with primary investigators, key external experts (KEE), study sites, team members, and internal stakeholders, such that it reflects clinical practice, evolving landscape, regulatory and reimbursement requirements, and meets the strategic program objectives.
- Participate or lead as needed the review and assessment of new opportunities and ESRs.
- Accountable for the relevance and accuracy of clinical science underpinning of clinical study based on detailed scientific review and consultation, for the clinical and scientific leadership and integrity of protocols and/or components of clinical plans and for the delivery of final protocol and its governance approval.
- Provides expert input into/lead the development of the protocol and related documents and the development and delivery of the clinical study report
- Full responsibility for the planning, implementation and daily operation of assigned drug development projects in hemato-oncology.
- Supports or leads interactions with global medical affairs, marketing companies, commercial, in collaboration with GCH/GCPL to ensure cross functional input into protocols.
- Responsible for timely responses to investigational study sites for local ICF changes, protocol & EC/IRB questions/requests. Contribute to development and delivery of face to face or virtual investigator and monitor training.
- Support the development of clinical components of regulatory and EC/IRB submission documents for instances where marketing approval is warranted
- Prepare clinical development plans that integrate pre-clinical and early clinical findings while working to ensure cross-functional alignment on an ongoing basis throughout the early phases of clinical development.
- Present and defend protocols and clinical development plans at internal governance forums.
- Serve as Medical Monitor, responsible for the safety monitoring of clinical trials, and as medical expert for Phase I/II or Phase III studies, innovating the process from protocol development thorough individual study report and coordinated regulatory documentation.
- Prepare various official and regulatory documents for Regulatory and other agencies, such as Dossiers, BLAs, INDs, Safety and Annual reports, handling of responses to regulatory agencies regarding questions about complex clinical development issues (e.g., safety or efficacy).
- Implement clinical R&D policies, SOPs and related directives.
- Review potential in-licensing candidates and present recommendations to Senior Management groups.
- Support any needed due diligence and prepare/present medically sound strategy and plans associated with advanced opportunities.
- Contribute and support Department/Clinical initiatives to improve the quality and content of all clinical programs as well as the cross functional/organization processes designed to effectively deliver our R&D portfolio.
- Serve as mentor of less experienced staff that may include physicians or scientists
Minimum Requirements:
- MD or international equivalent is required
- Medical hemato-oncology clinical training is required
- Minimum of 4 years of relevant experience
- Board Certification is preferred
- Significant clinical research experience (in industry, academic or CRO environment) related to drug development, design and/or conduct of clinical studies in oncology and/or malignant hematology is required.
- Possesses detailed knowledge of Good Clinical Practice (GCP) and other regulations governing clinical research.
- Possesses general knowledge of 1) medical monitoring; 2) Regulatory approval process in relevant countries; 3) pharmaceutical industry/R&D operations; 4) marketing and commercial fundamentals.
- Drug Development/Clinical Development Planning: Demonstrates a proven ability to both independently complete, and lead peers in completion in components of complex plans, related documents, appropriate methodologies, measures, analytical plans and evaluation tools.
- Strong communication & presentation skills to clearly communicate scientific concepts /data to leadership committees both internally or externally
Working at AstraZeneca
Here you’ll have the chance to create a substantial difference to patients’ lives! With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and crafting the patient ecosystem.
Next Steps? !
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
The annual base pay ranges from $288,059.20 - 432,088.80 Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Find out more and follow AstraZeneca on:
LinkedIn https://www.linkedin.com/company/1603/
Facebook https://www.facebook.com/astrazenecacareers/
Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
Date Posted
22-Oct-2026Closing Date
30-Oct-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
See All 200+ Medical Director Jobs in Cambridge
Find roles in Cambridge that match your experience and apply in just a few clicks.
Find Medical Director JobsMedical Director Job Market in Cambridge
Who's Hiring
- Takeda Pharmaceuticals34
- Biogen23
- AstraZeneca17
- IPSEN11
- Editas Medicine11
Top Industries Hiring
- Healthcare & Medical Services
- Biotechnology & Pharmaceuticals
Medical Director Jobs in Cambridge: Frequently Asked Questions
How do I get a medical director job in Cambridge?
The strongest path into a medical director role in Cambridge is through the city's biotech and pharmaceutical corridor in Kendall Square, where clinical development and medical affairs positions are especially active. Candidates with direct therapeutic area expertise, experience presenting to regulatory bodies, or a background at a Cambridge-area academic medical center tend to stand out. Building visibility through local clinical networks and biotech-focused professional communities accelerates the search considerably.
Which companies hire medical directors in Cambridge?
Employers hiring medical directors in Cambridge right now include Takeda Pharmaceuticals, Biogen, and AstraZeneca, based on current listings on Migrate Mate as of October 2026. Cambridge's employer base skews heavily toward life sciences companies, from early-stage biotechs to large pharmaceutical and medical device firms, alongside academic health systems affiliated with nearby research institutions.
Are there remote medical director jobs in Cambridge?
Yes, though with limits. Medical director roles that are primarily clinical or site-based require on-site presence, while medical affairs, regulatory, and health economics positions are more commonly remote-eligible. About 78% of medical director openings tied to Cambridge are remote or hybrid as of October 2026, reflecting the desk-intensive nature of many biotech and pharma roles. Strategic and advisory functions tend to be the most location-flexible.
How can I get a medical director job in Cambridge with little or no experience?
The most realistic entry path in Cambridge is through a medical science liaison or clinical research physician role at one of the area's many early-stage biotech companies, which often promote internally as programs advance. Cambridge's dense pipeline of Series B and Series C companies frequently hire physicians transitioning from academic or clinical practice into industry for the first time. Fellowship programs at affiliated academic institutions can also bridge clinical training into a first industry medical director title.
Which industries hire the most medical directors in Cambridge?
The sectors hiring the most medical directors in Cambridge are Healthcare & Medical Services and Biotechnology & Pharmaceuticals, based on current listings on Migrate Mate as of October 2026. Cambridge's concentration of biotech headquarters, pharmaceutical research campuses, and health technology startups in and around Kendall Square makes it one of the most active markets nationally for physician leaders in industry roles.
Related Jobs in Massachusetts
See All 200+ Medical Director Jobs in Cambridge
Find roles in Cambridge that match your experience and apply in just a few clicks.
Find Medical Director Jobs